424 research outputs found
Reporting of prognostic markers: current problems and development of guidelines for evidence-based practice in the future
- Author
- A J Sutton
- AJ Sutton
- B Friedberg
- CC Parker
- CL Vale
- D Heney
- D R Jones
- DG Altman
- DG Altman
- DG Altman
- DJR Hutchon
- EGJ Zandbergen
- F Berthold
- J Sakamoto
- JL Fleiss
- JM Maris
- K R Abrams
- L Duchateau
- L Rushton
- LA Stewart
- LA Stewart
- M Blettner
- M Egger
- MG Mott
- MKB Parmar
- MP Look
- N Eche
- P C Lambert
- PC Lambert
- R D Riley
- RD Riley
- S A Burchill
- W Sauerbrei
- Publication venue
- Nature Publishing Group
- Publication date
- 15/04/2003
- Field of study
Prognostic markers help to stratify patients for treatment by identifying patients with different risks of outcome (e.g. recurrence of disease), and are important tools in the management of cancer and many other diseases. Systematic review and meta-analytical approaches to identifying the most valuable prognostic markers are needed because (sometimes conflicting) evidence relating to markers is often published across a number of studies. To investigate the practicality of this approach, an empirical investigation of a systematic review of tumour markers for neuroblastoma was performed; 260 studies of prognostic markers were identified, which considered 130 different markers
A Retrospective Cohort Study of the Potency of lipid-lowering therapy and Race-gender Differences in LDL cholesterol control
- Author
- A Ferrara
- B McGinnis
- Barbara J Turner
- BJ Turner
- Christopher S Hollenbeak
- D Litaker
- DC Chan
- DM Becker
- DM Mann
- E Mostaghel
- ES Ford
- Expert Panel on Detection
- GA Mensah
- I Gouni-Berthold
- I Hartz
- JG O'Meara
- JG O'Meara
- KC Ferdinand
- KR Bailey
- L Casebeer
- L Cho
- M Sharma
- MA Brookhart
- Mark Weiner
- MB Yilmaz
- ME Chernew
- MJ Pletcher
- MN Willson
- R Gross
- R Hou
- RA Hayward
- RD Santos
- RH Chapman
- RL Fong
- RL Sedjo
- RW Grant
- SD Persell
- Simon SK Tang
- SM Grundy
- T Lagu
- TB Gibson
- TD Sequist
- TL Mark
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Reasons for race and gender differences in controlling elevated low density lipoprotein (LDL) cholesterol may be related to variations in prescribed lipid-lowering therapy. We examined the effect of lipid-lowering drug treatment and potency on time until LDL control for black and white women and men with a baseline elevated LDL.</p> <p>Methods</p> <p>We studied 3,484 older hypertensive patients with dyslipidemia in 6 primary care practices over a 4-year timeframe. Potency of lipid-lowering drugs calculated for each treated day and summed to assess total potency for at least 6 and up to 24 months. Cox models of time to LDL control within two years and logistic regression models of control within 6 months by race-gender adjust for: demographics, clinical, health care delivery, primary/specialty care, LDL measurement, and drug potency.</p> <p>Results</p> <p>Time to LDL control decreased as lipid-lowering drug potency increased (P < 0.001). Black women (N = 1,440) received the highest potency therapy (P < 0.001) yet were less likely to achieve LDL control than white men (N = 717) (fully adjusted hazard ratio [HR] 0.66 [95% CI 0.56-0.78]). Black men (N = 666) and white women (N = 661) also had lower adjusted HRs of LDL control (0.82 [95% CI 0.69, 0.98] and 0.75 [95% CI 0.64-0.88], respectively) than white men. Logistic regression models of LDL control by 6 months and other sensitivity models affirmed these results.</p> <p>Conclusions</p> <p>Black women and, to a lesser extent, black men and white women were less likely to achieve LDL control than white men after accounting for lipid-lowering drug potency as well as diverse patient and provider factors. Future work should focus on the contributions of medication adherence and response to treatment to these clinically important differences.</p
Is Mn-Bound Substrate Water Protonated in the S2 State of Photosystem II?
- Author
- A Guskov
- A Kawamori
- AR Holzwarth
- B Epel
- B Kok
- B Nöring
- CP Aznar
- DA Berthold
- EM Sproviero
- G Hendry
- G Hendry
- G Renger
- GC Dismukes
- H Yamada
- H-A Chu
- J Messinger
- J Messinger
- J Messinger
- J Messinger
- J Yano
- J Yano
- JH Su
- Ji-Hu Su
- JM Peloquin
- Johannes Messinger
- JP Dekker
- KA Åhrling
- KN Ferreira
- L Kulik
- LV Kulik
- LV Kulik
- M Haumann
- M Lundberg
- MCW Evans
- PEM Siegbahn
- R Fiege
- R Tagore
- R Tagore
- RD Britt
- RJ Debus
- S Isgandarova
- S Styring
- S Turconi
- S Zein
- T Noguchi
- T Noguchi
- T Wydrzynski
- T Wydrzynski
- TC Weng
- VJ DeRose
- VK Yachandra
- VK Yachandra
- W Hillier
- W Hillier
- W Liang
- W Lubitz
- W Lubitz
- X-S Tang
- XS Tang
- Y Kimura
- Ö Hansson
- Publication venue
- Springer Vienna
- Publication date
- 01/01/2009
- Field of study
In spite of great progress in resolving the geometric structure of the water-splitting Mn4OxCa cluster in photosystem II, the binding sites and modes of the two substrate water molecules are still insufficiently characterized. While time-resolved membrane-inlet mass spectrometry measurements indicate that both substrate water molecules are bound to the oxygen-evolving complex (OEC) in the S2 and S3 states (Hendry and Wydrzynski in Biochemistry 41:13328–13334, 2002), it is not known (1) if they are both Mn-bound, (2) if they are terminal or bridging ligands, and (3) in what protonation state they are bound in the different oxidation states Si (i = 0, 1, 2, 3, 4) of the OEC. By employing 17O hyperfine sublevel correlation (HYSCORE) spectroscopy we recently demonstrated that in the S2 state there is only one (type of) Mn-bound oxygen that is water exchangeable. We therefore tentatively identified this oxygen as one substrate ‘water’ molecule, and on the basis of the finding that it has a hyperfine interaction of about 10 MHz with the electron spin of the Mn4OxCa cluster, we suggest that it is bound as a Mn–O–Mn bridge within a bis-μ2 oxo-bridged unit (Su et al. in J Am Chem Soc 130:786–787, 2008). Employing pulse electron paramagnetic resonance, 1H/2H Mims electron-nuclear double resonance and 2H-HYSCORE spectroscopies together with 1H/2H-exchange here, we test this hypothesis by probing the protonation state of this exchangeable oxygen. We conclude that this oxygen is fully deprotonated. This result is discussed in the light of earlier reports in the literature
Local Extinction in the Bird Assemblage in the Greater Beijing Area from 1877 to 2006
- Author
- A David
- A David
- AF Zuur
- AJ Stattersfield
- AP Paterson
- B Ebenman
- Benjamin D. Bravery
- BP Zitske
- C Wood
- CD Thomas
- Csaba Moskát
- D Gondhalekar
- D Nunez
- DB Wake
- DN Bonter
- DT Ning
- E Padoa-Schioppa
- F Gill
- GD Wilder
- H Qian
- HC Wang
- HG Xu
- I Newton
- IMD Maclean
- International BirdLife
- International BirdLife
- J Liu
- J MacKinnon
- J Yuan
- JA Pounds
- JC Axmacher
- JCZ Woinarski
- Jing Cai
- JP Haskell
- JV Remsen Jr
- JY Xiao
- KP Burnham
- KS Bawa
- LN Tang
- M Brazil
- M Castelletta
- M Kutner
- MH Tan
- Miguel Pedrono
- Olivier Pays
- P Berthold
- Philippe Chouteau
- PM Bennett
- QH Sun
- R Jiang Z.
- RB Harris
- RD Wu
- RL Hutto
- RL Roberts
- S Droege
- S MacKinnon
- S Zhao
- SK Skagen
- T Enters
- TH Shaw
- XB Sheng
- Y Fang
- Y Jun
- Y Ohno
- Y Xie
- YQ Xu
- Z Xie
- ZH Jiang
- Zhigang Jiang
- Zhongqiu Li
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Recent growth in industrialization and the modernization of agricultural activities, combined with human population growth, has greatly modified China’s natural environment, particularly in the vicinity of large cities. We compared avifauna checklists made between 1877 and 1938 with current checklists to determine the extent of local bird extinctions during the last century in the greater Beijing area. Our study shows that of the 411 bird species recorded from 1877–1938, 45 (10.9%) were no longer recorded from 2004–2006. Birds recorded as ‘rare’ in 1938 were more likely to have disappeared in subsequent years. Migrant status also influenced the probability of local bird extinction with winter migrants being the most affected class. Moreover, larger birds were more likely to have disappeared than smaller ones, potentially explained by differential ecological requirements and anthropogenic exploitation. Although our habitat descriptions and diet classification were not predictors of local bird extinction, the ecological processes driving local bird extinction are discussed in the light of historical changes that have impacted this region since the end of the 1930 s. Our results are of importance to the broader conservation of bird wildlife
Green Sturgeon Physical Habitat Use in the Coastal Pacific Ocean
- Author
- A Merems
- AB Stein
- Anonymous
- B McCune
- B McCune
- B Van Horne
- BA Hawkins
- BX Semmens
- CG Lowe
- DA Fox
- David D. Huff
- DB Hayes
- DJ Wright
- DL Erickson
- DL Erickson
- DL Erickson
- DL Erickson
- DW Roberts
- DW Welch
- E Rochard
- EA Fairchild
- ER Lundblad
- Ethan A. Mora
- F Ferretti
- FM Parauka
- FM Parauka
- GM Viswanathan
- J Fox
- J Monk
- J Munro
- J Oksanen
- JA Nelder
- JAF Diniz
- JB Johnson
- JB Kruskal
- JC Heublein
- JE Fitch
- JMV Hoef
- JR Bray
- JT Kelly
- K Bartoń
- K Evans
- K Winker
- KJ Sulak
- KP Burnham
- LA Comeau
- M Donnellan
- M Salemaa
- MA Young
- MD Erdey-Heydorn
- ML Moser
- NM Nasby-Lucas
- P Afonso
- P Berthold
- P Segurado
- PA Stephens
- PB Adams
- PB Moyle
- PM Mather
- Polly S. Rankin
- R Ihaka
- R Virtanen
- RD Cook
- RE Edwards
- RL Benson
- RW Hannah
- RW Laney
- S Weisberg
- Sharyn Jane Goldstien
- SJ Parker
- SN Wood
- ST Lindley
- ST Lindley
- ST Ross
- Steven T. Lindley
- TM Grothues
- VP Godambe
- WE Bemis
- WN Venables
- Publication venue
- Public Library of Science
- Publication date
- 22/09/2011
- Field of study
The green sturgeon (Acipenser medirostris) is a highly migratory, oceanic, anadromous species with a complex life history that makes it vulnerable to species-wide threats in both freshwater and at sea. Green sturgeon population declines have preceded legal protection and curtailment of activities in marine environments deemed to increase its extinction risk. Yet, its marine habitat is poorly understood. We built a statistical model to characterize green sturgeon marine habitat using data from a coastal tracking array located along the Siletz Reef near Newport, Oregon, USA that recorded the passage of 37 acoustically tagged green sturgeon. We classified seafloor physical habitat features with high-resolution bathymetric and backscatter data. We then described the distribution of habitat components and their relationship to green sturgeon presence using ordination and subsequently used generalized linear model selection to identify important habitat components. Finally, we summarized depth and temperature recordings from seven green sturgeon present off the Oregon coast that were fitted with pop-off archival geolocation tags. Our analyses indicated that green sturgeon, on average, spent a longer duration in areas with high seafloor complexity, especially where a greater proportion of the substrate consists of boulders. Green sturgeon in marine habitats are primarily found at depths of 20–60 meters and from 9.5–16.0°C. Many sturgeon in this study were likely migrating in a northward direction, moving deeper, and may have been using complex seafloor habitat because it coincides with the distribution of benthic prey taxa or provides refuge from predators. Identifying important green sturgeon marine habitat is an essential step towards accurately defining the conditions that are necessary for its survival and will eventually yield range-wide, spatially explicit predictions of green sturgeon distribution
Genome-Wide Analysis of Transcriptional Reprogramming in Mouse Models of Acute Myeloid Leukaemia
- Author
- A Cozzio
- A Subramanian
- AD Wood
- AJ Tipping
- AM Melnick
- Andrew J. Bannister
- Anthony D. Whetton
- AP Boyle
- AP Fejes
- AT Look
- AV Krivtsov
- Axel Imhof
- BB Zeisig
- Berthold Göttgens
- BJ Huntly
- Brian J. Huntly
- Brynn T. Kvinlaug
- BS Carver
- CW So
- D Hanahan
- DA Persons
- DJ Park
- Dominik Spensberger
- DR Rhodes
- E Spooncer
- EA Eklund
- Elaine Spooncer
- F Rosenbauer
- FY Tsai
- GG Wang
- GS Eichler
- H Harigae
- IJ Donaldson
- J Visvader
- JA Kennedy
- JE Pimanda
- JE Pimanda
- JH Martens
- JL Hess
- JM Wettenhall
- JR Landry
- K Deguchi
- KA Romer
- L Bullinger
- M Camos
- M Carapeti
- M Heuser
- MA Chapman
- Mark A. Dawson
- ME Ross
- MG Guenther
- MJ Weiss
- NC Gutierrez
- ND Heintzman
- ND Heintzman
- Nicolas Bonadies
- NK Wilson
- NK Wilson
- P Baldi
- P Du
- PJ Valk
- PM Ayton
- R Tonelli
- RD Hawkins
- RM Ayala
- RW Stam
- Samuel D. Foster
- SD Foster
- SH Orkin
- SJ Ho Sui
- SJ Horton
- SJ Zhang
- SM Lin
- T Katsumoto
- TH Rabbitts
- Wai-In Chan
- WY Chan
- Z Wang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Acute leukaemias are commonly caused by mutations that corrupt the transcriptional circuitry of haematopoietic stem/progenitor cells. However, the mechanisms underlying large-scale transcriptional reprogramming remain largely unknown. Here we investigated transcriptional reprogramming at genome-scale in mouse retroviral transplant models of acute myeloid leukaemia (AML) using both gene-expression profiling and ChIP-sequencing. We identified several thousand candidate regulatory regions with altered levels of histone acetylation that were characterised by differential distribution of consensus motifs for key haematopoietic transcription factors including Gata2, Gfi1 and Sfpi1/Pu.1. In particular, downregulation of Gata2 expression was mirrored by abundant GATA motifs in regions of reduced histone acetylation suggesting an important role in leukaemogenic transcriptional reprogramming. Forced re-expression of Gata2 was not compatible with sustained growth of leukaemic cells thus suggesting a previously unrecognised role for Gata2 in downregulation during the development of AML. Additionally, large scale human AML datasets revealed significantly higher expression of GATA2 in CD34+ cells from healthy controls compared with AML blast cells. The integrated genome-scale analysis applied in this study represents a valuable and widely applicable approach to study the transcriptional control of both normal and aberrant haematopoiesis and to identify critical factors responsible for transcriptional reprogramming in human cancer
Large expert-curated database for benchmarking document similarity detection in biomedical literature search
- Author
- Aanei CM
- Abid MB
- Abramowitz MK
- Abu-Zaid A
- Afnan M
- Agarabi C
- Ahmad R
- Aizat WM
- Al-Farha AA
- Al-Lawama M
- Alanio A
- Alaux C
- Albiol J
- Albrecht DR
- Albuquerque LG
- Alimba CG
- Allardyce J
- Almeida GMF
- Alonso-Caneiro D
- Alper OM
- Amer SEDR
- Amiya E
- Ammerman BA
- Amorim RM
- An Q
- Andersen SU
- Aplin JD
- Argyropoulos C
- Armitage C
- Ascher DB
- Ashry M
- Asmann YW
- Assaeed AM
- Atack JM
- Atanasov AG
- Atchison DA
- Atkins GJ
- Atlas L
- Avery SV
- Avillach P
- Baade PD
- Backman L
- Badie C
- Bae T
- Baier D
- Baker CI
- Bakkach J
- Baldi A
- Ball E
- Bannon R
- Bansal A
- Bardot O
- Barnett AG
- Barraud P
- Basharat Z
- Basner M
- Batra J
- Baumert P
- Bazanova OM
- Beale A
- Beck CR
- Becker D
- Beddoe T
- Bell ML
- Benezeth Y
- Bengtsson-Palme J
- Berbesque C
- Berezikov E
- Bergsland N
- Berners-Price S
- Bernhardt P
- Berrevoet F
- Berry E
- Berthold M
- Bessa TB
- Beyene TJ
- Biedermann PHW
- Bijleveld E
- Billington C
- Birch J
- Bittner F
- Bitzer M
- Blakely RD
- Blanck O
- Blaskovich MAT
- Bleackley M
- Blombach F
- Blum R
- Boehme KA
- Boelaert M
- Bogdanos D
- Bonvin AMJJ
- Bosch C
- Bosch O
- Boudreau SA
- Bourgoin T
- Bourke E
- Bouvard D
- Boykin LM
- Bradley G
- Bradshaw W
- Bramoweth AD
- Brand T
- Braubach O
- Braun D
- Braun RJ
- Brenneisen P
- Bridges KM
- Brown JAL
- Brown P
- Browngardt C
- Brownlie J
- Bruhl A
- Bukowy-Bieryllo Z
- Bull JA
- Burt A
- Bush SJ
- Butler LM
- Byrareddy SN
- Byrne HJ
- Cabantous S
- Cai Y
- Calatayud S
- Campana LG
- Campbell M
- Candal E
- Cao Z
- Cao Z
- Cardoso P
- Carlson K
- Carter D
- Cascella M
- Casillas S
- Castelvetro V
- Caswell PT
- Catry T
- Cavalli G
- Cernava T
- Cerovsky V
- Chacko G
- Chagoyen M
- Chakraborty S
- Chan SS
- Chandrasekaran AR
- Chatzitheochari S
- Chavez-Fumagalli MA
- Chen B
- Chen C-E
- Chen C-S
- Chen DF
- Chen H
- Chen H
- Chen J-T
- Chen X
- Chen Y
- Cheng C
- Cheng J
- Cheng S
- Cheung JTK
- Chinapaw M
- Chinopoulos C
- Cho WCS
- Chong L
- Chowdhury D
- Chung H-J
- Chwalibog A
- Ciresi A
- Cobine PA
- Cockcroft S
- Coelho LP
- Colella V
- Conesa A
- Conway A
- Cook PA
- Cooper DN
- Cooper J
- Coqueret O
- Corea EM
- Cosacak MI
- Costa BM
- Costa E
- Costa VD
- Coupland C
- Crawford SY
- Cruz AD
- Cui H
- Cui Q
- Cuiv PO
- Culver DC
- Cuypers M
- Cyr N
- D'Angiulli A
- Dahms TES
- Dai Z
- Daigle F
- Dalgleish R
- Dalrymple BP
- Danchin A
- Danielsen HE
- Darras S
- Daulatabad SV
- Davidson SM
- Day DA
- de Keersmaecker K
- de Leeuw F-E
- Dean LT
- Debrabant B
- Degirmenci V
- del Tredici AL
- Delahay RM
- Demaison L
- Denzel MS
- Deschodt M
- Devkota HP
- Devriendt K
- Dhariwal R
- Diao J
- Ding J
- Dings RPM
- Diouf B
- Dixon R
- Dlamini SV
- Dogan Y
- Domingues HS
- Dong XC
- Donner CF
- Dono M
- Doxey AC
- Dressick W
- Drevon CA
- Duan H
- Ducho C
- Ducommun B
- Dudley KJ
- Dufies M
- Duijf PHG
- Dumaz N
- Dwarakanath BS
- Ebell MH
- Echeverria N
- Ecke T
- Eckweiler D
- Eerola T
- Effiong A
- Ehret F
- Eisenhardt S
- Eixarch E
- El-Adawy H
- El-Esawi MA
- Elkum N
- Emmrich JV
- Engel MS
- Engel N
- Epp T
- Erickson TB
- Esfahlani SS
- Eskelinen E-L
- Eskew EA
- Esnakul AK
- Eustace AJ
- Evangelou E
- Fairhead M
- Falk S
- Fallah M
- Falter-Wagner CM
- Fan X
- Farber DB
- Faville MJ
- Feghali KA
- Fejzo MS
- Fernandez-Triana J
- Festa F
- Feteira A
- Feyerabend F
- Fierz W
- Filipp FV
- Fiona .
- Flegel WA
- Flood-Page P
- Florio T
- Forano E
- Forsayeth J
- Fox SA
- Franks SJ
- Frentiu FD
- Friebe M
- Frilander MJ
- Fu X
- Fujita S
- Furuta S
- Fuss J
- Gabrielsen M
- Gajda M
- Galea I
- Galluzzi L
- Gani F
- Ganpule AP
- Gao J
- Garcia-Alix A
- Gatchell M
- Gaullier G
- Gedye K
- Gelfer Y
- Ghelardi E
- Gill MR
- Gilliham M
- Giordano M
- Giunta C
- Gladue DP
- Gleeson PA
- Gloyn L
- Gnasso A
- Goarant C
- Gobet A
- Goggs R
- Gong H
- Gonzalezlez-Prendes R
- Goodin A
- Goodyear CS
- Gora D
- Gough MJ
- Govender P
- Govinden U
- Goyal R
- Graham EB
- Graham KE
- Grande-Perez A
- Graves PM
- Greene G
- Greenwald NF
- Greidanus H
- Greiff V
- Grice D
- Grimm DG
- Groen EJN
- Gruber J
- Grunau C
- Grundle DS
- Gruneberg P
- Grybos M
- Guisado JL
- Gumede N
- Gumulya Y
- Guo Y
- Gurevich VV
- Gurney-Champion OJ
- Gusev O
- Gutierrez-Sacristan A
- Habes M
- Hacker E
- Hage SR
- Hagen G
- Hahn S
- Haller DM
- Hammerschmidt S
- Han H
- Han J
- Han Q
- Han R
- Handfield M
- Hanson J
- Haore G
- Hapuarachchi HC
- Harder T
- Hardingham JE
- Harrison P
- Hartmann MD
- Harvey DJ
- Haston S
- Heck M
- Heers M
- Heffler E
- Heinrich M
- Helantera H
- Herbelet S
- Hew KF
- Higginbottom DB
- Higuchi Y
- Hilton R
- Hiroi N
- Hobbs E
- Hodzic E
- Hoenner X
- Hojsgaard D
- Hone A
- Hongoh Y
- Honjo K
- Horbar J
- Hori H
- Hu G
- Hu P
- Huber HP
- Huber M
- Hueso LE
- Huirne J
- Hurt L
- Huttner FJ
- Idborg H
- Ide K
- Ikeo K
- Ikonomopoulou MP
- Ingley E
- Jakeman PM
- Janga SC
- Janzen T
- Jayaraman J
- Jeltsch A
- Jensen A
- Jeurissen P
- Jia H
- Jia H
- Jia S
- Jiang F
- Jiang J
- Jiang X
- Jibb LA
- Jin Y
- Jo D
- Johnson AM
- Johnson DM
- Johnston M
- Jongen S
- Jonscher KR
- Jorens PG
- Jorgensen JOL
- Josse C
- Joubert JW
- Jung S-H
- Junior AM
- Jurman G
- Kabra D
- Kahan T
- Kaiser S
- Kamagata K
- Kamboj SK
- Kamiya H
- Kane NC
- Kang Y-K
- Karamanos Y
- Karmakar C
- Karp NA
- Kasian O
- Kauppila JH
- Kaye LK
- Kelly R
- Kelly S
- Kenna R
- Kennedy J
- Kersten B
- Khalaf RA
- Khalid JM
- Khan MM
- Khatlani T
- Khider T
- Kijanka GS
- Kim Y-M
- King SRB
- Kinyanjui T
- Kish JK
- Klempnauer K-H
- Kleppe A
- Klump H
- Kluz T
- Knox P
- Kobayashi T
- Kobold S
- Koch K-W
- Kohanbash G
- Kohls G
- Kohonen-Corish MRJ
- Koleva-Kolarova RG
- Kong X
- Konkle-Parker D
- Korpela KM
- Kostrikis LG
- Kraiczy P
- Kratz H
- Krause G
- Krebsbach PH
- Kristensen SR
- Kristiansson E
- Kueberuwa G
- Kugler J-M
- Kulkarni A
- Kumar G
- Kumar N
- Kumar N
- Kumari P
- Kunimatsu A
- Kurdak H
- Kurgan L
- Kurniawan NA
- Kwon YD
- Lachat C
- Lacy-Colson J
- Lagisz M
- Lai HM
- Laky B
- Lalaouna D
- Lammerding J
- Lange M
- Larrosa M
- Laslett AL
- Latif A
- Lau CL
- Lauschke VM
- LeClair EE
- Lee K-W
- Lee M-S
- Lee M-Y
- Lee S
- Li B
- Li G
- Li J
- Li J
- Li J
- Li Z
- Liang D
- Liang S
- Lidbury BA
- Lieb K
- Liehr T
- Liew AWC
- Lim CJ
- Lim YY
- Lin MZ
- Lindsey ML
- Line P-D
- Liu D
- Liu E
- Liu F
- Liu F
- Liu H
- Liu H
- Liu S
- Liu X
- Liu Y-P
- Lloyd VK
- Lo T-W
- Locci E
- Loft ND
- Loidl J
- Lopez-Escamez JA
- Lopez-Ruiz FJ
- Lorenzen J
- Lorkowski S
- Lovell NH
- Lu H
- Lu J-J
- Lu Q
- Lu W
- Lu Z
- Luengo GS
- Lund BA
- Lundh L-G
- Lussier AA
- Luu AM
- Lynch I
- Lysy PA
- Ma C
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- Publication venue
- OXFORD UNIV PRESS
- Publication date
- 29/10/2019
- Field of study
Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency–Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research
Measurements of Higgs bosons decaying to bottom quarks from vector boson fusion production with the ATLAS experiment at √=13TeV
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- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/06/2021
- Field of study
The paper presents a measurement of the Standard Model Higgs Boson decaying to b-quark pairs in the vector boson fusion (VBF) production mode. A sample corresponding to 126 fb−1 of s√=13TeV proton–proton collision data, collected with the ATLAS experiment at the Large Hadron Collider, is analyzed utilizing an adversarial neural network for event classification. The signal strength, defined as the ratio of the measured signal yield to that predicted by the Standard Model for VBF Higgs production, is measured to be 0.95+0.38−0.36 , corresponding to an observed (expected) significance of 2.6 (2.8) standard deviations from the background only hypothesis. The results are additionally combined with an analysis of Higgs bosons decaying to b-quarks, produced via VBF in association with a photon
The ATLAS inner detector trigger performance in pp collisions at 13 TeV during LHC Run 2
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- AbouZeid OS
- Abraham NL
- Abramowicz H
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- Chevalerias TJA
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- Zambito S
- Zanzi D
- Zeissner SV
- Zeitnitz C
- Zemaityte G
- Zeng JC
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zgubic M
- Zhang B
- Zhang DF
- Zhang G
- Zhang J
- Zhang K
- Zhang L
- Zhang L
- Zhang M
- Zhang R
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- Zhang X
- Zhang X
- Zhang Y
- Zhang Z
- Zhao P
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng Z
- Zhong D
- Zhou B
- Zhou C
- Zhou H
- Zhou M
- Zhou N
- Zhou Y
- Zhu C
- Zhu CG
- Zhu H
- Zhu HL
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zieminska D
- Zimine NI
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zou R
- Zou W
- Zwalinski L
- Publication venue
- Publication date
- 01/01/2022
- Field of study
The design and performance of the inner detector trigger for the high level trigger of the ATLAS experiment at the Large Hadron Collider during the 2016-2018 data taking period is discussed. In 2016, 2017, and 2018 the ATLAS detector recorded 35.6 fb(-1), 46.9 fb(-1), and 60.6 fb(-1) respectively of proton-proton collision data at a centre-of-mass energy of 13TeV. In order to deal with the very high interaction multiplicities per bunch crossing expected with the 13TeV collisions the inner detector trigger was redesigned during the long shutdown of the Large Hadron Collider from 2013 until 2015. An overview of these developments is provided and the performance of the tracking in the trigger for the muon, electron, tau and b-jet signatures is discussed. The high performance of the inner detector trigger with these extreme interaction multiplicities demonstrates how the inner detector tracking continues to lie at the heart of the trigger performance and is essential in enabling the ATLAS physics programme
Measurement of the tt¯tt¯ production cross section in pp collisions at √s=13 TeV with the ATLAS detector
- Author
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- Åkesson TPA
- Öncel ÖO
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 16/11/2021
- Field of study
A measurement of four-top-quark production using proton-proton collision data at a centre-of-mass energy of 13 TeV collected by the ATLAS detector at the Large Hadron Collider corresponding to an integrated luminosity of 139 fb−1 is presented. Events are selected if they contain a single lepton (electron or muon) or an opposite-sign lepton pair, in association with multiple jets. The events are categorised according to the number of jets and how likely these are to contain b-hadrons. A multivariate technique is then used to discriminate between signal and background events. The measured four-top-quark production cross section is found to be 26+17−15 fb, with a corresponding observed (expected) significance of 1.9 (1.0) standard deviations over the background-only hypothesis. The result is combined with the previous measurement performed by the ATLAS Collaboration in the multilepton final state. The combined four-top-quark production cross section is measured to be 24+7−6 fb, with a corresponding observed (expected) signal significance of 4.7 (2.6) standard deviations over the background-only predictions. It is consistent within 2.0 standard deviations with the Standard Model expectation of 12.0 ± 2.4 fb
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