Observation of nuclei with energies 8-30 MeV per nucleon in the Earth's magnetosphere at the altitudes 350 KM

Observations of the flux of nuclei with an energy of IO MeV per nucleon on the Salyut-7 Station in September 1984 are presented. The observed flux is smaller by a factor of 50 than the flux detected in May, 1981

Neutron Rich Hypernuclei in Chiral Soliton Model

The binding energies of neutron rich strangeness $S=-1$ hypernuclei are estimated in the chiral soliton approach using the bound state rigid oscillator version of the SU(3) quantization model. Additional binding of strange hypernuclei in comparison with nonstrange neutron rich nuclei takes place at not large values of atomic (baryon) numbers, $A=B\leq\sim 10$. This effect becomes stronger with increasing isospin of nuclides, and for "nuclear variant" of the model with rescaled Skyrme constant $e$. Total binding energies of (Lambda)He-8 and recently discovered (Lambda)H-6 satisfactorily agree with experimental data. Hypernuclei (Lambda)H-7, (Lambda)He-9 are predicted to be bound stronger in comparison with their nonstrange analogues H-7, He-9; hypernuclei (Lambda)Li-10, (Lambda)Li-11, (Lambda)Be-12, (Lambda)Be-13, etc. are bound stronger in the nuclear variant of the model.Comment: 8 pages, 4 tables; amendments made, data on binding energy of (Lambda)He-8 and references added; prepared for the conferences Quarks-2012 and HYP201

Сегетальная флора некоторых регионов России: характеристика таксономической структуры

The authors' data on the weed species composition in 8 geographic regions of the Russian Federation were laid at the basis of this survey. The segetal flora comprised weeds of cereals, root crops, and perennial grasses. The composition and taxonomic structure of weed species were analyzed. The total number of weedy plants encompassed 686 plant species. The level of regional weed species diversity was positively related to the area planted. Altai Territory, Udmurtia, and Rostov Province had the greatest weed species diversity, with more than 300 species, while Vologda Province had the lowest diversity (193 species). Most species-rich plant families (Asteraceae Dumort., Poaceae Barnhart, Fabaceae Lindl., Brassicaceae Burnet), genera (Potentila L., Artemisia L., Veronica L., Chenopodium L., Silene L., Trifolium L.), their subsequences, contributions of single-species families (17-39%) and genera (57-74%) were relatively stable systematic structure indicators. Only 18% of the species were common for all the regions. In each region there were region-specific groups of species. Weed species compositions in geographically close regions - the European part of Russia and the Urals - showed the greatest similarity. As for geographically distant regions (Altai Territory and Rostov Province), their weedy species compositions were distant and contained large groups of region-specific species. © 2020 All-Russian Institute of Plant Genetic Resources -Federal Research Center. All rights reserved.This work was supported in part by the Russian Foundation for Basic Research (projects 17-44-020402 р_а, 19-016-00135), state budget funds (AAAA-A18-118011990151-7), and as part of the implementation of the state task on the topic: “Vascular plants of Eurasia: taxonomy, flora, plant resources” (AAAA-A19-119031290052-1)

Strangeness nuclear physics: a critical review on selected topics

Selected topics in strangeness nuclear physics are critically reviewed. This includes production, structure and weak decay of $\Lambda$--Hypernuclei, the $\bar K$ nuclear interaction and the possible existence of $\bar K$ bound states in nuclei. Perspectives for future studies on these issues are also outlined.Comment: 63 pages, 51 figures, accepted for publication on European Physical Journal

О СЛУЧАЯХ ТРАНСФУЗИОННО-АССОЦИИРОВАНОГО ПОВРЕЖДЕНИЯ ЛЕГКИХ В КЛИНИЧЕСКОЙ ПРАКТИКЕ

Preparation of this publication was motivated by a desire to present contemporary authors look at one of the most important branches of critical care medicine - transfusion therapy and related complications, such as transfusion-related lung injury (TRALI). The article describes the causes, pathogenesis, diagnosis and therapy of TRALI patients in critical condition. In this article attention is paid to the diagnosis of TRALI, associated with transfusion of blood components, modern diagnosis criteria. The authors describe the clinical symptoms, treatment schema and propose prevention protocol of TRALI. In order to determine the incidence of TRALI in medical practice transfusion therapy data in 1900 patients was analyzed. The development of this complication was found in 12 patients, 5 patients had «possible TRALI», which is comparable with the literature data. In 5 patients and 11 donors at a laboratory study anti-leukocyte antibodies were found. The important role of prevention, based on the immune mechanisms of the pathogenesis of TRALI is marked.Подготовка публикации вызвана желанием авторов представить современный взгляд на один из важнейших разделов медицины критических состояний - трансфузионную терапию и связанные с ней осложнения, в частности, трансфузионно-ассоциированное повреждение легких (transfusion-related acute lung injury - TRALI). Освещаются причины, патогенез, диагностика и лечение TRALI у пациентов в критических состояниях. Уделено внимание диагностике TRALI, ассоциированному с трансфузией компонентов крови, современным критериям установления диагноза. Рассмотрены особенности клинической картины и терапии данной патологии, предложен протокол профилактики TRALI. В целях выяснения частоты встречаемости TRALI в лечебной практике проведен анализ результатов трансфузионной терапии у 2100 пациентов. В результате анализа установлено развитие данного осложнения у 12 пациентов, у пациентов «возможно TRALI», что соответствует литературным данным. У 5 пациентов и 11 доноров при лабораторном исследовании были обнаружены антилей-коцитарные антитела. Подчеркнута важная роль профилактики, основанной на иммунном механизме патогенеза TRALI

Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes

BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events

Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial

Aims  The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results  Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion  After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p

Fragmentation and Multifragmentation of 10.6A GeV Gold Nuclei

We present the results of a study performed on the interactions of 10.6A GeV gold nuclei in nuclear emulsions. In a minimum bias sample of 1311 interac- tions, 5260 helium nuclei and 2622 heavy fragments were observed as Au projec- tile fragments. The experimental data are analyzed with particular emphasis of target separation interactions in emulsions and study of criticalexponents. Multiplicity distributions of the fast-moving projectile fragments are inves- tigated. Charged fragment moments, conditional moments as well as two and three -body asymmetries of the fast moving projectile particles are determined in terms of the total charge remaining bound in the multiply charged projectile fragments. Some differences in the average yields of helium nuclei and heavier fragments are observed, which may be attributed to a target effect. However, two and three-body asymmetries and conditional moments indicate that the breakup mechanism of the projectile seems to be independent of target mass. We looked for evidence of critical point observable in finite nuclei by study the resulting charged fragments distributions. We have obtained the values for the critical exponents gamma, beta and tau and compare our results with those at lower energy experiment (1.0A GeV data). The values suggest that a phase transition like behavior, is observed.Comment: latex, revtex, 28 pages, 12 figures, 3tables, submitted to Europysics Journal