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Papers from U.S. Department of Energy Science Undergraduate Laboratory Internship Program (SULI) 2007
A collection of student and intern research papers from Stanford Linear Accelerator center dealing with accelerator physics, crystal structure, BABAR, the GLAST mission, etc
Transmembrane protein 16A (TMEM16A) is a Ca2+ -regulated Cl- secretory channel in mouse airways
For almost two decades, it has been postulated that calcium-activated Cl- channels (CaCCs) play a role in airway epithelial Cl- secretion, but until recently, the molecular identity of the airway CaCC(s) was unknown. Recent studies have unequivocally identified TMEM16A as a glandular epithelial CaCC. We have studied the airway bioelectrics of neonatal mice homozygous for a null allele of Tmem16a (Tmem16a-/ -) to investigate the role of this channel in Cl- secretion in airway surface epithelium. When compared with wild-type tracheas, the Tmem16a-/- tracheas exhibited a >60% reduction in purinoceptor (UTP)-regulated CaCC activity. Other members of the Tmem16 gene family,including Tmem16f and Tmem16k, were also detected by reverse transcription-PCR in neonatal tracheal epithelium, suggesting that other family members could be considered as contributing to the small residual UTP response. TMEM16A, however, appeared to contribute little to unstimulated Cl- secretion, whereas studies with cystic fibrosis transmembrane conductance regulator (CFTR)-deficient mice and wild-type littermates revealed that unstimulated Cl- secretion reflected âŒ50% CFTR activity and âŒ50% non-Tmem16a activity. Interestingly, the tracheas of both the Tmem16a-/- and the CFTR-/- mice exhibited similar congenital cartilaginous defects that may reflect a common Cl- secretory defect mediated by the molecularly distinct Cl- channels. Importantly, the residual CaCC activity in Tmem16a-/- mice appeared inadequate for normal airway hydration because Tmem16a-/- tracheas exhibited significant, neonatal, lumenal mucus accumulation. Our data suggest that TMEM16A CaCC-mediated Cl- secretion appears to be necessary for normal airway surface liquid homeostasis
Confinement and scaling in deep inelastic scattering
We show that parton confinement in the final state generates large
corrections to Bjorken scaling, thus leaving less room for the logarithmic
corrections. In particular, the -scaling violations at large are
entirely described in terms of power corrections. For treatment of these
non-perturbative effects, we derive a new expansion in powers of for
the structure function that is free of infra-red singularities and which
reduces corrections to the leading term. The leading term represents scattering
from an off-mass-shell parton, which keeps the same virtual mass in the final
state. It is found that this quasi-free term is a function of a new variable
, which coincides with the Bjorken variable for . The
two variables are very different, however, at finite . In particular, the
variable depends on the invariant mass of the spectator particles.
Analysis of the data at large shows excellent scaling in the variable , and determines the value of the diquark mass to be close to zero. -scaling allows us to extract the structure function near the elastic
threshold. It is found to behave as . Predictions for the
structure functions based on -scaling are made.Comment: Discussion of target mass corrections is added. Accepted for
publication in Phys. Rev.
Measurement of the Proton and Deuteron Spin Structure Functions g2 and Asymmetry A2
We have measured the spin structure functions g2p and g2d and the virtual
photon asymmetries A2p and A2d over the kinematic range 0.02 < x < 0.8 and 1.0
< Q^2 < 30(GeV/c)^2 by scattering 38.8 GeV longitudinally polarized electrons
from transversely polarized NH3 and 6LiD targets.The absolute value of A2 is
significantly smaller than the sqrt{R} positivity limit over the measured
range, while g2 is consistent with the twist-2 Wandzura-Wilczek calculation. We
obtain results for the twist-3 reduced matrix elements d2p, d2d and d2n. The
Burkhardt-Cottingham sum rule integral - int(g2(x)dx) is reported for the range
0.02 < x < 0.8.Comment: 12 pages, 4 figures, 1 tabl
A-dependence of nuclear transparency in quasielastic A(e,e'p) at high Q^2
The A-dependence of the quasielastic A(e,e'p) reaction has been studied at
SLAC with H-2, C, Fe, and Au nuclei at momentum transfers Q^2 = 1, 3, 5, and
6.8 (GeV/c)^2. We extract the nuclear transparency T(A,Q^2), a measure of the
average probability that the struck proton escapes from the nucleus A without
interaction. Several calculations predict a significant increase in T with
momentum transfer, a phenomenon known as Color Transparency. No significant
rise within errors is seen for any of the nuclei studied.Comment: 5 pages incl. 2 figures, Caltech preprint OAP-73
Precision Measurement of the Proton and Deuteron Spin Structure Functions g2 and Asymmetries A2
We have measured the spin structure functions g2p and g2d and the virtual
photon asymmetries A2p and A2d over the kinematic range 0.02 < x < 0.8 and 0.7
< Q^2 < 20 GeV^2 by scattering 29.1 and 32.3 GeV longitudinally polarized
electrons from transversely polarized NH3 and 6LiD targets. Our measured g2
approximately follows the twist-2 Wandzura-Wilczek calculation. The twist-3
reduced matrix elements d2p and d2n are less than two standard deviations from
zero. The data are inconsistent with the Burkhardt-Cottingham sum rule if there
is no pathological behavior as x->0. The Efremov-Leader-Teryaev integral is
consistent with zero within our measured kinematic range. The absolute value of
A2 is significantly smaller than the sqrt[R(1+A1)/2] limit.Comment: 12 pages, 4 figures, 2 table
Momentum transfer dependence of nuclear transparency from the quasielastic 12C(e,eâp) reaction
The cross section for quasielastic 12C(e,eâp) scattering has been measured at momentum transfer Q2=1, 3, 5, and 6.8 (GeV/c)2. The results are consistent with scattering from a single nucleon as the dominant process. The nuclear transparency is obtained and compared with theoretical calculations that incorporate color transparency effects. No significant rise of the transparency with Q2 is observed
Measurements of the -Dependence of the Proton and Neutron Spin Structure Functions g1p and g1n
The structure functions g1p and g1n have been measured over the range 0.014 <
x < 0.9 and 1 < Q2 < 40 GeV2 using deep-inelastic scattering of 48 GeV
longitudinally polarized electrons from polarized protons and deuterons. We
find that the Q2 dependence of g1p (g1n) at fixed x is very similar to that of
the spin-averaged structure function F1p (F1n). From a NLO QCD fit to all
available data we find at
Q2=5 GeV2, in agreement with the Bjorken sum rule prediction of 0.182 \pm
0.005.Comment: 17 pages, 3 figures. Submitted to Physics Letters
Large enhancement of deuteron polarization with frequency modulated microwaves
We report a large enhancement of 1.7 in deuteron polarization up to values of
0.6 due to frequency modulation of the polarizing microwaves in a two liters
polarized target using the method of dynamic nuclear polarization. This target
was used during a deep inelastic polarized muon-deuteron scattering experiment
at CERN. Measurements of the electron paramagnetic resonance absorption spectra
show that frequency modulation gives rise to additional microwave absorption in
the spectral wings. Although these results are not understood theoretically,
they may provide a useful testing ground for the deeper understanding of
dynamic nuclear polarization.Comment: 10 pages, including the figures coming in uuencoded compressed tar
files in poltar.uu, which also brings cernart.sty and crna12.sty files neede
Inclusive electron scattering from nuclei at xâ1
The inclusive A(e,eâČ) cross section for xâ1 was measured on 2H, C, Fe, and Au for momentum transfers Q2 from 1 to 6.8 (GeV/c)2. The scaling behavior of the data was examined in the region of transition from y scaling to x scaling. Throughout this transitional region, the data exhibit Ο scaling, reminiscent of the Bloom-Gilman duality seen in free nucleon scattering
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