Detecting the Stimulated Decay of Axions at Radio Frequencies

Assuming axion-like particles account for the entirety of the dark matter in the Universe, we study the possibility of detecting their decay into photons at radio frequencies. We discuss different astrophysical targets, such as dwarf spheroidal galaxies, the Galactic Center and halo, and galaxy clusters. The presence of an ambient radiation field leads to a stimulated enhancement of the decay rate; depending on the environment and the mass of the axion, the effect of stimulated emission may amplify the photon flux by serval orders of magnitude. For axion-photon couplings allowed by astrophysical and laboratory constraints(and possibly favored by stellar cooling), we find the signal to be within the reach of next-generation radio telescopes such as the Square Kilometer Array.Comment: Minor changes, references added, matches published versio

Driving Sustainable land productivity through doubled-up legume technology on small farms

United States Agency for International Developmen

Measuring sustainable intensification in smallholder agroecosystems: A review

Sustainable intensification (SI) is at the forefront of food security discussions as a means to meet the growing demand for agricultural production while conserving land and other resources. A broader definition of SI is emerging that takes into account the human condition, nutrition and social equity. Next steps require identification of indicators and associated metrics, to track progress, assess tradeoffs and identify synergies. Through a systematic, qualitative review of the literature we identified SI indicators, with a primary focus on African smallholder farming systems. We assessed indicators and metrics for which there is consensus, and those that remain contested. We conclude that, while numerous metrics for evaluating SI systems exist, many often-cited indicators lack strong sets of associated metrics

On the Origin of Gauge Symmetries and Fundamental Constants

A statistical mechanism is proposed for symmetrization of an extra space. The conditions and rate of attainment of a symmetric configuration and, as a consequence, the appearance of gauge invariance in low-energy physics is discussed. It is shown that, under some conditions, this situation occurs only after completion of the inflationary stage. The dependence of the constants $\hbar$ and G on the geometry of the extra space and the initial parameters of the Lagrangian of the gravitational field with higher derivatives are analyzed.Comment: 9 pages, minor correction

Cell-laden hydrogel as a clinical-relevant 3D model for analyzing neuroblastoma growth, immunophenotype, and susceptibility to therapies

High risk Neuroblastoma (NB) includes aggressive, metastatic solid tumors of childhood. The survival rate improved only modestly, despite the use of combination therapies including novel immunotherapies based on the antibody mediated targeting of tumor-associated surface ligands. Treatment failures may be due to the lack of adequate in vitro models for studying, in a given patient, the efficacy of potential therapeutics, including those aimed to enhance anti-tumor immune responses. We here propose a 3D alginate-based hydrogel as extracellular microenvironment to evaluate the effects of the three-dimensionality on biological and immunological properties of NB cells. NB cell lines grown within the 3D alginate spheres presented spheroid morphology, optimal survival, and proliferation capabilities, and a reduced sensitivity to the cytotoxic effect of imatinib mesylate. 3D cultured NB cells were also evaluated for the constitutive and IFN-y-induced expression of surface molecules capable of tuning the anti-tumor activity of NK cells including immune checkpoint ligands. In particular, IFN-y induced de novo expression of high amounts of HLA-I molecules, which protected NB cells from the attack mediated by KIR/KIR-L matched NK cells. Moreover, in the 3D alginate spheres, the cytokine increased the expression of the immune checkpoint ligands PD-Ls and B7-H3 while virtually abrogating that of PVR, a ligand of DNAM-1 activating receptor, whose expression correlates with high susceptibility to NK-mediated killing. Our 3D model highlighted molecular features that more closely resemble the immunophenotypic variants occurring in vivo and not fully appreciated in classical 2D culture conditions.Thus, based on our results, 3D alginate-based hydrogels might represent a clinical-relevant cell culture platform where to test the efficacy of personalized therapeutic approaches aimed to optimize the current and innovative immune based therapies in a very systematic and reliable way