Determinación del ángulo de giro para la extracción de plugs en núcleos preservados usando imágenes de tomografía de rayos X

The plugs are subsamples extracted from drilling cores, which are used to measure directly the properties associated with the rock and its interactions with the fluid. Any petrophysics model must have laboratory data from the samples to be calibrated. Due to this, it is important that samples are representative and in a good condition. This research proposes a methodology to determine exactly the location of interest points, including the turning angle of the core for its further extraction. This guarantees the integrity and representativeness when the interest zone is selected through well logging. The methodology uses X-ray tomography images on axial, radial, and vertical cuts. It was possible to create equations to measure in scaled images the real dip angle in the cylindric images and vertical cuts. It was also possible to create two nomograms that allow calculating the turning angle of the drilling core, once the dip data of the interest structure is calculated.Los plugs son submuestras extraídas de núcleos de perforación, los cuales son usados para medir directamente propiedades asociadas a la roca y a la interacción con el fluido; cualquier modelo petrofísico debe tener datos de laboratorio provenientes de estos para su debida calibración, de allí su importancia. En consecuencia, el presente trabajo plantea una metodología que permite determinar con exactitud la ubicación de puntos de interés, incluido el ángulo de giro del núcleo, para su posterior extracción; esto asegura la integridad y representatividad, una vez que exista la ubicación de la zona de interés mediante registros de pozo. La metodología usa imágenes de tomografía de rayos X en los cortes axiales, radiales y verticales. Se encontraron ecuaciones que permiten medir directamente en imágenes escaladas el ángulo de buzamiento real en las imágenes cilíndricas y el aparente en los cortes verticales; adicionalmente, se crearon dos nomogramas que permiten determinar el ángulo de giro del núcleo de perforación, una vez calculados los datos de buzamiento de la estructura planar de interés

Small vessel microembolization and acute glomerulonephritis following infection of aesthetic filler implants

Background: The systemic consequences of esthetic filler injections are poorly understood. Case presentation: We report a patient with a past history of subcutaneous injection of aesthetic filler material in the lower legs, who presented with post-infectious glomerulonephritis following necrotic leg ulcers at the injection site. Kidney biopsy revealed the presence of translucent, non-birefringent microspherical bodies compatible with polymethylmetacrylate (PMMA) microspheres in some capillary lumens. This had not previously been described. PMMA is a biphasic aesthetical filler composed of polymethylmetacrylate microspheres suspended in a biodegradable bovine collagen carrier. The solid phase (PMMA microspheres) persists in tissues for years. Although PMMA was thought to not disseminate systemically, tissue necrosis may have favored systemic dissemination of the microspheres, although entry in the circulation and microembolization at the time of administration cannot be ruled out. Conclusions: In conclusion, aesthetic filler implants may cause microembolization into small vessels. Recognition of the characteristic morphology may expedite diagnosis and avoid unnecessary further testing.AO and CMC were supported by ISCIII and FEDER funds PI13/00047, REDinREN RD012/0021, Comunidad de Madrid CIFRA S2010/BMD-2378 and Programa Intensificación Actividad Investigadora. BFF by ISCIII Joan Rodes

Adjuvant Effect of Titanium Brushes in Peri-Implant Surgical Treatment: A Systematic Review

Background: the prognosis of peri-implant surgery can be affected by poor decontamination of the implant surface, which could be improved with the use of titanium brushes. The objectives of this systematic review were to evaluate the effectiveness of titanium brushes in the decontamination of the implant surface in terms of plaque index, probing depth, bleeding on probing and bone loss/gain; as well as its effectiveness according to the type of peri-implant bone defect. Methods: an electronic search was carried out in the PubMed, Scopus, Cochrane and Embase databases, as well as a manual search. The search strategy included four keywords: “Peri-implantitis”, “Periimplantitis”, “Implant Surface Decontamination” and “Titanium Brush”. Randomized controlled studies published in the last 10 years were included and systematic reviews, in vitro studies and animal studies were excluded. Results: 142 references were found, from which only four articles met the inclusion criteria. All of the studies included in the present review reported beneficial results in terms of probing depth, gingival index and radiographic bone loss and gain after implant surface decontamination adjuvated by titanium brushes. Conclusions: titanium rotary brushes show improvements in the evolution and prognosis of peri-implant surgery, although more long-term studies are needed to draw more solid conclusionsOdontologí

O FEMINISMO NA LITERATURA: A IMPORTÂNCIA DA VISIBILIDADE DA MULHER NO ENSINO DE LITERATURA NA EDUCAÇÃO BÁSICA ATRAVÉS DO TEXTO COMPANHEIRAS DE ENEIDA DE MORAES

The present work aims to present a teaching practice of literary literacy through the chronicle Companheiras, written by Eneida de Moraes, with the application of the basic sequence proposed by Rildo Cosson (2014) and the proposals of the interaction with the literary text. Specifically, the focus of qualitative-bibliographic research is a proposal for the application of a reading project for high school classes. In order to show the relevance of female authorship and protagonism in literature studies in basic education, aiming to systematize motivational reading practice that generates satisfactory results regarding the interpretation of the literary work. Since the first contact in the development of the individual as a reader most often occurs in schools. Also from the theoretical basis, the aim is to understand the voices of women in literature and to bring reading practices according to the studies of Duarte (2003), Cosson (2014), Hollanda (1993), Cândido (1989) and to what extent the work with the literary text can corroborate the acquisition of multiple languages ”‹”‹by the students. The humanizing power which the literary text has over the individual. Finally, we sought to promote a humanized didactic sequence, with female voices, in dialogue with cultural studies.O presente trabalho tem por objetivo apresentar uma prática docente de letramento literário por meio da crônica Companheiras, da escritora Eneida de Moraes, com a aplicação da sequência básica proposta por Rildo Cosson (2014) e das propostas da interação com o texto literário. Especificamente, o foco da pesquisa-bibliográfica de cunho qualitativo consiste em uma proposta de aplicação de um projeto de leitura para turmas de Ensino Médio. Com intuito de mostrar a relevância da autoria e do protagonismo feminino nos estudos de literatura na educação básica, objetivando sistematizar prática de leitura motivacional que gere resultados satisfatórios quanto à interpretação da obra literária. Visto que o primeiro contato no que tange ao desenvolvimento do indivíduo como leitor, na maioria das vezes, ocorre nas escolas. Ainda sob o ponto de vista teórico, busca-se entender as vozes das mulheres na literatura e trazer práticas de leitura segundo os estudos de Duarte (2003), Cosson (2014), Hollanda (1993),Cândido (1989)e em que medida o trabalho com o texto literário pode corroborar na aquisição de múltiplas linguagens pelos discentes. O poder humanizador que o texto literário possui sobre o indivíduo.Por fim, buscou-se promover uma sequência didática humanizada, com vozes femininas, dialogando com os estudos culturais

Effect of statin use on outcomes of adults with candidemia

Background: Statins have immunomodulatory properties and hinder Candida growth. However, it is unknown whether they may improve prognosis in patients with candidemia. We sought to determine the effect of prior statin use on the clinical outcomes of patients suffering candidemia. Methods and Findings: Multicenter cohort study of hospitalized adults with candidemia between 2005 and 2011 in six hospitals in Spain, Brazil and Argentina. Of 326 candidemias, 44 (13.5%) occurred in statin users and 282 (86.5%) in statin non-users. The median value of APACHE II at candidemia diagnosis was similar between groups (18 vs. 16; p=.36). Candida albicans was the most commonly isolated species, followed by C. parapsilosis, C. tropicalis, C. glabrata, and C. krusei. There were no differences regarding appropriate empirical antifungal treatment. Statin users had a lower early (5 d) case-fatality rate than non-users (4.5 vs. 17%; p=.031). This effect was not observed with other cardiovascular drugs (aspirin, beta blockers and ACE inhibitors). Independent factor related to early case-fatality rate was APACHE II score (AOR, 1.08; 95% CI, 1.03-1.14; p=.002). An appropriate empirical antifungal therapy (AOR, 0.11; 95% CI, 0.04-0.26; p=<.001) and prior statin use were independently associated with lower early case-fatality (AOR, 0.17; 95% CI, 0.03-0.93; p=.041). Fourteen days (14d) and overall (30d) case-fatality rates were similar between groups (27% vs. 29%; p=0.77 and 40% vs. 44%; p=.66). Conclusions: The use of statins might have a beneficial effect on outcomes of patients with candidemia. This hypothesis deserves further evaluation in randomized trials

Lectura de contexto y abordaje psicosocial desde los enfoques narrativos. Piedecuesta, Bucaramanga, Medellín y Vélez.

En el presente trabajo se analizarán y valorarán estudios de caso, que presentan situaciones psicosociales traumáticas y en crisis. A partir de este ejercicio propuesto, se busca la apropiación de la temática de las estrategias de abordaje psicosocial, partiendo desde una perspectiva narrativa. Este informe se propone reflejar la comprensión significativa de los desarrollos temáticos de las unidades propuestas del diplomado; con el fin de brindarnos un acercamiento conceptual a los enfoques narrativos y de esta manera generar argumentos con una postura clara y coherente desde la técnica Análisis del Relato en un escenario específico. A través del planteamiento de preguntas se busca un acercamiento psicosocial ético y proactivo que contribuyan en la superación de las condiciones de victimización. Se planteará el estudio de caso “Caso Pandurí”, donde se realizó el respectivo análisis y se generaron reflexiones sobre su abordaje, proponiéndose estrategias de acompañamiento psicosocial, teniendo en cuenta los conceptos aprendidos.In the present work, case studies will be analyzed and evaluated, which present traumatic and crisis psychosocial situations. From this proposed exercise, the appropriation of the theme of the psychosocial approach strategies is sought, starting from a narrative perspective. This report aims to reflect the significant understanding of the thematic developments of the proposed units of the diploma course; in order to provide a conceptual approach to narrative approaches and thus generate arguments with a clear and consistent position from the technique Story Analysis in a specific scenario. Through the posing of questions, an ethical and proactive psychosocial approach is sought that contributes to overcoming the conditions of victimization. The case study "Caso Pandurí" will be presented, where the respective analysis was carried out and reflections were generated on its approach, proposing psychosocial accompaniment strategies, taking into account the concepts learned

Granulocytes-Rich Thrombi in Cerebral Large Vessel Occlusion Are Associated with Increased Stiffness and Poorer Revascularization Outcomes

Altres ajuts: acords transformatius de la UABWe aim to identify a profile of intracranial thrombus resistant to recanalization by mechanical thrombectomy (MT) in acute stroke treatment. The first extracted clot of each MT was analyzed by flow cytometry obtaining the composition of the main leukocyte populations: granulocytes, monocytes, and lymphocytes. Demographics, reperfusion treatment, and grade of recanalization were registered. MT failure (MTF) was defined as final thrombolysis in cerebral infarction score IIa or lower and/or need of permanent intracranial stenting as a rescue therapy. To explore the relationship between stiffness of intracranial clots and cellular composition, unconfined compression tests were performed in other cohorts of cases. Thrombi obtained in 225 patients were analyzed. MTF were observed in 30 cases (13%). MTF was associated with atherosclerosis etiology (33.3% vs. 15.9%; p = 0.021) and higher number of passes (3 vs. 2; p < 0.001). Clot analysis of MTF showed higher percentage of granulocytes [82.46 vs. 68.90% p < 0.001] and lower percentage of monocytes [9.18% vs.17.34%, p < 0.001] in comparison to successful MT cases. The proportion of clot granulocytes (aOR 1.07; 95% CI 1.01-1.14) remained an independent marker of MTF. Among thirty-eight clots mechanically tested, there was a positive correlation between granulocyte proportion and thrombi stiffness (Pearson's r = 0.35, p = 0.032), with a median clot stiffness of 30.2 (IQR, 18.9-42.7) kPa. Granulocytes-rich thrombi are harder to capture by mechanical thrombectomy due to increased stiffness, so a proportion of intracranial granulocytes might be useful to guide personalized endovascular procedures in acute stroke treatment. Supplementary Information: The online version contains supplementary material available at 10.1007/s13311-023-01385-1

La Facultad de Ciencias Exactas, Físicas y Naturales

se analiza el momento fundacionalpublishedVersionFil: Scotto, Carolina. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Filosofía; Argentina.Fil: Gordillo, Mónica. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Valdemarca, Laura. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Valdemarca, Laura. Universidad Nacional de Córdoba. Facultad de Derecho y Ciencias Sociales; Argentina.Fil: Chaves, Liliana. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Dain, Mariana. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Cecchetto, Gabriela. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Departamento de Geografía; Argentina.Fil: Favaccio, Carolina A. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Grisendi, Ezequiel. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Departamento de Antropología; Argentina.Fil: Requena, Pablo Manuel. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Philp, Marta. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Malecki, Juan Sebastián. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Coria, Adela. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Ciencias de la Educación; Argentina.Fil: Puttini, María Paula. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Blanco, Jessica. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Iparraguirre, Pablo. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Zabala, Mariela Eleonora. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Carli, María Cristina de. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Abratte, Juan Pablo. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Ciencias de la Educación; Argentina.Fil: Barrera, Julieta. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Laurenti, Alessandra. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Fil: Bruno, María Sol. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades. Escuela de Historia; Argentina.Otras Historia y Arqueologí

Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma

PURPOSE: CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple primary melanoma (SMP) and compare the data with those for patients from Spain to establish bases for melanoma genetic counseling in Latin America. METHODS: CDKN2A and MC1R were sequenced in 186 Latin American patients from Argentina, Brazil, Chile, Mexico, and Uruguay, and in 904 Spanish patients. Clinical and phenotypic data were obtained. RESULTS: Overall, 24 and 14% of melanoma-prone families in Latin America and Spain, respectively, had mutations in CDKN2A. Latin American families had CDKN2A mutations more frequently (P = 0.014) than Spanish ones. Of patients with SMP, 10% of those from Latin America and 8.5% of those from Spain had mutations in CDKN2A (P = 0.623). The most recurrent CDKN2A mutations were c.-34G>T and p.G101W. Latin American patients had fairer hair (P = 0.016) and skin (P < 0.001) and a higher prevalence of MC1R variants (P = 0.003) compared with Spanish patients. CONCLUSION: The inclusion criteria for genetic counseling of melanoma in Latin America may be the same criteria used in Spain, as suggested in areas with low to medium incidence, SMP with at least two melanomas, or families with at least two cases among first- or second-degree relatives.Genet Med 18 7, 727-736