Assembling and (Re)assembling critical infrastructure resilience in Khulna City, Bangladesh

Extreme Weather Events continue to cause shocking losses of life and long-term damage at scales, depths and complexities that elude robust and accountable calculation, expression and reparation. Cyclones and storm surges can wipe out entire towns, and overwhelm vulnerable built and lived environments. It was storm surges that was integral to the destructive power of Hurricane Katrina in the USA (2005), Typhoon Haiyan in the Philippines (2013), as well as Cyclone Nargis (2008) and the 1970 Bhola Cyclone in the Bay of Bengal. This paper report on work which concerns itself with the question of, given what we know already about such extreme weather events, and their associated critical infrastructure impacts and recovery trajectories, what scenarios, insights and tools might we develop to enable critical infrastructures which are resilient? With several of the world’s most climate vulnerable cities situated in well-peopled and rapidly growing urban areas near coasts, our case study of Khulna City speaks globally into a resilience discourse, through critical infrastructure, disaster risk reduction, through spatial data science and high visualisation. With a current population of 1.4 million estimated to rise to 2.9 million by 2030, dense historical Khulna City may well continue to perform a critical role in regional economic development and as well as a destination for environmental refugees. Working as part of the EU—CIRCLE consortium, we conduct a case study into cyclones and storm surges affecting the critical infrastructure then discuss salient developments of loss modelling. The research aims to contribute towards a practical framework that stimulates adaptive learning across multiple stakeholders and organisational genres

Comparative study of statistical skin detection algorithms for sub-continental human images

Most of the researches done in the fields of skin detection has been trained and tested on human images of African, Mongolian and Anglo-Saxon ethnic origins for face recognition, human motion detection, pornographic and nude image prediction, etc. Although, there are several intensity invariant approaches to skin detection, the skin color of Indian sub-continentals have not been focused separately. The approach of this research is to make a comparative study between three image segmentation approaches using Indian sub-continental human images, to optimize the detection criteria and to find some efficient parameters to detect the skin area from these images. The experiments observed that HSV color model based approach to Indian sub-continental skin detection is more suitable with considerable success rate of 91.1% true positives and 88.1% true negatives

Monoclonal antibodies to various epitopes of HBs antigen inhibit HBV infection.

BACKGROUND AND AIM: Antibodies against the "a" determinant of hepatitis B surface antigen (HBsAg) are able to neutralize circulating HBV particles and to prevent HBV infection. It has been proposed, that a single amino acid exchange may allow the virus to escape the immune response. We used a set of monoclonal antibodies (MAbs) to investigate whether a single mutation may account for virus escape from humoral immunity. METHODS: Nine murine HBsAg specific MAbs were raised. Reactivity of all antibodies with 14 recombinant mutants of HBsAg was assessed by ELISA. HBV infection of HepaRG cells was used to evaluate viral neutralization capacity of MAbs in vitro. RESULTS: All MAbs were able to inhibit the establishment of HBV infection in a dose dependent fashion, but recognition of HBsAg variants varied. The MAbs were classified into 3 subgroups based on their pattern of reactivity to the HBsAg variants. Accordingly, three MAbs showed weak reactivity (<40%) to variants with mutations within the first loop of "a" determinant, five MAbs displayed negligible binding to variants with mutations within the second loop and one MAb lost its binding to variants having mutations in both loops of the "a" determinant. CONCLUSIONS: Our results indicate that antibodies against different epitopes of the "a" determinant of HBsAg are able to neutralize HBV. It seems that mutations within a single or a limited number of amino acids within this determinant can hardly result in viral escape. These results have important implications for the development of antibody-based therapies against HBV

Holocene erosion of the Lesser Himalaya triggered by intensified summer monsoon

Climate is one of the principal controls setting rates of continental erosion. Here we present the results of a provenance analysis of Holocene sediments from the Indus delta in order to assess climatic controls on erosion over millennial time scales. Bulk sediment Nd isotope analysis reveals a number of changes during the late Pleistocene and early Holocene (at 14–20, 11–12 and 8–9 ka) away from erosion of the Karakoram and toward more sediment flux from the Himalaya. Radiometric Ar-Ar dating of muscovite and U-Pb dating of zircon sand grains indicate that the Lesser Himalaya eroded relatively more strongly than the Greater Himalaya as global climate warmed and the summer monsoon intensified after 14 ka. Monsoon rains appear to be the primary force controlling erosion across the western Himalaya, at least over millennial time scales. This variation is preserved with no apparent lag in sediments from the delta, but not in the deep Arabian Sea, due to sediment buffering on the continental shelf

Monsoon control over erosion patterns in the Western Himalaya: possible feed-back into the tectonic evolution

The Indus Delta is constructed of sediment eroded from the western Himalaya and since 20 ka has been subjected to strong variations in monsoon intensity. Provenance changes rapidly at 12-8 ka, although bulk and heavy mineral content remains relatively unchanged. Bulk sediment analyses shows more negative εNd and higher 87Sr/86Sr values, peaking around 8-9 ka. Apatite fission track ages and biotite Ar-Ar ages show younger grains ages at 8-9 ka compared to at the Last Glacial Maximum (LGM). At the same time δ13C climbs from -23 to -20‰, suggestive of a shift from terrestrial to more marine organic carbon as Early Holocene sea level rose. U-Pb zircon ages suggest enhanced erosion of the Lesser Himalaya and a relative reduction in erosion from the Transhimalaya and Karakoram since the LGM. The shift in erosion to the south correlates with those regions now affected by the heaviest summer monsoon rains. The focused erosion along the southern edge of Tibet required by current tectonic models for the Greater Himalaya would be impossible to achieve without a strong summer monsoon. Our work supports the idea that although long-term monsoon strengthening is caused by uplift of the Tibetan Plateau, monsoon-driven erosion controls Himalayan tectonic evolution