B\"acklund transformation for non-relativistic Chern-Simons vortices

A B\"acklund transformation yielding the static non-relativistic Chern-Simons vortices of Jackiw and Pi is presented.Comment: 7 pages plain Te

Monitoreo hidrogeoquímico de acuíferos cársicos costeros afectados por intrusión salina

The quality of the underground waters in many carsic coastal aquifers has been deteriorated as a result of bad farm practice, overexploitation, bad designs of the exploitation systems, occurrence of long dry periods, contamination, saline intrusion, conexion of aquifers of different hydrochemical characteristics and because that the methodology used to monitoring the quality has not been good in order to implement adequate exploitation of this valuable resource. The present work propose a new methodology for the analysis the data obtained from the monitoring of underground water in aquifers affected by saline intrusion, as a result of a detailed hydrochemical study of the South Coastal of the Camagüey province, Cuba.En muchos acuíferos cársicos costeros se ha deteriorado la calidad del agua subterránea como resultado de malas prácticas agrícolas, sobreexplotación, malos diseños de los sistemas de explotación, ocurrencia de períodos secos prolongados, contaminación, intrusión salina y conexión de acuíferos de características hidroquímicas distintas; todo esto aparejado a que no ha sido utilizada una adecuada metodología de monitoreo de calidad que permita implementar políticas adecuadas de explotación de este valioso recurso. El presente trabajo tiene como objetivo proponer una nueva metodología para el análisis de los datos obtenidos en la actividad de monitoreo del agua subterránea en acuíferos afectados por la intrusión salina, como resultado del estudio hidrogeoquímico detallado de la Costera Sur de la provincia de Camagüey, Cuba

Planeamiento del turismo y Geografía. Desarrollo en Cuba en los últimos 40 años

Cuba in 90' decade, has been forced to developed the tourism as a means to improve to heal the serious situation of its economy. However, the activity is ilotnot new in the country. In the work it is approached like it has been the development of the tourism in Cuba, fundamentally in the last forty years, and the contributions that the geographical studies and planning for the best development in the same one.Cuba en la década de los años 90, se ha visto precisada a desarrollar el turismo como vía de salida de la crisis económica en que se vio envuelta su economía. Sin embargo, la actividad no es nueva en el país. En el trabajo se aborda como ha sido el desarrollo del turismo en Cuba, fundamentalmente en los últimos cuarenta años, y los aportes que los estudios geográficos y de planificación han hecho al mejor desenvolvimiento de la misma

The non-linear Schr\"odinger equation and the conformal properties of non-relativistic space-time

The cubic non-linear Schr\"odinger equation where the coefficient of the nonlinear term is a function $F(t,x)$ only passes the Painlev\'e test of Weiss, Tabor, and Carnevale only for $F=(a+bt)^{-1}$, where $a$ and $b$ are constants. This is explained by transforming the time-dependent system into the constant-coefficient NLS by means of a time-dependent non-linear transformation, related to the conformal properties of non-relativistic space-time. A similar argument explains the integrability of the NLS in a uniform force field or in an oscillator background.Comment: Thoroughly revised version, in the light of new interest in non-relativistic conformal tranformation, with a new reference list. 8 pages, LaTex, no figures. To be published in Int. J. Theor. Phy

Molecular diagnosis of Pseudoterranova decipiens s.s in human, France

Background: Anisakis and Pseudoterranova are the main genera involved in human infections caused by nematodes of the Anisakidae family. Species identification is complicated due to the lack of differential morphological characteristics at the larval stage, thus requiring molecular differentiation. Pseudoterranova larvae ingested through raw fish are spontaneously eliminated in most cases, but mechanical removal by means of endoscopy might be required. To date, only very few cases of Pseudoterranova infection have been reported in France. Case presentation: A 19-year-old woman from Northeastern France detected, while brushing her teeth, a larva exiting through her mouth. The patient who presented with headache, diarrhea, and abdominal cramps reported having eaten baked cod. The worm was a fourth-stage larva with a size of 22 × 0.9 mm, and molecular biology identified it as Pseudoterranova decipiens sensu stricto (s. s.). In a second P. decipiens infection case, occurring a few months later, a worm exited through the patient’s nose after she had eaten raw sea bream. Conclusion: These two cases demonstrate that Pseudoterranova infection is not uncommon among French patients. Therefore, molecular techniques should be more widely applied for a better characterization of anisakidosis epidemiology in France

Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients

Background: Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with invasive fungal infections. Candida albicans IFA IgG has been recently commercialized for germ tube antibody detection (CAGTA). This test provides a rapid and simple diagnosis of IC (84.4% sensitivity and 94.7% specificity). The aim of this study is to identify the patients who could be benefited by the use of CAGTA test in critical care setting. Methods: A prospective, cohort, observational multicentre study was carried out in six medical/surgical Intensive care units (ICU) of tertiary-care Spanish hospitals. Candida albicans Germ Tube Antibody test was performed twice a week if predetermined risk factors were present, and serologically demonstrated candidiasis was considered if the testing serum dilution was >= 1: 160 in at least one sample and no other microbiological evidence of invasive candidiasis was found. Results: Fifty-three critically ill non-neutropenic patients (37.7% post surgery) were included. Twenty-two patients (41.5%) had CAGTA-positive results, none of them with positive blood culture for Candida. Neither corrected colonization index nor antifungal treatment had influence on CAGTA results. This finding could corroborate that the CAGTA may be an important biomarker to distinguish between colonization and infection in these patients. The presence of acute renal failure at the beginning of the study was more frequent in CAGTA-negative patients. Previous surgery was statistically more frequent in CAGTA-positive patients. Conclusions: This study identified previous surgery as the principal clinical factor associated with CAGTA-positive results and emphasises the utility of this promising technique, which was not influenced by high Candida colonization or antifungal treatment. Our results suggest that detection of CAGTA may be important for the diagnosis of invasive candidiasis in surgical patients admitted in ICU.This study has been supported by a Pfizer research gran

National Outbreak of Acanthamoeba Keratitis Associated with Use of a Contact Lens Solution, United States

Premarket standardized testing for Acanthamoeba spp. is warranted

Chemical and protein structural basis for biological crosstalk between PPARα and COX enzymes

We have previously validated a probabilistic framework that combined computational approaches for predicting the biological activities of small molecule drugs. Molecule comparison methods included molecular structural similarity metrics and similarity computed from lexical analysis of text in drug package inserts. Here we present an analysis of novel drug/target predictions, focusing on those that were not obvious based on known pharmacological crosstalk. Considering those cases where the predicted target was an enzyme with known 3D structure allowed incorporation of information from molecular docking and protein binding pocket similarity in addition to ligand-based comparisons. Taken together, the combination of orthogonal information sources led to investigation of a surprising predicted relationship between a transcription factor and an enzyme, specifically, PPARα and the cyclooxygenase enzymes. These predictions were confirmed by direct biochemical experiments which validate the approach and show for the first time that PPARα agonists are cyclooxygenase inhibitors