PoN-S : a systematic approach for applying the Physics of Notation (PoN)

Visual Modeling Languages (VMLs) are important instruments of communication between modelers and stakeholders. Thus, it is important to provide guidelines for designing VMLs. The most widespread approach for analyzing and designing concrete syntaxes for VMLs is the so-called Physics of Notation (PoN). PoN has been successfully applied in the analysis of several VMLs. However, despite its popularity, the application of PoN principles for designing VMLs has been limited. This paper presents a systematic approach for applying PoN in the design of the concrete syntax of VMLs. We propose here a design process establishing activities to be performed, their connection to PoN principles, as well as criteria for grouping PoN principles that guide this process. Moreover, we present a case study in which a visual notation for representing Ontology Pattern Languages is designed

Tailoring Three-Point Functions and Integrability III. Classical Tunneling

We compute three-point functions between one large classical operator and two large BPS operators at weak coupling. We consider operators made out of the scalars of N=4 SYM, dual to strings moving in the sphere. The three-point function exponentiates and can be thought of as a classical tunneling process in which the classical string-like operator decays into two classical BPS states. From an Integrability/Condensed Matter point of view, we simplified inner products of spin chain Bethe states in a classical limit corresponding to long wavelength excitations above the ferromagnetic vacuum. As a by-product we solved a new long-range Ising model in the thermodynamic limit.Comment: 37 pages, 10 figure

Dissolution dominating calcification process in polar pteropods close to the point of aragonite undersaturation

Thecosome pteropods are abundant upper-ocean zooplankton that build aragonite shells. Ocean acidification results in the lowering of aragonite saturation levels in the surface layers, and several incubation studies have shown that rates of calcification in these organisms decrease as a result. This study provides a weight-specific net calcification rate function for thecosome pteropods that includes both rates of dissolution and calcification over a range of plausible future aragonite saturation states (Omega_Ar). We measured gross dissolution in the pteropod Limacina helicina antarctica in the Scotia Sea (Southern Ocean) by incubating living specimens across a range of aragonite saturation states for a maximum of 14 days. Specimens started dissolving almost immediately upon exposure to undersaturated conditions (Omega_Ar,0.8), losing 1.4% of shell mass per day. The observed rate of gross dissolution was different from that predicted by rate law kinetics of aragonite dissolution, in being higher at Var levels slightly above 1 and lower at Omega_Ar levels of between 1 and 0.8. This indicates that shell mass is affected by even transitional levels of saturation, but there is, nevertheless, some partial means of protection for shells when in undersaturated conditions. A function for gross dissolution against Var derived from the present observations was compared to a function for gross calcification derived by a different study, and showed that dissolution became the dominating process even at Omega_Ar levels close to 1, with net shell growth ceasing at an Omega_Ar of 1.03. Gross dissolution increasingly dominated net change in shell mass as saturation levels decreased below 1. As well as influencing their viability, such dissolution of pteropod shells in the surface layers will result in slower sinking velocities and decreased carbon and carbonate fluxes to the deep ocean

Tripartite Entanglement in Noninertial Frame

The tripartite entanglement is examined when one of the three parties moves with a uniform acceleration with respect to other parties. As Unruh effect indicates, the tripartite entanglement exhibits a decreasing behavior with increasing the acceleration. Unlike the bipartite entanglement, however, the tripartite entanglement does not completely vanish in the infinite acceleration limit. If the three parties, for example, share the Greenberger-Horne-Zeilinger or W-state initially, the corresponding $\pi$-tangle, one of the measures for tripartite entanglement, is shown to be $\pi/6 \sim 0.524$ or 0.176 in this limit, respectively. This fact indicates that the tripartite quantum information processing may be possible even if one of the parties approaches to the Rindler horizon. The physical implications of this striking result are discussed in the context of black hole physics.Comment: 19 pages, 5 figure

Experimental Study on the Effect of Initial Temperature on CHF in a Vertical Annulus Narrow Channel with Bilateral Heated

Study on understanding of the complexities of boiling in the narrow channel which was occured in a severe accident on nuclear power plant has been carried out in experimentally using simulation apparatus in order to achieve the safety management capability. Critical Heat Flux (CHF) is one important parameter to control heat during transient accident. The methodology of research is an experiment using experiment apparatus called HeaTiNG-01 test section with modifications in the outside pipe using stainless steel material as the reactor vessel wall simulation. Experiments were conducted by heating the heated rod as a simulation of debris until the desired initial temperature by bilateral heated. Then water with a saturation temperature in atmospheric was poured gravitationally into the narrow channel. Data acquisition system recorded temperature changes in transient during the cooling process. The transient temperature profile in double heating surface and rewetting point (rewet fronts) was characterized. Experiment was conducted at three initial temperature variations i.e. 650oC, 750oC and 850oC and using channel width 1 mm. Experiment data was used to calculate heat flux then to fitting CHF form boiling curve. The results showed that CHF in outer pipe is higher than heated rod, these conditions explain that more heat is released through the outer pipe, so that the heat control can be done from outside the system to reduce the temperature quickly. The average value of CHF for each vertical position 100 mm and 400 mm at outer pipe are 380 kW/m2 and 733 kW/m2, and then at the heated rod are 250 kW/m2 and 497 kW/m2. Received: 20 November 2010; Revised: 25 July 2011; Accepted: 08 August 201

Fixed-Parameter Tractability of Token Jumping on Planar Graphs

Suppose that we are given two independent sets $I_0$ and $I_r$ of a graph such that $|I_0| = |I_r|$, and imagine that a token is placed on each vertex in $I_0$. The token jumping problem is to determine whether there exists a sequence of independent sets which transforms $I_0$ into $I_r$ so that each independent set in the sequence results from the previous one by moving exactly one token to another vertex. This problem is known to be PSPACE-complete even for planar graphs of maximum degree three, and W[1]-hard for general graphs when parameterized by the number of tokens. In this paper, we present a fixed-parameter algorithm for the token jumping problem on planar graphs, where the parameter is only the number of tokens. Furthermore, the algorithm can be modified so that it finds a shortest sequence for a yes-instance. The same scheme of the algorithms can be applied to a wider class of graphs, $K_{3,t}$-free graphs for any fixed integer $t \ge 3$, and it yields fixed-parameter algorithms

Remote activation of host cell DNA synthesis in uninfected cells signalled by infected cells in advance of virus transmission.

Viruses modulate cellular processes and metabolism in diverse ways, but these are almost universally studied in the infected cell itself. Here, we study spatial organization of DNA synthesis during multiround transmission of herpes simplex virus (HSV) using pulse-labeling with ethynyl nucleotides and cycloaddition of azide fluorophores. We report a hitherto unknown and unexpected outcome of virus-host interaction. Consistent with the current understanding of the single-step growth cycle, HSV suppresses host DNA synthesis and promotes viral DNA synthesis in spatially segregated compartments within the cell. In striking contrast, during progressive rounds of infection initiated at a single cell, we observe that infection induces a clear and pronounced stimulation of cellular DNA replication in remote uninfected cells. This induced DNA synthesis was observed in hundreds of uninfected cells at the extended border, outside the perimeter of the progressing infection. Moreover, using pulse-chase analysis, we show that this activation is maintained, resulting in a propagating wave of host DNA synthesis continually in advance of infection. As the virus reaches and infects these activated cells, host DNA synthesis is then shut off and replaced with virus DNA synthesis. Using nonpropagating viruses or conditioned medium, we demonstrate a paracrine effector of uninfected cell DNA synthesis in remote cells continually in advance of infection. These findings have significant implications, likely with broad applicability, for our understanding of the ways in which virus infection manipulates cell processes not only in the infected cell itself but also now in remote uninfected cells, as well as of mechanisms governing host DNA synthesis. IMPORTANCE We show that during infection initiated by a single particle with progressive cell-cell virus transmission (i.e., the normal situation), HSV induces host DNA synthesis in uninfected cells, mediated by a virus-induced paracrine effector. The field has had no conception that this process occurs, and the work changes our interpretation of virus-host interaction during advancing infection and has implications for understanding controls of host DNA synthesis. Our findings demonstrate the utility of chemical biology techniques in analysis of infection processes, reveal distinct processes when infection is examined in multiround transmission versus single-step growth curves, and reveal a hitherto-unknown process in virus infection, likely relevant for other viruses (and other infectious agents) and for remote signaling of other processes, including transcription and protein synthesis

Spatial and temporal variations of aerosols around Beijing in summer 2006: Model evaluation and source apportionment

Regional aerosol model calculations were made using the Weather Research and Forecasting (WRF)-Community Multiscale Air Quality (CMAQ) and WRF-chem models to study spatial and temporal variations of aerosols around Beijing, China, in the summer of 2006, when the Campaigns of Air Quality Research in Beijing and Surrounding Region 2006 (CAREBeijing) intensive campaign was conducted. Model calculations captured temporal variations of primary (such as elemental carbon. (EC)) and secondary (such as sulfate) aerosols observed in and around Beijing. The spatial distributions of aerosol optical depth observed by the MODTS satellite sensors were also reproduced over northeast China. Model calculations showed distinct differences in spatial distributions between primary and secondary aerosols in association with synoptic-scale meteorology. Secondary aerosols increased in air around Beijing on a scale of about 1000 × 1000 km2 under an anticyclonic pressure system. This air mass was transported northward from the high anthropogenic emission area extending south of Beijing with continuous photochemical production. Subsequent cold front passage brought clean air from the north, and polluted air around Beijing was swept to the south of Beijing. This cycle was repeated about once a week and was found to be responsible for observed enhancements/reductions of aerosols at the intensive measurement sites. In contrast to secondary aerosols, the spatial distributions of primary aerosols (EC) reflected those of emissions, resulting in only slight variability despite the changes in synopticscale meteorology. In accordance with these results, source apportionment simulations revealed that primary aerosols around Beijing were controlled by emissions within 100 km around Beijing within the preceding 24 h, while emissions as far as 500 km and within the preceding 3 days were found to affect secondary aerosols. Copyright 2009 by the American Geophysical Union

Estimation of Para Red Dye in Chilli Powder and Tomato Sauces by a Simple Spectrophotmetric Method followed by Thin layer Chromatography

A number of grinded chilli powder samples and tomato sauce samples were collected from various localities of Karachi city. All the samples were estimated for the presence of para red which is an azo dye and more specifically belongs from the group of sudan dyes. According to the regulation of various governmental agencies its use in food is strictly prohibited because of its ability to form carcinogenic compounds. Although there were a number of sophisticated chromatographic methods for the estimation of this dye but we developed here a simple, convenient, expeditious spectrophotometric method followed by thin layer chromatography technique and compared the results by single point and multiple point external standard methods. On the basis of these results we also specify the localities of Karachi city where the contamination is more prominent. © JASE