Transformations among Pure Multipartite Entangled States via Local Operations Are Almost Never Possible

Local operations assisted by classical communication (LOCC) constitute the free operations in entanglement theory. Hence, the determination of LOCC transformations is crucial for the understanding of entanglement. We characterize here almost all LOCC transformations among pure multipartite multilevel states. Combined with the analogous results for qubit states shown by Gour \emph{et al.} [J. Math. Phys. 58, 092204 (2017)], this gives a characterization of almost all local transformations among multipartite pure states. We show that nontrivial LOCC transformations among generic, fully entangled, pure states are almost never possible. Thus, almost all multipartite states are isolated. They can neither be deterministically obtained from local-unitary-inequivalent (LU-inequivalent) states via local operations, nor can they be deterministically transformed to pure, fully entangled LU-inequivalent states. In order to derive this result, we prove a more general statement, namely, that, generically, a state possesses no nontrivial local symmetry. We discuss further consequences of this result for the characterization of optimal, probabilistic single copy and probabilistic multi-copy LOCC transformations and the characterization of LU-equivalence classes of multipartite pure states.Comment: 13 pages main text + 10 pages appendix, 1 figure; close to published versio

Using Think-Alouds to Uncover Expert-Novice Gaps in AAC Intervention Planning Skills

Because few studies have explored preservice speech-language pathologists’ (SLP’s) learning outcomes in augmentative and alternative communication (AAC) coursework and clinical practica, there is a need to investigate student learning in this area. This article represents a portion of a larger study that explored the expert-novice gap in planning for intervention with children who use AAC. The companion article reports clinical reasoning skills, whereas the present study revealed intervention planning skills. The methods are the consistent with those reported in the companion article. In summary, eight novice (i.e. preservice) SLPs and eight expert SLPs completed think-aloud tasks while they developed intervention plans. Verbal data were transcribed and analyzed qualitatively. Eight intervention planning skills emerged from the data: selecting treatment style, planning activities, selecting or developing materials, planning teaching strategies, selecting targets, goal setting, collecting data, and feature matching. Considerable overlap across expert and novice performance was observed in some areas, while minor differences were noted in other skills. Expert-novice gaps were identified in two areas, developing a treatment style and feature matching. Familiarity with expert-novice gaps in intervention planning has implications for preservice instruction in AAC

Clinical Reasoning Skills in AAC Intervention Planning: Investigating the Expert-Novice Gap

Clinical reasoning skills underlie the decisions speech-language pathologists (SLPs) make during practice. Although clinical reasoning is included in speech-language pathology accreditation standards in the United States, there is limited research on preservice SLPs’ development or use of clinical reasoning skills. Because clinical reasoning skills specific to augmentative and alternative communication (AAC) service provision have not been identified or reported in depth, this qualitative study focused on two cases of children with developmental disabilities who used AAC systems. Eight novice (i.e. preservice) SLPs and eight expert SLPs completed think-aloud tasks while they developed intervention plans, which made their clinical reasoning skills observable. Responses were transcribed for qualitative analysis. Six clinical reasoning skills were identified: summarizing, interpreting, hypothesizing, rationalizing, comparing and deferring. Expert and novices used four of these clinical reasoning skills similarly; however, there were differences among the remaining two skills. Novices deferred more frequently during the tasks and were limited in their ability to make comparisons to the fictional cases as compared to the experts. The expert-novice gap in clinical reasoning presents implications for teaching preservice SLPs in the classroom and the clinic

The QED Structure of the Photon

Measurements of the QED structure of the photon based on the reaction ee --> ee \gamma(*)(P^2)\gamma*(Q^2) --> ee mumu are discussed. This review is an update of the discussion of the results on the QED structure of the photon presented in Refs.[1], and covers the published measurements of the photon structure functions F_2, F_A nd F_B and of the differential cross-section dsig/dx for the exchange of two virtual photons.Comment: Invited talk given at the 7th International Workshop on Deep Inelastic Scattering and QCD, April 19 to 23, 1999, Zeuthen, to appear in the proceedings. 8pages 4 figure

Dynamics of P. falciparum gametocytemia in symptomatic patients in an area of intense perennial transmission in Tanzania.

We investigated the dynamics of Plasmodium falciparum gametocytemia in symptomatic patients attending a local dispensary in the Kilombero district, Tanzania. Consenting individuals aged one and above, with varying asexual and sexual parasitemias were treated appropriately and asked to return weekly for 28 days. Gametocyte prevalence was highest on Day 7 of follow-up in all age groups (overall 30.5%). Multifactorial analysis showed that young age (chi2 = 18.4; P = 0.004), high asexual parasitemia on presentation (chi2 = 19.4; P = 0.0007) and gametocyte positivity on presentation (chi2 = 29.4; P = 0.001) were all significantly associated with the presence of gametocytes on Days 7 and 14 of follow-up. High presentation of asexual parasitemia alone was positively correlated with higher gametocyte densities on both days of follow-up (F4, 297 = 2.0; P = 0.049). Gametocyte incidence rates decreased significantly with age (chi2 = 7.6, P < 0.005). In summary, in this group of chloroquine-treated individuals, gametocyte prevalence and incidence rates decreased with age, while densities remained relatively constant

Dynamics of P. Falciparum Gametocytemia in Symptomatic Patients in an Area of Intense Perennial Transmission in Tanzania.

We investigated the dynamics of Plasmodium falciparum gametocytemia in symptomatic patients attending a local dispensary in the Kilombero district, Tanzania. Consenting individuals aged one and above, with varying asexual and sexual parasitemias were treated appropriately and asked to return weekly for 28 days. Gametocyte prevalence was highest on Day 7 of follow-up in all age groups (overall 30.5%). Multifactorial analysis showed that young age (chi2 = 18.4; P = 0.004), high asexual parasitemia on presentation (chi2 = 19.4; P = 0.0007) and gametocyte positivity on presentation (chi2 = 29.4; P = 0.001) were all significantly associated with the presence of gametocytes on Days 7 and 14 of follow-up. High presentation of asexual parasitemia alone was positively correlated with higher gametocyte densities on both days of follow-up (F4, 297 = 2.0; P = 0.049). Gametocyte incidence rates decreased significantly with age (chi2 = 7.6, P < 0.005). In summary, in this group of chloroquine-treated individuals, gametocyte prevalence and incidence rates decreased with age, while densities remained relatively constant

Estimation of the infectious reservoir of Plasmodium falciparum in natural vector populations based on oocyst size

A method for determining the infectious reservoir of malaria (K) and vector survival rate (P) by measuring oocyst size and discriminating between the most recent and other infections is described. In the laboratory the mean diameter of 3 d oocysts in Anopheles gambiae, kept at 26 °C, was 11·5 μm and the mean diameter at day 5 was 24·5 μm. Oocyst sizes in wild caught mosquitoes from southern Tanzania, that had fed on the occupants of bed nets with holes in the sides, were more variable. 2060 A. gambiae s.l. and 1982 A. Funestus were examined for oocysts 3 d after feeding; 796 and 654 oocysts from the 153 and 170 infected females, respectively, were measured. Because of misclassification errors, the use of a simple cut-off model, in which all oocysts less than 17.5 μm in diameter were considered to have arisen from the most recent feed, was thought to overestimate K and underestimate P. A statistical model which allows for overlap in the oocyst size distributions is described. Estimates of the infectious reservoir derived from this model were 2.8% for A. gambiae s.l. and 4.2% for A. funestus, and the estimated survival rates per gonotrophic cycle were 65.5% and 52.9%, respectively. The utility of measuring oocyst size in naturally infected mosquitoes is discusse

Lipolytic sensitivity to catecholamines in patients with human immunodeficiency virus infection

Lipolysis is higher in patients with acquired immunodeficiency syndrome (AIDS) than in healthy control subjects. To evaluate whether this increase in lipolysis is related to increased beta-adrenergic sensitivity, we compared the lipolytic response to epinephrine (approximately 15 ng x kg(-1) x min(-1)) of six AIDS patients with that of six matched control subjects. Lipolysis was measured by infusion of [2H2]glycerol and [2H2]palmitate. The baseline rates of appearance of palmitate (2.06 +/- 0.21 compared with 1.45 +/- 0.07 micromol x kg(-1) x min(-1)) and glycerol (2.35 +/- 0.16 compared with 1.35 +/- 0.06 micromol x kg(-1) x min(-1)) were higher in AIDS patients (P <0.05). The absolute increase in lipolysis, an indicator of the responsiveness to epinephrine, was not different between groups for the rate of appearance of palmitate (86 +/- 14 compared with 75 +/- 7 micromol x L(-1) x min(-1)) or glycerol (79 +/- 13 compared with 59 +/- 6 micromol x L(-1) x min(-1)). Plasma concentrations of epinephrine were not different between groups. Lipolysis was higher whereas the lipolytic response to epinephrine was normal in AIDS patients. Increased lipolytic sensitivity to catecholamines is not the cause of increased lipolysis in AID

Beurteilung der Milchqualität und Schwachstellenanalyse des Produktionsprozesses in ökologisch bewirtschafteten Milchviehbetrieben unter besonderer Berücksichtigung des Bacillus cereus

Versuch I: Aktuelle Erhebung über die Milchqualität von ökologisch wirtschaftenden im Vergleich zu konventionell wirtschaftenden Betrieben Ziel des Versuches war es, verschiedene betriebliche Gegebenheiten und die Milchqualitätsparameter von ökologisch und von konventionell wirtschaftenden Betrieben gegenüberzustellen, zu vergleichen und die Unterschiede zu begründen. Dafür wurden 15 ökologisch und 13 konventionell wirtschaftende Milchviehbetriebe in Westfalen ausgewählt und um ihr Einverständnis gebeten, an dieser Untersuchung teilzunehmen. Zunächst erfolgte die Anfertigung der für die Befragung erforderlichen Checklisten für die Produktionsbereiche Melken, Fütterung, Haltung und Management. Nach Fertigstellung der Checklisten wurden die Betriebe zweimal im Abstand von ca. einem halben Jahr besucht und die einzelnen Daten in den Checklisten erhoben. Anschließend konnten die Erhebungsdaten den Komplexen Eutergesundheit, Stoffwechsel, Fruchtbarkeit und Fundament zugeteilt werden. Die erhobenen Daten deckten eine große Bandbreite an Vorsorgemaßnahmen, Risikofaktoren und Beobachtungen im Hinblick auf die vier Krankheitskomplexe ab. In dem betrachteten Zeitraum von Juni 2002 bis Oktober 2003 standen die Daten der regelmäßigen Güteprüfung in der Hoftankmilch und der monatlichen Milchleistungsprüfung im Gesamtgemelk zur Auswertung zur Verfügung. Bei den Ergebnissen ist hervorzuheben, dass die ökologisch wirtschaftenden Betriebsleiter im Vergleich zu den konventionell wirtschaftenden Betriebsleitern häufiger hygienische Maßnahmen in den Bereichen „Melken“ und „Liegeflächen“ durchführen. Im Bezug auf das Gesundheitsmanagement wäre es für ökologisch wirtschaftenden Betriebsleitern ratsam, häufiger Maßnahmen zur regelmäßigen Kontrolle der Gesundheit, zur Behandlung bei Überschreitung der Grenzwerte und zur abschließenden Kontrolluntersuchung zu ergreifen. Das ausgearbeitete Konzept zur Schwachstellenanalyse ist in erster Linie – aufgrund der Ergebnisse – auf ökologisch wirtschaftenden Betrieben bei Vorhandensein der aufgeführten Schwachstellen anzuwenden, gleichermaßen aber auch auf konventionell wirtschaftenden Betrieben mit entsprechendem Gefährdungspotential. . Versuch IIb: Beurteilung der Bedeutung des Bacillus cereus für die Haltbarkeit und Verarbeitung der Milch Die Kontamination mit Bacillus cereus erfolgte in der Molkerei, nicht schon auf den Erzeugerbetrieben. In zwei Versuchsreihen zur Bedeutung von B. cereus für die Haltbarkeit der Biomilch zeigte sich der Verderb unabhängig von der zugegebenen B.cereus-Menge als durch den Geruch zuerst erkennbar

Integrated transcriptomic and proteomic analyses ofP. falciparumgametocytes: molecular insight into sex-specific processes and translational repression

Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here, we report the first transcriptome analysis of male and female Plasmodium falciparum gametocytes coupled with a comprehensive proteome analysis. In male gametocytes there is an enrichment of proteins involved in the formation of flagellated gametes; proteins involved in DNA replication, chromatin organization and axoneme formation. On the other hand, female gametocytes are enriched in proteins required for zygote formation and functions after fertilization; protein-, lipid- and energy-metabolism. Integration of transcriptome and proteome data revealed 512 highly expressed maternal transcripts without corresponding protein expression indicating large scale translational repression in P. falciparum female gametocytes for the first time. Despite a high degree of conservation between Plasmodium species, 260 of these 'repressed transcripts' have not been previously described. Moreover, for some of these genes, protein expression is only reported in oocysts and sporozoites indicating that repressed transcripts can be partitioned into short- and long-term storage. Finally, these data sets provide an essential resource for identification of vaccine/drug targets and for further mechanistic studies