119 research outputs found
The Impact of Global Warming and Anoxia on Marine Benthic Community Dynamics: an Example from the Toarcian (Early Jurassic)
The Pliensbachian-Toarcian (Early Jurassic) fossil record is an archive of natural data of benthic community response to global warming and marine long-term hypoxia and anoxia. In the early Toarcian mean temperatures increased by the same order of magnitude as that predicted for the near future; laminated, organic-rich, black shales were deposited in many shallow water epicontinental basins; and a biotic crisis occurred in the marine realm, with the extinction of approximately 5% of families and 26% of genera. High-resolution quantitative abundance data of benthic invertebrates were collected from the Cleveland Basin (North Yorkshire, UK), and analysed with multivariate statistical methods to detect how the fauna responded to environmental changes during the early Toarcian. Twelve biofacies were identified. Their changes through time closely resemble the pattern of faunal degradation and recovery observed in modern habitats affected by anoxia. All four successional stages of community structure recorded in modern studies are recognised in the fossil data (i.e. Stage III: climax; II: transitional; I: pioneer; 0: highly disturbed). Two main faunal turnover events occurred: (i) at the onset of anoxia, with the extinction of most benthic species and the survival of a few adapted to thrive in low-oxygen conditions (Stages I to 0) and (ii) in the recovery, when newly evolved species colonized the re-oxygenated soft sediments and the path of recovery did not retrace of pattern of ecological degradation (Stages I to II). The ordination of samples coupled with sedimentological and palaeotemperature proxy data indicate that the onset of anoxia and the extinction horizon coincide with both a rise in temperature and sea level. Our study of how faunal associations co-vary with long and short term sea level and temperature changes has implications for predicting the long-term effects of “dead zones” in modern oceans
Alcohol affects neuronal substrates of response inhibition but not of perceptual processing of stimuli signalling a stop response
Alcohol impairs inhibitory control, including the ability to terminate an initiated action. While there is increasing knowledge about neural mechanisms involved in response inhibition, the level at which alcohol impairs such mechanisms remains poorly understood. Thirty-nine healthy social drinkers received either 0.4g/kg or 0.8g/kg of alcohol, or placebo, and performed two variants of a Visual Stop-signal task during acquisition of functional magnetic resonance imaging (fMRI) data. The two task variants differed only in their instructions: in the classic variant (VSST), participants inhibited their response to a “Go-stimulus” when it was followed by a “Stop-stimulus”. In the control variant (VSST_C), participants responded to the “Go-stimulus” even if it was followed by a “Stop-stimulus”. Comparison of successful Stop-trials (Sstop)>Go, and unsuccessful Stop-trials (Ustop)>Sstop between the three beverage groups enabled the identification of alcohol effects on functional neural circuits supporting inhibitory behaviour and error processing. Alcohol impaired inhibitory control as measured by the Stop-signal reaction time, but did not affect other aspects of VSST performance, nor performance on the VSST_C. The low alcohol dose evoked changes in neural activity within prefrontal, temporal, occipital and motor cortices. The high alcohol dose evoked changes in activity in areas affected by the low dose but importantly induced changes in activity within subcortical centres including the globus pallidus and thalamus. Alcohol did not affect neural correlates of perceptual processing of infrequent cues, as revealed by conjunction analyses of VSST and VSST_C tasks. Alcohol ingestion compromises the inhibitory control of action by modulating cortical regions supporting attentional, sensorimotor and action-planning processes. At higher doses the impact of alcohol also extends to affect subcortical nodes of fronto-basal ganglia- thalamo-cortical motor circuits. In contrast, alcohol appears to have little impact on the early visual processing of infrequent perceptual cues. These observations clarify clinically-important effects of alcohol on behaviour
Light Stop Decay in the MSSM with Minimal Flavour Violation
In supersymmetric scenarios with a light stop particle and a
small mass difference to the lightest supersymmetric particle (LSP) assumed to
be the lightest neutralino, the flavour changing neutral current decay
can be the dominant decay channel and can
exceed the four-body stop decay for certain parameter values. In the framework
of Minimal Flavour Violation (MFV) this decay is CKM-suppressed, thus inducing
long stop lifetimes. Stop decay length measurements at the LHC can then be
exploited to test models with minimal flavour breaking through Standard Model
Yukawa couplings. The decay width has been given some time ago by an
approximate formula, which takes into account the leading logarithms of the MFV
scale. In this paper we calculate the exact one-loop decay width in the
framework of MFV. The comparison with the approximate result exhibits
deviations of the order of 10% for large MFV scales due to the neglected
non-logarithmic terms in the approximate decay formula. The difference in the
branching ratios is negligible. The large logarithms have to be resummed. The
resummation is performed by the solution of the renormalization group
equations. The comparison of the exact one-loop result and the tree level
flavour changing neutral current decay, which incorporates the resummed
logarithms, demonstrates that the resummation effects are important and should
be taken into account.Comment: 29 page
Persistence of Pathogens with Short Infectious Periods in Seasonal Tick Populations: The Relative Importance of Three Transmission Routes
BACKGROUND: The flaviviruses causing tick-borne encephalitis (TBE) persist at low but consistent levels in tick populations, despite short infectious periods in their mammalian hosts and transmission periods constrained by distinctly seasonal tick life cycles. In addition to systemic and vertical transmission, cofeeding transmission has been proposed as an important route for the persistence of TBE-causing viruses. Because cofeeding transmission requires ticks to feed simultaneously, the timing of tick activity may be critical to pathogen persistence. Existing models of tick-borne diseases do not incorporate all transmission routes and tick seasonality. Our aim is to evaluate the influence of seasonality on the relative importance of different transmission routes by using a comprehensive mathematical model. METHODOLOGY/PRINCIPAL FINDINGS: We developed a stage-structured population model that includes tick seasonality and evaluated the relative importance of the transmission routes for pathogens with short infectious periods, in particular Powassan virus (POWV) and the related "deer tick virus," emergent encephalitis-causing flaviviruses in North America. We used the next generation matrix method to calculate the basic reproductive ratio and performed elasticity analyses. We confirmed that cofeeding transmission is critically important for such pathogens to persist in seasonal tick populations over the reasonable range of parameter values. At higher but still plausible rates of vertical transmission, our model suggests that vertical transmission can strongly enhance pathogen prevalence when it operates in combination with cofeeding transmission. CONCLUSIONS/SIGNIFICANCE: Our results demonstrate that the consistent prevalence of POWV observed in tick populations could be maintained by a combination of low vertical, intermediate cofeeding and high systemic transmission rates. When vertical transmission is weak, nymphal ticks support integral parts of the transmission cycle that are critical for maintaining the pathogen. We also extended the model to pathogens that cause chronic infections in hosts and found that cofeeding transmission could contribute to elevating prevalence even in these systems. Therefore, the common assumption that cofeeding transmission is not relevant in models of chronic host infection, such as Lyme disease, could lead to underestimating pathogen prevalence
Demographic responses of Daphnia magna fed transgenic Bt-maize
The food/feed quality of a variety of genetically modified (GM) maize expressing Cry1Ab Bt-toxin was tested over the life-cycle of Daphnia magna, an arthropod commonly used as model organism in ecotoxicological studies. Demographic responses were compared between animals fed GM or unmodified (UM) near isogenic maize, with and without the addition of predator smell. Age-specific data on survival and birth rates were integrated and analysed using life tables and Leslie matrices. Survival, fecundity and population growth rate (PGR) data generally disfavoured transgenic Bt-maize as feed for D. magna compared to animals fed the unmodified (UM) near isogenic line of maize. Decomposition of age-specific effects revealed that the most important contributions to a reduced PGR in the GM-fed group came from both fecundity and survival differences early in life. We conclude that juvenile and young adult stages are the most sensitive experimental units and should be prioritized in future research. These stages are often omitted in toxicological/ecotoxicological studies and in feeding trials
A niche remedy for the dynamical problems of neutral theory
We demonstrate how niche theory and Hubbell's original formulation of neutral
theory can be blended together into a general framework modeling the combined
effects of selection, drift, speciation, and dispersal on community dynamics.
This framework connects many seemingly unrelated ecological population models,
and allows for quantitative predictions to be made about the impact of niche
stabilizing and destabilizing forces on population extinction times and
abundance distributions. In particular, the existence of niche stabilizing
forces in our blended framework can simultaneously resolve two major problems
with the dynamics of neutral theory, namely predictions of species lifetimes
that are too short and species ages that are too long.Comment: 47 pages, 4 figures, Accepted to Theoretical Ecolog
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution
APOBEC3 enzymes are cytosine deaminases implicated in cancer. Precisely when APOBEC3 expression is induced during cancer development remains to be defined. Here we show that specific APOBEC3 genes are upregulated in breast DCIS, and in pre-invasive lung cancer lesions coincident with cellular proliferation. We observe evidence of APOBEC3-mediated subclonal mutagenesis propagated from TRACERx pre-invasive to invasive NSCLC lesions. We find that APOBEC3B exacerbates DNA replication stress and chromosomal instability through incomplete replication of genomic DNA, manifested by accumulation of mitotic ultrafine bridges and 53BP1 nuclear bodies in the G1 phase of the cell cycle. Analysis of TRACERx NSCLC clinical samples and mouse lung cancer models, revealed APOBEC3B expression driving replication stress and chromosome missegregation. We propose that APOBEC3 is functionally implicated in the onset of chromosomal instability and somatic mutational heterogeneity in pre-invasive disease, providing fuel for selection early in cancer evolution
Effects of branching spatial structure and life history on the asymptotic growth rate of a population
Author Posting. © The Author(s), 2009. This is the author's version of the work. It is posted here by permission of Springer for personal use, not for redistribution. The definitive version was published in Theoretical Ecology 3 (2010): 137-152, doi:10.1007/s12080-009-0058-0.The dendritic structure of a river network creates directional dispersal and a hierarchical
arrangement of habitats. These two features have important consequences for the
ecological dynamics of species living within the network.We apply matrix population models to a stage-structured population in a network of habitat patches connected in a dendritic
arrangement. By considering a range of life histories and dispersal patterns, both constant
in time and seasonal, we illustrate how spatial structure, directional dispersal, survival, and
reproduction interact to determine population growth rate and distribution. We investigate
the sensitivity of the asymptotic growth rate to the demographic parameters of the model,
the system size, and the connections between the patches. Although some general patterns
emerge, we find that a species’ mode of reproduction and dispersal are quite important in its
response to changes in its life history parameters or in the spatial structure. The framework
we use here can be customized to incorporate a wide range of demographic and dispersal
scenarios.Funding for this work came from the James S. McDonnell Foundation (EEG, HJL, WFF). MGN was supported by grants from the National Science Foundation (CMG-0530830, OCE-0326734, ATM-0428122)
Analysis of techni-dilaton as a dark matter candidate
The almost conformal dynamics of walking technicolor (TC) implies the
existence of the approximate scale invariance, which breaks down spontaneously
by the condensation of anti-techni and techni-fermions. According to the
Goldstone theorem, a spinless, parity-even particle, called techni-dilaton
(TD), then emerges at low energy. If TC exhibits an extreme walking, TD mass is
parametrically much smaller than that of techni-fermions (around 1 TeV), while
its decay constant is comparable to the cutoff scale of walking TC. We analyze
the light, decoupled TD as a dark matter candidate and study cosmological
productions of TD, both thermal and non-thermal, in the early Universe. The
thermal population is governed dominantly by single TD production processes
involving vertices breaking the scale symmetry, while the non-thermal
population is by the vacuum misalignment and is accumulated via harmonic and
coherent oscillations of misaligned classical TD fields. The non-thermal
population turns out to be dominant and large enough to explain the abundance
of presently observed dark matter, while the thermal population is highly
suppressed due to the large TD decay constant. Several cosmological and
astrophysical limits on the light, decoupled TD are examined to find that the
TD mass is constrained to be in a range between 0.01 eV and 500 eV. From the
combined constraints on cosmological productions and astrophysical
observations, we find that the light, decoupled TD can be a good dark matter
candidate with the mass around a few hundreds of eV for typical models of
(extreme) walking TC. We finally mention possible designated experiments to
detect the TD dark matter.Comment: 26 pages. 16 figures; v2, expanded Section 2.4 on composite Higgs in
light of newly discovered Higgs-like particle at LH
Empirical Models of Transitions between Coral Reef States: Effects of Region, Protection, and Environmental Change
There has been substantial recent change in coral reef communities. To date, most analyses have focussed on static patterns or changes in single variables such as coral cover. However, little is known about how community-level changes occur at large spatial scales. Here, we develop Markov models of annual changes in coral and macroalgal cover in the Caribbean and Great Barrier Reef (GBR) regions
- …