Voltage-current and voltage-flux characteristics of asymmetric high TC DC SQUIDs

We report measurements of transfer functions and flux shifts of 20 on-chip high T$_C$ DC SQUIDs half of which were made purposely geometrically asymmetric. All of these SQUIDs were fabricated using standard high T$_C$ thin film technology and they were single layer ones, having 140 nm thickness of YBa$_2$Cu$_3$O$_{7-x}$ film deposited by laser ablation onto MgO bicrystal substrates with 24$^0$ misorientation angle. For every SQUID the parameters of its intrinsic asymmetry, i. e., the density of critical current and resistivity of every junction, were measured directly and independently. We showed that the main reason for the on-chip spreading of SQUIDs' voltage-current and voltage-flux characteristics was the intrinsic asymmetry. We found that for SQUIDs with a relative large inductance ($L>120$ pH) both the voltage modulation and the transfer function were not very sensitive to the junctions asymmetry, whereas SQUIDs with smaller inductance ($L\simeq 65-75$ pH) were more sensitive. The results obtained in the paper are important for the implementation in the sensitive instruments based on high T$_C$ SQUID arrays and gratings.Comment: 11 pages, 4 tables, 17 figures This version is substantially modified. The Introduction and Section 2 are completely rewritten, while experimental part is mainly the same as in previous versio

DNA mismatch repair-dependent DNA damage responses and cancer

Canonical DNA mismatch repair (MMR) excises base-base mismatches to increase the fidelity of DNA replication. Thus, loss of MMR leads to increased spontaneous mutagenesis. MMR genes also are involved in the suppression of mutagenic, and the induction of protective, responses to various types of DNA damage. In this review we describe these non-canonical roles of MMR at different lesion types. Loss of non-canonical MMR gene functions may have important ramifications for the prevention, development and treatment of colorectal cancer associated with inherited MMR gene defects in Lynch syndrome. This graphical review pays tribute to Samuel H. Wilson. Sam not only made seminal contributions to understanding base excision repair, particularly with respect to structure-function relationships in DNA polymerase beta but also, as Editor of DNA Repair, has maintained a high standard of the journal.Genome Instability and Cance

Promoting occupational health through gamification and e-coaching: A 5-month user engagement study

Social gamification systems have shown potential for promoting healthy lifestyles, but applying them to occupational settings faces unique design challenges. While occupational settings offer natural communities for social interaction, fairness issues due to heterogeneous personal goals and privacy concerns increase the difficulty of designing engaging games. We explored a two-level game-design, where the first level related to achieving personal goals and the second level was a privacy-protected social competition to maximize goal compliance among colleagues. The solution was strengthened by employing occupational physicians who personalized users’ goals and coached them remotely. The design was evaluated in a 5-month study with 53 employees from a Dutch university. Results suggested that the application helped half of the participants to improve their lifestyles, and most appreciated the role of the physician in goal-setting. However, long-term user engagement was undermined by the scalability-motivated design choice of one-way communication between employees and their physician. Implications for social gamification design in occupational health are discussed

Anomalous Periodicity of the Current-Phase Relationship of Grain-Boundary Josephson Junctions in High-Tc Superconductors

The current-phase relation (CPR) for asymmetric 45 degree Josephson junctions between two d-wave superconductors has been predicted to exhibit an anomalous periodicity. We have used the single-junction interferometer to investigate the CPR for this kind of junctions in YBCO thin films. Half-fluxon periodicity has been experimentally found, providing a novel source of evidence for the d-wave symmetry of the pairing state of the cuprates.Comment: 4 pages, 5 figure

The design of a game-based training environment to enhance health care professionals’ skills in using eMental health:Study protocol for the user requirements analysis

Background: E–mental health (EMH) offers various possibilities for mental health care delivery, with many studies demonstrating its clinical efficacy. However, the uptake of EMH technologies by mental health care professionals remains to be low. One of the reasons for this is the lack of knowledge and skills in using these technologies. Skill enhancement by means of serious gaming has been shown to be effective in other areas but has not yet been applied to the development of EMH skills of mental health care professionals. Objective: The aim of this paper is to describe a study protocol for the user requirements analysis for the design of a game-based training environment for mental health care professionals to enhance their skills in EMH. Methods: The user requirements are formulated using three complementary outputs: personas (lively descriptions of potential users), scenarios (situations that require EMH skills), and prerequisites (required technical and organizational conditions). We collected the data using a questionnaire, co-design sessions, and interviews. The questionnaire was used to determine mental health care professionals’ characteristics, attitudes, and skill levels regarding EMH and was distributed among mental health care professionals in the Netherlands. This led to a number of recognizable subuser groups as the basis for personas. Co-design sessions with mental health care professionals resulted in further specification of the personas and an identification of different user scenarios for the game-based training environment. Interviews with mental health care professionals helped to determine the preferences of mental health care professionals regarding training in EMH and the technical and organizational conditions required for the prospective game-based training environment to be used in practice. This combination of requirement elicitation methods allows for a good representation of the target population in terms of both a broad view of user needs (through the large N questionnaire) and an in-depth understanding of specific design requirements (through interviews and co-design). Results: The questionnaire was filled by 432 respondents; three co-design sessions with mental health care professionals and 17 interviews were conducted. The data have been analyzed, and a full paper on the results is expected to be submitted in the first half of 2021. Conclusions: To develop an environment that can effectively support professionals’ EMH skill development, it is important to offer training possibilities that address the specific needs of mental health care professionals. The approach described in this protocol incorporates elements that enable the design of a playful training environment that is user driven and flexible and considers the technical and organizational prerequisites that influence its implementation in practice. It describes a protocol that is replicable and provides a methodology for user requirements analyses in other projects and health care areas

Paramagnetic effect in YBaCuO grain boundary junctions

A detailed investigation of the magnetic response of YBaCuO grain boundary Josephson junctions has been carried out using both radio-frequency measurements and Scanning SQUID Microscopy. In a nominally zero-field-cooled regime we observed a paramagnetic response at low external fields for 45 degree asymmetric grain boundaries. We argue that the observed phenomenology results from the d-wave order parameter symmetry and depends on Andreev bound states.Comment: To be published in Phys. Rev.

Examples of superconducting technology application: sensing and interfacing

Technological processes for the fabrication of low- and high- Tc Josephson junctions, aimed for certain applications, are described. On the one hand, the integration of low- Tc superconductor digital electronics with superconducting sensor arrays enables input signal processing with quantum limited resolution at millikelvin temperatures. We describe this mixed signal superconductor technology for analogue sensor readout and signal multiplexing for operating temperatures down to 300 mK. On the other hand, by making use of modern high- Tc Josephson junction technology, sensitive magnetometers, which require a modest cooling power, can be developed. Examples of the application of the mentioned processes are shown