Effect of clozapine on immunoglobulin M plasma levels

Clozapine is an atypical antipsychotic medication indicated for the treatment of patients who fail to respond to standard antipsychotic treatment. It possesses immunomodulatory properties and requires regular counts of white blood cells and absolute neutrophils. It has been reported to mediate several effects on humoral immunity, such as altering the levels of antibody-producing cytokines [Hinze-Selch et al. 1998]. Selective immunoglobulin M immunodeficiency (SIgMD) is a rare form of dysgammaglobulinaemia characterized by a selective, low level of immunoglobulin M (IgM) in conjunction with normal T cell numbers and function, and with no other identifiable immunodeficiencies. It can occur as either a primary or secondary condition and displays an estimated prevalence of 0.03%– 3%. Secondary SIgMD can be associated with malignancy, autoimmune disorders, gastrointestinal diseases and/or immunosuppressive treatments [Goldstein et al. 2006]..

Melanoma maligno gastrointestinal de origen primario desconocido: Reporte de caso

One of the unusual characteristics of cutaneous melanoma is its ability to metastasize in the small intestine. It is often diagnosed during autopsies of cutaneous melanoma patients. Metastatic deposits have been found in 50% to 60% of these autopsies, but less than 2% to 4% of patients diagnosed with melanoma have gastrointestinal metastasis during the course of the disease. Between 4% and 9% of gastrointestinal melanoma cases have unknown primary tumors. Rapid identification and resection of melanoma in the digestive tract could improve the patient survival rate and prevent complications such as intestinal obstructions from occurring. We present a rare clinical case of gastrointestinal melanoma of unknown primary origin. The patient had a clinical picture of nausea, hyporexia, epigastralgia, fatigue, paresthesias in the right dorsal region and had lost nine kilograms in three weeks. An abdominal CT scan showed three predominantly isodense liver lesions in the parenchyma, with some areas of lower density located in segments 2,5,7 and 8 of the liver. These were biopsied. Upper digestive tract endoscopy took biopsy samples of two hyperpigmented lesions in the second portion of the duodenum. Histopathological examination showed malignant melanoma. All typical locations of primary melanoma were excluded during the diagnostic procedure. © 2019 Asociaciones Colombianas de Gastroenterología, Endoscopia digestiva, Coloproctología y Hepatología

Stationary cosmology in group field theory

Group field theory (GFT) models for quantum gravity coupled to a massless scalar field give rise to cosmological models that reproduce the (expanding or contracting) dynamics of homogeneous and isotropic spacetimes in general relativity at low energies, while including high-energy corrections that lead to singularity resolution by a “bounce.” Here we investigate two possibilities for obtaining stationary solutions in GFT cosmology, which could be useful as an analog of Minkowski spacetime. We first focus on a limit in which interactions are neglected and the effective Newton’s constant in GFT cosmology is taken to zero. In this limit, we derive an effective Friedmann equation that shows no stationary solutions but departures from the trivial classical dynamics falling off rapidly, similar to the usual correction terms responsible for the bounce. Since the effective Newton’s constant needs to be exactly zero, the scenario is fine-tuned. A more satisfactory approach is obtained in a weakly interacting model: we find bound states with sharply peaked volume, representing a stationary semiclassical cosmology, and show that coherent states peaked around the minimum of the potential remain stable with small quantum fluctuations, and only small oscillations around a nearly constant volume. These coherent states realize the idea of a “quantum gravity condensate.

Effect of calcium sulfate source on the hydration of calcium sulfoaluminate eco-cement

The availability of cements, including eco-cements, with tailored mechanical properties is very important for special applications in the building industry. Here we report a full study of the hydration of calcium sulfoaluminate eco-cements with different sulfate sources (gypsum, bassanite and anhydrite) and two water/cement ratios (0.50 and 0.65). These parameters have been chosen because they are known to strongly modify the mechanical properties of the resulting mortars and concretes. The applied multitechnique characterization includes: phase assemblage by Rietveld method, evolved heat, conductivity, rheology, compressive strength and expansion/retraction measurements. The dissolution rate of the sulfate sources is key to control the hydration reactions. Bassanite dissolves very fast and hence the initial setting time of the pastes and mortars is too short (20 min) to produce homogeneous samples. Anhydrite dissolves slowly so, at 1 hydration-day, the amount of ettringite formed (20 wt%) is lower than that in gypsum pastes (26 wt%) (w/c = 0.50), producing mortars with lower compressive strengths. After 3 hydration-days, anhydrite pastes showed slightly larger ettringite contents and hence, mortars with slightly higher compressive strengths. Ettringite content is the chief parameter to explain the strength development in these eco-cements.Universidad de Málaga. Campus de Excelencia Interncaional Andalucía Tech

Estudio de poblaciones de maíz y de fríjol en el sistema maíz x fríjol voluble para clima medio conservando constantes las distancias de siembra.

El objetivo del estudio fué determinar las poblaciones más adecuadas de maíz y fríjol en el sistema maíz-fríjol voluble en asociación. El diseño estadístico utilizado fue un factorial 3 x 3 en bloques al azar con 9 tratamientos. Se hizo además un análisis de presupuestos parciales para determinar el ingreso por tratamiento. Se observó que el incremento en la población de una de las especies aumenta su producción en detrimento de la otra. Se concluyó que es económico para el agricultor convertir el monocultivo de maíz en asocio maíz x fríjol voluble, además del efecto benéfico de la leguminosaFríjol-Phaseolus vulgarisMaíz-Zea may

Analysis of plasmaspheric hiss wave amplitudes inferred from low-altitude POES electron data: Technique sensitivity analysis

A novel technique capable of inferring wave amplitudes from low-altitude electron measurements from the Polar Operational Environmental Satellites (POES) spacecraft has been previously proposed to construct a global dynamic model of chorus and plasmaspheric hiss waves. In this paper we focus on plasmaspheric hiss, which is an incoherent broadband emission that plays a dominant role in the loss of energetic electrons from the inner magnetosphere. We analyze the sensitivity of the POES technique to different inputs used to infer the hiss wave amplitudes during three conjunction events with the Van Allen Probes. These amplitudes are calculated with different input models of the plasma density, wave frequency spectrum, and electron energy spectrum, and the results are compared to the wave observations from the twin Van Allen Probes. Only one parameter is varied at a time in order to isolate its effect on the output, while the two other inputs are set to the values observed by the Van Allen Probes. The results show that the predicted hiss amplitudes are most sensitive to the adopted frequency spectrum, followed by the plasma density, but they are not very sensitive to the electron energy spectrum. Moreover, the standard Gaussian representation of the wave frequency spectrum (centered at 550 Hz) peaks at frequencies that are much higher than those observed in individual cases as well as in statistical wave distributions, which produces large overestimates of the hiss wave amplitude. For this reason, a realistic statistical model of the wave frequency spectrum should be used in the POES technique to infer the plasmaspheric hiss wave intensity rather than a standard Gaussian distribution, since the former better reproduces the observed plasmaspheric hiss wave amplitudes

Neurologic phenotype of Schimke immuno-osseous dysplasia and neurodevelopmental expression of SMARCAL1

Schimke immuno-osseous dysplasia (OMIM 242900) is an uncommon autosomal-recessive multisystem disease caused by mutations in SMARCAL1 (swi/snf-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1), a gene encoding a putative chromatin remodeling protein. Neurologic manifestations identified to date relate to enhanced atherosclerosis and cerebrovascular disease. Based on a clinical survey, we determined that half of Schimke immuno-osseous dysplasia patients have a small head circumference, and 15% have social, language, motor, or cognitive abnormalities. Postmortem examination of 2 Schimke immuno-osseous dysplasia patients showed low brain weights and subtle brain histologic abnormalities suggestive of perturbed neuron-glial migration such as heterotopia, irregular cortical thickness, incomplete gyral formation, and poor definition of cortical layers. We found that SMARCAL1 is highly expressed in the developing and adult mouse and human brain, including neural precursors and neuronal lineage cells. These observations suggest that SMARCAL1 deficiency may influence brain development and function in addition to its previously recognized effect on cerebral circulation