Tessier number 30 clefts with congenital heart defects

Introduction: Midline cleft of mandible, classified as Tessier 30 clefts is extremely rare, with less than 100 reported cases in the latest studies. Variations in severity and associated malformations have been reported before. Case Presentation: In this report, we present the first documented Iranian case of Tessier 30 with median cleft of lower lip and bifid tongue concomitant with congenital heart defects. Conclusions: We explain embryologic origin, differential diagnosis, other associated anomalies and its treatment by reviewing literature. © 2015, Iranian Red Crescent Medical Journal

Viscous Torque and Dissipation in the Inner Region of a Thin Accretion Disk: Implications for Measuring Black Hole Spin

We consider a simple Newtonian model of a steady accretion disk around a black hole. The model is based on height-integrated hydrodynamic equations, alpha-viscosity, and a pseudo-Newtonian potential that results in an innermost stable circular orbit (ISCO) that closely approximates the one predicted by GR. We find that the hydrodynamic models exhibit increasing deviations from the standard disk model of Shakura & Sunyaev as disk thickness H/R or the value of alpha increases. The latter is an analytical model in which the viscous torque is assumed to vanish at the ISCO. We consider the implications of the results for attempts to estimate black hole spin by using the standard disk model to fit continuum spectra of black hole accretion disks. We find that the error in the spin estimate is quite modest so long as H/R < 0.1 and alpha < 0.2. At worst the error in the estimated value of the spin parameter is 0.1 for a non-spinning black hole; the error is much less for a rapidly spinning hole. We also consider the density and disk thickness contrast between the gas in the disk and that inside the ISCO. The contrast needs to be large if black hole spin is to be successfully estimated by fitting the relativistically-broadened X-ray line profile of fluorescent iron emission from reflection off an accretion disk. In our hydrodynamic models, the contrast in density and thickness is low when H/R>0.1, sugesting that the iron line technique may be most reliable in extemely thin disks. We caution that these results have been obtained with a viscous hydrodynamic model and need to be confirmed with MHD simulations of radiatively cooled thin disks.Comment: 32 pages, 10 figures; accepted by Ap

Area Invariance of Apparent Horizons under Arbitrary Boosts

It is a well known analytic result in general relativity that the 2-dimensional area of the apparent horizon of a black hole remains invariant regardless of the motion of the observer, and in fact is independent of the $t=constant$ slice, which can be quite arbitrary in general relativity. Nonetheless the explicit computation of horizon area is often substantially more difficult in some frames (complicated by the coordinate form of the metric), than in other frames. Here we give an explicit demonstration for very restricted metric forms of (Schwarzschild and Kerr) vacuum black holes. In the Kerr-Schild coordinate expression for these spacetimes they have an explicit Lorentz-invariant form. We consider {\it boosted} versions with the black hole moving through the coordinate system. Since these are stationary black hole spacetimes, the apparent horizons are two dimensional cross sections of their event horizons, so we compute the areas of apparent horizons in the boosted space with (boosted) $t = constant$, and obtain the same result as in the unboosted case. Note that while the invariance of area is generic, we deal only with black holes in the Kerr-Schild form, and consider only one particularly simple change of slicing which amounts to a boost. Even with these restrictions we find that the results illuminate the physics of the horizon as a null surface and provide a useful pedagogical tool. As far as we can determine, this is the first explicit calculation of this type demonstrating the area invariance of horizons. Further, these calculations are directly relevant to transformations that arise in computational representation of moving black holes. We present an application of this result to initial data for boosted black holes.Comment: 19 pages, 3 figures. Added a new section and 2 plots along with a coautho

Measuring the Spin of GRS 1915+105 with Relativistic Disk Reflection

GRS 1915+105 harbors one of the most massive known stellar black holes in the Galaxy. In May 2007, we observed GRS 1915+105 for 117 ksec in the low/hard state using Suzaku. We collected and analyzed the data with the HXD/PIN and XIS cameras spanning the energy range from 2.3-55 keV. Fits to the spectra with simple models reveal strong disk reflection through an Fe K emission line and a Compton back-scattering hump. We report constraints on the spin parameter of the black hole in GRS 1915+105 using relativistic disk reflection models. The model for the soft X-ray spectrum (i.e. < 10 keV) suggests a/M = 0.56(2) and excludes zero spin at the 4 sigma level of confidence. The model for the full broadband spectrum suggests that the spin may be higher, a/M = 0.98(1) (1 sigma confidence), and again excludes zero spin at the 2 sigma level of confidence. We discuss these results in the context of other spin constraints and inner disk studies in GRS 1915+105.Comment: Accepted for publication in Ap

The Race Between Stars and Quasars in Reionizing Cosmic Hydrogen

The cosmological background of ionizing radiation has been dominated by quasars once the Universe aged by ~2 billion years. At earlier times (redshifts z>3), the observed abundance of bright quasars declined sharply, implying that cosmic hydrogen was reionized by stars instead. Here, we explain the physical origin of the transition between the dominance of stars and quasars as a generic feature of structure formation in the concordance LCDM cosmology. At early times, the fraction of baryons in galaxies grows faster than the maximum (Eddington-limited) growth rate possible for quasars. As a result, quasars were not able to catch up with the rapid early growth of stellar mass in their host galaxies.Comment: 5 pages, 1 figure, Accepted for publication in JCA

Measuring the spin of the primary black hole in OJ287

The compact binary system in OJ287 is modelled to contain a spinning primary black hole with an accretion disk and a non-spinning secondary black hole. Using Post Newtonian (PN) accurate equations that include 2.5PN accurate non-spinning contributions, the leading order general relativistic and classical spin-orbit terms, the orbit of the binary black hole in OJ287 is calculated and as expected it depends on the spin of the primary black hole. Using the orbital solution, the specific times when the orbit of the secondary crosses the accretion disk of the primary are evaluated such that the record of observed outbursts from 1913 up to 2007 is reproduced. The timings of the outbursts are quite sensitive to the spin value. In order to reproduce all the known outbursts, including a newly discovered one in 1957, the Kerr parameter of the primary has to be $0.28 \pm 0.08$. The quadrupole-moment contributions to the equations of motion allow us to constrain the `no-hair' parameter to be $1.0\:\pm\:0.3$ where 0.3 is the one sigma error. This supports the `black hole no-hair theorem' within the achievable precision. It should be possible to test the present estimate in 2015 when the next outburst is due. The timing of the 2015 outburst is a strong function of the spin: if the spin is 0.36 of the maximal value allowed in general relativity, the outburst begins in early November 2015, while the same event starts in the end of January 2016 if the spin is 0.2Comment: 12 pages, 6 figure

Long XMM observation of the Narrow-Line Seyfert 1 galaxy IRAS13224-3809: rapid variability, high spin and a soft lag

Results are presented from a 500ks long XMM-Newton observation of the Narrow-Line Seyfert 1 galaxy IRAS13224-3809. The source is rapidly variable on timescales down to a few 100s. The spectrum shows strong broad Fe-K and L emission features which are interpreted as arising from reflection from the inner parts of an accretion disc around a rapidly spinning black hole. Assuming a power-law emissivity for the reflected flux and that the innermost radius corresponds to the innermost stable circular orbit, the black hole spin is measured to be 0.988 with a statistical precision better than one per cent. Systematic uncertainties are discussed. A soft X-ray lag of 100s confirms this scenario. The bulk of the power-law continuum source is located at a radius of 2-3 gravitational radii.Comment: 7 pages, 14 figures, submitted to MNRA

Black Hole Spin via Continuum Fitting and the Role of Spin in Powering Transient Jets

The spins of ten stellar black holes have been measured using the continuum-fitting method. These black holes are located in two distinct classes of X-ray binary systems, one that is persistently X-ray bright and another that is transient. Both the persistent and transient black holes remain for long periods in a state where their spectra are dominated by a thermal accretion disk component. The spin of a black hole of known mass and distance can be measured by fitting this thermal continuum spectrum to the thin-disk model of Novikov and Thorne; the key fit parameter is the radius of the inner edge of the black hole's accretion disk. Strong observational and theoretical evidence links the inner-disk radius to the radius of the innermost stable circular orbit, which is trivially related to the dimensionless spin parameter a_* of the black hole (|a_*| < 1). The ten spins that have so far been measured by this continuum-fitting method range widely from a_* \approx 0 to a_* > 0.95. The robustness of the method is demonstrated by the dozens or hundreds of independent and consistent measurements of spin that have been obtained for several black holes, and through careful consideration of many sources of systematic error. Among the results discussed is a dichotomy between the transient and persistent black holes; the latter have higher spins and larger masses. Also discussed is recently discovered evidence in the transient sources for a correlation between the power of ballistic jets and black hole spin.Comment: 30 pages. Accepted for publication in Space Science Reviews. Also to appear in hard cover in the Space Sciences Series of ISSI "The Physics of Accretion onto Black Holes" (Springer Publisher). Changes to Sections 5.2, 6.1 and 7.4. Section 7.4 responds to Russell et al. 2013 (MNRAS, 431, 405) who find no evidence for a correlation between the power of ballistic jets and black hole spi

Orbital resonances in discs around braneworld Kerr black holes

Rotating black holes in the brany universe of the Randall-Sundrum type are described by the Kerr geometry with a tidal charge b representing the interaction of the brany black hole and the bulk spacetime. For b<0 rotating black holes with dimensionless spin a>1 are allowed. We investigate the role of the tidal charge b in the orbital resonance model of QPOs in black hole systems. The orbital Keplerian, the radial and vertical epicyclic frequencies of the equatorial, quasicircular geodetical motion are given and their radial profiles are discussed. The resonant conditions are given in three astrophysically relevant situations: for direct (parametric) resonances, for the relativistic precession model, and for some trapped oscillations of the warped discs, with resonant combinational frequencies. It is shown, how b could influence matching of the observational data indicating the 3:2 frequency ratio observed in GRS 1915+105 microquasar with prediction of the orbital resonance model; limits on allowed range of the black hole parameters a and b are established. The "magic" dimensionless black hole spin enabling presence of strong resonant phenomena at the radius where \nu_K:\nu_{\theta}:\nu_r=3:2:1 is determined in dependence on b. Such strong resonances could be relevant even in sources with highly scattered resonant frequencies, as those expected in Sgr A*. The specific values of a and b are given also for existence of specific radius where \nu_K:\nu_{\theta}:\nu_r=s:t:u with 5>=s>t>u being small natural numbers. It is shown that for some ratios such situation is impossible in the field of black holes. We can conclude that analysing the microquasars high-frequency QPOs in the framework of orbital resonance models, we can put relevant limits on the tidal charge of brany Kerr black holes.Comment: 31 pages, 19 figures, to appear in General Relativity and Gravitatio

Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumor cell killing and an enhanced antifungal variant

The plant defensin NaD1 is a potent antifungal molecule that also targets tumor cells with a high efficiency. We examined the features of NaD1 that contribute to these two activities by producing a series of chimeras with NaD2, a defensin that has relatively poor activity against fungi and no activity against tumor cells. All plant defensins have a common tertiary structure known as a cysteine-stabilized alpha-beta motif which consists of an alpha helix and a triple-stranded beta-sheet stabilized by four disulfide bonds. The chimeras were produced by replacing loops 1 to 7, the sequences between each of the conserved cysteine residues on NaD1, with the corresponding loops from NaD2. The loop 5 swap replaced the sequence motif (SKILRR) that mediates tight binding with phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2] and is essential for the potent cytotoxic effect of NaD1 on tumor cells. Consistent with previous reports, there was a strong correlation between PI(4,5)P-2 binding and the tumor cell killing activity of all of the chimeras. However, this correlation did not extend to antifungal activity. Some of the loop swap chimeras were efficient antifungal molecules, even though they bound poorly to PI(4,5)P-2, suggesting that additional mechanisms operate against fungal cells. Unexpectedly, the loop 1B swap chimera was 10 times more active than NaD1 against filamentous fungi. This led to the conclusion that defensin loops have evolved as modular components that combine to make antifungal molecules with variable mechanisms of action and that artificial combinations of loops can increase antifungal activity compared to that of the natural variants