34 research outputs found

    Open data from the third observing run of LIGO, Virgo, KAGRA, and GEO

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    The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages

    Nalp3 Inflammasome Activation in Neutrophilic Asthma

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    Introduction Non-cystic fi brosis (CF) bronchiectasis is an important cause of respiratory morbidity in both developing and developed countries. Antibiotics are considered standard therapy in the treatment of this condition. In this Cochrane review, we examined the evidence for the effi cacy of short courses (4 weeks or less) for non-CF bronchiectasis in children and adults. Methods The Cochrane Airways Group performed a literature search, in accordance with Cochrane methodology. This included the Cochrane Central Register of Controlled Trials and clinical trial registers. Inclusion criteria were randomized controlled trials (RCT) comparing outcomes with use of antibiotics (intravenous, oral or inhaled) versus placebo or usual care (control), for periods of ≤4 weeks, in non-cystic fi brosis bronchiectasis. Results 187 abstracts were reviewed. A single eligible study showed a small benefi t, when compared to placebo, of 4 weeks of inhaled antibiotic therapy in adults with bronchiectasis and pseudomonas in their sputum. There were no studies in children and no studies on oral or intravenous antibiotics. Conclusion There is insuffi cient evidence in the current literature to make reasonable conclusions about the effi cacy of short course antibiotics in the management of adults and children with non-CF bronchiectasis. Until further evidence is available, adherence to current treatment guidelines is recommended
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