Managers Handbook for Software Development

Methods and aids for the management of software development projects are presented. The recommendations are based on analyses and experiences with flight dynamics software development. The management aspects of organizing the project, producing a development plan, estimation costs, scheduling, staffing, preparing deliverable documents, using management tools, monitoring the project, conducting reviews, auditing, testing, and certifying are described

The Impact of Atmospheric Fluctuations on Degree-scale Imaging of the Cosmic Microwave Background

Fluctuations in the brightness of the Earth's atmosphere originating from water vapor are an important source of noise for ground-based instruments attempting to measure anisotropy in the Cosmic Microwave Background. This paper presents a model for the atmospheric fluctuations and derives simple expressions to predict the contribution of the atmosphere to experimental measurements. Data from the South Pole and from the Atacama Desert in Chile, two of the driest places on Earth, are used to assess the level of fluctuations at each site.Comment: 29 pages, 7 figures, 1 table, appears in The Astrophysical Journa

The 1996 Soft State Transitions of Cygnus X-1

We report continuous monitoring of Cygnus X-1 in the 1.3 to 200 keV band using ASM/RXTE and BATSE/CGRO for about 200 days from 1996 February 21 to 1996 early September. During this period Cygnus X-1 experienced a hard-to-soft and then a soft-to-hard state transition. The low-energy X-ray (1.3-12 keV) and high-energy X-ray (20-200 keV) fluxes are strongly anti-correlated during this period. During the state transitions flux variations of about a factor of 5 and 15 were seen in the 1.3-3.0 keV and 100-200 keV bands, respectively, while the average 4.8-12 keV flux remains almost unchanged. The net effect of this pivoting is that the total 1.3-200 keV luminosity remained unchanged to within about 15%. The bolometric luminosity in the soft state may be as high as 50-70% above the hard state luminosity, after color corrections for the luminosity below 1.3 keV. The blackbody component flux and temperature increase in the soft state is probably caused by a combination of the optically thick disk mass accretion rate increase and a decrease of the inner disk radius.Comment: 18 pages, 1 PostScript figure. Accepted for ApJ

Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells

Monoamine oxidases (MAOs) are mitochondrial enzymes which control the levels of neurotransmitters in the brain and dietary amines in peripheral tissues via oxidative deamination. MAO has also been implicated in cell signalling. In this study, we describe the MAO-A isoform as functional in apoptosis induced by staurosporine (STS) in human dopaminergic neuroblastoma cells (SH-SY5Y). Increased levels of MAO-A activity were induced by STS, accompanied by increased MAO-A protein and activation of the initiator of the intrinsic pathway, caspase 9, and the executioner caspase 3. MAO-A mRNA levels were unaffected by STS, suggesting that changes in MAO-A protein are due to post-transcriptional events. Two unrelated MAO-A inhibitors reduced caspase activation. STS treatment resulted in sustained activation of the mitogen-activated protein kinase pathway enzymes extracellular regulated kinase, c-jun terminal kinase and p38, and depletion of the anti-apoptotic protein Bcl-2. These changes were significantly reversed by MAO inhibition. Production of reactive oxygen species was increased following STS exposure, which was blocked by both MAO inhibition and the antioxidant N-acetylcysteine. Therefore our data provide evidence that MAO-A, through its production of reactive oxygen species as a by-product of its catalytic activity on the mitochondrial surface, is recruited by the cell to enhance apoptotic signalling

ASMs and Operational Algorithmic Completeness of Lambda Calculus

We show that lambda calculus is a computation model which can step by step simulate any sequential deterministic algorithm for any computable function over integers or words or any datatype. More formally, given an algorithm above a family of computable functions (taken as primitive tools, i.e., kind of oracle functions for the algorithm), for every constant K big enough, each computation step of the algorithm can be simulated by exactly K successive reductions in a natural extension of lambda calculus with constants for functions in the above considered family. The proof is based on a fixed point technique in lambda calculus and on Gurevich sequential Thesis which allows to identify sequential deterministic algorithms with Abstract State Machines. This extends to algorithms for partial computable functions in such a way that finite computations ending with exceptions are associated to finite reductions leading to terms with a particular very simple feature.Comment: 37 page

New XMM-Newton analysis of three bright X-ray sources in M31 globular clusters, including a new black hole candidate

We present detailed analysis of three globular cluster X-ray sources in the XMM-Newton extended survey of M31. The X-ray counterpart to the M31 globular cluster Bo 45 (XBo 45) was observed with XMM-Newton on 2006 December 26. Its combined pn+MOS 0.3--10 keV lightcurve exhibited a r.m.s variability of ~10%, and its 0.3--7.0 keV emission spectrum was well described by an absorbed power law with photon index 1.44$\pm$0.12. Its variability and emission is characteristic of low mass X-ray binaries (LMXBs) in the low-hard state, whether the accretor is a neutron star or black hole. Such behaviour is typically observed at luminosities \la10% Eddington. However, XBo 45 exhibited this behaviour at an unabsorbed, 0.3--10 keV luminosity of 2.5$\pm0.2\times 10^{38}$ erg s$^{-1}$, or{~140%} Eddington for a 1.4 $M_{\odot}$ neutron star accreting hydrogen. Hence, we identify XBo 45 as a new candidate black hole LMXB. XBo 45 appears to have been consistently bright for ~30 years, consistent with theoretical prediction for a globular cluster black hole binary formed via tidal capture. Bo 375 was observed in the 2007, January 2 XMM-Newton observation, and has a two-component spectrum that is typical for a bright neutron star LMXB. Bo 135 was observed in the same field as Bo 45, and could contain either a black hole or neutron star.Comment: Accepted by ApJ, 16 pages, 5 figures. This version includes the final changes made at the request of the refere

Tests of Lorentz violation in muon antineutrino to electron antineutrino oscillations

A recently developed Standard-Model Extension (SME) formalism for neutrino oscillations that includes Lorentz and CPT violation is used to analyze the sidereal time variation of the neutrino event excess measured by the Liquid Scintillator Neutrino Detector (LSND) experiment. The LSND experiment, performed at Los Alamos National Laboratory, observed an excess, consistent with neutrino oscillations, of ${\bar\nu}_e$ in a beam of ${\bar\nu}_\mu$. It is determined that the LSND oscillation signal is consistent with no sidereal variation. However, there are several combinations of SME coefficients that describe the LSND data; both with and without sidereal variations. The scale of Lorentz and CPT violation extracted from the LSND data is of order $10^{-19}$ GeV for the SME coefficients $a_L$ and $E \times c_L$. This solution for Lorentz and CPT violating neutrino oscillations may be tested by other short baseline neutrino oscillation experiments, such as the MiniBooNE experiment.Comment: 10 pages, 10 figures, 2 tables, uses revtex4 replaced with version to be published in Physical Review D, 11 pages, 11 figures, 2 tables, uses revtex

Gesture analysis for physics education researchers

Systematic observations of student gestures can not only fill in gaps in students' verbal expressions, but can also offer valuable information about student ideas, including their source, their novelty to the speaker, and their construction in real time. This paper provides a review of the research in gesture analysis that is most relevant to physics education researchers and illustrates gesture analysis for the purpose of better understanding student thinking about physics.Comment: 14 page

Exploring high-end climate change scenarios for flood protection of the Netherlands

This international scientific assessment has been carried out at the request of the Dutch Delta Committee. The "Deltacommissie" requested that the assessment explore the high-end climate change scenarios for flood protection of the Netherlands. It is a state-of–the art scientific assessment of the upper bound values and longer term projections (for sea level rise up to 2200) of climate induced sea level rise, changing storm surge conditions and peak discharge of river Rhine. It comprises a review of recent studies, model projections and expert opinions of more than 20 leading climate scientists from different countries around the North Sea, Australia and the US

Limits on the Peculiar Velocities of Two Distant Clusters Using the Kinematic Sunyaev-Zel'dovich Effect

We report millimeter-wavelength observations of the Sunyaev-Zel'dovich (S-Z) effect in two distant galaxy clusters. A relativistically correct analysis of the S-Z data is combined with the results of X-ray observations to determine the radial peculiar velocities v_r of the clusters. We observed Abell 2163 (z=.201) in three mm-wavelength bands centered at 2.1, 1.4, and 1.1 mm. We report a significant detection of the thermal component of the S-Z effect seen as both a decrement in the brightness of the CMB at 2.1 mm, and as an increment at 1.1 mm. Including uncertainties due to the calibration of the instrument, distribution and temperature of the IC gas, and astrophysical confusion, a simultaneous fit to the data in all three bands gives v_r=+490 +1370/-880 km/s at 68% confidence. We observed Abell 1689 (z=.181) in the 2.1 and 1.4 mm bands. Including the same detailed accounting of uncertainty, a simultaneous fit to the data in both bands gives v_r=+170 +815/-630 km/s. The limits on the peculiar velocities of A2163 and A1689 correspond to deviations from the uniform Hubble flow of <= 2-3%.Comment: 21 pages, 13 postscript figures, LaTeX(aaspptwo.sty), ApJ(in press