Fall Protection Training: A Case Study Using Cbt for Latino Construction Workers

Latino construction workers are at an increased risk of worksite injuries and fatalities due to language, cultural barriers, and ineffective training. This case-study investigated computer-based video training (CBT) for scaffold safety. The CBT training was developed using a participatory approach involving direct input from Latino roofers and framers. This paper focuses on evaluation-improvement of training that combined workers’ ideas of a safe work environment with OSHA standards. Researchers investigated the appropriateness and effectiveness of a brief CBT presentation addressing fall protection and scaffold use among Latino roofers. The results indicated that Latino construction workers at a roofing company in Colorado gained knowledge (p-value \u3c0.05) and liked the use of a culturally appropriate educational video as a method of training. The positive reactions to the training intervention are encouraging and support information and communication technologies (ICTs) for training Latino construction workers with lessons learned for follow-up training and evaluation

Paleoambientes de la cuenca media del río Luján (Buenos Aires, Argentina) durante el último período glacial (EIO 4-2)

El objetivo de este trabajo es definir unidades depositacionales y realizar inferencias paleoambientales a partir del análisis de facies y del contenido paleobiológico (moluscos, fitolitos y diatomeas) de depósitos acotados cronológicamente entre ca. <70.000 años y 11.000 años AP., Estadios Isotópicos de Oxígeno (EIO) 4 a 2, para la cuenca media del río Luján. Se seleccionaron tres secciones en las cuales se realizaron un total de siete perfiles estratigráficos de detalle y donde se extrajeron las muestras para los análisis sedimentológico, del contenido paleobiológico y para dataciones. Los depósitos estudiados fueron agrupados en cinco facies sedimentarias (F1, F2, F3, F4 y F5), ubicados cronológicamente y correlacionados con unidades semejantes descriptas por otros autores. Se reconocieron varias discontinuidades erosivas y de estabilidad para el lapso Pleistoceno tardío-Holoceno, las que permitieron definir cinco unidades depositacionales (UD). La presencia en el río Luján de una barranca, donde se exponen depósitos de edad Pleistoceno tardío-Holoceno, está estrechamente asociada a la incisión de los depósitos de relleno de antiguas depresiones interconectadas, ocurrida durante el Holoceno. Esto permitió inferir que la paleotopografía de esta área ha ejercido un control determinante en la existencia de barrancas con afloramientos del Pleistoceno tardío–Holoceno. Aún cuando las sucesiones son incompletas y las dataciones no permiten ajustar el inicio y la finalización de las UD para el lapso EIO 4 a 2, el análisis facial sugiere la existencia de una marcada variabilidad ambiental durante ese lapso, para el noreste de la provincia de Buenos Aires. En función del análisis facial se interpretó que el ambiente de depositación correspondió a sistemas fluvio-lacustres efímeros y eólicos, con sedimentación para el lapso ca. <70.000 años - <11.00014C años AP, bajo condiciones áridas, principalmente climas seco-subhúmedo y semiárido. Durante al menos una parte del EIO4 y durante el EIO2 habría ocurrido depositación eólica predominante, durante intervalos climáticos sub-húmedos secos. En tanto durante el EIO3 habrían tenido lugar eventos aluvionales episódicos bajo condiciones climáticas subhúmedas a subhúmedas secas o fuertemente estacionales y con alternancia de fases sub-húmedas-húmedas. Esto indicaría que las acumulaciones habrían tenido lugar mayormente en ambientes depositacionales con déficit hídrico aunque de variado grado. Las características geomorfológicas y las evidencias sedimentológicas y paleobiológicas permitieron inferir que el clima fue el forzante principal en el desarrollo de la sucesión sedimentaria

Aggressive Behavior in School-aged Children: Clusters based on Anger, Empathy and Testosterone and Cortisol Measures

The aim of this piece of research was to study the existence of clusters based on anger, empathy and cortisol and testosterone measures associated with aggressive behavior in school-aged children. The sample group comprised 139 eight-year-old children (80 boys and 59 girls). Aggressive behavior was measured using the Direct and Indirect Aggression Scale. Both psychological and biological variables were used to determine psychobiological profiles. The psychological variables considered were trait anger, measured using the State-Trait Anger Expression Inventory for Children and Adolescents, and empathy, measured using the Empathy Quotient-Child Version. Testosterone and cortisol concentrations were measured through saliva samples and analyzed using an ELISA (Enzyme-linked immunosorbent assay). A Cluster Analysis revealed three clusters which were clearly different as regards their psychological and biological characteristics. The analysis of variance (ANOVA) revealed that the cluster characterized by having higher anger levels, lower empathy levels and higher testosterone and cortisol levels was more aggressive than the other two (p < .0001, η2 = .19). The results indicate that studying psychological and biological variables together may help establish differentiated aggression patterns among children

Superparamagnetic iron oxide nanoparticles decorated mesoporous silica nanosystem for combined antibiofilm therapy

A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.Depto. de Química en Ciencias FarmacéuticasFac. de FarmaciaTRUEpu

Exciton-plasmon states in nanoscale materials: breakdown of the Tamm-Dancoff approximation

Within the Tamm-Dancoff approximation ab initio approaches describe excitons as packets of electron-hole pairs propagating only forward in time. However, we show that in nanoscale materials excitons and plasmons hybridize, creating exciton--plasmon states where the electron-hole pairs oscillate back and forth in time. Then, as exemplified by the trans-azobenzene molecule and carbon nanotubes, the Tamm-Dancoff approximation yields errors as large as the accuracy claimed in ab initio calculations. Instead, we propose a general and efficient approach that avoids the Tamm--Dancoff approximation, and correctly describes excitons, plasmons and exciton-plasmon states

The role of PKD1 in aging-related neurodegeneration: Structural and functional imaging studies

Trabajo presentado en el Second Spanish Molecular Imaging Network (SMIN) Meeting, celebrado en Madrid (España) el 26 de febrero de 2018

Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer

Cetuximab is a standard-of-care treatment for RAS wild-type metastatic colorectal cancer (mCRC) but not for those harbor a KRAS mutation since MAPK pathway is constitutively activated. Nevertheless, cetuximab also exerts its effect by its immunomodulatory activity despite the presence of RAS mutation. The aim of this study was to determine the impact of polymorphism FcγRIIIa V158F and killer immunoglobulin-like receptor (KIR) genes on the outcome of mCRC patients with KRAS mutations treated with cetuximab. This multicenter Phase II clinical trial included 70 mCRC patients with KRAS mutated. We found KIR2DS4 gene was significantly associated with OS (HR 2.27; 95% CI, 1.08–4.77; P = 0.03). In non-functional receptor homozygotes the median OS was 2.6 months longer than in carriers of one copy of full receptor. Multivariate analysis confirmed KIR2DS4 as a favorable prognostic marker for OS (HR 6.71) in mCRC patients with KRAS mutation treated with cetuximab. These data support the potential therapeutic of cetuximab in KRAS mutated mCRC carrying non-functional receptor KIR2DS4 since these patients significantly prolong their OS even after heavily treatment. KIR2DS4 typing could be used as predictive marker for identifying RAS mutated patients that could benefit from combination approaches of anti-EGFR monoclonal antibodies and other immunotherapies to overcome the resistance mediated by mutation in RAS.This clinical trial was approved and supported by Merck S.L., an affiliate of Merck KGaA, Darmstadt. Germany [research project number 2010-023580-18, date: 05-06-2014

Neuroprotective role of PKD1 against ischemic and kainic acid-induced brain injury

Trabajo presentado en el Second Spanish Molecular Imaging Network (SMIN) Meeting, celebrado en Madrid (España) el 26 de febrero de 2018

Kidins220 sets the threshold for survival of neural stem cells and progenitors to sustain adult neurogenesis

In the adult mammalian brain, neural stem cells (NSCs) located in highly restricted niches sustain the generation of new neurons that integrate into existing circuits. A reduction in adult neurogenesis is linked to ageing and neurodegeneration, whereas dysregulation of proliferation and survival of NSCs have been hypothesized to be at the origin of glioma. Thus, unravelling the molecular underpinnings of the regulated activation that NSCs must undergo to proliferate and generate new progeny is of considerable relevance. Current research has identified cues promoting or restraining NSCs activation. Yet, whether NSCs depend on external signals to survive or if intrinsic factors establish a threshold for sustaining their viability remains elusive, even if this knowledge could involve potential for devising novel therapeutic strategies. Kidins220 (Kinase D-interacting substrate of 220 kDa) is an essential effector of crucial pathways for neuronal survival and differentiation. It is dramatically altered in cancer and in neurological and neurodegenerative disorders, emerging as a regulatory molecule with important functions in human disease. Herein, we discover severe neurogenic deficits and hippocampal-based spatial memory defects accompanied by increased neuroblast death and high loss of newly formed neurons in Kidins220 deficient mice. Mechanistically, we demonstrate that Kidins220-dependent activation of AKT in response to EGF restraints GSK3 activity preventing NSCs apoptosis. We also show that NSCs with Kidins220 can survive with lower concentrations of EGF than the ones lacking this molecule. Hence, Kidins220 levels set a molecular threshold for survival in response to mitogens, allowing adult NSCs growth and expansion. Our study identifies Kidins220 as a key player for sensing the availability of growth factors to sustain adult neurogenesis, uncovering a molecular link that may help paving the way towards neurorepair