Gauged Laplacians on quantum Hopf bundles

We study gauged Laplacian operators on line bundles on a quantum 2-dimensional sphere. Symmetry under the (co)-action of a quantum group allows for their complete diagonalization. These operators describe `excitations moving on the quantum sphere' in the field of a magnetic monopole. The energies are not invariant under the exchange monopole/antimonopole, that is under inverting the direction of the magnetic field. There are potential applications to models of quantum Hall effect.Comment: v2: latex; 32 pages. Papers re-organized; no major changes, several minor ones. Commun. Math. Phys. In pres

A Hopf bundle over a quantum four-sphere from the symplectic group

We construct a quantum version of the SU(2) Hopf bundle $S^7 \to S^4$. The quantum sphere $S^7_q$ arises from the symplectic group $Sp_q(2)$ and a quantum 4-sphere $S^4_q$ is obtained via a suitable self-adjoint idempotent $p$ whose entries generate the algebra $A(S^4_q)$ of polynomial functions over it. This projection determines a deformation of an (anti-)instanton bundle over the classical sphere $S^4$. We compute the fundamental $K$-homology class of $S^4_q$ and pair it with the class of $p$ in the $K$-theory getting the value -1 for the topological charge. There is a right coaction of $SU_q(2)$ on $S^7_q$ such that the algebra $A(S^7_q)$ is a non trivial quantum principal bundle over $A(S^4_q)$ with structure quantum group $A(SU_q(2))$.Comment: 27 pages. Latex. v2 several substantial changes and improvements; to appear in CM

Noncommutative families of instantons

We construct $\theta$-deformations of the classical groups SL(2,H) and Sp(2). Coacting on the basic instanton on a noncommutative four-sphere $S^4_\theta$, we construct a noncommutative family of instantons of charge 1. The family is parametrized by the quantum quotient of $SL_\theta(2,H)$ by $Sp_\theta(2)$.Comment: v2: Minor changes; computation of the pairing at the end of Sect. 5.1 improve

"Emocionarte" las artes plásticas como medio para fortalecer la expresión de las emociones en los niños y niñas de transición B del colegio Claustro Moderno.

Fortalecer la exteriorización y manejo de emociones partiendo de la inteligencia emocional en los niños y niñas del grado Transición B, del Colegio Claustro Moderno, por medio de las artes plásticas.Emocionarte busca ser un medio para la expresión de emociones, pero, más allá de eso, busca también visualizar en cada niño y niña su sentir frente a la vida, el entorno, las situaciones que no comprende y que de cierto modo se le salen de las manos; todo ser humano necesita una especie de “liberación” de aquello que le genera malestar pero además, comprenderlo, pues es clave para tener una emocionalidad más equilibrada, y que mejor que lograr todo esto por medio del arte. Para tal fin a continuación se describe la manera en que se desarrollan las sesiones

Consecuencias del régimen simple de tributación para las personas naturales y jurídicas de la ciudad de Cúcuta

Los impuestos que contribuyen los ciudadanos se definen por ser erogaciones de gran importancia y pertinencia para la implementación de políticas públicas por parte del órgano coercitivo, en síntesis, del Estado. Esta erogación económica es una de las acciones consideradas como algunos por innecesarias, argumentando que solamente son cobrados hacia la población de estratos medio y bajo, sin embargo, otros mencionan que es uno de los deberes más importantes que deben cumplir los ciudadanos en búsqueda de ser partícipes en la generación de cambios y progresos sociales para la sociedad en general. La metodología implementada en la investigación corresponde a la mixta, en donde se utiliza tanto el enfoque cualitativo como cuantitativo, obteniendo información relacionada con los objetivos planteados en la investigación. Entre los resultados obtenidos se identifica que algunas personas argumentan la participación en la contribución de impuesto en el régimen simple y otros desconocen las consecuencias que se presentan, siendo un escenario oportuno para ofrecer información y exponer las características y aspectos más notorios de este régimen. Finalizando por conclusión se determina que la cultura en la contribución de impuestos es muy mínima y debe ser incentivada por medio de capacitaciones y demás actuaciones para que la sociedad logre comprender la importancia de los impuestos.The taxes that citizens contribute are defined as being expenditures of great importance and relevance for the implementation of public policies by the coercive body, in short, of the State. This economic outlay is one of the actions considered as some by unnecessary, arguing that they are only charged towards the population of middle and low strata, however, others mention that it is one of the most important duties that citizens must fulfill in search of being Participants in the generation of changes and social progress for society in general. The methodology implemented in the research corresponds to the mixed one, where both the qualitative and quantitative approach is used, obtaining information related to the objectives set in the research. Among the results obtained, it is identified that some people argue the participation in the tax contribution in the simple regime and others do not know the consequences that arise, being an opportune scenario to offer information and expose the most notorious characteristics and aspects of this regime. Finalizing by conclusion it is determined that the culture in the tax contribution is very minimal and should be encouraged through training and other actions so that society can understand the importance of taxes

A new MEFV gene mutation in an Iranian patient with familial Mediterranean fever.

Familial mediterranean fever (FMF) is an inherited autoinflammatory disorder characterized by recurrent episodes of fever and painful inflammation involving the intra-abdominal organs, the lungs and the joints, which is highly prevalent in specific ethnic groups including the Iranians. We report a 12-year-old boy from Iran, with a clinical history of recurrent fever. Based on the suggestive clinical data, mutational analysis revealed the presence of the novel c.1945C>T heterozygous variant in exon 10, which leads to a leucine to phenylalanine change at position 649 of the protein. The mutation was inherited from the mother. This novel mutation lies in exon 10 of the MEFV gene, which encodes for a domain called B30.2-SPRY, located in the C-terminal region of the pyrin protein and contains the most frequent mutations associated with FMF. The present report expands the spectrum of MEFV gene mutations associated with FMF. The uniqueness of this study, compared with other published case reports, consists in the new mutation found in the MEFV gene. In fact, new mutations in this gene are of high interest, in order to better understand the role of this gene in autoinflammation

Towards the genetic basis of cerebral venous thrombosis-the BEAST Consortium: a study protocol.

INTRODUCTION: Cerebral venous thrombosis (CVT) is a rare cerebrovascular condition accounting for <1% of all stroke cases and mainly affects young adults. Its genetic aetiology is not clearly elucidated. METHODS AND ANALYSIS: To better understand the genetic basis of CVT, we have established an international biobank of CVT cases, Biorepository to Establish the Aetiology of Sinovenous Thrombosis (BEAST) which aims to recruit highly phenotyped cases initially of European descent and later from other populations. To date we have recruited 745 CVT cases from 12 research centres. As an initial step, the consortium plans to undertake a genome-wide association analysis of CVT using the Illumina Infinium HumanCoreExome BeadChip to assess the association and impact of common and low-frequency genetic variants on CVT risk by using a case-control study design. Replication will be performed to confirm putative findings. Furthermore, we aim to identify interactions of genetic variants with several environmental and comorbidity factors which will likely contribute to improve the understanding of the biological mechanisms underlying this complex disease. ETHICS AND DISSEMINATION: BEAST meets all ethical standards set by local institutional review boards for each of the participating sites. The research outcomes will be published in international peer-reviewed open-access journals with high impact and visibility. The results will be presented at national and international meetings to highlight the contributions into improving the understanding of the mechanisms underlying this uncommon but important disease. This international DNA repository will become an important resource for investigators in the field of haematological and vascular disorders

Coma in adult cerebral venous thrombosis:The BEAST study

Background and purpose: Coma is an independent predictor of poor clinical outcomes in cerebral venous thrombosis (CVT). We aimed to describe the association of age, sex, and radiological characteristics of adult coma patients with CVT. Methods: We used data from the international, multicentre prospective observational BEAST (Biorepository to Establish the Aetiology of Sinovenous Thrombosis) study. Only positively associated variables with coma with &lt;10% missing data in univariate analysis were considered for the multivariate logistic regression model. Results: Of the 596 adult patients with CVT (75.7% women), 53 (8.9%) patients suffered coma. Despite being a female-predominant disease, the prevalence of coma was higher among men than women (13.1% vs. 7.5%, p = 0.04). Transverse sinus thrombosis was least likely to be associated with coma (23.9% vs. 73.3%, p &lt; 0.001). The prevalence of superior sagittal sinus thrombosis was higher among men than women in the coma sample (73.6% vs. 37.5%, p = 0.01). Men were significantly older than women, with a median (interquartile range) age of 51 (38.5–60) versus 40 (33–47) years in the coma (p = 0.04) and 44.5 (34–58) versus 37 (29–48) years in the non-coma sample (p &lt; 0.001), respectively. Furthermore, an age-and superior sagittal sinus-adjusted multivariate logistic regression model found male sex (odds ratio = 1.8, 95% confidence interval [CI] = 1.0–3.4, p = 0.04 to be an independent predictor of coma in CVT, with an area under the receiver operating characteristic curve of 0.61 (95% CI = 0.52–0.68, p = 0.01). Conclusions: Although CVT is a female-predominant disease, men were older and nearly twice as likely to suffer from coma than women