213 research outputs found
Electrodynamics of quasi-two-dimensional BEDT-TTF charge transfer salts
We consider the millimeter-wave electrodynamics specific to
quasi-two-dimensional conductors and superconductors based on the organic donor
molecule BEDT-TTF. Using realistic physical parameters, we examine the current
polarizations that result for different oscillating (GHz) electric and magnetic
field polarizations. We show that, in general, it is possible to discriminate
between effects (dissipation and dispersion) due to in-plane and interlayer ac
currents. However, we also show that it is not possible to selectively probe
any single component of the in-plane conductivity tensor, and that excitation
of interlayer currents is strongly influenced by the sample geometry and the
electromagnetic field polarization.Comment: 5 pages including 3 figures Minor correction to figure
Evidence for LineLike Vortex Liquid Phase in TlBaCaCuO Probed by the Josephson Plasma Resonance
We measured the Josephson plasma resonance (JPR) in optimally doped
TlBaCaCuO thin films using terahertz time-domain
spectroscopy in transmission. The temperature and magnetic field dependence of
the JPR frequency shows that the c-axis correlations of pancake vortices remain
intact at the transition from the vortex solid to the liquid phase. In this
respect TlBaCaCuO films, withanisotropy parameter
, are similar to the less anisotropic
YBaCuO rather than to the most
anisotropic BiSrCaCuO single crystals ).Comment: Submitted to Physical Review Letter
Ultrasound attenuation in gap-anisotropic systems
Transverse ultrasound attenuation provides a weakly-coupled probe of momentum
current correlations in electronic systems. We develop a simple theory for the
interpretation of transverse ultrasound attenuation coefficients in systems
with nodal gap anisotropy. Applying this theory we show how ultrasound can
delineate between extended-s and d-wave scenarios for the cuprate
superconductors.Comment: Uuencode file: 4 pages (Revtex), 3 figures. Some references adde
Fractional vortices on grain boundaries --- the case for broken time reversal symmetry in high temperature superconductors
We discuss the problem of broken time reversal symmetry near grain boundaries
in a d-wave superconductor based on a Ginzburg-Landau theory. It is shown that
such a state can lead to fractional vortices on the grain boundary. Both
analytical and numerical results show the structure of this type of state.Comment: 9 pages, RevTeX, 5 postscript figures include
The amyloid precursor protein controls PIKfyve function
While the Amyloid Precursor Protein (APP) plays a central role in Alzheimer's disease, its cellular function still remains largely unclear. It was our goal to establish APP function which will provide insights into APP's implication in Alzheimer's disease. Using our recently developed proteo-liposome assay we established the interactome of APP's intracellular domain (known as AICD), thereby identifying novel APP interactors that provide mechanistic insights into APP function. By combining biochemical, cell biological and genetic approaches we validated the functional significance of one of these novel interactors. Here we show that APP binds the PIKfyve complex, an essential kinase for the synthesis of the endosomal phosphoinositide phosphatidylinositol-3,5-bisphosphate. This signalling lipid plays a crucial role in endosomal homeostasis and receptor sorting. Loss of PIKfyve function by mutation causes profound neurodegeneration in mammals. Using C. elegans genetics we demonstrate that APP functionally cooperates with PIKfyve in vivo. This regulation is required for maintaining endosomal and neuronal function. Our findings establish an unexpected role for APP in the regulation of endosomal phosphoinositide metabolism with dramatic consequences for endosomal biology and important implications for our understanding of Alzheimer's disease
Error sources and data limitations for the prediction ofsurface gravity: a case study using benchmarks
Gravity-based heights require gravity values at levelled benchmarks (BMs), whichsometimes have to be predicted from surrounding observations. We use EGM2008 andthe Australian National Gravity Database (ANGD) as examples of model and terrestrialobserved data respectively to predict gravity at Australian national levelling network(ANLN) BMs. The aim is to quantify errors that may propagate into the predicted BMgravity values and then into gravimetric height corrections (HCs). Our results indicatethat an approximate ±1 arc-minute horizontal position error of the BMs causesmaximum errors in EGM2008 BM gravity of ~ 22 mGal (~55 mm in the HC at ~2200 melevation) and ~18 mGal for ANGD BM gravity because the values are not computed atthe true location of the BM. We use RTM (residual terrain modelling) techniques toshow that ~50% of EGM2008 BM gravity error in a moderately mountainous regioncan be accounted for by signal omission. Non-representative sampling of ANGDgravity in this region may cause errors of up to 50 mGals (~120 mm for the Helmertorthometric correction at ~2200 m elevation). For modelled gravity at BMs to beviable, levelling networks need horizontal BM positions accurate to a few metres, whileRTM techniques can be used to reduce signal omission error. Unrepresentative gravitysampling in mountains can be remedied by denser and more representative re-surveys,and/or gravity can be forward modelled into regions of sparser gravity
Management of acute hypercortisolism
An occasional patient with Cushing's syndrome may require urgent management primarily because the chronic ravages of hypercortisolism have caused the patient to be in a precarious metabolic condition. The side effects of prolonged excess corticosteroids increase the risk of operations in such patients and must be considered in overall management. Among the many effects of hypercortisolism to be considered are hypertension, diabetes, ocular hypertension, myopathies, dermatologic changes including skin infection, pancreatitis, osteoporosis, pathological fractures, peptic ulcers, renal calculi, coagulopathies, hypokalemia, poor wound healing, and increased susceptibility to infection. The most effective way to avert these complications is by earlier diagnosis and definitive treatment of Cushing's syndrome. The present report includes a review of the etiology and diagnosis of Cushing's syndrome and the management of problems associated with hypercortisolism . Il est possible qu'un malade atteint de maladie de Cushing ait besoin d'ĂȘtre traitĂ© sans attente en raisons de troubles mĂ©taboliques sĂ©vĂšres dus aux effets nocifs de l'hypercortisolisme chronique qui augmentent les risques opĂ©ratoires et doivent ĂȘtre pris en considĂ©ration avant tout traitement. Il en est ainsi de l'hypertension, du diabĂšte, de l'hypertension intra-oculaire, des lĂ©sions dermiques comprenant l'infection cutanĂ©e, la pancrĂ©atite, l'ostĂ©oporose, les fractures pathologiques, l'ulcĂšre peptique, les calculs rĂ©naux, les coagulopathies, l'hypokaliĂ©mie, la lenteur du processus de cicatrisation et l'augmentation de la suceptibilitĂ© Ă l'infection.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41309/1/268_2005_Article_BF01655367.pd
The ecogenetic link between demography and evolution : can we bridge the gap between theory and data?
Calls to understand the links between ecology and evolution have been common for decades. Population dynamics, i.e. the demographic changes in populations, arise from life history decisions of individuals and thus are a product of selection, and selection, on the contrary, can be modified by such dynamical properties of the population as density and stability. It follows that generating predictions and testing them correctly requires considering this ecogenetic feedback loop whenever traits have demographic consequences, mediated via density dependence (or frequency dependence). This is not an easy challenge, and arguably theory has advanced at a greater pace than empirical research. However, theory would benefit from more interaction between related fields, as is evident in the many near-synonymous names that the ecogenetic loop has attracted. We also list encouraging examples where empiricists have shown feasible ways of addressing the question, ranging from advanced data analysis to experiments and comparative analyses of phylogenetic data
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Energetic particle influence on the Earth's atmosphere
This manuscript gives an up-to-date and comprehensive overview of the effects of energetic particle precipitation (EPP) onto the whole atmosphere, from the lower thermosphere/mesosphere through the stratosphere and troposphere, to the surface. The paper summarizes the different sources and energies of particles, principally
galactic cosmic rays (GCRs), solar energetic particles (SEPs) and energetic electron precipitation (EEP). All the proposed mechanisms by which EPP can affect the atmosphere
are discussed, including chemical changes in the upper atmosphere and lower thermosphere, chemistry-dynamics feedbacks, the global electric circuit and cloud formation. The role of energetic particles in Earthâs atmosphere is a multi-disciplinary problem that requires expertise from a range of scientific backgrounds. To assist with this synergy, summary tables are provided, which are intended to evaluate the level of current knowledge of the effects of energetic particles on processes in the entire atmosphere
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