Post-vaccination Symptoms with Second Dose of AstraZeneca in a Sample of Immunized Population of Ecuadorian Public Servants

Since AstraZeneca is a new vaccine against SARSCOV2, it should be monitored worldwide. This study presents the adverse reactions caused by the second dose of the AstraZeneca vaccine. Thequantitative, descriptive, cross-sectional research used a validated survey conducted on 428 public staff who were vaccinated with the second dose of the ChAdOx1-S vaccine at the Escuela Superior Politécnica de Chimborazo, the results were processed in Jamovi. 289 respondents reported having symptoms after inoculation, women (13.15%) presented more symptoms than men (7.27%). Most of the symptoms, both local and systemic, were mild and subsided with the administration of oral analgesics and lasted up to three days in 50% of the cases. AstraZeneca’s vaccine proves to be a safe biologic vaccine to generate antibodies against SARSCOV” in the adult population, and its use is therefore recommended. Keywords: drug-related side effects and adverse reactions, coronavirus infections, pharmacovigilance Resumen Introducción: Dado que se trata de una nueva vacuna contra el SARSCOV2, debe ser monitoreada a nivel mundial, el presente estudio presenta las reacciones adversas presentadas con la segunda dosis de la vacuna AstraZeneca. Materiales y Métodos: La presente investigación cuantitativa, descriptiva, transversal, utilizó una encuesta validada aplicada a 428 funcionarios públicos que fueron vacunados con la segunda dosis de la vacuna ChAdOx1- S en la Escuela Superior Politécnica de Chimborazo, los resultados fueron procesados en Jamovi . Resultados: 289 encuestados informaron tener síntomas después de la inoculación, las mujeres (13,15%) presentaron más síntomas que los hombres (7,27%). La mayoría de los síntomas, tanto locales como sistémicos, fueron leves y cedieron con la administración de analgésicos orales y duraron hasta tres días en el 50% de los casos. Conclusiones: La vacuna de AstraZeneca demuestra ser una vacuna biológica segura para generar anticuerpos frente al SARSCOV” en la población adulta, por lo que se recomienda su uso. Palabras Clave: kwd2

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

A nucleotide binding rectification Brownian ratchet model for translocation of Y-family DNA polymerases

Y-family DNA polymerases are characterized by low-fidelity synthesis on undamaged DNA and ability to catalyze translesion synthesis over the damaged DNA. Their translocation along the DNA template is an important event during processive DNA synthesis. In this work we present a Brownian ratchet model for this translocation, where the directed translocation is rectified by the nucleotide binding to the polymerase. Using the model, different features of the available structures for Dpo4, Dbh and polymerase ι in binary and ternary forms can be easily explained. Other dynamic properties of the Y-family polymerases such as the fast translocation event upon dNTP binding for Dpo4 and the considerable variations of the processivity among the polymerases can also be well explained by using the model. In addition, some predicted results of the DNA synthesis rate versus the external force acting on Dpo4 and Dbh polymerases are presented. Moreover, we compare the effect of the external force on the DNA synthesis rate of the Y-family polymerase with that of the replicative DNA polymerase

Euclid preparation: LVIII. Detecting extragalactic globular clusters in the Euclid survey

\ua9 The Authors 2025.Extragalactic globular clusters (EGCs) are an abundant and powerful tracer of galaxy dynamics and formation, and their own formation and evolution is also a matter of extensive debate. The compact nature of globular clusters means that they are hard to spatially resolve and thus study outside the Local Group. In this work we have examined how well EGCs will be detectable in images from the Euclid telescope, using both simulated pre-launch images and the first early-release observations of the Fornax galaxy cluster. The Euclid Wide Survey will provide high-spatial resolution VIS imaging in the broad IE band as well as near-infrared photometry (YE, JE, and HE). We estimate that the 24 719 known galaxies within 100 Mpc in the footprint of the Euclid survey host around 830 000 EGCs of which about 350 000 are within the survey\u27s detection limits. For about half of these EGCs, three infrared colours will be available as well. For any galaxy within 50 Mpc the brighter half of its GC luminosity function will be detectable by the Euclid Wide Survey. The detectability of EGCs is mainly driven by the residual surface brightness of their host galaxy. We find that an automated machine-learning EGC-classification method based on real Euclid data of the Fornax galaxy cluster provides an efficient method to generate high purity and high completeness GC candidate catalogues. We confirm that EGCs are spatially resolved compared to pure point sources in VIS images of Fornax. Our analysis of both simulated and first on-sky data show that Euclid will increase the number of GCs accessible with high-resolution imaging substantially compared to previous surveys, and will permit the study of GCs in the outskirts of their hosts. Euclid is unique in enabling systematic studies of EGCs in a spatially unbiased and homogeneous manner and is primed to improve our understanding of many understudied aspects of GC astrophysics

Euclid II. The VIS instrument

This paper presents the specification, design, and development of the Visible Camera (VIS) on the European Space Agency's mission. VIS is a large optical-band imager with a field of view of 0.54 deg$^2$ sampled at with an array of 609 Megapixels and a spatial resolution of . It will be used to survey approximately 14 000 deg$^2$ of extragalactic sky to measure the distortion of galaxies in the redshift range $z=0.1$--1.5 resulting from weak gravitational lensing, one of the two principal cosmology probes leveraged by With photometric redshifts, the distribution of dark matter can be mapped in three dimensions, and the extent to which this has changed with look-back time can be used to constrain the nature of dark energy and theories of gravity. The entire VIS focal plane will be transmitted to provide the largest images of the Universe from space to date, specified to reach AB with a signal-to-noise ratio S/N in a single broad E (r+i+z)$band over a six-year survey. The particularly challenging aspects of the instrument are the control and calibration of observational biases, which lead to stringent performance requirements and calibration regimes. With its combination of spatial resolution, calibration knowledge, depth, and area covering most of the extra-Galactic sky, VIS will also provide a legacy data set for many other fields. This paper discusses the rationale behind the conception of VIS and describes the instrument design and development, before reporting the prelaunch performance derived from ground calibrations and brief results from the in-orbit commissioning. VIS should reach fainter than AB =25$ with $S/N 10$ for galaxies with a full width at half maximum of in a diameter aperture over the Wide Survey, and $m_ AB for a Deep Survey that will cover more than 50 deg$^2$. The paper also describes how the instrument works with the telescope and survey, and with the science data processing, to extract the cosmological information

Euclid: Early Release Observations of ram-pressure stripping in the Perseus cluster: Detection of parsec-scale star formation within the low surface brightness stripped tails of UGC 2665 and MCG +07-07-070

\ua9 2025 EDP Sciences. All rights reserved.Euclid is delivering optical and near-infrared imaging data over 14 000 deg2 on the sky at spatial resolution and surface brightness levels that can be used to understand the morphological transformation of galaxies within groups and clusters. Using the Early Release Observations (ERO) of the Perseus cluster, we demonstrate the capability offered by Euclid in studying the nature of perturbations for galaxies in clusters. Filamentary structures are observed along the discs of two spiral galaxies, UGC 2665 and MCG +07-07-070, with no extended diffuse emission expected from tidal interactions at surface brightness levels of a30 mag arcseca 2. The detected features exhibit a good correspondence in morphology between optical and near-infrared wavelengths, with a surface brightness of a25 mag arcseca 2, and the knots within the features have sizes of a 100 pc, as observed through IE imaging. Using the Euclid, CFHT, UVIT, and LOFAR 144 MHz radio continuum observations, we conducted a detailed analysis to understand the origin of the detected features. We constructed the Euclid IEaYE, YEaHE, and CFHT u ar, g ai colour-colour plane and show that these features contain recent star formation events, which are also indicated by their Hα and NUV emissions. Euclid colours alone are insufficient for studying stellar population ages in unresolved star-forming regions, which require multi-wavelength optical imaging data. There are features with red colours that can be explained by dust being stripped along with the gas in these regions. The morphological shape, orientation, and mean age of the stellar population, combined with the presence of extended radio continuum cometary tails can be consistently explained if these features formed during a recent ram-pressure stripping event. This result further confirms the exceptional qualities of Euclid in the study of galaxy evolution in dense environments

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone