Potensi Efek Antiinflamasi Air Kelapa Muda dalam Menurunkan Kadar Tumor Necrosis Factor-α, Interleukin, dan Prostaglandin E2 pada Pasien Demam Berdarah Dengue (Dbd)

Indonesia merupakan negara dengan kasus DBD tertinggi di Asia Tenggara. Menurut data Kementrian Kesehatan Republik Indonesia, tercatat sampai tahun 2009 masyarakat Indonesia yang terkena kasus DBD mencapai 158.192 kasus. Air kelapa muda memiliki potensi yang besar sebagai agen antiinflamasi pada Pasien DBD yang berperan melalui inhibisi Nuclear Factor Kappa B dalam Menurunkan Kadar Tumor Necrosis Factor-α, Interleukin dan Prostaglandin E2. Perlu dilakukannya penelitian lebih lanjut mengenai efek antiinflamasi air kelapa muda, terutama pada inflamasi penyakit DBD sehingga nantinya air kelapa muda dapat dikembangkan sebagai tatalaksana baru bagi pasien DBD

Living in the shadow of Mauna Loa

Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Comparative Media Studies, 2013.Cataloged from PDF version of thesis.Includes bibliographical references (pages 30-44).One of Hawaii's most dangerous natural hazards is sitting in plain sight: Mauna Loa volcano. The mighty mountain makes up more than fifty percent of the island and is the largest volcano on Earth. Since 1843, when people started rigorously recording Mauna Loa's eruptive activity, the volcano has produced raging lava flows, billowing sulfuricrich clouds, and giant ground cracks, as well as triggered earthquakes, landslides, and even tsunamis. While geologists and emergency managers are concerned about and actively preparing for a future eruption, Hawaii's general public is largely ignorant or apathetic to their risk. This thesis explores what a future Mauna Loa eruption may look like in terms of geology, disaster response, and damage. It also identifies and profiles the most threatened Hawaiian communities and industries, as well as explores the factors driving differences in risk perception across various stakeholders on the island.by Zahra R. Hirji.Thesis (S.M. in Science Writing)--Massachusetts Institute of Technology, Dept. of Comparative Media Studies, 2013

Cultural cooperation between Russia and Japan

It is necessary to conduct an analysis of relations between Japan and Russia to determine the main trends and prospects for joint development. The purpose of the article is to study and disclose the stages of development of cultural relations between Russia and Japan and determine its features, highlight the most pressing problems of relations and identify possible ways to build strong interstate relations. The methodological basis of the study is the analytical method, for a comprehensive analysis of the changes that occurred during the development of cultural relations between Japan and Russia. Also a prerequisite is compliance with the principles of historicism and objectivity. In the course of studying used the method of study and systematization of literature. As a result of studying the problem, we can evaluate the historical development of cultural relations between Russia and Japan. Assess the state of relations between Russia and Japan and uncover limitations and growth points to strengthen relations between Japan and Russia. The results of this study can be useful as Japanologists and to specialists dealing with the problems of Asia-Pacific as a whole

Study of microRNAs-21/221 as potential breast cancer biomarkers in Egyptian women

microRNAs (miRNAs) play an important role in cancer prognosis. They are small molecules, approximately 17–25 nucleotides in length, and their high stability in human serum supports their use as novel diagnostic biomarkers of cancer and other pathological conditions. In this study, we analyzed the expression patterns of miR-21 and miR-221 in the serum from a total of 100 Egyptian female subjects with breast cancer, fibroadenoma, and healthy control subjects. Using microarray-based expression profiling followed by real-time polymerase chain reaction validation, we compared the levels of the two circulating miRNAs in the serum of patients with breast cancer (n = 50), fibroadenoma (n = 25), and healthy controls (n = 25). The miRNA SNORD68 was chosen as the housekeeping endogenous control. We found that the serum levels of miR-21 and miR-221 were significantly overexpressed in breast cancer patients compared to normal controls and fibroadenoma patients. Receiver Operating Characteristic (ROC) curve analysis revealed that miR-21 has greater potential in discriminating between breast cancer patients and the control group, while miR-221 has greater potential in discriminating between breast cancer and fibroadenoma patients. Classification models using k-Nearest Neighbor (kNN), Naïve Bayes (NB), and Random Forests (RF) were developed using expression levels of both miR-21 and miR-221. Best classification performance was achieved by NB Classification models, reaching 91% of correct classification. Furthermore, relative miR-221 expression was associated with histological tumor grades. Therefore, it may be concluded that both miR-21 and miR-221 can be used to differentiate between breast cancer patients and healthy controls, but that the diagnostic accuracy of serum miR-21 is superior to miR-221 for breast cancer prediction. miR-221 has more diagnostic power in discriminating between breast cancer and fibroadenoma patients. The overexpression of miR-221 has been associated with the breast cancer grade. We also demonstrated that the combined expression of miR-21 and miR-221can be successfully applied as breast cancer biomarkers

Peningkatan Kemampuan Menulis Karangan Deskripsi Menggunakan Media Lingkungan pada Peserta Didik Madrasah Ibtidaiyah

This study aims to improve the ability to write the essay in class V student of Muhammadiyah Elementary School Ketapang Mangrove River . Learners have not been able to master the assessment indicators fabricated. Enterprises using the problem solving environment. Learning activities fabricate divided into : ( 1 ) the initial activity , which is observed object is determined by the teacher , ( 2 ) core activities , ie writing essays using the media environment , and ( 3 ) closing activities , namely revise essays , giving boosters and inference about the material being studied . Based on observation and reflection in the learning environment of media use essay writing descriptions : ( 1 ) in the first cycle of acquisition total score balanced number of students in the three aspects of assessment are fabricated 899 ( 64 ) , and ( 2 ) in the second cycle total score of students in the three assessment aspect fabricated into 10989 (78). it was concluded that the use of media in teaching Indonesian environment can enhance the ability of learners to write essays

Oct-2 DNA binding transcription factor: functional consequences of phosphorylation and glycosylation

Phosphorylation and O-GlcNAc modification often induce conformational changes and allow the protein to specifically interact with other proteins. Interplay of phosphorylation and O-GlcNAc modification at the same conserved site may result in the protein undergoing functional switches. We describe that at conserved Ser/Thr residues of human Oct-2, alternative phosphorylation and O-GlcNAc modification (Yin Yang sites) can be predicted by the YinOYang1.2 method. We propose here that alternative phosphorylation and O-GlcNAc modification at Ser191 in the N-terminal region, Ser271 and 274 in the linker region of two POU sub-domains and Thr301 and Ser323 in the POUh subdomain are involved in the differential binding behavior of Oct-2 to the octamer DNA motif. This implies that phosphorylation or O-GlcNAc modification of the same amino acid may result in a different binding capacity of the modified protein. In the C-terminal domain, Ser371, 389 and 394 are additional Yin Yang sites that could be involved in the modulation of Oct-2 binding propertie

Semi-autonomous vehicles as a cognitive assistive device for older adults

Losing the capacity to drive due to age-related cognitive decline can have a detrimental impact on the daily life functioning of older adults living alone and in remote areas. Semi-autonomous vehicles (SAVs) could have the potential to preserve driving independence of this population with high health needs. This paper explores if SAVs could be used as a cognitive assistive device for older aging drivers with cognitive challenges. We illustrate the impact of age-related changes of cognitive functions on driving capacity. Furthermore, following an overview on the current state of SAVs, we propose a model for connecting cognitive health needs of older drivers to SAVs. The model demonstrates the connections between cognitive changes experienced by aging drivers, their impact on actual driving, car sensors' features, and vehicle automation. Finally, we present challenges that should be considered when using the constantly changing smart vehicle technology, adapting it to aging drivers and vice versa. This paper sheds light on age-related cognitive characteristics that should be considered when developing future SAVs manufacturing policies which may potentially help decrease the impact of cognitive change on older adult drivers

Different secretion patterns of matrix metalloproteinases and IL-8 and effect of corticotropin-releasing hormone in preterm and term cervical fibroblasts

The aims of the present study were to compare the levels of mRNA and protein expression of matrix metalloproteinase (MMP)-1, -3, -8 and -9 in human cervical tissue in preterm and term labor as well as not in labor and to determine if corticotropin-releasing hormone (CRH) has an effect on MMP-1, -3 and interleukin (IL)-8 secretion in both preterm and term cervical fibroblasts. Cervical biopsies were taken from 60 women: 18 at preterm labor, 7 at preterm not in labor, 18 at term labor and 17 at term not in labor. ELISA and Immulite were used for protein and real-time RT–PCR for mRNA analysis. Cervical fibroblast cultures were incubated for 18 h with different CRH concentrations (10−13–10−6 M). The mRNA expression of MMP-1, -3 and -9 was higher in laboring groups compared with term not in labor. Protein levels of MMP-8 and -9 were higher in term in labor group compared with non-laboring groups. There were no significant differences in mRNA and protein expression between the preterm and respective term control groups. CRH significantly increased secretion of IL-8 in preterm and term cervical fibroblasts compared with controls. The secretion of IL-8 and MMP-1 was significantly higher and MMP-3 secretion lower in preterm cervical fibroblasts. In conclusion, cervical ripening at preterm seems to be a similar inflammatory process as at term with CRH involved. However, preterm and term cervical fibroblasts might have different phenotypes based on different secretion patterns of IL-8, MMP-1 and MMP-3

Novel Coronavirus Cough Database: NoCoCoDa

The current pandemic associated with the novel coronavirus (COVID-19) presents a new area of research with its own set of challenges. Creating unobtrusive remote monitoring tools for medical professionals that may aid in diagnosis, monitoring and contact tracing could lead to more efficient and accurate treatments, especially in this time of physical distancing. Audio based sensing methods can address this by measuring the frequency, severity and characteristics of the COVID-19 cough. However, the feasibility of accumulating coughs directly from patients is low in the short term. This article introduces a novel database (NoCoCoDa), which contains COVID-19 cough events obtained through public media intervi

Exploring the Relationship Between Schizophrenia and Cardiovascular Disease:A Genetic Correlation and Multivariable Mendelian Randomization Study

Individuals with schizophrenia have a reduced life-expectancy compared to the general population, largely due to an increased risk of cardiovascular disease (CVD). Clinical and epidemiological studies have been unable to unravel the nature of this relationship. We obtained summary-data of genome-wide-association studies of schizophrenia (N = 130 644), heart failure (N = 977 323), coronary artery disease (N = 332 477), systolic and diastolic blood pressure (N = 757 601), heart rate variability (N = 46 952), QT interval (N = 103 331), early repolarization and dilated cardiomyopathy ECG patterns (N = 63 700). We computed genetic correlations and conducted bi-directional Mendelian randomization (MR) to assess causality. With multivariable MR, we investigated whether causal effects were mediated by smoking, body mass index, physical activity, lipid levels, or type 2 diabetes. Genetic correlations between schizophrenia and CVD were close to zero (−0.02–0.04). There was evidence that liability to schizophrenia causally increases heart failure risk. This effect remained consistent with multivariable MR. There was also evidence that liability to schizophrenia increases early repolarization pattern, largely mediated by BMI and lipids. Finally, there was evidence that liability to schizophrenia increases heart rate variability, a direction of effect contrasting clinical studies. There was weak evidence that higher systolic blood pressure increases schizophrenia risk. Our finding that liability to schizophrenia increases heart failure is consistent with the notion that schizophrenia involves a systemic dysregulation of the body with detrimental effects on the heart. To decrease cardiovascular mortality among individuals with schizophrenia, priority should lie with optimal treatment in early stages of psychosis