Playing in or out of character: User role differences in the experience of Interactive Storytelling

Interactive storytelling (IS) is a promising new entertainment technology synthesizing preauthored narrative with dynamic user interaction. Existing IS prototypes employ different modes to involve users in a story, ranging from individual avatar control to comprehensive control over the virtual environment. The current experiment tested whether different player modes (exerting local vs. global influence) yield different user experiences (e.g., senses of immersion vs. control). A within-subject design involved 34 participants playing the cinematic IS drama "Emo Emma

A Study Of Human T-Cell Lines Generated From Multiple Sclerosis Patients And Controls By Stimulation With Peptides Of Myelin Basic Protein

We generated T-cell lines from the peripheral blood of controls and of patients with multiple sclerosis (MS) by stimulation with overlapping synthetic peptides representing the entire sequences of all four isoforms of human myelin basic protein (MBP). The T-cell lines reacted to a wide range of epitopes in the major isoforms of MBP and to epitopes that were present only in the minor isoforms. Many MS patients and controls had T-cells responding to one or more cryptic MBP epitopes, as indicated by the generation of a peptide-specific T-cell line(s) by stimulation with synthetic peptides but not by stimulation with whole MBP. About one-third of the peptide-generated lines were cytotoxic. Although we have shown that this technique of peptide stimulation is effective in generating human antiviral cytotoxic CD8+ T-cell lines, all the cytotoxic MBP-specific lines generated by this method were predominantly CD4+. Our study did not reveal any significant differences, between MS patients and controls, in reactivity to epitopes within any of the isoforms of MBP

Cluster Model of Decagonal Tilings

A relaxed version of Gummelt's covering rules for the aperiodic decagon is considered, which produces certain random-tiling-type structures. These structures are precisely characterized, along with their relationships to various other random tiling ensembles. The relaxed covering rule has a natural realization in terms of a vertex cluster in the Penrose pentagon tiling. Using Monte Carlo simulations, it is shown that the structures obtained by maximizing the density of this cluster are the same as those produced by the corresponding covering rules. The entropy density of the covering ensemble is determined using the entropic sampling algorithm. If the model is extended by an additional coupling between neighboring clusters, perfectly ordered structures are obtained, like those produced by Gummelt's perfect covering rules.Comment: 10 pages, 20 figures, RevTeX; minor changes; to be published in Phys. Rev.

Restoration of supersymmetric Slavnov-Taylor and Ward identities in presence of soft and spontaneous symmetry breaking

Supersymmetric Slavnov-Taylor and Ward identities are investigated in presence of soft and spontaneous symmetry breaking. We consider an abelian model where soft supersymmetry breaking yields a mass splitting between electron and selectron and triggers spontaneous symmetry breaking, and we derive corresponding identities that relate the electron and selectron masses with the Yukawa coupling. We demonstrate that the identities are valid in dimensional reduction and invalid in dimensional regularization and compute the necessary symmetry-restoring counterterms.Comment: 35 pages, LaTeX, 9 postscript figure

Impact of chirality on the photoinduced charge transfer in linked systems containing naproxen enantiomers

[EN] The model reaction of photoinduced donor-acceptor interaction in linked systems (dyads) has been used to study the comparative reactivity of a well-known anti-inflammatory drug, (S)-naproxen (NPX) and its (R)-isomer. (R)- or (S)-NPX in these dyads is linked to (S)-N-methylpyrrolidine (Pyr) using a linear or cyclic amino acid bridge (AA or CyAA), to give (R)-/(S)-NPX-AA-(S)-Pyr flexible and (R)-/(S)-NPX-CyAA-(S)-Pyr rigid dyads. The donor-acceptor interaction is reminiscent of the binding (partial charge transfer, CT) and electron transfer (ET) processes involved in the extensively studied inhibition of the cyclooxygenase enzymes (COXs) by the NPX enantiomers. Besides that, both optical isomers undergo oxidative metabolism by enzymes from the P450 family, which also includes ET. The scheme proposed for the excitation quenching of the (R)- and (S)-NPX excited state in these dyads is based on the joint analysis of the chemically induced dynamic nuclear polarization (CIDNP) and fluorescence data. The H-1 CIDNP effects in this system appear in the back electron transfer in the biradical-zwitterion (BZ), which is formed via dyad photoirradiation. The rate constants of individual steps in the proposed scheme and the fluorescence quantum yields of the local excited (LE) states and exciplexes show stereoselectivity. It depends on the bridge's length, structure and solvent polarity. The CIDNP effects (experimental and calculated) also demonstrate stereodifferentiation. The exciplex quantum yields and the rates of formation are larger for the dyads containing (R)-NPX, which let us suggest a higher contribution from the CT processes with the (R)-optical isomer.The work was supported by the Russian Foundation for Fundamental Research (14-03-00192, 14-03-00692). All QS calculations were carried out on a cluster computer in the regional center for shared computer equipment at the Ufa Institute of Chemistry of RAS.Khramtsova, E.; Sosnovsky, D.; Ageeva, A.; Nuin Plá, NE.; Marín García, ML.; Purtov, P.; Borisevich, S.... (2016). Impact of chirality on the photoinduced charge transfer in linked systems containing naproxen enantiomers. Physical Chemistry Chemical Physics. 18(18):12733-12741. https://doi.org/10.1039/C5CP07305GS1273312741181

Implementing NICE guidelines for the psychological treatment of depression and anxiety disorders: The IAPT experience

The Improving Access to Psychological Therapies (IAPT) programme is a large-scale initiative that aims to greatly increase the availability of NICE recommended psychological treatment for depression and anxiety disorders within the National Health Service in England. This article describes the background to the programme, the arguments on which it is based, the therapist training scheme, the clinical service model, and a summary of progress to date. At mid-point in a national roll-out of the programme progress is generally in line with expectation, and a large number of people who would not otherwise have had the opportunity to receive evidence-based psychological treatment have accessed, and benefited from, the new IAPT services. Planned future developments and challenges for the programme are briefly described

Arithmetic progressions in sets of fractional dimension

Let E\subset\rr be a closed set of Hausdorff dimension $\alpha$. We prove that if $\alpha$ is sufficiently close to 1, and if $E$ supports a probabilistic measure obeying appropriate dimensionality and Fourier decay conditions, then $E$ contains non-trivial 3-term arithmetic progressions.Comment: 42 page

Constraints on Dark Matter Annihilation in Clusters of Galaxies with the Fermi Large Area Telescope

Nearby clusters and groups of galaxies are potentially bright sources of high-energy gamma-ray emission resulting from the pair-annihilation of dark matter particles. However, no significant gamma-ray emission has been detected so far from clusters in the first 11 months of observations with the Fermi Large Area Telescope. We interpret this non-detection in terms of constraints on dark matter particle properties. In particular for leptonic annihilation final states and particle masses greater than ~200 GeV, gamma-ray emission from inverse Compton scattering of CMB photons is expected to dominate the dark matter annihilation signal from clusters, and our gamma-ray limits exclude large regions of the parameter space that would give a good fit to the recent anomalous Pamela and Fermi-LAT electron-positron measurements. We also present constraints on the annihilation of more standard dark matter candidates, such as the lightest neutralino of supersymmetric models. The constraints are particularly strong when including the fact that clusters are known to contain substructure at least on galaxy scales, increasing the expected gamma-ray flux by a factor of ~5 over a smooth-halo assumption. We also explore the effect of uncertainties in cluster dark matter density profiles, finding a systematic uncertainty in the constraints of roughly a factor of two, but similar overall conclusions. In this work, we focus on deriving limits on dark matter models; a more general consideration of the Fermi-LAT data on clusters and clusters as gamma-ray sources is forthcoming.Comment: accepted to JCAP, Corresponding authors: T.E. Jeltema and S. Profumo, minor revisions to be consistent with accepted versio