135 research outputs found
Eutectic colony formation: A phase field study
Eutectic two-phase cells, also known as eutectic colonies, are commonly
observed during the solidification of ternary alloys when the composition is
close to a binary eutectic valley. In analogy with the solidification cells
formed in dilute binary alloys, colony formation is triggered by a
morphological instability of a macroscopically planar eutectic solidification
front due to the rejection by both solid phases of a ternary impurity that
diffuses in the liquid. Here we develop a phase-field model of a binary
eutectic with a dilute ternary impurity and we investigate by dynamical
simulations both the initial linear regime of this instability, and the
subsequent highly nonlinear evolution of the interface that leads to fully
developed two-phase cells with a spacing much larger than the lamellar spacing.
We find a good overall agreement with our recent linear stability analysis [M.
Plapp and A. Karma, Phys. Rev. E 60, 6865 (1999)], which predicts a
destabilization of the front by long-wavelength modes that may be stationary or
oscillatory. A fine comparison, however, reveals that the assumption commonly
attributed to Cahn that lamella grow perpendicular to the envelope of the
solidification front is weakly violated in the phase-field simulations. We show
that, even though weak, this violation has an important quantitative effect on
the stability properties of the eutectic front. We also investigate the
dynamics of fully developed colonies and find that the large-scale envelope of
the composite eutectic front does not converge to a steady state, but exhibits
cell elimination and tip-splitting events up to the largest times simulated.Comment: 18 pages, 18 EPS figures, RevTeX twocolumn, submitted to Phys. Rev.
Highest densities of mountain hares ( Lepus timidus ) associated with ecologically restored bog but not grouse moorland management
Over the last 20 years, ecological restoration of degraded habitats has become common in conservation practice. Mountain hares (Lepus timidus scoticus) were surveyed during 2017â2021 using 830 km of line transects in the Peak District National Park, England. Historically degraded bog areas were previously reported having low hare numbers. Following bog restoration, we found hare densities of 32.6 individuals kmâ2, notably higher than neighboring degraded (unrestored) bog with 24.4 hares kmâ2. Hare density on restored peatland was 2.7 times higher than on bogs managed for grouse shooting at 12.2 hares kmâ2 and 3.3 times higher than on heather moorland managed for grouse shooting at 10.0 hares kmâ2. Yearly estimates varied most on habitats managed for grouse, perhaps indicative of the impact of habitat management, for example, heather burning and/or possible hare culling to control potential tick-borne louping ill virus in gamebirds. Acid grassland used for sheep farming had a similar density to grouse moorland at 11.8 hares kmâ2. Unmanaged dwarf shrub heath had the lowest density at 4.8 hares kmâ2. Hare populations are characterized by significant yearly fluctuations, those in the study area increasing by 60% between 2017 and 2018 before declining by ca. 15% by 2020 and remaining stable to 2021. During an earlier survey in 2002, total abundance throughout the Peak District National Park was estimated at 3361 (95% CI: 2431â4612) hares. The present study estimated 3562 (2291â5624) hares suggesting a stable population over the last two decades despite fluctuations likely influenced by weather and anthropogenic factors. Mountain hares in the Peak District favored bog habitats and were associated with restored peatland habitat. Wildlife management should be cognizant of hare density variation between habitats, which may have implications for local extinction risk
Towards a quantitative phase-field model of two-phase solidification
We construct a diffuse-interface model of two-phase solidification that
quantitatively reproduces the classic free boundary problem on solid-liquid
interfaces in the thin-interface limit. Convergence tests and comparisons with
boundary integral simulations of eutectic growth show good accuracy for
steady-state lamellae, but the results for limit cycles depend on the interface
thickness through the trijunction behavior. This raises the fundamental issue
of diffuse multiple-junction dynamics.Comment: 4 pages, 2 figures. Better final discussion. 1 reference adde
EPR-Bell Nonlocality, Lorentz Invariance, and Bohmian Quantum Theory
We discuss the problem of finding a Lorentz invariant extension of Bohmian
mechanics. Due to the nonlocality of the theory there is (for systems of more
than one particle) no obvious way to achieve such an extension. We present a
model invariant under a certain limit of Lorentz transformations, a limit
retaining the characteristic feature of relativity, the non-existence of
absolute time resp. simultaneity. The analysis of this model exemplifies an
important property of any Bohmian quantum theory: the quantum equilibrium
distribution cannot simultaneously be realized in all
Lorentz frames of reference.Comment: 24 pages, LaTex, 4 figure
Is The Amphibian Tree of Life really fatally flawed?
Wiens (2007 , Q. Rev. Biol. 82, 55â56) recently published a severe critique of Frost et al.'s (2006, Bull. Am. Mus. Nat. Hist. 297, 1â370) monographic study of amphibian systematics, concluding that it is âa disasterâ and recommending that readers âsimply ignore this studyâ. Beyond the hyperbole, Wiens raised four general objections that he regarded as âfatal flawsâ: (1) the sampling design was insufficient for the generic changes made and taxonomic changes were made without including all type species; (2) the nuclear gene most commonly used in amphibian phylogenetics, RAG-1, was not included, nor were the morphological characters that had justified the older taxonomy; (3) the analytical method employed is questionable because equally weighted parsimony âassumes that all characters are evolving at equal ratesâ; and (4) the results were at times âclearly erroneousâ, as evidenced by the inferred non-monophyly of marsupial frogs. In this paper we respond to these criticisms. In brief: (1) the study of Frost et al. did not exist in a vacuum and we discussed our evidence and evidence previously obtained by others that documented the non-monophyletic taxa that we corrected. Beyond that, we agree that all type species should ideally be included, but inclusion of all potentially relevant type species is not feasible in a study of the magnitude of Frost et al. and we contend that this should not prevent progress in the formulation of phylogenetic hypotheses or their application outside of systematics. (2) Rhodopsin, a gene included by Frost et al. is the nuclear gene that is most commonly used in amphibian systematics, not RAG-1. Regardless, ignoring a study because of the absence of a single locus strikes us as unsound practice. With respect to previously hypothesized morphological synapomorphies, Frost et al. provided a lengthy review of the published evidence for all groups, and this was used to inform taxonomic decisions. We noted that confirming and reconciling all morphological transformation series published among previous studies needed to be done, and we included evidence from the only published data set at that time to explicitly code morphological characters (including a number of traditionally applied synapomorphies from adult morphology) across the bulk of the diversity of amphibians (Haas, 2003, Cladistics 19, 23â90). Moreover, the phylogenetic results of the Frost et al. study were largely consistent with previous morphological and molecular studies and where they differed, this was discussed with reference to the weight of evidence. (3) The claim that equally weighted parsimony assumes that all characters are evolving at equal rates has been shown to be false in both analytical and simulation studies. (4) The claimed âstrong supportâ for marsupial frog monophyly is questionable. Several studies have also found marsupial frogs to be non-monophyletic. Wiens et al. (2005, Syst. Biol. 54, 719â748) recovered marsupial frogs as monophyletic, but that result was strongly supported only by Bayesian clade confidence values (which are known to overestimate support) and bootstrap support in his parsimony analysis was <â50%. Further, in a more recent parsimony analysis of an expanded data set that included RAG-1 and the three traditional morphological synapomorphies of marsupial frogs, Wiens et al. (2006, Am. Nat. 168, 579â596) also found them to be non-monophyletic. Although we attempted to apply the rule of monophyly to the naming of taxonomic groups, our phylogenetic results are largely consistent with conventional views even if not with the taxonomy current at the time of our writing. Most of our taxonomic changes addressed examples of non-monophyly that had previously been known or suspected (e.g., the non-monophyly of traditional Hyperoliidae, Microhylidae, Hemiphractinae, Leptodactylidae, Phrynobatrachus , Ranidae, Rana , Bufo ; and the placement of Brachycephalus within â Eleutherodactylus â, and Lineatriton within â Pseudoeurycea â), and it is troubling that Wiens and others, as evidenced by recent publications, continue to perpetuate recognition of non-monophyletic taxonomic groups that so profoundly misrepresent what is known about amphibian phylogeny. © The Willi Hennig Society 2007.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74688/1/j.1096-0031.2007.00181.x.pd
Atividade secretĂłria de tubas uterinas com e sem patologia de porcas adultas nas fases folicular e luteĂnica
Differences in anatomy and potential hydraulic conductivity between root and stem of Caesalpinia echinata Lam. (Fabaceae)
Molecular Features of Cancers Exhibiting Exceptional Responses to Treatment
A small fraction of cancer patients with advanced disease survive significantly longer than patients with clinically comparable tumors. Molecular mechanisms for exceptional responses to therapy have been identified by genomic analysis of tumor biopsies from individual patients. Here, we analyzed tumor biopsies from an unbiased cohort of 111 exceptional responder patients using multiple platforms to profile genetic and epigenetic aberrations as well as the tumor microenvironment. Integrative analysis uncovered plausible mechanisms for the therapeutic response in nearly a quarter of the patients. The mechanisms were assigned to four broad categoriesâDNA damage response, intracellular signaling, immune engagement, and genetic alterations characteristic of favorable prognosisâwith many tumors falling into multiple categories. These analyses revealed synthetic lethal relationships that may be exploited therapeutically and rare genetic lesions that favor therapeutic success, while also providing a wealth of testable hypotheses regarding oncogenic mechanisms that may influence the response to cancer therapy. Profiling multi-platform genomics of 110 cancer patients with an exceptional therapeutic response, Wheeler et al. identify putative molecular mechanisms explaining this survival phenotype in âŒ23% of cases. Therapeutic success is related to rare molecular features of responding tumors, exploiting synthetic lethality and oncogene addiction
Physics with the KLOE-2 experiment at the upgraded DANE
Investigation at a --factory can shed light on several debated issues
in particle physics. We discuss: i) recent theoretical development and
experimental progress in kaon physics relevant for the Standard Model tests in
the flavor sector, ii) the sensitivity we can reach in probing CPT and Quantum
Mechanics from time evolution of entangled kaon states, iii) the interest for
improving on the present measurements of non-leptonic and radiative decays of
kaons and eta/eta mesons, iv) the contribution to understand the
nature of light scalar mesons, and v) the opportunity to search for narrow
di-lepton resonances suggested by recent models proposing a hidden dark-matter
sector. We also report on the physics in the continuum with the
measurements of (multi)hadronic cross sections and the study of gamma gamma
processes.Comment: 60 pages, 41 figures; added affiliation for one of the authors; added
reference to section
A thymidine kinase-deleted bovine herpesvirus 5 establishes latent infection but reactivates poorly in a sheep model
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