Preliminary vegetation map of the Espenberg Peninsula, Alaska, based on an Earth Resources Technology Satellite image

There are no author-identified significant results in this report

Effects of Quasi-Static Aberrations in Faint Companion Searches

We present the first results obtained at CFHT with the TRIDENT infrared camera, dedicated to the detection of faint companions close to bright nearby stars. The camera's main feature is the acquisition of three simultaneous images in three wavelengths (simultaneous differential imaging) across the methane absorption bandhead at 1.6 micron, that enables a precise subtraction of the primary star PSF while keeping the companion signal. The main limitation is non-common path aberrations between the three optical paths that slightly decorrelate the PSFs. Two types of PSF calibrations are combined with the differential simultaneous imaging technique to further attenuate the PSF: reference star subtraction and instrument rotation to smooth aberrations. It is shown that a faint companion with a DeltaH of 10 magnitudes would be detected at 0.5 arcsec from the primary.Comment: 12 pages, 10 figures, to appear in Astronomy with High Contrast Imaging, EAS Publications Serie

Airboat Use and Disturbance of Floating Mat Fen Wetlands in Interior Alaska, U.S.A.

The use of airboats is expanding in Alaska, particularly in the interior. This study describes the nature, magnitude, and distribution of disturbance caused by airboat trails over floating mat fen wetlands in the Tanana Flats near Fairbanks, Alaska. Airphoto interpretation showed over 300 km of airboat trails by 1995, with a 15% expansion of the trail system since 1989. Field sampling was done at 30 trail and adjacent control sites along this trail system to assess changes in hydrology, soils, and vegetation. Water velocities in the trails at two-thirds of the sites were at least an order of magnitude greater than velocities of less than 1.5 cm/sec in the control areas. On average, 30 cm of the 0.5-0.75 m thick floating mat has been removed or eroded by airboat traffic at the sampling locations. Nearly all emergent floating mat vegetation has been destroyed (5% cover remaining on average) so that the trails resemble a highly visible open water stream channel 2-3 m wide through the floating mats. Although the recovery and regrowth potential of floating mats in trails is high, recovery is unlikely in trails with continuing use.En Alaska, l'utilisation des hydroglisseurs est à la hausse, surtout à l'intérieur des terres. Cette étude décrit la nature, l'amplitude et la distribution des perturbations causées par le sillage des hydroglisseurs sur les zones humides de vasières à mattes flottantes situées dans les plaines marécageuses de Tanana près de Fairbanks (en Alaska). L'interprétation de photos a montré que, en 1995, les sillages d'hydroglisseurs s'étendaient sur plus de 300 km, ce qui correspond à une augmentation de 15 p. cent du réseau depuis 1989. On a procédé à un échantillonnage sur le terrain à 30 emplacements de sillages et aires témoins adjacentes le long du réseau en vue d'évaluer les changements dans l'hydrologie, les sols et la végétation. Dans deux tiers des emplacements, la vitesse de l'eau dans les sillages était d'au moins un ordre de grandeur supérieure aux vitesses de moins de 1,5 cm/sec dans les zones témoins. Aux endroits d'échantillonnage, 30 cm en moyenne de la matte flottante épaisse de 0,5 à 0,75 m a été enlevée ou érodée par la circulation de l'hydroglisseur. Presque toute la végétation de la matte flottante émergée a été détruite (il reste en moyenne 5 p. cent du couvert) de sorte que les sillages sont très visibles et forment un chenal d'eau ouverte de 2 à 3 m de large à travers les mattes flottantes. Bien que le potentiel de recouvrement et de repousse des mattes flottantes dans les sillages soit élevé, il est peu probable que ce recouvrement ait lieu dans les sillages qui sont utilisés de façon continue

Quelle régulation pour l’arrêt d’un protocole de recherche clinique de thérapie génique somatique ? État des lieux auprès des cliniciens-chercheurs européens

Depuis 2002, le débat sur les risques associés à la thérapie génique est initié suite à l’annonce que deux enfants inclus dans un essai thérapeutique impliquant une thérapie génique ont développé des effets indésirables important. En Janvier 2005, le débat sur les risques reprit suite à l’interruption du protocole sur les enfants bulle du Pr Fischer à l’hôpital Necker de Paris. Nous avons donc étudié le processus impliqué ainsi que la réflexion éthique associée aux décisions d’arrêt de protocole de recherche. Notre travail a été mené par une équipe pluridisciplinaire combinant chercheurs en santé, généticiens et éthiciens. Nous avons étudié la participation des chercheurs, des patients, des institutions officielles, des comités d’éthique ainsi que des associations de patients dans le processus de décision d’interruption d’un protocole de recherche.Nous avons également analysé les critères jugés les plus pertinents dans l’arrêt d’un protocole de recherche. Enfin nous avons analysé le point de vue des personnes directement impliquées dans la thérapie génique au moyen d’un questionnaire. Toutes les personnes contactées ont présenté un poster de recherche au congrès de la Société Européenne de Thérapie Génique. 62 personnes d’autant d’équipes de recherche différentes, de 17 pays, sur les 350 contactés ont répondu. Selon eux, la décision d’arrêt d’un protocole de recherche doit être prise suite à une consultation des chercheurs, des patients, du ministère de tutelle, d’une agence nationale de régulation ou d’un comité d’éthique ; la légitimité étant accordée à des décisions prises en commun par les chercheurs, les patients et les comités d’éthique. Les incidents sérieux et de façon plus surprenante, les incidents moins graves sont jugés comme étant des critères suffisants pour interrompre un essai. Nous avons fini par analyser les conséquences éthiques, telles que balance bénéfice/risque, processus de régulation ou responsabilité, de ces critères sur l’arrêt d’un protocole de recherche.In 2002, the debate on the risks of gene therapy was initiated following the annoucement that two children included in a clinical trial developed serious adverse effects. In January 2005, the debate was reignited following the interruption of the “bubble kids protocol” at the Hôpital Necker in Paris. We have thus investigated the ethical stakes involved in decisions to stop protocols. This work was carried out by a multidisciplinary team combining ethics researchers and geneticists. We studied the specific participation of researchers, patients, official institution, ethics committees and patient associations in the processes that can lead to an interruption of trial.We also analysed the criterion judged most relevant for halting a trial. Finally, we analyzed the perspective of the actors implicated directly in the provision of gene therapy, by means of a questionnaire. All the individuals contacted had presented a scientific poster at the European Society of Gene Therapy. 62 out of 350 persons, from 17 countries, responded to our questionnaire. According to these respondants, decisions to stop a trial should be taken after consultation with researchers, patients, the ministry, national agencies or ethics committees. Legitimacy was accorded to joint decision-making by researchers, patients and committees. Serious incidents, and surprisingly less serious incidents, clearly emerge as criterion for stopping a trial. We conclude by analyzing the ethical consequences, such as risk/benefit ratios, regulatory processes and responsibility, associated with these criterions and decisions to stop a trial

Hamiltonian of a spinning test-particle in curved spacetime

Using a Legendre transformation, we compute the unconstrained Hamiltonian of a spinning test-particle in a curved spacetime at linear order in the particle spin. The equations of motion of this unconstrained Hamiltonian coincide with the Mathisson-Papapetrou-Pirani equations. We then use the formalism of Dirac brackets to derive the constrained Hamiltonian and the corresponding phase-space algebra in the Newton-Wigner spin supplementary condition (SSC), suitably generalized to curved spacetime, and find that the phase-space algebra (q,p,S) is canonical at linear order in the particle spin. We provide explicit expressions for this Hamiltonian in a spherically symmetric spacetime, both in isotropic and spherical coordinates, and in the Kerr spacetime in Boyer-Lindquist coordinates. Furthermore, we find that our Hamiltonian, when expanded in Post-Newtonian (PN) orders, agrees with the Arnowitt-Deser-Misner (ADM) canonical Hamiltonian computed in PN theory in the test-particle limit. Notably, we recover the known spin-orbit couplings through 2.5PN order and the spin-spin couplings of type S_Kerr S (and S_Kerr^2) through 3PN order, S_Kerr being the spin of the Kerr spacetime. Our method allows one to compute the PN Hamiltonian at any order, in the test-particle limit and at linear order in the particle spin. As an application we compute it at 3.5PN order.Comment: Corrected typo in the ADM Hamiltonian at 3.5 PN order (eq. 6.20

The Globular Cluster System in the Inner Region of M87

1057 globular cluster candidates have been identified in a WFPC2 image of the inner region of M87. The Globular Cluster Luminosity Function (GCLF) can be well fit by a Gaussian profile with a mean value of m_V^0=23.67 +/- 0.07 mag and sigma=1.39 +/- 0.06 mag (compared to m_V^0=23.74 mag and sigma=1.44 mag from an earlier study using the same data by Whitmore it et al. 1995). The GCLF in five radial bins is found to be statistically the same at all points, showing no clear evidence of dynamical destruction processes based on the luminosity function (LF), in contradiction to the claim by Gnedin (1997). Similarly, there is no obvious correlation between the half light radius of the clusters and the galactocentric distance. The core radius of the globular cluster density distribution is R_c=56'', considerably larger than the core of the stellar component (R_c=6.8''). The mean color of the cluster candidates is V-I=1.09 mag which corresponds to an average metallicity of Fe/H = -0.74 dex. The color distribution is bimodal everywhere, with a blue peak at V-I=0.95 mag and a red peak at V-I=1.20 mag. The red population is only 0.1 magnitude bluer than the underlying galaxy, indicating that these clusters formed late in the metal enrichment history of the galaxy and were possibly created in a burst of star/cluster formation 3-6 Gyr after the blue population. We also find that both the red and the blue cluster distributions have a more elliptical shape (Hubble type E3.5) than the nearly spherical galaxy. The average half light radius of the clusters is ~2.5 pc which is comparable to the 3 pc average effective radius of the Milky Way clusters, though the red candidates are ~20% smaller than the blue ones.Comment: 40 pages, 17 figures, 4 tables, latex, accepted for publication in the Ap

Cosmic Ray Spectra in Nambu-Goldstone Dark Matter Models

We discuss the cosmic ray spectra in annihilating/decaying Nambu-Goldstone dark matter models. The recent observed positron/electron excesses at PAMELA and Fermi experiments are well fitted by the dark matter with a mass of 3TeV for the annihilating model, while with a mass of 6 TeV for the decaying model. We also show that the Nambu-Goldstone dark matter models predict a distinctive gamma-ray spectrum in a certain parameter space.Comment: 16 pages, 4 figure

Investigating the Influence of High-Speed Gantry Rotation in Cardiac CT on Motion Artifacts in Aortic Stenosis Patients Not Premedicated with β-Blockers: The FAST-CCT Randomized Trial Protocol.

Coronary CT angiography (CCTA) is increasingly used as a non-invasive tool to assess coronary artery disease (CAD). However, CCTA is subject to motion artifacts, potentially limiting its clinical utility. Despite faster (0.35 and 0.28 s/rot) gantry rotation times, low (60-65 bpm) heartbeat is recommended, and the use of β-blockers is often needed. Technological advancements have resulted in the development of faster rotation speeds (0.23 s/rot). However, their added value in patients not premedicated with β-blockers remains unclear. This prospective single-center, two-arm, randomized, controlled trial aims to assess the influence of fast rotation on coronary motion artifacts, diagnostic accuracy of CCTA for CAD, and patient safety. We will randomize a total of 142 patients aged ≥ 50 scheduled for an aortic stenosis work-up to receive CCTA with either a fast (0.23) or standard (0.28 s/rot) gantry speed. rate of CCTAs with coronary motion artifacts hindering interpretation. assessable coronary segments rate, diagnostic accuracy against invasive coronary angiography (ICA), motion artifact magnitude per segment, contrast-to-noise ratio (CNR), and patient ionizing radiation dose. The local ethics committee has approved the protocol. Potential significance: FAST-CCT may improve motion artifact reduction and diagnosis quality, thus eliminating the need for rate control and β-blocker administration. gov identifier: NCT05709652