1,586 research outputs found
Understanding the Random Displacement Model: From Ground-State Properties to Localization
We give a detailed survey of results obtained in the most recent half decade
which led to a deeper understanding of the random displacement model, a model
of a random Schr\"odinger operator which describes the quantum mechanics of an
electron in a structurally disordered medium. These results started by
identifying configurations which characterize minimal energy, then led to
Lifshitz tail bounds on the integrated density of states as well as a Wegner
estimate near the spectral minimum, which ultimately resulted in a proof of
spectral and dynamical localization at low energy for the multi-dimensional
random displacement model.Comment: 31 pages, 7 figures, final version, to appear in Proceedings of
"Spectral Days 2010", Santiago, Chile, September 20-24, 201
Variational analysis for a generalized spiked harmonic oscillator
A variational analysis is presented for the generalized spiked harmonic
oscillator Hamiltonian operator H, where H = -(d/dx)^2 + Bx^2+ A/x^2 +
lambda/x^alpha, and alpha and lambda are real positive parameters. The
formalism makes use of a basis provided by exact solutions of Schroedinger's
equation for the Gol'dman and Krivchenkov Hamiltonian (alpha = 2), and the
corresponding matrix elements that were previously found. For all the discrete
eigenvalues the method provides bounds which improve as the dimension of the
basis set is increased. Extension to the N-dimensional case in arbitrary
angular-momentum subspaces is also presented. By minimizing over the free
parameter A, we are able to reduce substantially the number of basis functions
needed for a given accuracy.Comment: 15 pages, 1 figur
Part of the D - dimensional Spiked harmonic oscillator spectra
The pseudoperturbative shifted - l expansion technique PSLET [5,20] is
generalized for states with arbitrary number of nodal zeros. Interdimensional
degeneracies, emerging from the isomorphism between angular momentum and
dimensionality of the central force Schrodinger equation, are used to construct
part of the D - dimensional spiked harmonic oscillator bound - states. PSLET
results are found to compare excellenly with those from direct numerical
integration and generalized variational methods [1,2].Comment: Latex file, 20 pages, to appear in J. Phys. A: Math. & Ge
Comparison of techniques for handling missing covariate data within prognostic modelling studies: a simulation study
Background: There is no consensus on the most appropriate approach to handle missing covariate data within prognostic modelling studies. Therefore a simulation study was performed to assess the effects of different missing data techniques on the performance of a prognostic model.
Methods: Datasets were generated to resemble the skewed distributions seen in a motivating breast cancer example. Multivariate missing data were imposed on four covariates using four different mechanisms; missing completely at random (MCAR), missing at random (MAR), missing not at random (MNAR) and a combination of all three mechanisms. Five amounts of incomplete cases from 5% to 75% were considered. Complete case analysis (CC), single imputation (SI) and five multiple imputation (MI) techniques available within the R statistical software were investigated: a) data augmentation (DA) approach assuming a multivariate normal distribution, b) DA assuming a general location model, c) regression switching imputation, d) regression switching with predictive mean matching (MICE-PMM) and e) flexible additive imputation models. A Cox proportional hazards model was fitted and appropriate estimates for the regression coefficients and model performance measures were obtained.
Results: Performing a CC analysis produced unbiased regression estimates, but inflated standard errors, which affected the significance of the covariates in the model with 25% or more missingness. Using SI, underestimated the variability; resulting in poor coverage even with 10% missingness. Of the MI approaches, applying MICE-PMM produced, in general, the least biased estimates and better coverage for the incomplete covariates and better model performance for all mechanisms. However, this MI approach still produced biased regression coefficient estimates for the incomplete skewed continuous covariates when 50% or more cases had missing data imposed with a MCAR, MAR or combined mechanism. When the missingness depended on the incomplete covariates, i.e. MNAR, estimates were biased with more than 10% incomplete cases for all MI approaches.
Conclusion: The results from this simulation study suggest that performing MICE-PMM may be the preferred MI approach provided that less than 50% of the cases have missing data and the missing data are not MNAR
PT-symetrically regularized Eckart,Poeschl-Teller and Hulthen potentials
Version 1: The well known Eckart's singular s-wave potential is
PT-symmetrically regularized and continued to the whole real line. The new
model remains exactly solvable and its bound states remain proportional to
Jacobi polynomials. Its real and discrete spectrum exhibits several unusual
features.
Version 2: Parity times time-reversal symmetry of complex Hamiltonians with
real spectra is usually interpreted as a weaker mathematical substitute for
Hermiticity. Perhaps an equally important role is played by the related
strengthened analyticity assumptions. In a constructive illustration we
complexify a few potentials solvable only in s-wave. Then we continue their
domain from semi-axis to the whole axis and get the new exactly solvable
models. Their energies come out real as expected. The new one-dimensional
spectra themselves differ quite significantly from their s-wave predecessors.Comment: Original 10-page letter ``PT-symmetrized exact solution of the
singular Eckart oscillator" is extended to a full pape
Ground-State of Charged Bosons Confined in a Harmonic Trap
We study a system composed of N identical charged bosons confined in a
harmonic trap. Upper and lower energy bounds are given. It is shown in the
large N limit that the ground-state energy is determined within an accuracy of
and that the mean field theory provides a reasonable result with
relative error of less than 16% for the binding energy .Comment: 15 page
Multiple imputation for estimating hazard ratios and predictive abilities in case-cohort surveys
<p>Abstract</p> <p>Background</p> <p>The weighted estimators generally used for analyzing case-cohort studies are not fully efficient and naive estimates of the predictive ability of a model from case-cohort data depend on the subcohort size. However, case-cohort studies represent a special type of incomplete data, and methods for analyzing incomplete data should be appropriate, in particular multiple imputation (MI).</p> <p>Methods</p> <p>We performed simulations to validate the MI approach for estimating hazard ratios and the predictive ability of a model or of an additional variable in case-cohort surveys. As an illustration, we analyzed a case-cohort survey from the Three-City study to estimate the predictive ability of D-dimer plasma concentration on coronary heart disease (CHD) and on vascular dementia (VaD) risks.</p> <p>Results</p> <p>When the imputation model of the phase-2 variable was correctly specified, MI estimates of hazard ratios and predictive abilities were similar to those obtained with full data. When the imputation model was misspecified, MI could provide biased estimates of hazard ratios and predictive abilities. In the Three-City case-cohort study, elevated D-dimer levels increased the risk of VaD (hazard ratio for two consecutive tertiles = 1.69, 95%CI: 1.63-1.74). However, D-dimer levels did not improve the predictive ability of the model.</p> <p>Conclusions</p> <p>MI is a simple approach for analyzing case-cohort data and provides an easy evaluation of the predictive ability of a model or of an additional variable.</p
Centerscope
Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.
Extending colonic mucosal microbiome analysis - Assessment of colonic lavage as a proxy for endoscopic colonic biopsies
This study was supported through GI Research funds and MRC Grant Ref: MR/M00533X/1 to GH.Peer reviewedPublisher PD
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