A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats

Abstract: Naked mole rats (NMRs) are subterranean eusocial mammals, known for their virtual absence of aging in their first 20 to 30 years of life, and their apparent resistance to cancer development. As such, this species has become an important biological model for investigating the physiological and molecular mechanisms behind cancer resistance. Two recent studies have discovered middle and late-aged worker (that is, non-breeding) NMRs in captive populations exhibiting neoplasms, consistent with cancer development, challenging the claim that NMRs are cancer resistant. These cases are possibly artefacts of inbreeding or certain rearing conditions in captivity, but they are also consistent with evolutionary theory.We present field data showing that worker NMRs live on average for 1 to 2 years. This, together with considerable knowledge about the biology of this species, provides the basis for an evolutionary explanation for why debilitating cancers in NMRs should be rare in captive populations and absent in the wild. Whereas workers are important for maintaining tunnels, colony defence, brood care, and foraging, they are highly vulnerable to predation. However, surviving workers either replace dead breeders, or assume other less active functions whilst preparing for possible dispersal. These countervailing forces (selection resulting in aging due to early-life investments in worker function, and selection for breeder longevity) along with the fact that all breeders derive from the worker morph, can explain the low levels of cancer observed by these recent studies in captive colonies. Because workers in the field typically never reach ages where cancer becomes a risk to performance or mortality, those rare observations of neoplastic growth should be confined to the artificial environments where workers survive to ages rarely if ever occurring in the wild. Thus, we predict that the worker phenotype fortuitously benefits from anti-aging and cancer protection in captive populations

An Independent Derivation of the Oxford Jet Kinetic Luminosity Formula

This letter presents a theoretical derivation of an estimate for a radio source jet kinetic luminosity. The expression yields jet powers that are quantitatively similar to a more sophisticated empirical relation published by the Willott, Blundell and Rawlings at Oxford. The formula allows one to estimate the jet kinetic luminosity from the measurement of the optically thin radio lobe emission in quasars and radio galaxies. Motivated by recent X-ray observation, the derivation assumes that most of the energy in the lobes is in plasma thermal energy with a negligible contribution from magnetic energy (not equipartition). The close agreement of the two independent expressions makes the veracity of these estimates seem very plausible.Comment: To appear in ApJ Letter

Vortex shear effects in layered superconductors

Motivated by recent transport and magnetization measurements in BSCCO samples [B. Khaykovich et. al., Phys. Rev. B 61, R9261 (2000)], we present a simple macroscopic model describing effects of inhomogeneous current distribution and shear in a layered superconductor. Parameters of the model are deduced from a microscopic calculation. Our model accounts for the strong current non-linearities and the re-entrant temperature dependence observed in the experiment.Comment: 11 pages, 7 figures, submitted to Phys. Rev.

Microscopic derivation of Ginzburg-Landau equations for coexistent states of superconductivity and magnetism

Ginzburg-Landau (GL) equations for the coexistent states of superconductivity and magnetism are derived microscopically from the extended Hubbard model with on-site repulsive and nearest-neighbor attractive interactions. In the derived GL free energy a cubic term that couples the spin-singlet and spin-triplet components of superconducting order parameters (SCOP) with magnetization exists. This term gives rise to a spin-triplet SCOP near the interface between a spin-singlet superconductor and a ferromagnet, consistent with previous theoretical studies based on the Bogoliubov de Gennes method and the quasiclassical Green's function theory. In coexistent states of singlet superconductivity and antiferromagnetism it leads to the occurrence of pi-triplet SCOPs.Comment: 18 page

The 74MHz System on the Very Large Array

The Naval Research Laboratory and the National Radio Astronomy Observatory completed implementation of a low frequency capability on the VLA at 73.8 MHz in 1998. This frequency band offers unprecedented sensitivity (~25 mJy/beam) and resolution (~25 arcsec) for low-frequency observations. We review the hardware, the calibration and imaging strategies, comparing them to those at higher frequencies, including aspects of interference excision and wide-field imaging. Ionospheric phase fluctuations pose the major difficulty in calibrating the array. Over restricted fields of view or at times of extremely quiescent ionospheric ``weather'', an angle-invariant calibration strategy can be used. In this approach a single phase correction is devised for each antenna, typically via self-calibration. Over larger fields of view or at times of more normal ionospheric ``weather'' when the ionospheric isoplanatic patch size is smaller than the field of view, we adopt a field-based strategy in which the phase correction depends upon location within the field of view. This second calibration strategy was implemented by modeling the ionosphere above the array using Zernike polynomials. Images of 3C sources of moderate strength are provided as examples of routine, angle-invariant calibration and imaging. Flux density measurements indicate that the 74 MHz flux scale at the VLA is stable to a few percent, and tied to the Baars et al. value of Cygnus A at the 5 percent level. We also present an example of a wide-field image, devoid of bright objects and containing hundreds of weaker sources, constructed from the field-based calibration. We close with a summary of lessons the 74 MHz system offers as a model for new and developing low-frequency telescopes. (Abridged)Comment: 73 pages, 46 jpeg figures, to appear in ApJ

Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET‐DD) study, a collaborative study carried out in 14 countries

Aims To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries. Methods People with diabetes aged 18–65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected. Results A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (PPPPP<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0–29.6%). Conclusions Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes

Prognostic value of estimated glomerular filtration rate in hospitalised older patients (over 65) with COVID-19 : a multicentre, European, observational cohort study

Acknowledgements: COPE Team Members (collaborators). Funding: No funding declared for this study. The Study was sponsored by Cardiff University who had no role on the study design, analysis or interpretation of the findings. BC is partially supported by the NIHR Maudsley Biomedical Research Centre at South London Maudsley NHS Foundation Trust, and King's College London. EAR received the Gwyn Seymour Scholarship from the Department of Medicine for the Elderly, NHS Grampian, as part of the Aberdeen Summer Research Scholarship Scheme, Aberdeen Clinical Academic Training Programme, University of Aberdeen.Peer reviewedPublisher PD

Deep Low-Frequency Radio Observations of the NOAO Bootes Field: I. Data Reduction and Catalog Construction

In this article we present deep, high-resolution radio interferometric observations at 153 MHz to complement the extensively studied NOAO Bootes field. We provide a description of the observations, data reduction and source catalog construction. From our single pointing GMRT observation of ~12 hours we obtain a high-resolution (26" x 22") image of ~11.3 square degrees, fully covering the Bootes field region and beyond. The image has a central noise level of ~1.0 mJy/beam, which rises to 2.0-2.5 mJy/beam at the field edge, placing it amongst the deepest ~150 MHz surveys to date. The catalog of 598 extracted sources is estimated to be ~92 percent complete for >10 mJy sources, while the estimated contamination with false detections is <1 percent. The low RMS position uncertainty of 1.24" facilitates accurate matching against catalogs at optical, infrared and other wavelengths. Differential source counts are determined down to <~10 mJy. There is no evidence for flattening of the counts towards lower flux densities as observed in deep radio surveys at higher frequencies, suggesting that our catalog is dominated by the classical radio-loud AGN population that explains the counts at higher flux densities. Combination with available deep 1.4 GHz observations yields an accurate determination of spectral indices for 417 sources down to the lowest 153 MHz flux densities, of which 16 have ultra-steep spectra with spectral indices below -1.3. We confirm that flattening of the median spectral index towards low flux densities also occurs at this frequency. The detection fraction of the radio sources in NIR Ks-band is found to drop with radio spectral index, which is in agreement with the known correlation between spectral index and redshift for brighter radio sources.Comment: 14 pages, 7 figures. Accepted for publication by A&A. Source catalog will be available from CDS soo