992 research outputs found

    Instrumentation of a mounted implement dynamometer

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    Youth Voice and the Promise and Peril of Affirmative Governmentality: An Analysis of New York City’s Borough Student Advisory Councils

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    This study addresses civil society and the state’s shifting approach towards the incorporation of youth in governmental decision-making since the 1990s, and the recent ascendance of youth voice councils as a method of civic engagement. It uses the New York City Youth Leadership Council Initiative and the Borough Student Advisory Councils as case studies. Relying on the author’s ethnographic participant observation and youth-voice frameworks, the paper provides an analysis of the individual, organizational and systems level effects of the New York Department of Education’s BSAC program. Further, the paper discusses affirmative governmentality as a lens through which to critically examine the use of youth councils and youth voice initiatives. The NYC case suggests that, even as youth voice expands in municipal government, it does so in narrow, scripted ways-- forwarding a model of affirmative governmentality in the process. The analysis raises questions about the opportunities and limits of youth councils as strategies for meaningful youth politicization

    The race between education and catastrophe: creating climate-sensitive cities

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    ‘History is a race between education and catastrophe’ (Gurría, 2013). This is the essence of the climate-change dilemma in human settlements today. How can cities act effectively to live with climate change? After a century, the world is bracing for a perfect storm with burgeoning populations drifting to the cities, resulting in anthropogenic greenhouse gases multiplying exponentially. Rapid urban development breaks down natural systems that sequester greenhouse gases, making cities unhealthy, unbalanced, and undesirable (Blakely & Carbonell, 2012). It is reported that ‘more people are killed from poor urban design and climate-change than terrorism’ (Birkeland, 2008), which is an immense ethical problem. My focus is on creating resilient Climate-Sensitive-Cities¼. This approach to tackling the urgency of climate change in cities is five-fold: 1. It audits vulnerability and coping capacity. 2. It addresses audit gaps by investing in accelerated learning for professions and communities to build capacity for resilience. 3. It appreciates that every individual can make a unique contribution to interdisciplinary capacity-building for addressing climate education through their own organisations and regions. 4. It realises that accelerated learning for the long-term investment in individuals within organisations includes collaborative coaching and partnering. 5. It recognises that optimism for a preferred future can be achieved in a world full of perverse incentives. Although there are many perspectives and prescribed actions from each discipline, my approach is founded on meta-scanning, with principle-based options that emerge from broad lessons from international and local successes. The crucial part of my work is to convert research into desirable actions in a way that demonstrates learning for better climate governance. The results of my endeavours include influence of policy and practices in fourteen countries and through professional bodies across disciplines. My contribution to transformational guidelines for international climate action transparency is recognised widely. This thesis comprises an exploration of philosophies, revisiting values, seeking answers to four research questions, a new lens with three perspectives, and project design to ensure higher fidelity with my statement of intent. My Doctorate establishes a framework that enables individuals to lead the way in climate-change practices. I intend to be a living example of such frameworks. The thesis concludes with new definitions for Climate-Sensitive-Cities¼ and Accelerated Learning. It also overlays triple loop policy development with the Climate Policy in Practice Cycle¼ as a means for funding and evaluating action. Finally, a manual for Master Classes delivered across fourteen countries works with a transformational change trajectory that articulates the journey from passive bystanding, to advocacy, to tipping points, to coping with success. Independent evaluations accelerate the uptake of these skills in governments, communities, professions, and most importantly, individuals. We need to learn, question old thinking, and relearn in order to adapt and live with the many facets of climate-change. Based on this rationale, I have structured my Doctorate to advance a deeper understanding of the technical, intellectual, and interpersonal skills required of an effective Sustainability Commissioner. Alvin Toffler stated ‘the illiterate of the 21st Century will not be those who cannot read and write, but those who cannot learn, unlearn, and relearn’ (ISLS, 2013). This is how we win the race of education over catastrophe

    Life History and Narrative Analysis: Feminist Methodologies Contextualizing Black Women\u27s Experiences with Severe Mental Illness

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    This paper discusses a methodological approach to research that enhances critical analysis by contextualizing qualitative research findings within participants\u27 individual experiences. We demonstrate the combined use of life history methods and feminist narrative analysis to explore Black women\u27s everyday experiences with mental illness, from their perspectives. These interpretive methods reach beyond pathologized conceptions of identity and adjustment that often narrowly characterize mental illness among Black women. Instead, these methods holistically describe a participant\u27s experiences and strategies she uses to pursue goals and enhance her life. The use of the methods is illustrated with examples from the life narrative of Maria, a Black woman living with serious mental illness. Our findings underscore the need for rigorous, culturally appropriate methods and further research to evaluate participants\u27 standpoints and needs, and interventions to facilitate understanding and improved outcomes

    Effect of Exposure Conditions on the Long-Term Dielectric Properties of Mortar Samples Containing ASR Gel

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    Alkali-silica reaction (ASR) is a chemical reaction between alkalis present in portland cement and amorphous or otherwise disordered siliceous minerals in particular aggregates. Through this reaction, reactive silica binds with hydroxyl and alkali ions and forms a gel, known as ASR gel. Recently, microwave materials characterization techniques have shown great potential for detecting ASR in mortar. However, the comprehensive understanding of variables that affect the extent of ASR in mortar and their interaction with microwave signals, in particular the effect of environmental exposure conditions requires more investigations. Therefore, parameters related to these conditions must be considered when using microwave techniques for ASR detection and evaluation. In this paper, the effect of exposure conditions on ASR gel formation and microwave dielectric properties of mortar samples is investigated. To this end, extended measurements of the complex dielectric constants of three different sets of mortar samples are presented at S-band (2.6-3.95 GHz). The samples were cast with potentially reactive ASR-aggregates and subjected to different environmental conditions. The results show slightly different permittivities for the differently stored samples, potentially indicating different amount of ASR gel. This observation was corroborated through UV fluorescence microscopy, where different amounts of ASR gel were observed in the samples. Moreover, the results indicate that ASR gel evolution may be better tracked through loss factor measurements, while pre-existing-gel may be better detected through permittivity measurements

    Role of chromodomain helicase DNA-binding protein 2 in DNA damage response signaling and tumorigenesis.

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    The chromodomain helicase DNA-binding proteins (CHDs) are known to affect transcription through their ability to remodel chromatin and modulate histone deacetylation. In an effort to understand the functional role of the CHD2 in mammals, we have generated a Chd2 mutant mouse model. Remarkably, the Chd2 protein appears to play a critical role in the development, hematopoiesis and tumor suppression. The Chd2 heterozygous mutant mice exhibit increased extramedullary hematopoiesis and susceptibility to lymphomas. At the cellular level, Chd2 mutants are defective in hematopoietic stem cell differentiation, accumulate higher levels of the chromatin-associated DNA damage response mediator, cH2AX, and exhibit an aberrant DNA damage response after X-ray irradiation. Our data suggest a direct role for the chromatin remodeling protein in DNA damage signaling and genome stability maintenance

    Influence of the annealing ambient on structural and optical properties of rare earth implanted GaN

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    GaN films were implanted with Er and Eu ions and rapid thermal annealing was performed at 1000, 1100 and 1200 ⁰C in vacuum, in flowing nitrogen gas or a mixture of NH₃ and N₂. Rutherford backscattering spectrometry in the channeling mode was used to study the evolution of damage introduction and recovery in the Ga sublattice and to monitor the rare earth profiles after annealing. The surface morphology of the samples was analyzed by scanning electron microscopy and the optical properties by room temperature cathodoluminescence (CL). Samples annealed in vacuum and N₂ already show the first signs of surface dissociation at 1000 ⁰C. At higher temperature, Ga droplets form, at the surface. However, samples annealed in NH₃+N₂ exhibit a very good recovery of the lattice along with a smooth surface. These samples also show the strongest CL intensity for the rare earth related emissions in the green (for Er) and red (for Eu). After annealing at 1200 ⁰C in NH₃+N₂ the Eu implanted sample reveals the channeling qualities of an unimplanted sample and a strong increase of CL intensity is observed

    Exosomes: From potential culprits to new therapeutic promise in the setting of cardiac fibrosis

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    Fibrosis is a significant global health problem associated with many inflammatory and degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis develops when extracellular matrix (ECM) remodeling becomes excessive or uncontrolled and is associated with nearly all forms of heart disease. Cardiac fibroblasts and myofibroblasts are the main effectors of ECM deposition and scar formation. The heart is a complex multicellular organ, where the various resident cell types communicate between themselves and with cells of the blood and immune systems. Exosomes, which are small extracellular vesicles, (EVs), contribute to cell-to-cell communication and their pathophysiological relevance and therapeutic potential is emerging. Here, we will critically review the role of endogenous exosomes as possible fibrosis mediators and discuss the possibility of using stem cell-derived and/or engineered exosomes as anti-fibrotic agents
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