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A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats
Abstract: Naked mole rats (NMRs) are subterranean eusocial mammals, known for their virtual absence of aging in their first 20 to 30 years of life, and their apparent resistance to cancer development. As such, this species has become an important biological model for investigating the physiological and molecular mechanisms behind cancer resistance. Two recent studies have discovered middle and late-aged worker (that is, non-breeding) NMRs in captive populations exhibiting neoplasms, consistent with cancer development, challenging the claim that NMRs are cancer resistant. These cases are possibly artefacts of inbreeding or certain rearing conditions in captivity, but they are also consistent with evolutionary theory.We present field data showing that worker NMRs live on average for 1 to 2 years. This, together with considerable knowledge about the biology of this species, provides the basis for an evolutionary explanation for why debilitating cancers in NMRs should be rare in captive populations and absent in the wild. Whereas workers are important for maintaining tunnels, colony defence, brood care, and foraging, they are highly vulnerable to predation. However, surviving workers either replace dead breeders, or assume other less active functions whilst preparing for possible dispersal. These countervailing forces (selection resulting in aging due to early-life investments in worker function, and selection for breeder longevity) along with the fact that all breeders derive from the worker morph, can explain the low levels of cancer observed by these recent studies in captive colonies. Because workers in the field typically never reach ages where cancer becomes a risk to performance or mortality, those rare observations of neoplastic growth should be confined to the artificial environments where workers survive to ages rarely if ever occurring in the wild. Thus, we predict that the worker phenotype fortuitously benefits from anti-aging and cancer protection in captive populations
An Independent Derivation of the Oxford Jet Kinetic Luminosity Formula
This letter presents a theoretical derivation of an estimate for a radio
source jet kinetic luminosity. The expression yields jet powers that are
quantitatively similar to a more sophisticated empirical relation published by
the Willott, Blundell and Rawlings at Oxford. The formula allows one to
estimate the jet kinetic luminosity from the measurement of the optically thin
radio lobe emission in quasars and radio galaxies. Motivated by recent X-ray
observation, the derivation assumes that most of the energy in the lobes is in
plasma thermal energy with a negligible contribution from magnetic energy (not
equipartition). The close agreement of the two independent expressions makes
the veracity of these estimates seem very plausible.Comment: To appear in ApJ Letter
Vortex shear effects in layered superconductors
Motivated by recent transport and magnetization measurements in BSCCO samples
[B. Khaykovich et. al., Phys. Rev. B 61, R9261 (2000)], we present a simple
macroscopic model describing effects of inhomogeneous current distribution and
shear in a layered superconductor. Parameters of the model are deduced from a
microscopic calculation. Our model accounts for the strong current
non-linearities and the re-entrant temperature dependence observed in the
experiment.Comment: 11 pages, 7 figures, submitted to Phys. Rev.
Microscopic derivation of Ginzburg-Landau equations for coexistent states of superconductivity and magnetism
Ginzburg-Landau (GL) equations for the coexistent states of superconductivity
and magnetism are derived microscopically from the extended Hubbard model with
on-site repulsive and nearest-neighbor attractive interactions. In the derived
GL free energy a cubic term that couples the spin-singlet and spin-triplet
components of superconducting order parameters (SCOP) with magnetization
exists. This term gives rise to a spin-triplet SCOP near the interface between
a spin-singlet superconductor and a ferromagnet, consistent with previous
theoretical studies based on the Bogoliubov de Gennes method and the
quasiclassical Green's function theory. In coexistent states of singlet
superconductivity and antiferromagnetism it leads to the occurrence of
pi-triplet SCOPs.Comment: 18 page
The 74MHz System on the Very Large Array
The Naval Research Laboratory and the National Radio Astronomy Observatory
completed implementation of a low frequency capability on the VLA at 73.8 MHz
in 1998. This frequency band offers unprecedented sensitivity (~25 mJy/beam)
and resolution (~25 arcsec) for low-frequency observations. We review the
hardware, the calibration and imaging strategies, comparing them to those at
higher frequencies, including aspects of interference excision and wide-field
imaging. Ionospheric phase fluctuations pose the major difficulty in
calibrating the array. Over restricted fields of view or at times of extremely
quiescent ionospheric ``weather'', an angle-invariant calibration strategy can
be used. In this approach a single phase correction is devised for each
antenna, typically via self-calibration. Over larger fields of view or at times
of more normal ionospheric ``weather'' when the ionospheric isoplanatic patch
size is smaller than the field of view, we adopt a field-based strategy in
which the phase correction depends upon location within the field of view. This
second calibration strategy was implemented by modeling the ionosphere above
the array using Zernike polynomials. Images of 3C sources of moderate strength
are provided as examples of routine, angle-invariant calibration and imaging.
Flux density measurements indicate that the 74 MHz flux scale at the VLA is
stable to a few percent, and tied to the Baars et al. value of Cygnus A at the
5 percent level. We also present an example of a wide-field image, devoid of
bright objects and containing hundreds of weaker sources, constructed from the
field-based calibration. We close with a summary of lessons the 74 MHz system
offers as a model for new and developing low-frequency telescopes. (Abridged)Comment: 73 pages, 46 jpeg figures, to appear in ApJ
A three-arm randomised controlled trial comparing Gonadotrophin Releasing Hormone (GnRH) agonist long regimen versus GnRH agonist short regimen versus GnRH antagonist regimen in women with a history of poor ovarian response undergoing in vitro fertilisation (IVF) treatment: Poor responders intervention trial (PRINT)
Prevalence and correlates of depressive disorders in people with Type 2 diabetes: results from the International Prevalence and Treatment of Diabetes and Depression (INTERPRET‐DD) study, a collaborative study carried out in 14 countries
Aims
To assess the prevalence and management of depressive disorders in people with Type 2 diabetes in different countries.
Methods
People with diabetes aged 18–65 years and treated in outpatient settings were recruited in 14 countries and underwent a psychiatric interview. Participants completed the Patient Health Questionnaire and the Problem Areas in Diabetes scale. Demographic and medical record data were collected.
Results
A total of 2783 people with Type 2 diabetes (45.3% men, mean duration of diabetes 8.8 years) participated. Overall, 10.6% were diagnosed with current major depressive disorder and 17.0% reported moderate to severe levels of depressive symptomatology (Patient Health Questionnaire scores >9). Multivariable analyses showed that, after controlling for country, current major depressive disorder was significantly associated with gender (women) (PPPPP<0.0001). The proportion of those with either current major depressive disorder or moderate to severe levels of depressive symptomatology who had a diagnosis or any treatment for their depression recorded in their medical records was extremely low and non-existent in many countries (0–29.6%).
Conclusions
Our international study, the largest of this type ever undertaken, shows that people with diabetes frequently have depressive disorders and also significant levels of depressive symptoms. Our findings indicate that the identification and appropriate care for psychological and psychiatric problems is not the norm and suggest a lack of the comprehensive approach to diabetes management that is needed to improve clinical outcomes
Prognostic value of estimated glomerular filtration rate in hospitalised older patients (over 65) with COVID-19 : a multicentre, European, observational cohort study
Acknowledgements: COPE Team Members (collaborators). Funding: No funding declared for this study. The Study was sponsored by Cardiff University who had no role on the study design, analysis or interpretation of the findings. BC is partially supported by the NIHR Maudsley Biomedical Research Centre at South London Maudsley NHS Foundation Trust, and King's College London. EAR received the Gwyn Seymour Scholarship from the Department of Medicine for the Elderly, NHS Grampian, as part of the Aberdeen Summer Research Scholarship Scheme, Aberdeen Clinical Academic Training Programme, University of Aberdeen.Peer reviewedPublisher PD
Deep Low-Frequency Radio Observations of the NOAO Bootes Field: I. Data Reduction and Catalog Construction
In this article we present deep, high-resolution radio interferometric
observations at 153 MHz to complement the extensively studied NOAO Bootes
field. We provide a description of the observations, data reduction and source
catalog construction. From our single pointing GMRT observation of ~12 hours we
obtain a high-resolution (26" x 22") image of ~11.3 square degrees, fully
covering the Bootes field region and beyond. The image has a central noise
level of ~1.0 mJy/beam, which rises to 2.0-2.5 mJy/beam at the field edge,
placing it amongst the deepest ~150 MHz surveys to date. The catalog of 598
extracted sources is estimated to be ~92 percent complete for >10 mJy sources,
while the estimated contamination with false detections is <1 percent. The low
RMS position uncertainty of 1.24" facilitates accurate matching against
catalogs at optical, infrared and other wavelengths. Differential source counts
are determined down to <~10 mJy. There is no evidence for flattening of the
counts towards lower flux densities as observed in deep radio surveys at higher
frequencies, suggesting that our catalog is dominated by the classical
radio-loud AGN population that explains the counts at higher flux densities.
Combination with available deep 1.4 GHz observations yields an accurate
determination of spectral indices for 417 sources down to the lowest 153 MHz
flux densities, of which 16 have ultra-steep spectra with spectral indices
below -1.3. We confirm that flattening of the median spectral index towards low
flux densities also occurs at this frequency. The detection fraction of the
radio sources in NIR Ks-band is found to drop with radio spectral index, which
is in agreement with the known correlation between spectral index and redshift
for brighter radio sources.Comment: 14 pages, 7 figures. Accepted for publication by A&A. Source catalog
will be available from CDS soo
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