COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Accessing Ancient Population Lifeways through the Study of Gastrointestinal Parasites: Paleoparasitology

International audiencePaleoparasitology is a discipline of bioarchaeology that studies human and animal parasites and their evolution through time. It is at the frontier between biological sciences and the humanities, and aims to provide valuable clues about the lifestyles of former populations. Through examples chosen among recent case studies, we show in this review how paleoparasitology contributes to issues related to food, health, hygiene, organic waste management, and site occupation by ancient populations, but also, in the longer term, to questions of the evolution of the human/animal relationship and the history of diseases. This article provides an overview of this research field, its history, its concepts, and in particular, its applications in archaeology and the history of diseases

Assessing the Parasitic Burden in a Late Antique Florentine Emergency Burial Site

International audienc

Accessing Ancient Population Lifeways through the Study of Gastrointestinal Parasites: Paleoparasitology

Paleoparasitology is a discipline of bioarchaeology that studies human and animal parasites and their evolution through time. It is at the frontier between biological sciences and the humanities, and aims to provide valuable clues about the lifestyles of former populations. Through examples chosen among recent case studies, we show in this review how paleoparasitology contributes to issues related to food, health, hygiene, organic waste management, and site occupation by ancient populations, but also, in the longer term, to questions of the evolution of the human/animal relationship and the history of diseases. This article provides an overview of this research field, its history, its concepts, and in particular, its applications in archaeology and the history of diseases

Ancient parasites from a peat bog: New insights into animal presence and husbandry in Crete over the past 2000 years

International audienc

Gastrointestinal parasite burden in 4th-5th c. CE Florence highlighted by microscopy and paleogenetics

International audienc

Efficacy and survival of biologic agents in psoriasis: a practical real-life 12-year experience in a French dermatology department

International audienceBackground: Drug survival in a real-life setting is critical to long-term use of biologics for psoriasis. Objective: We describe our 12-year experience with biologics in psoriasis patients. Patients and Methods: All patients treated with biologics including infliximab, adalimumab (ADA), etanercept (ETA), and ustekinumab (UST) for psoriasis vulgaris between January 2005 and December 2016 were retrospectively analyzed. Results: In total, 545 treatment series were administered to 269 patients, including 211 treatment series with ADA, 135 with ETA, 77 with infliximab, and 122 with UST. ADA and ETA were initiated most often as first-line therapy; 65.3% of treatment sequences were discontinued. UST had the highest drug survival. The major reason for treatment termination was a loss of efficacy (44.9%). Definitive discontinuation increased with the number of biologic therapy sequences. Limitations: Subjects were not randomized to the different treatments. Conclusions: In a long-term real-life setting, drug survival of UST is better than that of TNF-a inhibitors for both biologic-naive and biologic-experienced patients with psoriasis

Spatial organization of tobacco cell plasma membrane : characterization, and modulation upon elicitation

International audienc

Modification of Plasma Membrane Organization in Tobacco Cells Elicited by Cryptogein

International audienceLipid mixtures within artificial membranes undergo a separation into liquid-disordered and liquid-ordered phases. However, the existence of this segregation into microscopic liquid-ordered phases has been difficult to prove in living cells, and the precise organization of the plasma membrane into such phases has not been elucidated in plant cells. We developed a multispectral confocal microscopy approach to generate ratiometric images of the plasma membrane surface of Bright Yellow 2 tobacco (Nicotiana tabacum) suspension cells labeled with an environment sensitive fluorescent probe. This allowed the in vivo characterization of the global level of order of this membrane, by which we could demonstrate that an increase in its proportion of ordered phases transiently occurred in the early steps of the signaling triggered by cryptogein and flagellin, two elicitors of plant defense reactions. The use of fluorescence recovery after photobleaching revealed an increase in plasma membrane fluidity induced by cryptogein, but not by flagellin. Moreover, we characterized the spatial distribution of liquid-ordered phases on the membrane of living plant cells and monitored their variations induced by cryptogein elicitation. We analyze these results in the context of plant defense signaling, discuss their meaning within the framework of the "membrane raft" hypothesis, and propose a new mechanism of signaling platform formation in response to elicitor treatment