Ant routing algorithm for the Lightning Network

We propose a decentralized routing algorithm that can be implemented in Bitcoin Lightning Network. All nodes in the network contribute equally to path searching. The algorithm is inspired from ant path searching algorithms.Comment: 10 pages, 1 figur

Extension of formal conjugations between diffeomorphisms

We study the formal conjugacy properties of germs of complex analytic diffeomorphisms defined in the neighborhood of the origin of ${\mathbb C}^{n}$. More precisely, we are interested on the nature of formal conjugations along the fixed points set. We prove that there are formally conjugated local diffeomorphisms $\phi, \eta$ such that every formal conjugation $\hat{\sigma}$ (i.e. $\eta \circ \hat{\sigma} = \hat{\sigma} \circ \phi$) does not extend to the fixed points set $Fix (\phi)$ of $\phi$, meaning that it is not transversally formal (or semi-convergent) along $Fix (\phi)$. We focus on unfoldings of 1-dimensional tangent to the identity diffeomorphisms. We identify the geometrical configurations preventing formal conjugations to extend to the fixed points set: roughly speaking, either the unperturbed fiber is singular or generic fibers contain multiple fixed points.Comment: 34 page

Hybrid layers of etch-and-rinse versus self-etching adhesive systems

Objective: To evaluate the effectiveness in the formation of resin tags, adhesive lateral branches and hybrid layers of five adhesive systems, when bonding to dentine. Material and Methods: Flat dentin surfaces from 25 molars were bonded with several adhesive systems according to the manufacturers? instructions. Composite build-ups were constructed incrementally with Tetric Ceram. The Specimens were sectioned parallel to the long axis. One section was treated with phosphoric acid and sodium hypochlorite in order to reveal the hybrid layer formation. The other section was stored in 30% hydrochloric acid to detect resin tags and adhesive lateral branch formation. Results: The two etch-and-rinse self-priming adhesives exhibited thicker hybrid layers than those found in self-etching adhesive systems. The all-in-one adhesive showed droplet formation between the adhesive and the resin composite. The resin tags formed with the etch-and-rinse adhesives were much longer than those found with the self-etching adhesives. Lateral branch formation was observed in etch-and-rinse adhesives and in one of the self-etch adhesives Clearfil SE Bond (SEB). Conclusion: The formed hybrid layer obtained with the two-step selfetching adhesives and the etch-and-rinse systems were continuous and uniform in thickness. Droplets within the all-in-one adhesive layer may occur as a result of water absorption from dentin through osmosis, and may interfere with proper resin polymerization. Resin tags obtained with SEB and the etch-and-rinse adhesive systems showed lateral branches, which is a sign of proper resin infiltration

Influence of high pressure homogenization (HPH) on the structural stability of an egg/dairy emulsion

[EN] High pressure homogenization (HPH) is a novel non-thermal preservation technology, which can improve the microbiological quality of products without affecting their stability. The main objective of this paper is to study the influence of different HPH treatments on the structure of a sauce (an egg/dairy emulsion). in order to obtain the higher physicochemical stability. The oil-in-water emulsion was stable up to 100 MPa with the oil droplets surrounded by several layers of natural emulsifiers. Critical pressures, between 150 and 250 MPa, produced a destabilization of the emulsion thus causing a separation of phases. A coalescence phenomenon progressively occurred when pressure increased. This phenomenon was due to the loss of the natural emulsifier barrier. Changes on the electrophoretic pattern were also observed at high pressure levels, showing an insolubilization of proteins. Lipid fraction was observed to be chemically stable after the HPH treatment. (C) 2011 Elsevier Ltd. All rights reserved.Authors want to thank to the European Commission for the financial support (Project FP6-FOOD-023140), to the Ministerio de Educación y Ciencia (Spain) for the grant awarded to the author R. Marco-Molés, and to the Ministerio de Ciencia e Innovación (Spain) for the financial support (AGL2007-30951-E). Finally, authors thank to the University of Bologna (Italy) for providing the HPH treated samples.Marco-Molés, R.; Hernando Hernando, MI.; Llorca Martínez, ME.; Pérez-Munuera, I. (2012). Influence of high pressure homogenization (HPH) on the structural stability of an egg/dairy emulsion. Journal of Food Engineering. 109(4):652-658. https://doi.org/10.1016/j.jfoodeng.2011.11.031S652658109

Conjugation of the 9-kDa isoform of Granulysin with liposomes potentiates its cytotoxicity

Nine kDa granulysin (GRNLY) is a human cytolytic protein secreted by cytotoxic T lymphocytes (CTL) and NK cells of the immune system whose demonstrated physiological function is the elimination of bacteria and parasites. In previous studies by our group, the anti-tumor capacity of recombinant granulysin was demonstrated, both in vitro and in vivo. In the present work, we developed lipid nanoparticles whose surfaces can bind recombinant granulysin through the formation of a complex of coordination between the histidine tail of the protein and Ni2+ provided by a chelating lipid in the liposome composition and termed them LUV-GRNLY, for granulysin-bound large unilamellar vesicles. The objective of this formulation is to increase the granulysin concentration at the site of contact with the target cell and to increase the cytotoxicity of the administered dose. The results obtained in this work indicate that recombinant granulysin binds to the surface of the liposome with high efficiency and that its cytotoxicity is significantly increased when it is in association with liposomes. In addition, it has been demonstrated that the main mechanism of death induced by both granulysin and LUV-GRNLY is apoptosis. Jurkat-shBak cells are resistant to GRNLY and also to LUV-GRNLY, showing that LUV-GRNLY uses the mitochondrial apoptotic pathway to induce cell death. On the other hand, we show that LUV-GRNLY induces the expression of the pro-apoptotic members of the Bcl-2 family Bim and especially PUMA, although it also induced the expression of anti-apoptotic Bcl-xL. In conclusion, we demonstrate that binding of GRNLY to the surfaces of liposomes clearly augments its cytotoxic potential, with cell death executed mainly by the mitochondrial apoptotic pathway

Experimental transition probabilities in NII lines

Producción CientíficaThis work reports an extensive collection of 108 transition probabilities of NII lines in the visible spectral region, all of them measured in an emission experiment. Relative intensity measurements have been made on a pulsed discharge lamp and the absolute Aki values have been obtained by using the literature available data. Electron density and temperature range in this experiment from 0.2 to and from 17000 to 29000 K respectively. The first one has been simultaneously determined from two-wavelength interferometry and from the Stark broadening of HeI 471.3 nm, the second from Boltzmann-plot of NII lines and from NII/NI intensities ratios. The results are compared with the recent available literature.

Ministerio de Educación y Formación Profesional (grant PB-98-0356)Junta de Castilla y León (grant VA23-99

Verificación artroscópica del diagnóstico por resonancia magnética de las lesiones meniscales

La utilización de la Imagen por Resonancia Magnética (IRM) como prueba diagnóstica en la patología de la rodilla, se presenta como alternativa no invasiva fundamental. Se ha diseñado un protocolo a doble ciego junto al servicio de radiodiagnóstico de nuestro hospital a través del cual se han evaluado un total de 31 pacientes donde los hallazgos de la IRM son contrastados con la exploración artroscópica posterior. Para el menisco interno, la precisión diagnóstica de la IRM es del 93 % y del 87% para el externo. Como conclusiones de mayor relieve, la sensibilidad de la exploración fue del 90% para el interno y del 75% para el externo y respecto a la especificidad, en el interno resultó ser del 100% y del 91% en el externo. Los valores predictivo negativo y positivo fueron respectivamente del 85 y 100% en el menisco interno y del 84 y 75% en el externo. Se encontró mayor dificultad diagnóstica en la porción anterior del menisco externo y falta de precisión ocasional en definir el tipo y extensión de la lesión.The use of Magnetic Resonance Imaging (MIR) as a diagnostic trial in the pathology of the knee, has become an important non invasive alternative. We have designed a double blind protocol with the Department of Radiology through we have evaluated 31 patients analyzing the MRI results in relation with the arthroscopic findings. For the medial meniscus, the accuracy of the MRI was 93 % and 87% for the lateral. As main conclusions, the sensibility was 90% for the medial meniscus and 75% for the lateral one and about specificity, we found a result of 100% for the medial meniscus and 91% for the lateral. The negative and positive predictive values were respectively 85% and 100% for the medial and 84% and 75% for the lateral. We noted more diagnostic difficulties in the anterior portion of lateral meniscus and lack of precission in the determination of the type and extension of the meniscal injury

Reconstrucción del ligamento cruzado anterior con plastia mixta de semitendinoso y fibra de Kennedy-Lad

—Se han evaluado los resultados de la reconstrucción del ligamento cruzado anterior (LCA) con una plastia mixta de tendón del semitendinoso y fibra sintética de KennedyLAD en veinticinco pacientes con un mínimo de dos años de seguimiento postoperatorio (media de treinta y ocho meses). Se trataba en todos los casos de lesiones crónicas donde la cirugía consistió en la reconstrucción del LCA y meniscectomías parciales cuando fueron necesarias. La evaluación se llevó a cabo mediante pruebas funcionales (Lysholm) y clínicas (Marshall), pruebas de estabilidad manual (Lachman, pivot, cajón neutro anterior), medidas instrumentales de estabilidad con artrómetro (KT-1000), índice de actividad y apreciación subjetiva. Los datos indican que el comportamiento de la plastia es adecuado en el 92% de los casos proporcionando a los pacientes una función articular satisfactoria en su vida diaria incluyendo la actividad deportiva.The authors assess the results of the anterior cruciate ligament (ACL) reconstruction by means of a semitendinous tendon and Kennedy LAD composite graft. Minimum followup has been two years (mean of thirty eight months). In every cases the lesion was considered as chronic and surgery consisted of ACL reconstruction and partial meniscectomy if neccessary. Studies performed to asses the results included: functional (Lysholm) and clinical (Marshall) tests, manual stability tests (Lachman, pivot-shift, neutral anterior drawer), instrumented stability measurement (KT-1000 arthrometer), activity score and subjective patient self-assessment. The data collected indicate that the performance of the composite graft is adequate in 92% of the cases, allowing the patients a satisfactory knee joint function in their daily life including sporting activities

A note on hyperbolic leaves and wild laminations of rational functions

We study the affine orbifold laminations that were constructed by Lyubich and Minsky. An important question left open in their construction is whether these laminations are always locally compact. We show that this is not the case. The counterexample we construct has the property that the regular leaf space contains (many) hyperbolic leaves that intersect the Julia set; whether this can happen is itself a question raised by Lyubich and Minsky.Comment: 11 page

Exercise-based interventions to enhance long-term sustainability of physical activity in older adults: a systematic review and meta-analysis of randomized clinical trials

Older adults; Physical activity; AdherenceAdultos mayores; Actividad física; AdherenciaAdults majors; Activitat física; AdherènciaExercise is a form of physical activity (PA). PA is an important marker of health and quality of life in older adults. The purpose of this study was to conduct a systematic review of the literature to assess the effect of exercise-based interventions on an at least six-month follow up PA measure, and to describe the specific strategies implemented during the intervention to strengthen the sustainability of PA in community-dwelling 65+ year-old adults. We registered and conducted a systematic review and meta-analysis (PROSPERO: CRD42017070892) of randomized clinical trials (RCT). We searched three electronic databases during January 2018 to identify RCT assessing any type of exercise-based intervention. Studies had to report a pre-, post-, and at least 6-month post-intervention follow-up. To be included, at least one PA outcome had to be assessed. The effect of exercise-based interventions was assessed compared to active (e.g., a low-intensity type of exercise, such as stretching or toning activities) and non-active (e.g., usual care) control interventions at several time points. Secondary analyses were conducted, restricted to studies that reported specific strategies to enhance the sustainability of PA. The intervention effect was measured on self-reported and objective measures of time spent in PA, by means of standardized mean differences. Standardized mean differences of PA level were pooled. Pooled estimates of effect were computed with the DerSimonian–Laird method, applying a random effects model. The risk of bias was also assessed. We included 12 studies, comparing 18 exercise intervention groups to four active and nine non-active control groups. Nine studies reported specific strategies to enhance the long-term sustainability of PA. The strategies were mostly related to the self-efficacy, self-control, and behavior capability principles based on the social cognitive theory. Exercise interventions compared to active control showed inconclusive and heterogeneous results. When compared to non-active control, exercise interventions improved PA time at the six-months follow up (standardized mean difference (SMD) 0.30; 95%CI 0.15 to 0.44; four studies; 724 participants; I2 0%), but not at the one- or two-years follow-ups. No data were available on the mid- and long-term effect of adding strategies to enhance the sustainability of PA. Exercise interventions have small clinical benefits on PA levels in community-dwelling older adults, with a decline in the observed improvement after six months of the intervention cessation.The present study was funded by United States Department of Health & Human Services National Institutes of Health (NIH), USA, and NIH National Institute on Aging (NIA), USA, (K24 AG057728)