57 research outputs found
The immunohistochemical expression of leptin in lymph node metastasis from laryngeal squamous cell carcinoma (SCC)
Introduction: Leptin is a proteohormone produced predominantly by white adipocytes and primarily known for its key role in the control of food intake and sense of satiety. From its discover leptin has been found in different body districts, involved in always new functions and processes. In the last years numerous relationships between leptin and cancer has been found. The aim of this study is to test the leptin positivity in human primitive laryngeal squamous cell carcinoma (SCC) and in its lymph node metastasis. Materials and methods: Leptin positivity was detected by immunohistochemical analysis on pathological samples from 18 patients subjected to laryngectomy and neck dissection for SCC. Results: During the study we pointed out a statistically significant relationship (p < 0.05) between leptin positivity levels and tumor differentiation grade, in particular we observed that a decrease in tumor leptin production correlates with higher level of cancer histological dedifferentiation. Conclusion: Our research on leptin expression in laryngeal squamous neoplastic pathology is aimed to the attempt of establishing a more precise patient risk stratification thanks to a new marker able to give a contribution to the identification of patient with poor prognosis and at risk of failure of actual standard therapy
A three-dimensional view of the remnant of Nova Persei 1901 (GK Per)
We present a kinematical study of the optical ejecta of GK Per. It is based
on proper motions measurements of 282 knots from ~20 images spanning 25 years.
Doppler-shifts are also computed for 217 knots. The combination of proper
motions and radial velocities allows a unique 3-D view of the ejecta to be
obtained. The main results are: (1) the outflow is a thick shell in which knots
expand with a significant range of velocities, mostly between 600 and 1000
km/s; (2) kinematical ages indicate that knots have suffered only a modest
deceleration since their ejection a century ago; (3) no evidence for anisotropy
in the expansion rate is found; (4) velocity vectors are generally aligned
along the radial direction but a symmetric pattern of non-radial velocities is
also observed at specific directions; (5) the total Halpha+[NII] flux has been
linearly decreasing at a rate of 2.6 % per year in the last decade. The Eastern
nebular side is fading at a slower rate than the Western one. Some of the knots
displayed a rapid change of brightness during the 2004-2011 period. Over a
longer timescale, a progressive circularization and homogenization of the
nebula is taking place; (6) a kinematic distance of 400+-30 pc is determined.
These results raise some problems to the previous interpretations of the
evolution of GK Per. In particular, the idea of a strong interaction of the
outflow with the surrounding medium in the Southwest quadrant is not supported
by our data.Comment: Accepted for publication in The Astrophysical Journal (19 pages, 17
figures). Higher resolution version of this article (2.5 MB) is available at
http://www.aai.ee/~sinope/ApJ89291_liimets.pd
PARTISIPASI TENAGA KERJA WANITA DI USAHA BUNGA POTONG DI KELURAHAN KAKASKASEN II, KECAMATAN TOMOHON UTARA, KOTA TOMOHON
In this era of globalization, many efforts have done in order to earn money for the family. Efforts in agriculture be one choice of families and communities. In general, the development has opened up opportunities for women to engage in various businesses in the agricultural sector which has been dominated by men. The purpose of this study was to determine the participation of women owners or workers in the cut flower business in Kakaskasen II Village, North Tomohon sub district, Tomohon. The study lasted for 3 months, namely in November 2015 until January 2016, ranging from research preparation to the formulation of a research report. The data used in this study are primary and secondary data. Primary data was collected through direct interview to the respondents. Method of sample selection has used purposive sampling technique on nine women from 11 women as population who are owners or workers in the cut flower business. Data collection is a direct interview and observation (observation). Secondary data was collected from previous studies conducted by other researchers, but at the same location. Data analysis in this research using descriptive analysis and also using a Likert scale, with level 1 (underactive), 2 (active), 3 (highly active). This study found, based on an analysis using a Likert scale, that the number of female labor force participation index in the cut flower business (including planting, maintenance, cutting/ harvesting/buying, stringing, or sales) are at a point that 85.6% were categorized as high. Further analysis showed that the labor force participation rate of women in cut flower business with a score of up to 185 of the range of the number of ideal scoring the highest score was 216 and the lowest score was 72. Suggestions in this study, based on the conclusions derived, is the government should open up more opportunities to increase the number of business opportunities and work for women in cut flower business in order to alleviate the problem of female unemployment and poverty that exist in Tomohon City.*eprm
PARTISIPASI TENAGA KERJA WANITA DI USAHA BUNGA POTONG DI KELURAHAN KAKASKASEN II, KECAMATAN TOMOHON UTARA, KOTA TOMOHON
In this era of globalization, many efforts have done in order to earn money for the family. Efforts in agriculture be one choice of families and communities. In general, the development has opened up opportunities for women to engage in various businesses in the agricultural sector which has been dominated by men. The purpose of this study was to determine the participation of women owners or workers in the cut flower business in Kakaskasen II Village, North Tomohon sub district, Tomohon. The study lasted for 3 months, namely in November 2015 until January 2016, ranging from research preparation to the formulation of a research report. The data used in this study are primary and secondary data. Primary data was collected through direct interview to the respondents. Method of sample selection has used purposive sampling technique on nine women from 11 women as population who are owners or workers in the cut flower business. Data collection is a direct interview and observation (observation). Secondary data was collected from previous studies conducted by other researchers, but at the same location. Data analysis in this research using descriptive analysis and also using a Likert scale, with level 1 (underactive), 2 (active), 3 (highly active). This study found, based on an analysis using a Likert scale, that the number of female labor force participation index in the cut flower business (including planting, maintenance, cutting/ harvesting/buying, stringing, or sales) are at a point that 85.6% were categorized as high. Further analysis showed that the labor force participation rate of women in cut flower business with a score of up to 185 of the range of the number of ideal scoring the highest score was 216 and the lowest score was 72. Suggestions in this study, based on the conclusions derived, is the government should open up more opportunities to increase the number of business opportunities and work for women in cut flower business in order to alleviate the problem of female unemployment and poverty that exist in Tomohon City.*eprm
Partisipasi Tenaga Kerja Wanita di USAha Bunga Potong di Kelurahan Kakaskasen II, Kecamatan Tomohon Utara, Kota Tomohon
In this era of globalization, many efforts have done in order to earn money for the family. Efforts in agriculture be one choice of families and communities. In general, the development has opened up opportunities for women to engage in various businesses in the agricultural sector which has been dominated by men. The purpose of this study was to determine the participation of women owners or workers in the cut flower business in Kakaskasen II Village, North Tomohon sub district, Tomohon. The study lasted for 3 months, namely in November 2015 until January 2016, ranging from research preparation to the formulation of a research report. The data used in this study are primary and secondary data. Primary data was collected through direct interview to the respondents. Method of sample selection has used purposive sampling technique on nine women from 11 women as population who are owners or workers in the cut flower business. Data collection is a direct interview and observation (observation). Secondary data was collected from previous studies conducted by other researchers, but at the same location. Data analysis in this research using descriptive analysis and also using a Likert scale, with level 1 (underactive), 2 (active), 3 (highly active). This study found, based on an analysis using a Likert scale, that the number of female labor force participation index in the cut flower business (including planting, maintenance, cutting/ harvesting/buying, stringing, or sales) are at a point that 85.6% were categorized as high. Further analysis showed that the labor force participation rate of women in cut flower business with a score of up to 185 of the range of the number of ideal scoring the highest score was 216 and the lowest score was 72. Suggestions in this study, based on the conclusions derived, is the government should open up more opportunities to increase the number of business opportunities and work for women in cut flower business in order to alleviate the problem of female unemployment and poverty that exist in Tomohon City.*eprm
New insights into the outflows from R Aquarii
R Aquarii is a symbiotic binary surrounded by a large and complex nebula with
a prominent curved jet. It is one of the closest known symbiotic systems, and
therefore offers a unique opportunity to study the central regions of these
systems and the formation and evolution of astrophysical jets. We studied the
evolution of the central jet and outer nebula of R Aqr taking advantage of a
long term monitoring campaign of optical imaging, as well as of high-resolution
integral field spectroscopy. Narrow-band images acquired over a period of more
than 21 years are compared in order to study the expansion and evolution of all
components of the R Aqr nebula. The magnification method is used to derive the
kinematic ages of the features that appear to expand radially. Integral field
spectroscopy of the OIII 5007A emission is used to study the velocity structure
of the central regions of the jet. New extended features, further out than the
previously known hourglass nebula, are detected. The kinematic distance to R
Aqr is calculated to be 178 pc using the expansion of the large hourglass
nebula. This nebula of R Aqr is found to be roughly 650 years old, while the
inner regions have ages ranging from 125 to 290 years. The outer nebula is
found to be well described by a ballistic expansion, while for most components
of the jet strong deviations from such behaviour are found. We find that the
Northern jet is mostly red-shifted while its Southern part is blue-shifted,
apparently at odds with findings from previous studies but almost certainly a
consequence of the complex nature of the jet and variations in ionisation and
illumination between observations.Comment: 13 pages, 8 figures, accepted for publication in A&
Biomarkers in Laryngeal Squamous Cell Carcinoma: The Literature Review
Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer among head and neck cancers. Despite a lower incidence of laryngeal carcinoma, new diagnostic techniques, and more targeted therapies, the overall survival has not changed significantly in the last decades, leading to a negative prognosis in advanced stages. Recently, several studies have focused on the identification of biomarkers that may play a critical role in the pathogenesis of LSCC. Reviewing the literature on the main databases, this study aims to investigate the role of some biomarkers in LSCC that are correlated with oxidative stress and inflammation: heat shock proteins; metallothioneins; nuclear factor erythroid 2-related factor 2; heme oxygenase; cyclooxygenase-2; and micro ribonucleic acids. This review shows that biomarker expression depends on the type, grade of differentiation, stage, and site of carcinoma. In addition, the role of these biomarkers in LSCC is still little-known and little-studied. However, the study of biomarker expression and the detection of a possible correlation with patients’ epidemiological, clinicopathological, and therapeutics data may lead to better awareness and knowledge of the tumor, to the identification of the best therapeutic strategy, and the most proper follow-up protocol tailored for each patient. In conclusion, the achievement of these goals may improve the prognosis of LSCC patients
Modelling simple stellar populations in the near-ultraviolet to near-infrared with the X-shooter Spectral Library (XSL)
We present simple stellar population models based on the empirical X-shooter
Spectral Library (XSL) from NUV to NIR wavelengths. The unmatched
characteristics of relatively high resolution and extended wavelength coverage
( nm, ) of the XSL population models bring us closer to
bridging optical and NIR studies of intermediate and old stellar populations.
It is now common to find good agreement between observed and predicted NUV and
optical properties of stellar clusters due to our good understanding of the
main-sequence and early giant phases of stars. However, NIR spectra of
intermediate-age and old stellar populations are sensitive to cool K and M
giants. The asymptotic giant branch, especially the thermally pulsing
asymptotic giant branch, shapes the NIR spectra of Gyr old stellar
populations; the tip of the red giant branch defines the NIR spectra of
populations with ages larger than that. We construct sequences of the average
spectra of static giants, variable-rich giants, and C-rich giants to include in
the models separately. The models span the metallicity range
and ages above 50 Myr, a broader range in the NIR than in other models based on
empirical spectral libraries. Our models can reproduce the integrated optical
colours of the Coma cluster galaxies at the same level as other semi-empirical
models found in the literature. In the NIR, there are notable differences
between the colours of the models and Coma cluster galaxies. The XSL models
expand the range of predicted values of NIR indices compared to other models
based on empirical libraries. Our models make it possible to perform in-depth
studies of colours and spectral features consistently throughout the optical
and the NIR range to clarify the role of evolved cool stars in stellar
populations.Comment: 30 pages, 26 figures, accepted to Astronomy & Astrophysics, models
will be available on http://xsl.astro.unistra.fr/ upon publishin
Mapping Cumulative Environmental Risks: Examples from The EU NoMiracle Project
We present examples of cumulative chemical risk mapping methods developed within the NoMiracle project. The different examples illustrate the application of the concentration addition (CA) approach to pesticides at different scale, the integration in space of cumulative risks to individual organisms under the CA assumption, and two techniques to (1) integrate risks using data-driven, parametric statistical methods, and (2) cluster together areas with similar occurrence of different risk factors, respectively. The examples are used to discuss some general issues, particularly on the conventional nature of cumulative risk maps, and may provide some suggestions for the practice of cumulative risk mapping
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