Dualities in tree representations

A characterization of the tree T∗ such that BP(T∗) = ↔ DFUDS(T), the reversal of DFUDS(T) is given. An immediate consequence is a rigorous characterization of the tree T such that BP( T^) = DFUDS(T^). In summary, BP and DFUDS are unified within an encompassing framework, which might have the potential to imply future simplifications with regard to queries in BP and/or DFUDS. Immediate benefits displayed here are to identify so far unnoted commonalities in most recent work on the Range Minimum Query problem, and to provide improvements for the Minimum Length Interval Query problem

Comparative Pricing Analysis of Mecca’s Religious Tourism

This study compares the costing practices of three religious tourists groups. Specifically, the study compares the costs of Islamic religious tourism to Mecca among three groups: 1) Indonesia and India, 2) Lebanon and Tunisia, 3) Dubai and Qatar. The selection of the three groups was based on the following principle: Group 1: Represents the most populated and less affluent Islamic countries. Group 2: Represents the less affluent Arab States with moderate income Group 3: Represents the richest Arab Islamic countries in the world. Results indicate that countries with wealthy economies charge much higher prices for Hajj packages than those with moderate economies. However, the overall Hajj revenue is the highest ($940 millions) in the most populated Islamic countries (Indonesia). But for wealthy economies (Dubai) even though it’s ranked as the fifth in the number of pilgrims, its revenues ($220,433,572) are high enough to be in the third place. Operators’ pricing schemes fall into three independent categories: Competition-based Pricing, Consumer-based Pricing and Cost-based Pricing

Wearable Technology In Obstetrical Emergency Simulation: A Pilot Study

Background: Medical student involvement in clinical care of obstetrical emergencies is limited. Wearable technology, namely Google Glass, has been used to enhance the simulation experience for trainees at our institution. We present a pilot study that examines the utility of this technology in medical students’ education through remotely-conducted exercises in obstetric emergencies. Materials & Methods: A total of thirteen medical students accepted the opportunity to participate in an obstetric emergencies training exercise with remote monitoring. Students wore the Google Glass device while participating in two simulated obstetrical emergencies: shoulder dystocia and vaginal breech delivery. A remote instructor monitored the students’ performance and gave verbal instructions during the simulation. Students then filled out a questionnaire grading the effectiveness of the exercise. Results: Of all participating students, 55% reported Glass extremely valuable for their education. None reported it as not being valuable. 15% reported that Glass distracted them in their simulation activity. 100% of participants reported it being more than “successful in its potential to improve emergency obstetric care. 55% reported that Glass or a similar device is “extremely likely” to be incorporated into medicine. None reported that it is unlikely to be used in the future of medicine. Conclusions: Wearable technology has the potential to provide improved learner experience. This technology can be successfully used to provide student exposure to simulated emergencies. Further studies evaluating the participation of students and other learners in simulated obstetrical emergencies are needed to determine how effective wearable technology can become in medical education and ultimately patient care as well

Whole Genome Sequencing: A Powerful Tool for Understanding the Diversity of Genotypes and Phenotypes among COVID-19 Infected Patients to Help in Controlling Outbreaks

In Wuhan, China (December 2019), viral pneumonia cases of uncertain origin have been reported. The emergency has drawn global attention. To determine the pathogenic potential, joint efforts were conducted by Chinese Multidisciplinary Task Forces. An integral component of wide range of research applications is not only determining the causative agent but also the nucleic acid bases order in biological samples. Research techniques determining genetic material features and its order is called “sequencing”, classified into three generations. Moreover, the first sequencing attempt was conducted and a genetic link identified between samples isolated from China and other previously sequenced Coronaviruses. However, there was patient to patient diversity in terms of clinical and laboratory manifestations and diseases severity. After the genetic material of the causative agent was successfully sequenced, it was named the novel coronavirus causing COVID-19. Here, we review the genome sequences of novel coronavirus infected patients from different countries such as India, Bangladesh and Ecuador compared to China (first reported case), seeking not only to recognize similarities and differences between genome sequences of novel coronavirus, but also to compare them with other forms of coronaviruses family. Utilizing this data will assist in making right decisions minimizing negative consequences of the outbreak

Integrative taxonomic, ecological and genotyping study of charophyte populations from the egyptian western-desert oases and sinai peninsula

Present-day information available on the charophyte macroalgae in Egypt, including their phylogenetic affinities, remains largely incomplete. In this study, nine charophyte populations were collected from different aquatic biotopes across the Egyptian Western-Desert Oases and Sinai Peninsula. All populations were investigated using an integrative polyphasic approach including phylogenetic analyses inferred from the chloroplast-encoded gene (rbcL) and the internal transcribed spacer (ITS1) regions, in parallel with morphotaxonomic assignment, ultrastructure of the oospore walls, and autecology. The specimens identified belonged to the genera Chara, Nitella, and Tolypella, with predominance of the first genus to which five species were assigned though they presented some interesting aberrant taxonomic features: C. aspera, C. contraria, C. globata, C. tomentosa, and C. vulgaris. Based on our integrative study, the globally rare species C. globata was reported for the second time for the whole African continent. The genus Nitella was only represented by N. flagellifera, and based on the available literature, it is a new record for North Africa. Noteworthy, an interesting Tolypella sp., morphologically very similar to T. glomerata, was collected and characterized and finally designated with the working name ‘Tolypella sp. PBA–1704 from a desert, freshwater wetland’, mainly based on its concatenated rbcL+ITS1 phylogenetic position. This study not only improved our understanding on the diversity, biogeography and autecological preferences of charophytes in Egypt, but it also broadened our knowledge on this vulnerable algal group in North Africa, emphasizing the need of more in-depth research work in the future, particularly in the less–impacted desert habitats

Role of extended release quetiapine in the management of bipolar disorders

Atypical antipsychotics have become a widely utilized component of the bipolar disorder treatment armamentarium, with approximately 45% of bipolar patients prescribed atypicals. Over the last decade all atypical drugs except for clozapine have received a Food and Drug Administration (FDA) bipolar indication. In October 2008, the FDA approved quetiapine XR monotherapy for the treatment of acute depressive episodes of bipolar disorder and acute manic or mixed episodes in bipolar I disorder based on two placebo-control trials. Quetiapine was also approved as adjunct therapy with lithium and divalproex for the treatment of acute manic or mixed episodes as well as maintenance of bipolar I disorder. In contrast to immediate release quetiapine which may require a twice-daily regimen, the XR formulation is intended for once-daily administration. This drug profile of quetiapine XR will address chemistry, pharmacodynamics, pharmacokinetics, metabolism, safety and tolerability and clinical trials in bipolar disorder

Organizational Cynicism and Counterproductive Work Behaviors: An Empirical Study

The aim of this study was to test the relationship between the organizational cynicism (OC) of the employees and the Counterproductive Work Behaviors (CWB) exhibited by employees at work. This study was conducted on a stratified random sample consisting of (327) employees of Asyut University in the Arab Republic of Egypt. The data collected by the questionnaire prepared based on the organizational cynicism scale of Brandes, et al (1999) and the counterproductive work behaviors (CWB) scale of Fox (2001).The study found that the organizational cynicism (OC) was positively correlated with the Counterproductive Work Behaviors (CWB), where the significant correlation of the Behavioral dimension was followed by Affective dimension. However, the third dimension of organizational cynicism (belief dimension) has no relationship with the counterproductive behaviors at work. Based on these findings, the study reached some concluding remarks concerning organizational cynicism and counterproductive behaviors. Keywords: Organizational Cynicism, Counterproductive Work Behaviors, Assiut University, Egyp

Progesterone utility in the synthesis of steroidal heterocyclic compounds with antitumor activity

One–pot and efficient method for the synthesis of progesteronpyridine 5a-c, 6a-c and 7a,b and/or progesteronpyran derivatives 9a-c and 10a,b by condensation reaction of progesterone 1 with different aldehydes and active methylene compounds in the presence of ammonium acetate or piperidine.  New progesteronopyrimidine derivatives 12a-d and 13a, b were synthesized via interaction of progesterone 1 with urea or thiourea and/or guanidine reagents and aldehyde. Progesterone 1 was examined to synthesize heterocyclic compound 16 containing ?-Lactone chiral carbon via the reaction of hydrazone derivative 14 with phenyl isothiocyanate followed by boiling with chloroacetic acid in benzene. The biological activity of compounds 5a, 5b, 6b, 7a, 9b, 9c, 12a, 12c, and 13a were evaluated as growth inhibitors of the liver and the breast carcinoma human cell line (HEPG2 & MCF7). Compounds 13a, 12a and 7a showed a higher potency than the standard. Key Words: Progesterone, MCR’s (multicomponents reaction), (pyridine, pyran, pyrimidine, ?-Lactone) derivatives, HEPG2 & MCF7

Unexpected Diagnosis of Complete Androgen Insensitivity Syndrome (CAIS) During Inguinal Hernia Repair in 11-year-old-girl

Complete Androgen Insensitivity Syndrome (CAIS) is an X-link recessive genetic mutation of androgen receptor (AR) gene leading to complete inability of cell to respond to the androgens. CAIS occurs in 1 out of 20,400 XY live-birth babies, and affects about 1–2% of prepubertal girls that present with an inguinal hernia. Although individuals with CAIS have XY, those with grades 6 and 7 on the Quigley scale are born phenotypically female, without any signs of genital masculinization. Thus, individuals affected by CAIS develop a normal external female phenotype with normal female external genitalia, well-developed breast, absent uterus, and bilateral undescended testicles. The question of CAIS diagnosis does not come forward until the absent menses at the puberty is noted or accidentally during an inguinal hernia repair in a premenarchal girl. The present study reports a case of inguinal hernia repair on 11-year-old girl, which led to unexpected intraoperative notion of CAIS. The diagnostic work-up, genetic counseling, sex assignment, and the need for preoperative CAIS screening in girls with bilateral inguinal hernia are described and discussed. Keywords: DSD, CAIS, bilateral inguinal hernia, gonadectom