Low-Energy Shape Resonances of a Nucleobase in Water

When high-energy radiation passes through aqueous material, low-energy electrons are produced which cause DNA damage. Electronic states of anionic nucleobases have been suggested as an entrance channel to capture the electron. However, identifying these electronic resonances have been restricted to gas-phase electron-nucleobase studies and offer limited insight into the resonances available within the aqueous environment of DNA. Here, resonance and detachment energies of the micro-hydrated uracil pyrimidine nucleobase anion are determined by two-dimensional photoelectron spectroscopy and are shown to extrapolate linearly with cluster size. This extrapolation allows the corresponding resonance and detachment energies to be determined for uracil in aqueous solution as well as the reorganization energy associated with electron capture. Two shape resonances are clearly identified that can capture low-energy electrons and subsequently form the radical anion by solvent stabilization and internal conversion to the ground electronic state. The resonances and their dynamics probed here are the nucleobase-centered doorway states for low-energy electron capture and damage in DNA

Synchronous N-S and E-W extension at the Tibet-to-Himalaya transition in NW Bhutan

Despite ~50 Myr of continuous continent-continent collision, contractional structures in the Himalayan-Tibetan orogen are today limited to the northern and southern margins of the system, while extension dominates much of the interior. On the Tibetan Plateau, Cenozoic E-W extension has been accommodated by strike-slip faults and extensional grabens, while N-S extension at the Tibet-to-Himalaya transition has been accommodated by the South Tibetan fault system (STFS). The genetic relationship between N-S and E-W extension is disputed, although age constraints indicate temporal overlap of at least 7 Myr. In NW Bhutan the two intersect where the STFS basal detachment is cut by the Yadong cross structure (YCS), an extensional half graben that provides a rare opportunity to constrain relative timings. We report U-Pb zircon dates from four STFS footwall leucogranites consistent with episodic magmatism during the middle-late Miocene and in situ U(-Th)-Pb monazite and xenotime dates from three metasedimentary rocks ranging from late Oligocene to middle Miocene. We suggest that amphibolite facies footwall metamorphism was ongoing at the time the basal STFS detachment initiated as a ductile structure in the middle-late Miocene. Late-stage granitic intrusions may reflect footwall melting during extensional exhumation along the STFS, but post-metamorphic and post-intrusion fabrics suggest that most displacement occurred after emplacement of the youngest granites. Some of the oldest YCS-related fabrics are found in a deformed 14 Ma leucogranite, implying middle Miocene ductile deformation. This observation, along with evidence for subsequent brittle YCS deformation, suggests that N-S and E-W extensional structures in the area had protracted and overlapping deformation histories

Signatures of Electronic Nematic Phase at Isotropic-Nematic Phase Transition

The electronic nematic phase occurs when the point-group symmetry of the lattice structure is broken, due to electron-electron interactions. We study a model for the nematic phase on a square lattice with emphasis on the phase transition between isotropic and nematic phases within mean field theory. We find the transition to be first order, with dramatic changes in the Fermi surface topology accompanying the transition. Furthermore, we study the conductivity tensor and Hall constant as probes of the nematic phase and its transition. The relevance of our findings to Hall resistivity experiments in the high-$T_c$ cuprates is discussed.Comment: 5 pages, 3 figure

Foam Diagram Summation at Finite Temperature

We show that large-$N$ $\phi ^4$ theory is not trivial if one accepts the presence of a tachyon with a truly huge mass, and that it allows exact calculation. We use it to illustrate how to calculate the exact resummed pressure at finite temperature and verify that it is infrared and ultraviolet finite even in the zero-mass case. In 3 dimensions a residual effect of the resummed infrared divergences is that at low temperature or strong coupling the leading term in the interaction pressure becomes independent of the coupling and is 4/5 of the free-field pressure. In 4 dimensions the pressure is well-defined provided that the temperature is below the tachyon mass. We examine how rapidly this expansion converges and use our analysis to suggest how one might reorganise perturbation theory to improve the calculation of the pressure for the QCD plasma.Comment: 18 pages plain tex, with 8 figures embedded with epsf. Equation (2.15) has been corrected and the consequent changes made to the figures. A further analytic result has been added to the 3-dimensional calculatio

New insulating phases of two-dimensional electrons in high Landau levels: observation of sharp thresholds to conduction

The intriguing re-entrant integer quantized Hall states recently discovered in high Landau levels of high-mobility 2D electron systems are found to exhibit extremely non-linear transport. At small currents these states reflect insulating behavior of the electrons in the uppermost Landau level. At larger currents, however, a discontinuous and hysteretic transition to a conducting state is observed. These phenomena, found only in very narrow magnetic field ranges, are suggestive of the depinning of a charge density wave state, but other explanations can also be constructed.Comment: 5 pages, 5 figure

Quantum Hall ferromagnets, cooperative transport anisotropy, and the random field Ising model

We discuss the behaviour of a quantum Hall system when two Landau levels with opposite spin and combined filling factor near unity are brought into energetic coincidence using an in-plane component of magnetic field. We focus on the interpretation of recent experiments under these conditions [Zeitler et al, Phys. Rev. Lett. 86, 866 (2001); Pan et al, Phys. Rev. B 64, 121305 (2001)], in which a large resistance anisotropy develops at low temperatures. Modelling the systems involved as Ising quantum Hall ferromagnets, we suggest that this transport anisotropy reflects domain formation induced by a random field arising from isotropic sample surface roughness.Comment: 4 pages, submitted to Physical Review

Healthcare-associated outbreak of meticillin-resistant Staphylococcus aureus bacteraemia: role of a cryptic variant of an epidemic clone

BACKGROUND New strains of meticillin-resistant Staphylococcus aureus (MRSA) may be associated with changes in rates of disease or clinical presentation. Conventional typing techniques may not detect new clonal variants that underlie changes in epidemiology or clinical phenotype. AIM To investigate the role of clonal variants of MRSA in an outbreak of MRSA bacteraemia at a hospital in England. METHODS Bacteraemia isolates of the major UK lineages (EMRSA-15 and -16) from before and after the outbreak were analysed by whole-genome sequencing in the context of epidemiological and clinical data. For comparison, EMRSA-15 and -16 isolates from another hospital in England were sequenced. A clonal variant of EMRSA-16 was identified at the outbreak hospital and a molecular signature test designed to distinguish variant isolates among further EMRSA-16 strains. FINDINGS By whole-genome sequencing, EMRSA-16 isolates during the outbreak showed strikingly low genetic diversity (P < 1 × 10(-6), Monte Carlo test), compared with EMRSA-15 and EMRSA-16 isolates from before the outbreak or the comparator hospital, demonstrating the emergence of a clonal variant. The variant was indistinguishable from the ancestral strain by conventional typing. This clonal variant accounted for 64/72 (89%) of EMRSA-16 bacteraemia isolates at the outbreak hospital from 2006. CONCLUSIONS Evolutionary changes in epidemic MRSA strains not detected by conventional typing may be associated with changes in disease epidemiology. Rapid and affordable technologies for whole-genome sequencing are becoming available with the potential to identify and track the emergence of variants of highly clonal organisms

The effect of memory on relaxation in a scalar field theory

We derive a kinetic equation with a non-Markovian collision term which includes a memory effect, from Kadanoff-Baym equations in $\phi^4$ theory within the three-loop level for the two-particle irreducible (2PI) effective action. The memory effect is incorporated into the kinetic equation by a generalized Kadanoff-Baym ansatz.Based on the kinetic equations with and without the memory effect, we investigate an influence of this effect on decay of a single particle excitation with zero momentum in 3+1 dimensions and the spatially homogeneous case. Numerical results show that, while the time evolution of the zero mode is completely unaffected by the memory effect due to a separation of scales in the weak coupling regime, this effect leads first to faster relaxation than the case without it and then to slower relaxation as the coupling constant increases.Comment: 12 pages, 6 eps figure

Anisotropic transport in unidirectional lateral superlattice around half-filling of the second Landau level

We have observed marked transport anisotropy in short period (a=92 nm) unidirectional lateral superlattices around filling factors nu=5/2 and 7/2: magnetoresistance shows a sharp peak for current along the modulation grating while a dip appears for current across the grating. By altering the ratio a/l (with l=sqrt{hbar/eB_perp} the magnetic length) via changing the electron density n_e, it is shown that the nu=5/2 anisotropic features appear in the range 6.6 alt a/l alt 7.2 varying their intensities, becoming most conspicuous at a/l simeq 6.7. The peak/dip broadens with temperature roughly preserving its height/depth up to 250 mK. Tilt experiments reveal that the structures are slightly enhanced by an in-plane magnetic field B_| perpendicular to the grating but are almost completely destroyed by B_| parallel to the grating. The observations suggest the stabilization of a unidirectional charge-density-wave or stripe phase by weak external periodic modulation at the second Landau level.Comment: REVTeX, 5 pages, 3 figures, Some minor revisions, Added notes and reference