Application of LIBS in Detection of Antihyperglycemic Trace Elements in Momordica charantia

The present study exploits the information based on concentration of trace elements and minerals in understanding the role/mechanism of action of freeze-dried fruit powder suspended in distilled water of Momordica charantia (family: Cucurbitaceae) in diabetes treatment. Laser-induced break down spectroscopy (LIBS) spectra of plant product was recorded under optimized experimental conditions and analyzed. Several atomic lines such as Na, K, Mg, Ca, Fe, Al, etc. have been observed in the LIBS spectra of the above plant product. The concentrations of these minerals are determined by using calibration-free LIBS method. Correlation between the concentration of these elements/minerals and their defined role in diabetes management was studied in normal as well as diabetic animal model

The glycemic elemental profile of trichosanthes dioica: a LIBS-based study

The scientific evaluation of the antidiabetic efficacy of aqueous extract of Trichosanthes dioica fruits on streptozotocin-induced diabetic rats is being presented. The graded doses of the extract, viz., 500, 750, 1,000, and 1,250 mg/kg body weight (bw), were administered orally, and it was observed that the blood glucose concentration decreased in a dose-dependent manner. The dose of 1,000 mg/kg bw showed the maximum fall of 23.8% and 19.1% in blood glucose level (BGL) during fasting BGL and glucose tolerance test (GTT) studies, respectively, of nondiabetic rats. Whereas in the case of subdiabetic and mild diabetic models, the same dose showed reduction in BGL of 22.0% and 31.4% during GTT. The study also involves the first use of laser-induced breakdown spectroscopy as a sensitive analytical tool to detect the elemental profile responsible for the antidiabetic activity of aqueous extract of T. dioica fruits that exhibits the antidiabetic activity. High intensities of Ca, Mg, and Fe indicate large concentrations of these elements in the extract, since according to Boltzmann’s distribution law, intensities are directly proportional to concentrations. The higher concentrations of these glycemic elements, viz. Ca, Mg, and Fe, are responsible for the antidiabetic potential of T. dioica as well as other plant already reported by our research group

LIBS-Based Detection of Antioxidant Elements in Seeds of Emblica officinalis

The aim of the study was to determine the effect of the elements of the extract of seed from Emblica officinalis on antioxidant enzymes and osmotic fragility of erythrocytes membrane in normal as well as streptozotocin-induced severely diabetic albino Wister rats. The results revealed that the untreated diabetic rats exhibited increase in oxidative stress as indicated by significantly diminished activities of free radical scavenging enzymes such as catalase (CAT) and superoxide dismutase (SOD) by 37.5% (p

Development of Livelihood Index for Different Agro-Climatic Zones of India

A livelihood index has been developed for different agro-climatic zones of India, based on the secondary data for TE 2003. Six different sub-indices obtained are indicators of Infrastructure Status, Agricultural Status, Nutritional Status, Economic Status, Health and Sanitation Status and Food Availability Status in respective zones. A total of 57 variables have been considered for this study. Finally, a composite integrated livelihood index has been developed which indicates the livelihood status of different agro-climatic zones in the country. Also, 103 districts of low agricultural productivity have been identified within low livelihood regions. The results of this study have been compared with those of backward districts identified under Wage Employment Program by the Task Force of Planning Commission of India. It is found that about 60 per cent districts identified in this study are the same as identified by the Task Force. Further, the spatial distributions of the identified districts under the study have been mapped using GIS maps and it has been observed that almost same region of the country has been found to be most backward in both the studies. The study has revealed regional disparity in the development process and has suggested to formulate appropriate policies to bridge this disparity gap.Productivity Analysis, Resource /Energy Economics and Policy,

Post TURP obliterative urethral stricture: Unusual presentation and favourable result

AbstractIntroductionUrethral stricture is a well known complication after TURP. Most of the cases present with recurrence of lower urinary tract symptoms. Infrequently, cases of complete obliteration of urethra is diagnosed. Management of these rare cases is always challenging and associated with poor outcome.We report a case of post TURP obliterative urethral stricture that was managed successfully by holmium laser core through urethroplasty. On discharge patient was continent and voided well.ConclusionHolmium laser core through is a useful technique for management of these complicated cases with satisfying result. It should be done by experienced endourologist

Oilseed brassica in India: Demand, supply, policy perspective and future potential☆

India is the largest agrarian subcontinent supporting 26% world’s agricultural population on 12% arable land. India is also the fifth largest vegetable oil economy accounting 7.4% oilseeds, 5.8% oils and 6.1% oil meal production, and 9.3% of edible oil consumption in the world. Oilseeds are the second most important agricultural economy in India next to cereals growing at a pace of 4.1% per annum in the last three decades. Oilseed brassica shares 23.5% area and 24.2% production of total oilseeds in the country. Despite being the third largest producer (11.3%) of oilseed brassica after Canada and China in the world, India meets 57% of the domestic edible oil requirements through imports and ranked 7th largest importer of edible oils in the world. Oilseed brassica achieved significant growth in India in the past, however, the productivity levels are still low owing to large cultivation under rainfed situation, biotic and abiotic stresses, and resources crunch. It is also facing the challenges of low genotypic potential, climate change and price fluctuation. Though, it embraces the immense scope to increase the production in traditional and non-traditional areas in India with proper inputs, technological interventions, and suitable policy framework. This needs to develop strategies in a well-planned, targeted manner with multi-scientific inputs, policy interface and stable price systems to bring the desired growth in oilseeds brassica production, and to reduce the import of edible oils in the country

Urea treatment of straw.

BACKGROUND: Motivation is a critical factor in supporting sustained exercise, which in turn is associated with important health outcomes. Accordingly, research on exercise motivation from the perspective of self-determination theory (SDT) has grown considerably in recent years. Previous reviews have been mostly narrative and theoretical. Aiming at a more comprehensive review of empirical data, this article examines the empirical literature on the relations between key SDT-based constructs and exercise and physical activity behavioral outcomes. METHODS: This systematic review includes 66 empirical studies published up to June 2011, including experimental, cross-sectional, and prospective studies that have measured exercise causality orientations, autonomy/need support and need satisfaction, exercise motives (or goal contents), and exercise self-regulations and motivation. We also studied SDT-based interventions aimed at increasing exercise behavior. In all studies, actual or self-reported exercise/physical activity, including attendance, was analyzed as the dependent variable. Findings are summarized based on quantitative analysis of the evidence. RESULTS: The results show consistent support for a positive relation between more autonomous forms of motivation and exercise, with a trend towards identified regulation predicting initial/short-term adoption more strongly than intrinsic motivation, and intrinsic motivation being more predictive of long-term exercise adherence. The literature is also consistent in that competence satisfaction and more intrinsic motives positively predict exercise participation across a range of samples and settings. Mixed evidence was found concerning the role of other types of motives (e.g., health/fitness and body-related), and also the specific nature and consequences of introjected regulation. The majority of studies have employed descriptive (i.e., non-experimental) designs but similar results are found across cross-sectional, prospective, and experimental designs. CONCLUSION: Overall, the literature provides good evidence for the value of SDT in understanding exercise behavior, demonstrating the importance of autonomous (identified and intrinsic) regulations in fostering physical activity. Nevertheless, there remain some inconsistencies and mixed evidence with regard to the relations between specific SDT constructs and exercise. Particular limitations concerning the different associations explored in the literature are discussed in the context of refining the application of SDT to exercise and physical activity promotion, and integrating these with avenues for future research

SIRT1-NOX4 Signaling Axis Regulates Cancer Cachexia

Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-seq and follow-up analyses showed cancer cell-mediated SIRT1 loss induced NF-κB signaling in cachectic muscles that enhanced the expression of FOXO transcription factors and NADPH oxidase 4 (Nox4), a key regulator of reactive oxygen species production. Additionally, we observed a negative correlation between NOX4 expression and skeletal muscle fiber cross-sectional area in pancreatic cancer patients. Knocking out Nox4 in skeletal muscles or pharmacological blockade of Nox4 activity abrogated tumor-induced cachexia in mice. Thus, we conclude that targeting the Sirt1-Nox4 axis in muscles is an effective therapeutic intervention for mitigating pancreatic cancer-induced cachexia

Phi meson production in Au+Au and p+p collisions at sqrt (s)=200 GeV

We report the STAR measurement of Phi meson production in Au+Au and p+p collisions at sqrt (s)=200 GeV. Using the event mixing technique, the Phi spectra and yields are obtained at mid-rapidity for five centrality bins in Au+Au collisions and for non-singly-diffractive p+p collisions. It is found that the Phi transverse momentum distributions from Au+Au collisions are better fitted with a single-exponential while the p+p spectrum is better described by a double-exponential distribution. The measured nuclear modification factors indicate that Phi production in central Au+Au collisions is suppressed relative to peripheral collisions when scaled by the number of binary collisions. The systematics of versus centrality and the constant Phi/K- ratio versus beam species, centrality, and collision energy rule out kaon coalescence as the dominant mechanism for Phi production.Comment: 6 pages, 3 figures, submitted to Phys. Rev. Let