Delimitation of service areas in reverse logistics networks with multiple depots

WOS:000290258800003 (Nº de Acesso Web of Science)“Prémio Científico ISCTE-IUL 2012”This paper describes a heuristic approach for the definition of service (or influence) areas of multiple depots in a reverse logistics network. This work is based on a case study: the recyclable waste collection system with 5 depots that covers seven municipalities in the Alentejo region, southern Portugal. The system optimization considers two objectives, related with economic and organizational issues: minimizing the variable costs (function of the travelled distances by the collection vehicles), and the pursuit of equity, aiming at minimizing the workload differences among depots. The goal of balancing workloads poses a problem not usually treated in the existing literature. This fact required the development of a new approach with innovative elements adjusted to the existing circumstances

Performance Assessment of WhatsApp and IMO on Android Operating System (Lollipop and KitKat) during VoIP Calls using 3G or WiFi

This paper assesses the performance of mobile messaging and VoIP connections. We compared the CPU requirements of WhatsApp and IMO under different scenarios. This analysis also enabled a comparison of the performance of these applications on two Android operating system (OS) versions: KitKat or Lollipop. Two models of smartphones were considered, viz. Galaxy Note 4 and Galaxy S4. The applications behavior was statistically investigated for both sending and receiving VoIP calls. Connections have been examined over 3G and WiFi. The handset model plays a decisive role in CPU requirements of the application. t-tests shown that IMO has a statistical better performance that WhatsApp whatever be the Android at a significance level 1%, on Galaxy Note 4. In contrast, WhatsApp requires less CPU than IMO on Galaxy S4 whatever be the OS and access (3G/WiFi). Galaxy Note 4 using WiFi has always better performance than S4 in terms of processing

The role of type 4 phosphodiesterases in generating microdomains of cAMP: Large scale stochastic simulations

Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechanisms have been proposed to produce localized elevations in cAMP, known as microdomains: impeded diffusion, and high phosphodiesterase (PDE) activity. This paper investigates the mechanism of localized cAMP signaling using a computational model of the biochemical network in the HEK293 cell, which is a subset of pathways involved in PKA-dependent synaptic plasticity. This biochemical network includes cAMP production, PKA activation, and cAMP degradation by PDE activity. The model is implemented in NeuroRD: novel, computationally efficient, stochastic reaction-diffusion software, and is constrained by intracellular cAMP dynamics that were determined experimentally by real-time imaging using an Epac-based FRET sensor (H30). The model reproduces the high concentration cAMP microdomain in the submembrane region, distinct from the lower concentration of cAMP in the cytosol. Simulations further demonstrate that generation of the cAMP microdomain requires a pool of PDE4D anchored in the cytosol and also requires PKA-mediated phosphorylation of PDE4D which increases its activity. The microdomain does not require impeded diffusion of cAMP, confirming that barriers are not required for microdomains. The simulations reported here further demonstrate the utility of the new stochastic reaction-diffusion algorithm for exploring signaling pathways in spatially complex structures such as neurons

Two-band fast Hartley transform

This article has been made available through the Brunel Open Access Publishing Fund.Efficient algorithms have been developed over the past 30 years for computing the forward and inverse discrete Hartley transforms (DHTs). These are similar to the fast Fourier transform (FFT) algorithms for computing the discrete Fourier transform (DFT). Most of these methods seek to minimise the complexity of computations and or the number of operations. A new approach for the computation of the radix-2 fast Hartley transform (FHT) is presented. The proposed algorithm, based on a two-band decomposition of the input data, possesses a very regular structure, avoids the input or out data shuffling, requires slightly less multiplications than the existing approaches, but increases the number of additions

Qualidade Físico-química E Sensorial De Genótipos De Banana

Despite the diversity of banana varieties in Brazil, only a few cultivars have the proper agronomic traits and fruit quality for commercial exploitation. This study aimed at evaluating the physicochemical traits and sensorial acceptance of banana genotypes, in order to identify those with potential for commercial growing. Six improved banana genotypes were assessed (BRS Maravilha, PC 0101, FHIA 18, TM 2803, YB 4203 and BRS Caipira), as well as three commercial cultivars (Grand Naine, Pacovan and Prata Anã). Analyses of peel and pulp color, peel thickness, pulp yield, moisture, pH, soluble solids, titratable acidity, total carotenoids and sensorial acceptance were performed. The BRS Maravilha, FHIA 18, YB 4203 and BRS Caipira genotypes presented physicochemical traits similar to the Grand Naine, Pacovan and Prata Anã commercial cultivars. The BRS Maravilha and TM 2803 genotypes had sensorial acceptance similar to the Prata Anã and Grand Naine cultivars, and are therefore promising for commercial growing, with the advantage of being resistant to the black Sigatoka and Panama disease. © 2016, Universidade Federal De Goias (UFG). All Rights Reserved.461899

Measuring university-to-work success: development of a new scale

Purpose – The purpose of this paper is to develop a subjective multidimensional measure of early career success during university-to-work transition. Design/methodology/approach – The construct of university-to-work success (UWS) was defined in terms of intrinsic and extrinsic career outcomes, and a three-stage study was conducted to create a new scale. Findings – A preliminary set of items was developed and tested by judges. Results showed the items had good content validity. Factor analyses indicated a four-factor structure and a second-order model with subscales to assess: career insertion and satisfaction, confidence in career future, income and financial independence, and adaptation to work. Third, the authors sought to confirm the hypothesized model examining the comparative fit of the scale and two alternative models. Results showed that fits for both the first- and second-order models were acceptable. Research limitations/implications – The proposed model has sound psychometric qualities, although the validated version of the scale was not able to incorporate all constructs envisaged by the initial theoretical model. Results indicated some direction for further refinement. Practical implications – The scale could be used as a tool for self-assessment or as an outcome measure to assess the efficacy of university-to-work programs in applied settings. Originality/value – This study provides a useful single measure to assess early career success during the university-to-work transition, and might facilitate testing of causal models which could help identify factors relevant for successful transition.CAPES, Brasi

Particle Pair Production in Cosmological General Relativity

The Cosmological General Relativity (CGR) of Carmeli, a 5-dimensional (5-D) theory of time, space and velocity, predicts the existence of an acceleration a_0 = c / tau due to the expansion of the universe, where c is the speed of light in vacuum, tau = 1 / h is the Hubble-Carmeli time constant, where h is the Hubble constant at zero distance and no gravity. The Carmeli force on a particle of mass m is F_c = m a_0, a fifth force in nature. In CGR, the effective mass density rho_eff = rho - rho_c, where rho is the matter density and rho_c is the critical mass density which we identify with the vacuum mass density rho_vac = -rho_c. The fields resulting from the weak field solution of the Einstein field equations in 5-D CGR and the Carmeli force are used to hypothesize the production of a pair of particles. The mass of each particle is found to be m = tau c^3 / 4 G, where G is Newton's constant. The vacuum mass density derived from the physics is rho_vac = -rho_c = -3 / (8 pi G tau^2). The cosmic microwave background (CMB) black body radiation at the temperature T_o = 2.72548 K which fills that volume is found to have a relationship to the ionization energy of the Hydrogen atom. Define the radiation energy epsilon_gamma = (1 - g) m c^2 / N_gamma, where (1-g) is the fraction of the initial energy m c^2 which converts to photons, g is a function of the baryon density parameter Omega_b and N_gamma is the total number of photons in the CMB radiation field. We make the connection with the ionization energy of the first quantum level of the Hydrogen atom by the hypothesis epsilon_gamma = [(1 - g) m c^2] / N_gamma = alpha^2 mu c^2 / 2, where alpha is the fine-structure constant and mu = m_p f / (1 + f), where f= m_e / m_p with m_e the electron mass and m_p the proton mass.Comment: 14 pages, 0 figures. The final publication is available at springerlink.co

Bradykinin B2 receptor is essential to running-induced cell proliferation in the adult mouse hippocampus

Physical exercise is a strong external effector that induces precursor cell proliferation in the adult mouse hippocampus. Research into mechanisms has focused on central changes within the hippocampus and we have established that serotonin is the signaling factor that transduces physical activity into adult neurogenesis. Less focus has been given on potential peripheral signals that may cause pro-mitotic running effects. Vasoactive kinin peptides are important for blood pressure regulation and inflammatory processes to maintain cardiovascular homeostasis. Acting via the two receptors termed B1 (B1R) and B2R, the peptides also function in the brain. In particular, studies attribute B2R a role in cell proliferation and differentiation into neurons in vitro. Here, we determined B1R and B2R mRNA expression levels in the adult mouse hippocampus and prefrontal cortex in vivo, and in response to running exercise. Using mice depleted in either or both receptors, B1-knockout (KO), B2KO and B1/2KO we observed changes in running performance overnight and in running distances. However, voluntary exercise led to the known pro-mitotic effect in the dentate gyrus of B1KO mice while it was attenuated in B2KO accompanied by an increase in microglia cells. Our data identify B2R as an important factor in running-induced precursor cell proliferation

Estimation of morphoestructural traits in moxoto breed goats

The raising goat systems in Brazil are characterized as extensive or semi-extensive in the majority of them. In native breeds dominate the extensive system, being common introduction of exotic breed as Anglo Nubian and Boer. In addition, the geographic isolation difficulty change of sires, promote genetic isolation and changes in breed pattern, consequently. The objective of the present work were to evaluate eleven quantitative morphoestructural traits: raised to the withers (RW), raised to the entrance of croup (RC), thoracic perimeter (PT), width of croup (WC), length of croup (LC), width of head (WH), face length (FL), width of face (WF), ear size (ES), shin circumference of the cinnamon (CCi) of 313 Moxoto animal breed of several municipality of Pernambuco and Paraíba States, northeastern, semi arid region of Brazil. According to canonical analyses it is possible to verify diferentiation and sub populations formation.Os sistemas de produção de caprinos no Brasil caracterizam-se na sua maioria como extensivo ou semi-extensivo. Porém, na criação de caprinos nativos predomina o sistema ultra-extensivo, sendo comum a introdução de animais exóticos, principalmente das raças Anglo Nubiana e Boer para cruzamento com o rebanho local, fato que tem contribuído para diluição genética e perda das características raciais.. Além disso, o isolamento geográfico a que estão submetidos, dificulta a troca de reprodutores entre rebanhos, promove isolamento genético e como conseqüência final, mudanças no padrão racial. O presente trabalho teve como objetivo utilizar onze variáveis morfo-estruturais de natureza quantitativas, tais como: longitude da cabeça (LC); longitude do rosto (LR); largura da cabeça (LCa); comprimento do corpo (CC); perímetro torácico (PT); altura da cernelha (AC); altura da região sacral (ARS); largura da garupa (LG); longitude da garupa (LGa); perímetro da canela (PCa) e; tamanho da orelha (TO) de 313 animais da raça caprina Moxotó, de diferentes municípios dos Estados de Pernambuco e Paraíba, região semi-árida do Nordeste brasileiro. Pela análise canônica foi possível verificar diferenciação e formação de sub-populações dentro da raça

Nitrogen source on performance of feedlot young bulls fed hydrolyzed sugarcane bagasse diets

Oitenta e um machos não castrados das raças Nelore (27), Canchim (27) e Holandesa (27), com peso médio inicial de 360kg e idade média de 18 meses, foram utilizados para avaliar os efeitos da substituição de fonte de proteína verdadeira (farelo de soja), por nitrogênio não protéico (NNP), uréia ou amiréia (fonte de nitrogênio não protéico de suposta liberação gradativa) sobre o desempenho de bovinos confinados. O delineamento experimental foi o de blocos inteiramente ao acaso com três animais por baia e nove baias por tratamento. Os blocos foram delineados de acordo com o peso inicial e na raça. As rações experimentais continham BTPV (45% MS da dieta) e BIN (5% MS da dieta) como fontes de volumosos e 50% de concentrado. Os tratamentos consistiam de: 1) concentrado contendo farelo de soja (FS); 2) concentrado contendo uréia e 3) concentrado contendo amiréia (A-150S). O consumo de matéria seca (CMS) foi de 8,99; 7,43 e 7,69kg/dia, o ganho de peso diário (GPD) foi de 0,983; 0,368 e 0,404kg/dia e a conversão alimentar (CA) 9,56; 20,14 e 19,54kg MS/kg de ganho para os tratamentos FS, uréia e A-150S, respectivamente. As rações com FS apresentaram proporcionalmente maior (P<0,01) CMS e maior GPD e melhor CA em relação aos tratamentos uréia e A-150S. As rações com uréia e A-150S não diferiram (P>0,05) entre si. A substituição do FS por fontes de NNP reduziu o desempenho de bovino de corte em terminação.Eighty-one young bulls (27 Nellore, 27 Canchim, and 27 Holstein), averaging 18-month-old and weighting 360kg of initial body weight (BW), were used to evaluate the effects of nitrogen sources on feedlot performance. Treatments were assigned in a completely randomized block design using three steers per stall and nine per treatment. Blocks were defined by initial BW and breed. Experimental treatments were: 1) soybean meal, 2) urea, and 3) starea. Diets were isonitrogenous and isoenergetic composed by 50% concentrate and 50% forage (45% hydrolyzed sugarcane bagasse + 5% in natura sugarcane bagasse). Dry matter intakes (DMI) were 8.99, 7.43, and 7.69kg/day, average daily gains (ADG) were 0.983, 0.368, and 0.404kg/day and feed efficiencies were 9.56, 20.14, and 19.54kg DM/kg of gain for soybean meal, urea and starea treatments, respectively for steers fed. Diets with soybean meal showed proportionally higher (P<0.01) DMI, higher average daily gain and better feed efficiency compared to urea and starea diets. No differences (P>0.05) between urea and starea treatments were observed. Replacement of soybean meal by nonprotein nitrogen sources decreased the finishing beef steers performance