Musculoskeletal evaluation in severe haemophilia A patients from Latin America

There is a paucity of literature on haemophilia treatment in Latin American countries, a region characterized by rapidly improving systems of care, but with substantial disparities in treatment between countries. The aim of this study was to evaluate the musculoskeletal status of haemophilia patients from Latin America and to examine the relationship between musculoskeletal status and treatment practices across countries. The Committee of Latin America on the Therapeutics of Inhibitor Groups conducted a survey of its member country representatives on key aspects of haemophilia treatment in 10 countries. Musculoskeletal status of patients was obtained during routine comprehensive evaluations between March 2009 and March 2011. Eligible patients had severe haemophilia A (factor VIII <1%) without inhibitors (<0.6 BU mL−1) and were ≥5 years of age. Musculoskeletal status was compared between three groups of countries, based primarily on differences in the availability of long‐term prophylaxis. Overall, 143 patients (5–66 years of age) were enrolled from nine countries. In countries where long‐term prophylaxis had been available for at least 10 years (Group A), patients aged 5–10 years had significantly better mean World Federation of Hemophilia clinical scores, fewer target joints and fewer affected joints than patients from countries where long‐term prophylaxis has been available for about 5 years (Group B) or was not available (Group C). In Latin America, the musculoskeletal status of patients with severe haemophilia without inhibitors has improved significantly in association with the provision of long‐term prophylaxis. As more countries in Latin America institute this practice, further improvements are anticipated

Percepción de los formadores colegiales sobre el futuro profesional de esta nueva figura laboral en la farmacia comunitaria

Objetivo: Explorar la percepción de Formadores Colegiales con experiencia previa sobre su formación y sus funciones futurasen la implantación y sostenibilidad del servicio de Seguimiento Farmacoterapéutico en el ámbito de la farmacia comunitariaespañola. Método: Estudio cualitativo mediante la técnica del grupo focal. El coordinador de la reunión focal utilizó un guión temáticopreviamente elaborado que permitía explorar la opinión de los Formadores Colegiales sobre sus experiencias y percepciones acercadel futuro de esta nueva figura profesional. El contenido de la conversación fue registrado en una grabadora, transcrito en su totalidady posteriormente analizado mediante análisis de contenido. Resultados: La reunión grupal celebrada en la sede del Consejo General de Colegios Oficiales de Farmacéuticos, en Madrid, tuvo unaduración de 95 minutos. Participaron seis Formadores Colegiales. En función de los temas tratados se identificaron dos dimensiones;una primera que abarca las funciones que debe desempeñar un Formador Colegial (resaltando la función de motivador, facilitadorde la comunicación y formador metodológico y clínico) y una segunda en las que se describen las características que ese profesionaldebe tener para poder realizar su papel facilitador (entre las que destacan que debe ser un profesional contratado por el Colegio deFarmacéuticos correspondiente, con lugar físico de trabajo dentro del mismo, y con jornada laboral completa y flexible, entre otrascaracterísticas). Conclusiones: El presente artículo aporta información relevante sobre la figura innovadora del Formador Colegial, describiendo lascaracterísticas intrínsecas necesarias para desarrollar su labor y las funciones a desempeñar. Dicha información debería ser utilizadapor aquellos Colegios Oficiales de Farmacéuticos provinciales que deseen implantar Servicios Profesionales Farmacéuticos, talescomo el servicio de Seguimiento Farmacoterapéutico

Percepción de los formadores colegiales sobre el futuro profesional de esta nueva figura laboral en la farmacia comunitaria

Objetivo: Explorar la percepción de Formadores Colegiales con experiencia previa sobre su formación y sus funciones futurasen la implantación y sostenibilidad del servicio de Seguimiento Farmacoterapéutico en el ámbito de la farmacia comunitariaespañola. Método: Estudio cualitativo mediante la técnica del grupo focal. El coordinador de la reunión focal utilizó un guión temáticopreviamente elaborado que permitía explorar la opinión de los Formadores Colegiales sobre sus experiencias y percepciones acercadel futuro de esta nueva figura profesional. El contenido de la conversación fue registrado en una grabadora, transcrito en su totalidady posteriormente analizado mediante análisis de contenido. Resultados: La reunión grupal celebrada en la sede del Consejo General de Colegios Oficiales de Farmacéuticos, en Madrid, tuvo unaduración de 95 minutos. Participaron seis Formadores Colegiales. En función de los temas tratados se identificaron dos dimensiones;una primera que abarca las funciones que debe desempeñar un Formador Colegial (resaltando la función de motivador, facilitadorde la comunicación y formador metodológico y clínico) y una segunda en las que se describen las características que ese profesionaldebe tener para poder realizar su papel facilitador (entre las que destacan que debe ser un profesional contratado por el Colegio deFarmacéuticos correspondiente, con lugar físico de trabajo dentro del mismo, y con jornada laboral completa y flexible, entre otrascaracterísticas). Conclusiones: El presente artículo aporta información relevante sobre la figura innovadora del Formador Colegial, describiendo lascaracterísticas intrínsecas necesarias para desarrollar su labor y las funciones a desempeñar. Dicha información debería ser utilizadapor aquellos Colegios Oficiales de Farmacéuticos provinciales que deseen implantar Servicios Profesionales Farmacéuticos, talescomo el servicio de Seguimiento Farmacoterapéutico

Food and nutrition security discursive frames in the context of the Spanish economic crisis

[EN] The recent economic crisis in Spain has provoked a number of food and nutrition security (FNS) impacts that have fuelled a fragmented landscape of food-related debates, although these have not taken the form of a coherent and allembracing public discussion on national food security. This paper is an inductive analysis of such debates, mostly based on media coverage, in an attempt to disentangle the different discourse frames on FNS in Spain, and the role played by the economic crisis in the shaping and underpinning of such frames. For this purpose a frame matrix was constructed, paying particular attention to the stakeholders governance claims in order to confront frame-specific problems. Results show how stakeholders have used elements of the crisis to underpin or reinterpret their core arguments. In addition, governance claims have concentrated on the malfunctioning of the food chain, mostly due to unequal bargaining power, and the way this could be putting at risk crucial components of the food system and future FNS. Also, the short-termism of most stakeholders approaches obscures the long run threats to the Spanish food system.This research is part of the project "Assessment of the impact of global drivers of change on Europe's food security" (TRANSMANGO), granted by the EU under 7th Framework Programme, theme KBBE.2013.2.5-01, Grant agreement no: 613532. Authors gratefully appreciate the comments and suggestions made by the three anonymous reviewers and the editors of the Journal.OOrtiz Miranda, D.; Moreno Pérez, OM.; Arnalte Alegre, EV. (2016). Food and nutrition security discursive frames in the context of the Spanish economic crisis. Food Security. 8(3):665-677. https://doi.org/10.1007/s12571-016-0574-xS66567783Antentas, J. M., & Vivas, E. (2014). Impacto de la crisis en el derecho a una alimentación sana y saludable. Informe SESPAS 2014. Gaceta Sanitaria, 28(S1), 58–61.Brunori, G., Malandrin, V., & Rossi, A. (2013). Trade-off or convergence? The role of food security in the evolution of food discourse in Italy. Journal of Rural Studies, 29, 19–29.Candel, J. J., Breeman, G. E., Stiller, S. J., & Termeer, C. J. (2014). Disentangling the consensus frame of food security: the case of the EU common agricultural policy reform debate. Food Policy, 44, 47–58.CFS – Committee on World Food Security (2012). Coming to Terms with Terminology. http://www.fao.org/fsnforum/sites/default/files/file/Terminology/MD776(CFS___Coming_to_terms_with_Terminology).pdf . Accessed 6 Oct 2015.Cussó, X., & Garrabou, R. (2009). Dieta mediterránea y transición nutricional moderna en España. In L. G. Zubero, R. H. García, & J. M. Lázaro (Eds.), Economía Alimentaria en España durante el siglo XX (pp. 25–63). Madrid: MARM.De Schutter, O. (2014). The specter of productivism and food democracy. Wisconsin Law Review, 199, 199–233.DEFRA (2008). Ensuring the UK’s food security in a changing world. London: A Defra Discussion Paper.Díaz-Méndez, C., & Gómez-Benito, C. (2010). Nutrition and the Mediterranean diet. A historical and sociological analysis of the concept of a “healthy diet” in Spanish society. Food Policy, 35(5), 437–447.Dibden, J., Gibbs, D., & Cocklin, C. (2013). Framing GM crops as food security solution. Journal of Rural Studies, 29, 59–70.Ericksen, P. J. (2008). Conceptualizing food systems for global environmental change research. Global Environmental Change, 18, 234–245.FAO (2014). The State of the World’s Land and Water Resources for Food and Agriculture. http://www.fao.org/nr/solaw/maps-and-graphs/en/ . Accessed 25 Feb 2015.Fish, R., Lobley, M., & Winter, M. (2013). A license to produce? Farmer interpretations of the new food security agenda. Journal of Rural Studies, 29, 40–49.Grando, S., & Colombo, L. (2015). National Report. Italy. WP2 report Transmango EU-FP7.GREENPEACE (2014). Alimentos bajo amenaza. Valor económico de la polinización y vulnerabilidad de la agricultura española ante el declive de las abejas y otros polinizadores. Madrid: Greenpeace.Hertel, T. W. (2015). The challenges of sustainably feeding a growing planet. Food Security, 7, 185–198.Hispacoop (2012). Estudio sobre desperdicio de alimentos en los hogares. Madrid: Confederación Española de Cooperativas de Consumidores y Usuarios.Lang, T., & Heasman, M. (2004). Food wars. The global battle for mouths, Minds and Markets. London: Earthscan.Lawrence, G., & McMichael, P. (2012). The question of food security. International Journal of Sociology of Agriculture & Food, 19(2), 135–142.MAGRAMA. (2014). La balanza commercial agroalimentaria en 2013. Madrid.Maye, D., & Kirwan, J. (2013). Food security: a fractured consensus. Journal of Rural Studies, 29, 1–6.McKeon, N. (2015). Food security governance: empowering communities, regulating corporations. New York: Routledge.Mooney, P. H., & Hunt, S. A. (2009). Food security: the elaboration of contested claims to a consensus frame. Rural Sociology, 74(4), 469–497.Moreno, O. (2013). Reproducing productivism in Spanish agricultural systems. In D. Ortiz, A. Moragues, & E. Arnalte (Eds.), Agriculture in Mediterranean Europe: between old and new paradigms. Research in rural sociology and development (pp. 121–147). Bingley: Emerald Group Publishing Limited.Muñoz, C., & Sosvilla, S. (2014). Alimentamos el futuro. Informe económico 2013. Madrid: FIAB.OECC - Oficina Española de Cambio Climático (2006). Plan Nacional de Adaptación al Cambio Climático. Madrid.OECC-UCLM (2005). Evaluación Preliminar de los Impactos en España por Efecto del Cambio Climático. Madrid: MAGRAMA.Pangaribowo, E. H., Gerber, N., & Torero, M. (2013). Food and Nutrition Security Indicators: A Review. ZEF working paper no 108. Bonn: ZEF.Sáez-Almendros, S., Obrador, B., Bach-Faig, A., & Serra-Majem, L. (2013). Environmental footprints of Mediterranean versus Western dietary patterns: beyond the health benefits of the Mediterranean diet. Environmental Health, 12, 118.Shepherd, B. (2012). Thinking critically about food security. Security Dialogue, 43(3), 195–212.Sineiro, F. (2012). Situación actual, retos y perspectivas del vacuno de leche. Available at http://www.eumedia.es/portales/files/documentos/2-FSineiro.pdf . Accessed 19 Nov 2015.Van Gorp, B. (2007). The constructionist approach to framing: bringing culture back. Journal of Communication, 57, 60–78.Van Gorp, B., & van der Goot, M. J. (2012). Sustainable food and agriculture: Stakeholder’s frames. Communication, Culture & Critique, 5, 127–148.Vidal, R., Moliner, E., Pikula, A., Mena-Nieto, A., & Ortega, A. (2015). Comparison of the carbon footprint of different patient diets in a Spanish hospital. Journal of Health Services Research & Policy, 20(1), 39–44

Social sciences research in neglected tropical diseases 2: A bibliographic analysis

The official published version of the article can be found at the link below.Background There are strong arguments for social science and interdisciplinary research in the neglected tropical diseases. These diseases represent a rich and dynamic interplay between vector, host, and pathogen which occurs within social, physical and biological contexts. The overwhelming sense, however, is that neglected tropical diseases research is a biomedical endeavour largely excluding the social sciences. The purpose of this review is to provide a baseline for discussing the quantum and nature of the science that is being conducted, and the extent to which the social sciences are a part of that. Methods A bibliographic analysis was conducted of neglected tropical diseases related research papers published over the past 10 years in biomedical and social sciences. The analysis had textual and bibliometric facets, and focussed on chikungunya, dengue, visceral leishmaniasis, and onchocerciasis. Results There is substantial variation in the number of publications associated with each disease. The proportion of the research that is social science based appears remarkably consistent (<4%). A textual analysis, however, reveals a degree of misclassification by the abstracting service where a surprising proportion of the "social sciences" research was pure clinical research. Much of the social sciences research also tends to be "hand maiden" research focused on the implementation of biomedical solutions. Conclusion There is little evidence that scientists pay any attention to the complex social, cultural, biological, and environmental dynamic involved in human pathogenesis. There is little investigator driven social science and a poor presence of interdisciplinary science. The research needs more sophisticated funders and priority setters who are not beguiled by uncritical biomedical promises

A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis

This work was partially supported by the CENIT program from the Centro Tecnológico Industrial (CEN-20091016), grants from the Spanish Institute of Health Carlos III (ADE10/00026, PI09/02444, PI12/00511, Acción Transversal de Cáncer) grants from the Fondo de Investigacion Sanitaria/FEDER (08/1276, 08/0024, PS09/02368, 11/00219, 11/00681), and by COST office through COST action BM1206. SCB is supported by contracts from the Fondo de Investigación Sanitaria (CP 03-0070). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Centro Tecnológico IndustrialInstituto de Salud Carlos IIIFondo de Investigación Sanitaria / FEDE

Revealing the last 13,500 years of environmental history from the multiproxy record of a mountain lake (Lago Enol, northern Iberian Peninsula)

This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s10933-009-9387-7.We present the Holocene sequence from Lago Enol (43°16′N, 4°59′W, 1,070 m a.s.l.), Cantabrian Mountains, northern Spain. A multiproxy analysis provided comprehensive information about regional humidity and temperature changes. The analysis included sedimentological descriptions, physical properties, organic carbon and carbonate content, mineralogy and geochemical composition together with biological proxies including diatom and ostracod assemblages. A detailed pollen study enabled reconstruction of variations in vegetation cover, which were interpreted in the context of climate changes and human impact. Four distinct stages were recognized for the last 13,500 years: (1) a cold and dry episode that includes the Younger Dryas event (13,500–11,600 cal. year BP); (2) a humid and warmer period characterizing the onset of the Holocene (11,600–8,700 cal. year BP); (3) a tendency toward a drier climate during the middle Holocene (8,700–4,650 cal. year BP); and (4) a return to humid conditions following landscape modification by human activity (pastoral activities, deforestation) in the late Holocene (4,650–2,200 cal. year BP). Superimposed on relatively stable landscape conditions (e.g. maintenance of well established forests), the typical environmental variability of the southern European region is observed at this site.The Spanish Inter-Ministry Commission of Science and Technology (CICYT), the Spanish National Parks agency, the European Commission, the Spanish Ministry of Science, and the European Social Fund

Revealing the last 13,500 years of environmental history from the multiproxy record of a mountain lake (Lago Enol, northern Iberian Peninsula)

This is the author's accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/s10933-009-9387-7.We present the Holocene sequence from Lago Enol (43°16′N, 4°59′W, 1,070 m a.s.l.), Cantabrian Mountains, northern Spain. A multiproxy analysis provided comprehensive information about regional humidity and temperature changes. The analysis included sedimentological descriptions, physical properties, organic carbon and carbonate content, mineralogy and geochemical composition together with biological proxies including diatom and ostracod assemblages. A detailed pollen study enabled reconstruction of variations in vegetation cover, which were interpreted in the context of climate changes and human impact. Four distinct stages were recognized for the last 13,500 years: (1) a cold and dry episode that includes the Younger Dryas event (13,500–11,600 cal. year BP); (2) a humid and warmer period characterizing the onset of the Holocene (11,600–8,700 cal. year BP); (3) a tendency toward a drier climate during the middle Holocene (8,700–4,650 cal. year BP); and (4) a return to humid conditions following landscape modification by human activity (pastoral activities, deforestation) in the late Holocene (4,650–2,200 cal. year BP). Superimposed on relatively stable landscape conditions (e.g. maintenance of well established forests), the typical environmental variability of the southern European region is observed at this site.The Spanish Inter-Ministry Commission of Science and Technology (CICYT), the Spanish National Parks agency, the European Commission, the Spanish Ministry of Science, and the European Social Fund