Measurement of a side wall permeability effect in soil columns using fibre-optics sensing

Side-wall leakage - the preferential flow of water or pollutants near the wall of a side column - has been studied using in-situ fibre optical detection of a dye solution at the boundary and in the centre of a soil column

The role of stationary phases in reversed-phase liquid chromatography in the application of solvent optimization procedures

The development of liquid chromatographic separation procedures, which meet high standards of reliability and ruggedness, is of increasing importance. A number of software programs are available to make method development in laboratory practice less time consuming and also less dependent on the degree of knowledge of the analyst. Method development, as well as the subsequent routine analysis, generally start from the assumption of a constant column quality (that is, selectivity). In this study the role of the column in method development in reversed-phase liquid chromatography was investigated. It is shown that the influence of nominally identical stationary phases from different manufacturers on the results of method development procedures is significant. This also implies that the transferability of chromatographic separation conditions between "identical" columns is poor

Isospin Effects in Nuclear Multifragmentation

We develop an improved Statistical Multifragmentation Model that provides the capability to calculate calorimetric and isotopic observables with precision. With this new model we examine the influence of nuclear isospin on the fragment elemental and isotopic distributions. We show that the proposed improvements on the model are essential for studying isospin effects in nuclear multifragmentation. In particular, these calculations show that accurate comparisons to experimental data require that the nuclear masses, free energies and secondary decay must be handled with higher precision than many current models accord.Comment: 46 pages, 16 figure

DXA-derived hip shape is related to osteoarthritis:findings from in the MrOS cohort

BF conducted this research whilst on a clinical research primer fellowship awarded by the Elizabeth Blackwell Institute, University of Bristol, UK. This study was funded by Arthritis Research UK project grant ref 20244. CG is funded by Arthritis Research UK grant ref 20000. The Osteoporotic Fractures in Men (MrOS) Study is supported by National Institutes of Health funding. The following institutes provide support: the National Institute on Aging (NIA), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Center for Advancing Translational Sciences (NCATS), and NIH Roadmap for Medical Research under the following grant numbers: R01 AR052000, K24 AR048841, U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, and UL1 TR000128.Peer reviewedPostprin

Disruption of a structurally important extracellular element in the Glycine Receptor leads to decreased synaptic integration and signaling resulting in Severe Startle Disease

Functional impairments or trafficking defects of inhibitory glycine receptors (GlyRs) have been linked to human hyperekplexia/startle disease and autism spectrum disorders. We found that a lack of synaptic integration of GlyRs, together with disrupted receptor function, is responsible for a lethal startle phenotype in a novel spontaneous mouse mutant shaky, caused by a missense mutation, Q177K, located in the extracellular β8–β9 loop of the GlyR α1 subunit. Recently, structural data provided evidence that the flexibility of the β8–β9 loop is crucial for conformational transitions during opening and closing of the ion channel and represents a novel allosteric binding site in Cys-loop receptors. We identified the underlying neuropathological mechanisms in male and female shaky mice through a combination of protein biochemistry, immunocytochemistry, and both in vivo and in vitro electrophysiology. Increased expression of the mutant GlyR α1Q177K subunit in vivo was not sufficient to compensate for a decrease in synaptic integration of α1Q177Kβ GlyRs. The remaining synaptic heteromeric α1Q177Kβ GlyRs had decreased current amplitudes with significantly faster decay times. This functional disruption reveals an important role for the GlyR α1 subunit β8–β9 loop in initiating rearrangements within the extracellular–transmembrane GlyR interface and that this structural element is vital for inhibitory GlyR function, signaling, and synaptic clustering

Fragment Production in Non-central Collisions of Intermediate Energy Heavy Ions

The defining characteristics of fragment emission resulting from the non-central collision of 114Cd ions with 92Mo target nuclei at E/A = 50 MeV are presented. Charge correlations and average relative velocities for mid-velocity fragment emission exhibit significant differences when compared to standard statistical decay. These differences associated with similar velocity dissipation are indicative of the influence of the entrance channel dynamics on the fragment production process

Education inequalities in adult all-cause mortality: first national data for Australia using linked census and mortality data

BACKGROUND: National linked mortality and census data have not previously been available for Australia. We estimated education-based mortality inequalities from linked census and mortality data that are suitable for international comparisons. METHODS: We used the Australian Bureau of Statistics Death Registrations to Census file, with data on deaths (2011-2012) linked probabilistically to census data (linkage rate 81%). To assess validity, we compared mortality rates by age group (25-44, 45-64, 65-84 years), sex and area-inequality measures to those based on complete death registration data. We used negative binomial regression to quantify inequalities in all-cause mortality in relation to five levels of education ['Bachelor degree or higher' (highest) to 'no Year 12 and no post-secondary qualification' (lowest)], separately by sex and age group, adjusting for single year of age and correcting for linkage bias and missing education data. RESULTS: Mortality rates and area-based inequality estimates were comparable to published national estimates. Men aged 25-84 years with the lowest education had age-adjusted mortality rates 2.20 [95% confidence interval (CI): 2.08‒2.33] times those of men with the highest education. Among women, the rate ratio was 1.64 (1.55‒1.74). Rate ratios were 3.87 (3.38‒4.44) in men and 2.57 (2.15‒3.07) in women aged 25-44 years, decreasing to 1.68 (1.60‒1.76) in men and 1.44 (1.36‒1.53) in women aged 65-84 years. Absolute education inequalities increased with age. One in three to four deaths (31%) was associated with less than Bachelor level education. CONCLUSIONS: These linked national data enabled valid estimates of education inequality in mortality suitable for international comparisons. The magnitude of relative inequality is substantial and similar to that reported for other high-income countries.Rosemary J Korda, Nicholas Biddle, John Lynch, James Eynstone-Hinkins, Kay Soga, Emily Banks ... et al

Non-Thermal Behavior in Multifragment Decay

This research was sponsored by the National Science Foundation Grant NSF PHY-931478