72,976 research outputs found

    International Group Work for Sustainable Chemistry

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    As part of a transnational degree programme, students in the UK and China were linked together to carry out group work. This was enabled by having two versions of our FHEQ Level 4 Sustainable Chemistry module; in person for UK students, and by distance learning for Chinese students. Groups were instructed to discuss issues relating to the UN Sustainable Development Goals in their respective countries and report back individually. Students who found the assignment interesting were more likely to indicate they would keep in touch, while those students who had fewer interactions or found the assessment guidelines unclear found the assignment less interesting and were less likely to wish to remain in touch. This kind of assignment is an example of what can be done with links to other institutions around the world

    Relationship between antihypertensive medications and cognitive impairment: Part I. review of human studies and clinical trials

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    Purpose of review: There is an established association between hypertension and increased risk of poor cognitive performance and dementia including Alzheimer’s disease; however, associations between antihypertensive medications (AHMs) and dementia risk are less consistent. An increased interest in AHM has resulted in expanding publications; however, none of the recent reviews are comprehensive. Our extensive review includes 15 observational and randomized controlled trials (RCTs) published over the last 5 years, assessing the relationship between AHM and cognitive impairment. Recent findings: All classes of AHM showed similar result patterns in human studies with the majority of study results reporting point estimates below one and only a small number of studies (N = 15) reporting statistically significant results in favor of a specific class. Summary: Only a small number of studies reported statistically significant results in favor of a specific class of AHM. Methodological limitations of the studies prevent definitive conclusions. Further work is now needed to evaluate the class of AHM and cognitive outcomes in future RCTs, with a particular focus on the drugs with the promising results in both animals and human observational studies

    Building Data-Driven Pathways From Routinely Collected Hospital Data:A Case Study on Prostate Cancer

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    Background: Routinely collected data in hospitals is complex, typically heterogeneous, and scattered across multiple Hospital Information Systems (HIS). This big data, created as a byproduct of health care activities, has the potential to provide a better understanding of diseases, unearth hidden patterns, and improve services and cost. The extent and uses of such data rely on its quality, which is not consistently checked, nor fully understood. Nevertheless, using routine data for the construction of data-driven clinical pathways, describing processes and trends, is a key topic receiving increasing attention in the literature. Traditional algorithms do not cope well with unstructured processes or data, and do not produce clinically meaningful visualizations. Supporting systems that provide additional information, context, and quality assurance inspection are needed. Objective: The objective of the study is to explore how routine hospital data can be used to develop data-driven pathways that describe the journeys that patients take through care, and their potential uses in biomedical research; it proposes a framework for the construction, quality assessment, and visualization of patient pathways for clinical studies and decision support using a case study on prostate cancer. Methods: Data pertaining to prostate cancer patients were extracted from a large UK hospital from eight different HIS, validated, and complemented with information from the local cancer registry. Data-driven pathways were built for each of the 1904 patients and an expert knowledge base, containing rules on the prostate cancer biomarker, was used to assess the completeness and utility of the pathways for a specific clinical study. Software components were built to provide meaningful visualizations for the constructed pathways. Results: The proposed framework and pathway formalism enable the summarization, visualization, and querying of complex patient-centric clinical information, as well as the computation of quality indicators and dimensions. A novel graphical representation of the pathways allows the synthesis of such information. Conclusions: Clinical pathways built from routinely collected hospital data can unearth information about patients and diseases that may otherwise be unavailable or overlooked in hospitals. Data-driven clinical pathways allow for heterogeneous data (ie, semistructured and unstructured data) to be collated over a unified data model and for data quality dimensions to be assessed. This work has enabled further research on prostate cancer and its biomarkers, and on the development and application of methods to mine, compare, analyze, and visualize pathways constructed from routine data. This is an important development for the reuse of big data in hospitals

    Caracterisation Sensorielle, Physico-Chimique Et Microbiologique Du Beurre De Karite, Vitellaria paradoxa Des Marches De Cote D\'Ivoire

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    Les beurres de karité des marchés de Côte d\'Ivoire présentent des couleurs, odeurs et textures diverses, mais les beurres jaunes (67,9 %), rancis (33,99 %) et compacts (93,83 %) sont les plus dominants. Les caractéristiques physico-chimiques varient d\'une couleur à une autre. Les beurres de karité beige et jaune enregistrent des valeurs de taux d\'humidité (3,36 et 8,3 %), d\'indices d\'acide (12,80 et 14,97 mgKOH/g) et de peroxyde (17,92 et 14,70 mEgO2/kg) différentes et plus faibles que celles du beurre de karité gris (14,50 %, 17,32 mgKOH/g, 30,88 mEgO2/kg, respectivement). Ces beurres du marchés renferment des métaux lourds comme le plomb et le nickel à des proportions variables de 91,60 à 4,84 mg/kg (plomb) et, 3,07 à 1,27 mg/kg (nickel), mais aussi de fortes charges de Coliformes totaux (2.10+2/g), les levures et moisissures (1.10+4/g) et quelque fois des Salmonella.Shea butters from Côte d'Ivoire's markets present a wide diversity depending on colour, odour and texture, nevertheless yellow (67.9 %) rancid (33.99 %) and hard (93.83 %) shea buttets are dominant. Physicochemical characteristics are different according to colour. Beige and yellow shea butters had lower moisture content (3.36 and 8.3 %), acidity (12.80 and 14.97 mgKOH/g) and peroxide (17.92 and 14.70 mEgO2/kg) respectively, than the grey (14.50 %, 17.32 mgKOH/g, 30.88 mEgO2/kg, respectively). These butters contain heavy metals such as lead (91.60 to 4.84 mg/kg) and nickel (3.07 to 1.27 mg/kg). They also have high loads of Coliforms (2.10+2/g ), yeast and moulds (1.10+4/g), and sometimes Salmonella Keywords: Beurre de karité, Vitellaria paradoxa, propriétés, Côte d'Ivoire.Agronomie Africaine Vol. 20 (2) 2008: pp. 221-23

    Specifying ODP computational objects in Z

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    The computational viewpoint contained within the Reference Model of Open Distributed Processing (RM-ODP) shows how collections of objects can be configured within a distributed system to enable interworking. It prescribes certain capabilities that such objects are expected to possess and structuring rules that apply to how these objects can be configured with one another. This paper highlights how the specification language Z can be used to formalise these capabilities and the associated structuring rules, thereby enabling specifications of ODP systems from the computational viewpoint to be achieved

    Task relevance modulates the behavioural and neural effects of sensory predictions

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    The brain is thought to generate internal predictions to optimize behaviour. However, it is unclear whether predictions signalling is an automatic brain function or depends on task demands. Here, we manipulated the spatial/temporal predictability of visual targets, and the relevance of spatial/temporal information provided by auditory cues. We used magnetoencephalography (MEG) to measure participants' brain activity during task performance. Task relevance modulated the influence of predictions on behaviour: spatial/temporal predictability improved spatial/temporal discrimination accuracy, but not vice versa. To explain these effects, we used behavioural responses to estimate subjective predictions under an ideal-observer model. Model-based time-series of predictions and prediction errors (PEs) were associated with dissociable neural responses: predictions correlated with cue-induced beta-band activity in auditory regions and alpha-band activity in visual regions, while stimulus-bound PEs correlated with gamma-band activity in posterior regions. Crucially, task relevance modulated these spectral correlates, suggesting that current goals influence PE and prediction signalling

    Fluoride levels in UK infant milks.

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    Aim To provide a comprehensive report of fluoride concentration in UK infant milks and estimate their contribution to daily fluoride intake. Methods A total of 60 formula milk products available commercially or within a hospital environment were analysed, along with eight pasteurised cow’s milk samples. Formula milk products requiring preparation were reconstituted with fresh Leeds tap water (0.02 ppmF). Fluoride concentration was measured for all products directly using an ion selective electrode after addition of low-level total ionic strength adjustment buffer. Results The overall median fluoride concentration for the 68 infant milks was 0.025 ppmF, with a wide range of 0.002–0.282 ppmF. Analysis revealed variation between composition and manufacturer, in addition to differences between measured and labeled fluoride concentration. Although all products contained low fluoride concentration, the fluoride concentrations for formula milks used within the hospital setting (0.029 ppmF) were statistically higher in comparison to the commercial formula milk (0.016 ppmF) and cow’s milk (0.017 ppmF) products. The daily fluoride contribution from infant milks was low; 0.0034 mgF/kg body weight per day was estimated between birth and 6 months of age, further decreasing as intake of infant milk decreased with age. Conclusions Fluoride concentration of the analysed infant milks is low, providing minimal contribution towards total daily F intake and alone are unlikely to pose a threat for the development of dental fluorosis

    Simulating Emotions: An Active Inference Model of Emotional State Inference and Emotion Concept Learning

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    The ability to conceptualize and understand one’s own affective states and responses – or “Emotional awareness” (EA) – is reduced in multiple psychiatric populations; it is also positively correlated with a range of adaptive cognitive and emotional traits. While a growing body of work has investigated the neurocognitive basis of EA, the neurocomputational processes underlying this ability have received limited attention. Here, we present a formal Active Inference (AI) model of emotion conceptualization that can simulate the neurocomputational (Bayesian) processes associated with learning about emotion concepts and inferring the emotions one is feeling in a given moment. We validate the model and inherent constructs by showing (i) it can successfully acquire a repertoire of emotion concepts in its “childhood”, as well as (ii) acquire new emotion concepts in synthetic “adulthood,” and (iii) that these learning processes depend on early experiences, environmental stability, and habitual patterns of selective attention. These results offer a proof of principle that cognitive-emotional processes can be modeled formally, and highlight the potential for both theoretical and empirical extensions of this line of research on emotion and emotional disorders

    Drivers of risk perceptions about the invasive non-native plant Japanese knotweed in domestic gardens

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    This is the final version of the article. Available from Springer Verlag via the DOI in this record.How people perceive risks posed by invasive non-native plants (INNP) can influence attitudes and consequently likely influence behavioural decisions. Although some drivers of risk perception for INNP have been identified, research has not determined those for INNP in domestic gardens. This is concerning as domestic gardens are where people most commonly encounter INNP, and where impacts can be particularly acute. Using a survey approach, this study determined the drivers of perceptions of risk of INNP in domestic gardens and which risks most concern people. Japanese knotweed Fallopia japonica, in Cornwall, UK, where it is a problematic INNP in domestic gardens, was used as a case study. Possible drivers of risk were chosen a priori based on variables previously found to be important for environmental risks. Participants perceived Japanese knotweed to be less frequent on domestic property in Cornwall if their occupation involved the housing market, if they had not had Japanese knotweed in their own garden, if they did not know of Japanese knotweed within 5 km of their home, or if they were educated to degree level. Participants who thought that the consequences of Japanese knotweed being present on domestic property could be more severe had occupations that involved the housing market, knew of Japanese knotweed within 5 km of their home, or were older. Although concern about the damage Japanese knotweed could do to the structure of a property was reported as the second highest motivation to control it by the majority of participants, the perception of threat from this risk was rated as relatively low. The results of this study have implications for policy, risk communication, and garden management decisions. For example, there is a need for policy that provides support and resources for people to manage INNP in their local area. To reduce the impact and spread of INNP we highlight the need for clear and accurate risk communication within discourse about this issue. The drivers identified in this study could be used to target awareness campaigns to limit the development of over- or under-inflated risk perceptions.This project was funded as part of the Wildlife Research Co-Operative between the University of Exeter and the Animal and Plant Health Agency

    Facilitators and barriers to physical activity participation experienced by Aboriginal and Torres Strait Islander adults: A mixed methods systematic review protocol

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    Objective:To synthesize the existing research about physical activity and sport facilitators and barriers experienced by Aboriginal and Torres Strait Islander adults in Australia.Introduction:Physical activity and sport have cultural importance for First Nations peoples. Achieving health and broader benefits from physical activity and sport is impacted by experiences of both facilitators and barriers to participation. Identifying how to facilitate participation and overcome barriers to physical activity and sport is important to develop strategies to increase physical activity levels and sport participation among Aboriginal and Torres Strait Islander adults. Several studies have examined physical activity and sport facilitators and barriers experienced by Aboriginal and Torres Strait Islander adults, and collective synthesis of these studies can provide a more comprehensive understanding of their findings.Inclusion criteria:This mixed methods systematic review will consider studies that include Aboriginal and Torres Strait Islander peoples aged 18 years and over from any setting or region of Australia. Studies will be considered if they report on facilitators and barriers to physical activity and/or sport participation.Methods:Eleven databases will be searched, as well as gray literature sources, and a selection of websites containing resources relevant to physical activity participation for Aboriginal and Torres Strait Islander adults. Studies published in English will be included. No date limits will be set. After screening the titles and abstracts of identified citations, potentially relevant studies will be retrieved in full. Study selection, critical appraisal, data extraction, and data synthesis will be undertaken according to the convergent integrated approach to mixed methods reviews.Systematic review registration number:PROSPERO CRD42020162134
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