Observation of discrete time-crystalline order in a disordered dipolar many-body system

Understanding quantum dynamics away from equilibrium is an outstanding challenge in the modern physical sciences. It is well known that out-of-equilibrium systems can display a rich array of phenomena, ranging from self-organized synchronization to dynamical phase transitions. More recently, advances in the controlled manipulation of isolated many-body systems have enabled detailed studies of non-equilibrium phases in strongly interacting quantum matter. As a particularly striking example, the interplay of periodic driving, disorder, and strong interactions has recently been predicted to result in exotic "time-crystalline" phases, which spontaneously break the discrete time-translation symmetry of the underlying drive. Here, we report the experimental observation of such discrete time-crystalline order in a driven, disordered ensemble of $\sim 10^6$ dipolar spin impurities in diamond at room-temperature. We observe long-lived temporal correlations at integer multiples of the fundamental driving period, experimentally identify the phase boundary and find that the temporal order is protected by strong interactions; this order is remarkably stable against perturbations, even in the presence of slow thermalization. Our work opens the door to exploring dynamical phases of matter and controlling interacting, disordered many-body systems.Comment: 6 + 3 pages, 4 figure

Low phase noise diode laser oscillator for 1S-2S spectroscopy in atomic hydrogen

We report on a low-noise diode laser oscillator at 972 nm actively stabilized to an ultra-stable vibrationally- and thermally compensated reference cavity. To increase the fraction of laser power in the carrier we designed a 20 cm long external cavity diode laser with an intra-cavity electro-optical modulator. The fractional power in the carrier reaches 99.9% which corresponds to a rms phase noise of $\phi^2_\textrm{rms}=1\,\textrm{mrad}^2$ in 10\,MHz bandwidth. Using this oscillator we recorded 1S-2S spectra in atomic hydrogen and have not observed any significant loss of the excitation efficiency due to phase noise multiplication in the three consecutive 2-photon processes.Comment: 3 pages, 5 figure

Experimental Determination of Irreversible Entropy Production in out-of-Equilibrium Mesoscopic Quantum Systems

By making use of a recently proposed framework for the inference of thermodynamic irreversibility in bosonic quantum systems, we experimentally measure and characterize the entropy production rates in the non-equilibrium steady state of two different physical systems -- a micro-mechanical resonator and a Bose-Einstein condensate -- each coupled to a high finesse cavity and hence also subject to optical loss. Key features of our setups, such as cooling of the mechanical resonator and signatures of a structural quantum phase transition in the condensate are reflected in the entropy production rates. Our work demonstrates the possibility to explore irreversibility in driven mesoscopic quantum systems and paves the way to a systematic experimental assessment of entropy production beyond the microscopic limit

A Chemical Biology Solution to Problems with Studying Biologically Important but Unstable 9‑O-Acetyl Sialic Acids

9-O-Acetylation is a common natural modification on sialic acids (Sias) that terminate many vertebrate glycan chains. This ester group has striking effects on many biological phenomena, including microbe-host interactions, complement action, regulation of immune responses, sialidase action, cellular apoptosis, and tumor immunology. Despite such findings, 9-O-acetyl sialoglycoconjugates have remained largely understudied, primarily because of marked lability of the 9-O-acetyl group to even small pH variations and/or the action of mammalian or microbial esterases. Our current studies involving 9-O-acetylated sialoglycans on glycan microarrays revealed that even the most careful precautions cannot ensure complete stability of the 9-O-acetyl group. We now demonstrate a simple chemical biology solution to many of these problems by substituting the oxygen atom in the ester with a nitrogen atom, resulting in sialic acids with a chemically and biologically stable 9-N-acetyl group. We present an efficient one-pot multienzyme method to synthesize a sialoglycan containing 9-acetamido-9-deoxy-<i>N</i>-acetylneuraminic acid (Neu5Ac9NAc) and compare it to the one with naturally occurring 9-<i>O</i>-acetyl-<i>N</i>-acetylneuraminic acid (Neu5,9Ac₂). Conformational resemblance of the two molecules was confirmed by computational molecular dynamics simulations. Microarray studies showed that the Neu5Ac9NAc-sialoglycan is a ligand for viruses naturally recognizing Neu5,9Ac₂, with a similar affinity but with much improved stability in handling and study. Feeding of Neu5Ac9NAc or Neu5,9Ac₂ to mammalian cells resulted in comparable incorporation and surface expression as well as binding to 9-O-acetyl-Sia-specific viruses. However, cells fed with Neu5Ac9NAc remained resistant to viral esterases and showed a slower turnover. This simple approach opens numerous research opportunities that have heretofore proved intractable