Tailoring discrete quantum walk dynamics via extended initial conditions: Towards homogeneous probability distributions

We study the evolution of initially extended distributions in the coined quantum walk on the line by analyzing the dispersion relation of the process and its associated wave equations. This allows us, in particular, to devise an initially extended condition leading to a uniform probability distribution whose width increases linearly with time, with increasing homogeneity.Comment: 4 pages, 2 figure

First analysis of the updated ITPA global H-mode confinement database

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Validación y ajuste del modelo hidrogeológico conceptual de un humedal de la Llanura Pampeana, Provincia de Buenos Aires, Argentina

Comprender el funcionamiento hidrológico y la interacción de los diferentes cuerpos de agua presentes en un área específica son temas esenciales a la hora de planificar el uso racional del recurso hídrico. El objetivo de este trabajo es validar y ajustar el modelo hidrogeológico conceptual de un humedal de la llanura Pampeana Bonaerense mediante técnicas hidrogeoquími­cas e isotópicas. Se ha seleccionado la cuenca de la laguna La Brava (53.6 km2). La misma es una laguna permanente y somera con una superficie de 4.0 km2 y una profundidad máxima de 4.57 m. Se tomaron muestras para análisis fisicoquímico e isotópico en el agua subterránea, en la laguna y en los arroyos afluente y e.fluente a la misma. Para el muestreo en la laguna se diseñó una malla de muestreo regular en la cual se midieron in situ los principales parámetros fisicoquímicos a 5 profundidades diferentes y se tomaron muestras. La composición química del agua de la cuenca es de tipo bicarbonatada sódica. El carácter efluente-influente de este humedal pudo ser confirmado a través de las mediciones isotópicas e hidroquími­caso El análisis de la conductividad eléctrica en el humedal a diferentes profundidades hace pensar en una zona de recarga preferencial en el contacto de la laguna con el faldeo oriental de la Sierra La Brava, donde se evidencia una disminución importante de este parámetro. La información obtenida indica que la recarga al acu(fero en esta zona es influenciada por: la precipitación, la descarga proveniente del humedal, la concentración del escurrimiento superficial desde el frente montañoso hacia las depresiones interserranas y el aporte de agua proveniente del sistema de jisuras presente en las ortocuarcitas.Understanding the hydrological functioning and the interaction among the different water bodies present in a specific area are essential when planning the rational use of the hydric resource. The aim of the present paper is to validate and adjust the conceptual hydrogeological model for a wetland of the Buenos Aires Pampa Plain through hydrochemical and isotopic techniques. La Brava Wetland Basin (53.6 km2) has been selected. La Brava is a shallow and permanent wetland with an area of 4.0 km2 and a maximum depth of 4.57 m. Samples for physicochemical and isotopic analyses were taken from groundwater, the wetland, and in the inflow and outflow streams. A regular grid was designed for the wetland sampling to measure in situ the main physical and chemical parameters at 5 different depths. The chemical composition of the water in the basin is of sodium bicarbonate type. Hydrochemical and isotopic data allowed the confirmation of the effiuent-influent behavior of this wetland. Electrical conductivity analysis in the wetland at different depths shows a possible preferential recharge zone in the contact of the wetland with La Brava Hill, where an important decrease in this parameter was detected. The information obtained indicates that the recharge to the aquifer is influenced by: the rainfall, the wetland discharge, the concentration of surface ron-off from the range fringes to inter-range depressions and water input from the fault system present in the quartzites

Aspectos sobre operación y normativas de inversores fotovoltaicos para inyección a red de baja tensión

Se presenta en este trabajo un análisis sobre el funcionamiento y algunas consideraciones de operación de un inversor fotovoltaico para inyección de energía a la red de baja tensión. Más precisamente se estudian los inversores monofásicos sin transformador de aislamiento a la salida, los más utilizados en instalaciones de hasta 5kW. Así mismo se muestra un resumen de las diferentes normativas internacionales que deben satisfacer en torno a seguridad eléctrica, y conexión a red.An analysis on the functioning and considerations of operation of a photovoltaic inverter for power feed into the low voltage network is presented in this paper. More precisely the single-phase inverters without isolation transformer at the output, the most widely used systems up to 5 kW are studied. Also a summary of different international regulations to be met regarding electrical safety and grid code is shown.Tema 13: Generación distribuida.Facultad de Arquitectura y Urbanism

Aspectos sobre operación y normativas de inversores fotovoltaicos para inyección a red de baja tensión

Se presenta en este trabajo un análisis sobre el funcionamiento y algunas consideraciones de operación de un inversor fotovoltaico para inyección de energía a la red de baja tensión. Más precisamente se estudian los inversores monofásicos sin transformador de aislamiento a la salida, los más utilizados en instalaciones de hasta 5kW. Así mismo se muestra un resumen de las diferentes normativas internacionales que deben satisfacer en torno a seguridad eléctrica, y conexión a red.An analysis on the functioning and considerations of operation of a photovoltaic inverter for power feed into the low voltage network is presented in this paper. More precisely the single-phase inverters without isolation transformer at the output, the most widely used systems up to 5 kW are studied. Also a summary of different international regulations to be met regarding electrical safety and grid code is shown.Tema 13: Generación distribuida.Facultad de Arquitectura y Urbanism

Aspectos sobre operación y normativas de inversores fotovoltaicos para inyección a red de baja tensión

Se presenta en este trabajo un análisis sobre el funcionamiento y algunas consideraciones de operación de un inversor fotovoltaico para inyección de energía a la red de baja tensión. Más precisamente se estudian los inversores monofásicos sin transformador de aislamiento a la salida, los más utilizados en instalaciones de hasta 5kW. Así mismo se muestra un resumen de las diferentes normativas internacionales que deben satisfacer en torno a seguridad eléctrica, y conexión a red.An analysis on the functioning and considerations of operation of a photovoltaic inverter for power feed into the low voltage network is presented in this paper. More precisely the single-phase inverters without isolation transformer at the output, the most widely used systems up to 5 kW are studied. Also a summary of different international regulations to be met regarding electrical safety and grid code is shown.Tema 13: Generación distribuida.Facultad de Arquitectura y Urbanism

Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein.

BACKGROUND:Retroviruses HTLV-1 and HTLV-2 have homologous genomic structures but differ significantly in pathogenicity. HTLV-1 is associated with Adult T cell Leukemia (ATL), whereas infection by HTLV-2 has no association with neoplasia. Transformation of T lymphocytes by HTLV-1 is linked to the capacity of its oncoprotein Tax-1 to alter cell survival and cell cycle control mechanisms. Among these functions, Tax-1-mediated activation of cellular gene expression via the NF-κB pathway depends on Tax-1 post-translational modifications by ubiquitination and sumoylation. The Tax-2 protein of HTLV-2B (Tax-2B) is also modified by ubiquitination and sumoylation and activates the NF-κB pathway to a level similar to that of Tax-1. The present study aims to understand whether ubiquitination and sumoylation modifications are involved in Tax-2B-mediated activation of the NF-κB pathway.RESULTS:The comparison of Tax-1 and Tax-2B lysine to arginine substitution mutants revealed conserved patterns and levels of ubiquitination with notable difference in the lysine usage for sumoylation. Neither Tax-1 nor Tax-2B ubiquitination and sumoylation deficient mutants could activate the NF-κB pathway and fusion of ubiquitin or SUMO-1 to the C-terminus of the ubiquitination and sumoylation deficient Tax-2B mutant strikingly restored transcriptional activity. In addition, ubiquitinated forms of Tax-2B colocalized with RelA and IKKγ in prominent cytoplasmic structures associated with the Golgi apparatus, whereas colocalization of Tax-2B with the RelA subunit of NF-κB and the transcriptional coactivator p300 in punctate nuclear structures was dependent on Tax-2B sumoylation, as previously observed for Tax-1.CONCLUSIONS:Both Tax-1 and Tax-2 activate the NF-κB pathway via similar mechanisms involving ubiquitination and sumoylation. Therefore, the different transforming potential of HTLV-1 and HTLV-2 is unlikely to be related to different modes of activation of the canonical NF-κB pathway

A simple method for <i>N</i>-phenoxyethylation of anilines

We wanted to search for new reaction conditions to prepare the title compounds, to be checked later in novel syntheses of heterocyclic compounds. To the best of our knowledge, there was no report in the literature of any well-established method for the preparation of N-(2-phenoxyethyl)anilines 1.Facultad de Ciencias Exacta

Low-Dose Topiramate in Alcohol Dependence: A Single-Blind, Placebo-Controlled Study

Introduction:Topiramate (TOP) and anticonvulsants in general are considered safe and effective drugs for the treatment of alcohol dependence, even though TOP-induced adverse events are quite common, especially for high initial doses or if titration to 300 mg/d is too rapid. The aim of the present study was to assess the efficacy and tolerability profile of low-dose TOP for relapse prevention. METHODS: After detoxification, 52 patients were randomized into 2 groups as follows: 26 patients received 100 mg of TOP (oral, twice daily), titrated over 2 weeks, and 26 patients received placebo (PLA). Both groups underwent rehabilitation twice a week. RESULTS: After 6 weeks of treatment, compared with the PLA group, patients receiving TOP showed the following: (1) fewer drinking days (P &lt; 0.05); (2) less daily alcohol consumption (P &lt; 0.05); (3) more days of treatment (P &lt; 0.05); (4) reduced levels of craving (Obsessive-Compulsive Drinking Scale) and withdrawal symptoms (Clinical Institute Withdrawal Assessment for Alcohol-Revised); and (5) improvement of anxiety, depression, and obsessive-compulsive symptom severity (Symptom Check List 90 Revised). CONCLUSIONS: Despite the small sample size and the short follow-up period, the present PLA-controlled study demonstrated the potential usefulness of TOP, even when administered at a dosage of 100 mg/d, for the treatment of detoxified alcohol-dependent subjects, confirming results from previous studies testing higher doses of TOP