Diffuser/ejector system for a very high vacuum environment

Turbo jet engines are used to furnish the necessary high temperature, high volume, medium pressure gas to provide a high vacuum test environment at comparatively low cost for space engines at sea level. Moreover, the invention provides a unique way by use of the variable area ratio ejectors with a pair of meshing cones are used. The outer cone is arranged to translate fore and aft, and the inner cone is interchangeable with other cones having varying angles of taper

The Overlooked Potential of Generalized Linear Models in Astronomy-III: Bayesian Negative Binomial Regression and Globular Cluster Populations

In this paper, the third in a series illustrating the power of generalized linear models (GLMs) for the astronomical community, we elucidate the potential of the class of GLMs which handles count data. The size of a galaxy's globular cluster population $N_{\rm GC}$ is a prolonged puzzle in the astronomical literature. It falls in the category of count data analysis, yet it is usually modelled as if it were a continuous response variable. We have developed a Bayesian negative binomial regression model to study the connection between $N_{\rm GC}$ and the following galaxy properties: central black hole mass, dynamical bulge mass, bulge velocity dispersion, and absolute visual magnitude. The methodology introduced herein naturally accounts for heteroscedasticity, intrinsic scatter, errors in measurements in both axes (either discrete or continuous), and allows modelling the population of globular clusters on their natural scale as a non-negative integer variable. Prediction intervals of 99% around the trend for expected $N_{\rm GC}$comfortably envelope the data, notably including the Milky Way, which has hitherto been considered a problematic outlier. Finally, we demonstrate how random intercept models can incorporate information of each particular galaxy morphological type. Bayesian variable selection methodology allows for automatically identifying galaxy types with different productions of GCs, suggesting that on average S0 galaxies have a GC population 35% smaller than other types with similar brightness.Comment: 14 pages, 12 figures. Accepted for publication in MNRA

The low wind expansion velocity of metal-poor carbon stars in the Halo and the Sagittarius stream

We report the detection, from observations using the James Clerk Maxwell Telescope, of CO J $=$ 3$\to$ 2 transition lines in six carbon stars, selected as members of the Galactic Halo and having similar infrared colors. Just one Halo star had been detected in CO before this work. Infrared observations show that these stars are red (J-K $>$3), due to the presence of large dusty circumstellar envelopes. Radiative transfer models indicates that these stars are losing mass with rather large dust mass-loss rates in the range 1--3.3 $\times$$10^{-8}$M$_{\odot}$yr$^{-1}$, similar to what can be observed in the Galactic disc. We show that two of these stars are effectively in the Halo, one is likely linked to the stream of the Sagittarius Dwarf Spheroidal galaxy (Sgr dSph), and the other three stars certainly belong to the thick disc. The wind expansion velocities of the observed stars are low compared to carbon stars in the thin disc and are lower for the stars in the Halo and the Sgr dSph stream than in the thick disc. We discuss the possibility that the low expansion velocities result from the low metallicity of the Halo carbon stars. This implies that metal-poor carbon stars lose mass at a rate similar to metal-rich carbon stars, but with lower expansion velocities, as predicted by recent theoretical models. This result implies that the current estimates of mass-loss rates from carbon stars in Local Group galaxies will have to be reconsidered.Comment: 10 pages, 7 figures, accepted for publication in MNRA

The Overlooked Potential of Generalized Linear Models in Astronomy - I: Binomial Regression

Revealing hidden patterns in astronomical data is often the path to fundamental scientific breakthroughs; meanwhile the complexity of scientific inquiry increases as more subtle relationships are sought. Contemporary data analysis problems often elude the capabilities of classical statistical techniques, suggesting the use of cutting edge statistical methods. In this light, astronomers have overlooked a whole family of statistical techniques for exploratory data analysis and robust regression, the so-called Generalized Linear Models (GLMs). In this paper -- the first in a series aimed at illustrating the power of these methods in astronomical applications -- we elucidate the potential of a particular class of GLMs for handling binary/binomial data, the so-called logit and probit regression techniques, from both a maximum likelihood and a Bayesian perspective. As a case in point, we present the use of these GLMs to explore the conditions of star formation activity and metal enrichment in primordial minihaloes from cosmological hydro-simulations including detailed chemistry, gas physics, and stellar feedback. We predict that for a dark mini-halo with metallicity $\approx 1.3 \times 10^{-4} Z_{\bigodot}$, an increase of $1.2 \times 10^{-2}$ in the gas molecular fraction, increases the probability of star formation occurrence by a factor of 75%. Finally, we highlight the use of receiver operating characteristic curves as a diagnostic for binary classifiers, and ultimately we use these to demonstrate the competitive predictive performance of GLMs against the popular technique of artificial neural networks.Comment: 20 pages, 10 figures, 3 tables, accepted for publication in Astronomy and Computin

Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology:Implementing the Model and Reporting Results

In vivo tibial loading in mice is increasingly used to study bone adaptation and mechanotransduction. To achieve standardized and defined experimental conditions, loading parameters and animal-related factors must be considered when performing in vivo loading studies. In this review we discuss these loading and animal-related experimental conditions, present methods to assess bone adaptation, and suggest reporting guidelines. This review originated from presentations by each of the authors at the workshop “Developing Best Practices for Mouse Models of In Vivo Loading” during the Preclinical Models Section at the Orthopaedic Research Society Annual Meeting, San Diego, CA, March 2017. Following the meeting, the authors engaged in detailed discussions with consideration of relevant literature. The guidelines and recommendations in this review are provided to help researchers perform in vivo loading experiments in mice, and thus further our knowledge of bone adaptation and the mechanisms involved in mechanotransduction

Hybrid propagation physics for the design and modeling of astronomical observatories: a coronagraphic example

For diffraction-limited optical systems an accurate physical optics model is necessary to properly evaluate instrument performance. Astronomical observatories outfitted with coronagraphs for direct exoplanet imaging require physical optics models to simulate the effects of misalignment and diffraction. Accurate knowledge of the observatory's PSF is integral for the design of high-contrast imaging instruments and simulation of astrophysical observations. The state of the art is to model the misalignment, ray aberration, and diffraction across multiple software packages, which complicates the design process. Gaussian Beamlet Decomposition (GBD) is a ray-based method of diffraction calculation that has been widely implemented in commercial optical design software. By performing the coherent calculation with data from the ray model of the observatory, the ray aberration errors can be fed directly into the physical optics model of the coronagraph, enabling a more integrated model of the observatory. We develop a formal algorithm for the transfer-matrix method of GBD, and evaluate it against analytical results and a traditional physical optics model to assess the suitability of GBD for high-contrast imaging simulations. Our GBD simulations of the observatory PSF, when compared to the analytical Airy function, have a sum-normalized RMS difference of ~10^-6. These fields are then propagated through a Fraunhofer model of a exoplanet imaging coronagraph where the mean residual numerical contrast is 4x10^-11, with a maximum near the inner working angle at 5x10^-9. These results show considerable promise for the future development of GBD as a viable propagation technique in high-contrast imaging. We developed this algorithm in an open-source software package and outlined a path for its continued development to increase the fidelity and flexibility of diffraction simulations using GBD.Comment: 58 pages, 15 figures, preprint version for article in press. Accepted to SPIE's Journal of Astronomical Telescopes, Instruments, and Systems on October 23 202

Worth a Glance: Using Eye Movements to Investigate the Cognitive Neuroscience of Memory

Results of several investigations indicate that eye movements can reveal memory for elements of previous experience. These effects of memory on eye movement behavior can emerge very rapidly, changing the efficiency and even the nature of visual processing without appealing to verbal reports and without requiring conscious recollection. This aspect of eye movement based memory investigations is particularly useful when eye movement methods are used with special populations (e.g., young children, elderly individuals, and patients with severe amnesia), and also permits use of comparable paradigms in animals and humans, helping to bridge different memory literatures and permitting cross-species generalizations. Unique characteristics of eye movement methods have produced findings that challenge long-held views about the nature of memory, its organization in the brain, and its failures in special populations. Recently, eye movement methods have been successfully combined with neuroimaging techniques such as fMRI, single-unit recording, and magnetoencephalography, permitting more sophisticated investigations of memory. Ultimately, combined use of eye-tracking with neuropsychological and neuroimaging methods promises to provide a more comprehensive account of brain–behavior relationships and adheres to the “converging evidence” approach to cognitive neuroscience

Intraoperative electrocochleographic characteristics of auditory neuropathy spectrum disorder in cochlear implant subjects

Auditory neuropathy spectrum disorder (ANSD) is characterized by an apparent discrepancy between measures of cochlear and neural function based on auditory brainstem response (ABR) testing. Clinical indicators of ANSD are a present cochlear microphonic (CM) with small or absent wave V. Many identified ANSD patients have speech impairment severe enough that cochlear implantation (CI) is indicated. To better understand the cochleae identified with ANSD that lead to a CI, we performed intraoperative round window electrocochleography (ECochG) to tone bursts in children (n = 167) and adults (n = 163). Magnitudes of the responses to tones of different frequencies were summed to measure the “total response” (ECochG-TR), a metric often dominated by hair cell activity, and auditory nerve activity was estimated visually from the compound action potential (CAP) and auditory nerve neurophonic (ANN) as a ranked “Nerve Score”. Subjects identified as ANSD (45 ears in children, 3 in adults) had higher values of ECochG-TR than adult and pediatric subjects also receiving CIs not identified as ANSD. However, nerve scores of the ANSD group were similar to the other cohorts, although dominated by the ANN to low frequencies more than in the non-ANSD groups. To high frequencies, the common morphology of ANSD cases was a large CM and summating potential, and small or absent CAP. Common morphologies in other groups were either only a CM, or a combination of CM and CAP. These results indicate that responses to high frequencies, derived primarily from hair cells, are the main source of the CM used to evaluate ANSD in the clinical setting. However, the clinical tests do not capture the wide range of neural activity seen to low frequency sounds

The String Calculation of QCD Wilson Loops on Arbitrary Surfaces

Compact string expressions are found for non-intersecting Wilson loops in SU(N) Yang-Mills theory on any surface (orientable or nonorientable) as a weighted sum over covers of the surface. All terms from the coupled chiral sectors of the 1/N expansion of the Wilson loop expectation values are included.Comment: 10 pages, LaTeX, no figure