324 research outputs found
A Tale of Three Cities: Crime and Displacement after Hurricane Katrina
When Hurricane Katrina struck New Orleans in August 2005, it greatly disrupted both the physical and social structures of that community. One consequence of the hurricane was the displacement of large numbers of New Orleans residents to other cities, including Houston, San Antonio, and Phoenix. There has been media speculation that such a grand-scale population displacement led to increased crime in communities that were recipient of large numbers of displaced New Orleans residents. This study was a case study of three cities with somewhat different experiences with Katrina\u27s diaspora. Time series analysis was used to examine the pre- and post-Katrina trends in six Part I offenses (murder, robbery, aggravated assault, rape, burglary, and auto theft) to assess any impact of such large-scale population shifts on crime in host communities. Contrary to much popular speculation, only modest effects were found on crime. Social disorganization theory was used to frame both the analysis and the interpretation of these result
Chandra detection of the radio and optical double hot spot of 3C 351
In this letter we report a Chandra X-ray detection of the double northern hot
spot of the radio quasar 3C 351. The hot spot has also been observed in the
optical with the Hubble Space Telescope (R-band) and with the 3.5m. Telescopio
Nazionale Galileo (B-band). The radio-to-optical and X-ray spectra are
interpreted as the results of the synchrotron and synchrotron-self-Compton
(SSC) mechanisms, respectively, with hot-spot magnetic field strengths ~3 times
smaller than the equipartition values. In the framework of shock acceleration
theory, we show that the requirement for such a relatively small field strength
is in agreement with the fitted synchrotron spectral models and with the sizes
of the hot spots. Finally, we show that the combination of a lower magnetic
field strength with the high frequencies of the synchrotron cut-off in the
fitted synchrotron spectra provides strong evidence for electron acceleration
in the hot spots.Comment: 16 pag. + 2 .PS figures (fig.2 color), ApJ Letter in pres
Immunohistochemical localization of NPY, VIP and 5-HT in the thyroid gland of the lizard, Podarcis sicula.
The thyroid gland of the lizard Podarcis sicula was immunohistochemically studied in adult male specimens using specific antibodies against NPY, VIP and 5-HT and the avidin-biotin peroxidase complex (ABC) procedure to localize the three peptides. Fine beaded VIP-immunoreactive nerve fibers ran between the follicles, and VIP-immunoreactivity was evenly distributed in the apical cytoplasm of follicular cells. NPY-immunoreactive fibers were found around the follicles, and, in the cells, immunoreactivity was localizated only in the cellular apices. Immunoreactivity to 5-HT was observed in the colloid, with a concentration in the follicular lumen exceeding that in the follicular cells. In fact, most follicles showed immunoreactivity in the cytoplasmic bridges formed between the apical portion of the follicular cells and the colloid
Routine Crime in Exceptional Times: The Impact of the 2002 Winter Olympics on Citizen Demand for Police Services
Despite their rich theoretical and practical importance, criminologists have paid scant attention to the patterns of crime and the responses to crime during exceptional events. Throughout the world large-scale political, social, economic, cultural, and sporting events have become commonplace. Natural disasters such as blackouts, hurricanes, tornadoes, and tsunamis present similar opportunities. Such events often tax the capacities of jurisdictions to provide safety and security in response to the exceptional event, as well as to meet the “routine” public safety needs. This article examines “routine” crime as measured by calls for police service, official crime reports, and police arrests in Salt Lake City before, during, and after the 2002 Olympic Games. The analyses suggest that while a rather benign demographic among attendees and the presence of large numbers of social control agents might have been expected to decrease calls for police service for minor crime, it actually increased in Salt Lake during this period. The implications of these findings are considered for theories of routine activities, as well as systems capacity
Ultrasound and cone beam CT fusion for liver ablation : technical note
Purpose: To assess the feasibility of fusion imaging between intraprocedural ultrasound (US) and contrast-enhanced cone-beam CT (CBCT) for small (< 2 cm) hepatocellular carcinoma (HCC). Materials and methods: Six patients (five males, one female, age range 58\u201380, mean 69 years), with small (mean diameter 16.8 mm) HCC poorly visible at US underwent percutaneous microwave ablation under US/CBCT fusion guidance. During general anesthesia with apnea control, a contrast- enhanced CBCT was acquired with an active tracker. Subsequently, real time US images were fused with CBCT images, and treatment performed under fusion imaging guidance. Feasibility of fusion imaging and percutaneous ablation were assessed, correct targeting (distance from center of tumor and center of ablation area <5 mm) and one-month primary technical efficacy were evaluated. Major and minor complications as well as overall procedural time were recorded. Results: US/CBCT fusion was feasible in all cases, allowing for completion of the treatment as previously planned (technical success 100%). Correct targeting was achieved in 4/6 cases (66%), while in two cases, center of tumor and center of ablated area were respectively 7 and 8 mm distant. At 1 month CT scan, all tumors were completely ablated (primary technical efficacy 100%). No major or minor complications occurred. Mean overall procedure time was 127 min. Conclusions: US/CBCT fusion is a feasible technique for liver ablation, and might represent a useful tool to increase the correct targeting of poorly US-visible HCC nodules in the angio suite
Safety and Security at Special Events: The Case of the Salt Lake City Olympic Games
Special events offer the potential for considerable threats to public safety. Perhaps no other special event rivals the Olympic Games in scope, duration, and potential for threat to communities, participants, and dignitaries. This paper reports on the results of a study of safety and security at the Salt Lake Olympic Games by a team of researchers with wide-ranging access to operations, personnel and documents from the security effort at the 2002 Winter Games. This paper focuses on three specific areas: changing definitions of safety and security during the Games; the development and maintenance of organizational structures and interaction; and lessons learned for other large-scale events. The goal of this paper is to document some of the challenges of establishing a temporary security organization. The paper concludes that building such organizations require for their success a major focus on creating a set of shared assumptions and working relationships
Food at the heart of the Empire. Dietary reconstruction for Imperial Rome inhabitants
This paper aims to provide a broad diet reconstruction for people buried in archaeologically defined contexts in Rome (first to third centuries CE), in order to combine archaeological and biological evidence focusing on dietary preferences in Imperial Rome. A sample of 214 human bones recovered from 6 funerary contexts was selected for carbon and nitrogen stable isotope analysis. The baseline for the terrestrial protein component of the diet was set using 17 coeval faunal remains recovered from excavations at Rome supplemented by previously published data for the same geographic and chronological frames. δ13C ranges from − 19.9 to − 14.8‰, whereas δ15N values are between 7.2 and 10.0‰. The values are consistent with an overall diet mainly based on terrestrial resources. All the human samples rely on a higher trophic level than the primary consumer faunal samples. Certainly, C3 plants played a pivotal role in the dietary habits. However, C4 plants also seem to have been consumed, albeit they were not as widespread and were not always used for human consumption. The environment played a critical role also for Romans of lower social classes. The topographical location determined the preferential consumption of food that people could obtain from their neighborhood
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer’s Disease (AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein are detected in eyes from AD patients and transgenic animals in correlation with inflammation, reduction of synapses, visual deficits, loss of retinal cells and nerve fiber. However, neither the pathological relevance of other post-translational tau modifications—such as truncation with generation of toxic fragments—nor the potential neuroprotective action induced by their in vivo clearance have been investigated in the context of AD retinal degeneration. We have recently developed a monoclonal tau antibody (12A12mAb) which selectively targets the neurotoxic 20–22 kDa NH2-derived peptide generated from pathological truncation at the N-terminal domain of tau without cross-reacting with its full-length normal protein. Previous studies have shown that 12A12mAb, when intravenously (i.v.)-injected into 6-month-old Tg2576 animals, markedly improves their AD-like, behavioural and neuropathological syndrome. By taking advantage of this well-established tau-directed immunization regimen, we found that 12A12mAb administration also exerts a beneficial action on biochemical, morphological and metabolic parameters (i.e. APP/Aβ processing, tau hyperphosphorylation, neuroinflammation, synaptic proteins, microtubule stability, mitochondria-based energy production, neuronal death) associated with ocular injury in the AD phenotype. These findings prospect translational implications in the AD field by: (1) showing for the first time that cleavage of tau takes part in several pathological changes occurring in vivo in affected retinas and vitreous bodies and that its deleterious effects are successfully antagonized by administration of the specific 12A12mAb; (2) shedding further insights on the tight connections between neurosensory retina and brain, in particular following tau-based immunotherapy. In our view, the parallel response we detected in this preclinical animal model, both in the eye and in the hippocampus, following i.v. 12A12mAb injection opens novel diagnostic and therapeutic avenues for the clinical management of cerebral and extracerebral AD signs in human beings
Health-related quality of life in patients with primary open-angle glaucoma. An Italian multicentre observational study
Purpose: As a progressive condition, glaucoma may impair health-related quality of life (HRQoL), due to vision loss and
other factors. This study evaluated HRQoL in a cohort of patients treated for primary open-angle glaucoma (POAG) and
assessed its association with clinical features.
Methods: This was an Italian, multicentre, cross-sectional, observational study with the subgroup of newly diagnosed
patients with POAG prospectively followed up for one year. Patients with previous or new diagnosis (or strong clinical
suspicion) of POAG aged >18 years were considered eligible. Information was collected on demographic characteristics,
medical history, clinical presentation and POAG treatments. HRQoL was measured using the 25-item National Eye
Institute Visual Function Questionnaire (NEI-VFQ-25) and Glaucoma Symptom Scale (GSS). Subscale and total scores
were obtained and a Pearson correlation coefficient between instruments’ scores calculated.
Results: A total of 3227 patients were enrolled from 2012 to 2013 and 3169 were analysed. Mean age was 66.9 years. A
total of 93.8% had a previous diagnosis (median duration: 8.0 years). Median values for mean deviation and pattern
standard deviation were 3.9 and 3.6 dB, respectively. Mean scores on most subscales of the NEI-VFQ-25 exceeded 75.0
and mean GSS subscale scores ranged between 70.8 and 79.7 (with a total mean score of 74.8). HRQoL scores on both
scales were significantly inversely associated with POAG severity.
Conclusion: In this large sample of Italians treated for POAG, disease severity was limited and HRQoL scores were high.
QoL decreased with advancing disease severity. These findings confirm the role of vision loss in impairing QoL in POAG,
underlying the importance of timely detection and appropriate treatment
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