1,143 research outputs found
Benchmarking performance of commonly used proteomics biomarker discovery platform-towards clinical proteomics standarization
Comunicaciones a congreso
Directed current due to broken time-space symmetry
We consider the classical dynamics of a particle in a one-dimensional
space-periodic potential U(X) = U(X+2\pi) under the influence of a
time-periodic space-homogeneous external field E(t)=E(t+T). If E(t) is neither
symmetric function of t nor antisymmetric under time shifts , an ensemble of trajectories with zero current at t=0 yields a nonzero
finite current as . We explain this effect using symmetry
considerations and perturbation theory. Finally we add dissipation (friction)
and demonstrate that the resulting set of attractors keeps the broken symmetry
property in the basins of attraction and leads to directed currents as well.Comment: 2 figure
Precision Mass Measurements of 129-131Cd and Their Impact on Stellar Nucleosynthesis via the Rapid Neutron Capture Process
Masses adjacent to the classical waiting-point nuclide 130Cd have been
measured by using the Penning- trap spectrometer ISOLTRAP at ISOLDE/CERN. We
find a significant deviation of over 400 keV from earlier values evaluated by
using nuclear beta-decay data. The new measurements show the reduction of the N
= 82 shell gap below the doubly magic 132Sn. The nucleosynthesis associated
with the ejected wind from type-II supernovae as well as from compact object
binary mergers is studied, by using state-of-the-art hydrodynamic simulations.
We find a consistent and direct impact of the newly measured masses on the
calculated abundances in the A = 128 - 132 region and a reduction of the
uncertainties from the precision mass input data
Effect of SpinâOrbit Coupling on Phonon-Mediated Magnetic Relaxation in a Series of Zero-Valent Vanadium, Niobium, and Tantalum Isocyanide Complexes.
Spin-vibronic coupling leads to spin relaxation in paramagnetic molecules, and an understanding of factors that contribute to this phenomenon is essential for designing next-generation spintronics technology, including single-molecule magnets and spin-based qubits, wherein long-lifetime magnetic ground states are desired. We report spectroscopic and magnetic characterization of the isoelectronic and isostructural series of homoleptic zerovalent transition metal triad M(CNDipp)6 (M = V, Nb, Ta; CNDipp = 2,6-diisopropylphenyl isocyanide) and show experimentally the significant increase in spin relaxation rate upon going from V to Nb to Ta. Correlated electronic calculations and first principle spinâphonon computations support the role of spinâorbit coupling in modulating spinâphonon relaxation. Our results provide experimental evidence that increasing magnetic anisotropy through spinâorbit coupling interactions leads to increased spinâvibronic relaxation, which is detrimental to long spin lifetime in paramagnetic molecules
Probing the N = 32 shell closure below the magic proton number Z = 20: Mass measurements of the exotic isotopes 52,53K
The recently confirmed neutron-shell closure at N = 32 has been investigated
for the first time below the magic proton number Z = 20 with mass measurements
of the exotic isotopes 52,53K, the latter being the shortest-lived nuclide
investigated at the online mass spectrometer ISOLTRAP. The resulting
two-neutron separation energies reveal a 3 MeV shell gap at N = 32, slightly
lower than for 52Ca, highlighting the doubly-magic nature of this nuclide.
Skyrme-Hartree-Fock-Boguliubov and ab initio Gorkov-Green function calculations
are challenged by the new measurements but reproduce qualitatively the observed
shell effect.Comment: 5 pages, 5 figure
Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation
Scope
Vascular smooth muscle cell (VSMC) proliferation is involved in the pathogenesis of cardiovascular disease, making the identification of new counteracting agents and their mechanisms of action relevant. Ginger and its constituents have been reported to improve cardiovascular health, but no studies exist addressing a potential interference with VSMC proliferation.
Methods and results
The dichloromethane extract of ginger inhibited VSMC proliferation when monitored by resazurin metabolic conversion (IC50Â = 2.5 ÎŒg/mL). The examination of major constituents from ginger yielded [6]-shogaol as the most active compound (IC50Â = 2.7 ÎŒM). In the tested concentration range [6]-shogaol did not exhibit cytotoxicity toward VSMC and did not interfere with endothelial cell proliferation. [6]-shogaol inhibited DNA synthesis and induced accumulation of the VSMC in the G0/G1Â cell-cycle phase accompanied with activation of the nuclear factor-erythroid 2-related factor 2 (Nrf2)/HO-1 pathway. Since [6]-shogaol lost its antiproliferative activity in the presence of the heme oxygenase-1 (HO-1) inhibitor tin protoporphyrin IX, HO-1 induction appears to contribute to the antiproliferative effect.
Conclusion
This study demonstrates for the first time inhibitory potential of ginger constituents on VSMC proliferation. The presented data suggest that [6]-shogaol exerts its antiproliferative effect through accumulation of cells in the G0/G1Â cell-cycle phase associated with activation of the Nrf2/HO-1 pathway
Optically induced coherent intra-band dynamics in disordered semiconductors
On the basis of a tight-binding model for a strongly disordered semiconductor
with correlated conduction- and valence band disorder a new coherent dynamical
intra-band effect is analyzed. For systems that are excited by two, specially
designed ultrashort light-pulse sequences delayed by tau relatively to each
other echo-like phenomena are predicted to occur. In addition to the inter-band
photon echo which shows up at exactly t=2*tau relative to the first pulse, the
system responds with two spontaneous intra-band current pulses preceding and
following the appearance of the photon echo. The temporal splitting depends on
the electron-hole mass ratio. Calculating the population relaxation rate due to
Coulomb scattering, it is concluded that the predicted new dynamical effect
should be experimentally observable in an interacting and strongly disordered
system, such as the Quantum-Coulomb-Glass.Comment: to be published in Physical Review B15 February 200
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