Central Extension of a New W∞W_\infty - Type Algebra

The central extension of a new infinite dimensional algebra which has both $W_\infty$ and affine $sl(2,R)$ as subalgebras is found. The critical dimension of the corresponding string model is $D=5$.Comment: 6p., LaTeX, IC/94/20

A U(1) Current Algebra Model Coupled to 2D-Gravity

We consider a simple model of a scalar field with $U(1)$ current algebra gauge symmetry coupled to $2D$-gravity in order to clarify the origin of Stuckelberg symmetry in the $w_{\infty}$-gravity theory. An analogous symmetry takes place in our model too. The possible central extension of the complete symmetry algebra and the corresponding critical dimension have been found. The analysis of the Hamiltonian and the constraints shows that the generators of the current algebra, the reparametrization and the Stuckelberg symmetries are not independent. The connection of the model with $w_{1+\infty}-$ and $W_{1+\infty}$-gravity is discussed.Comment: INRNE-TH/02/93, LaTeX, 11 pages, (slight change of title and other minor changes

Productivity analysis and costs of wheel cable skidder during salvage logging in European beech stand

Salvage logging is increasing in Central Europe because of the growth of severe meteorological events, and timber harvesting in these conditions is challenging in terms of both productivity performances and safety of the operations. In recent years, with the increase of natural calamities, several researchers studied machinery productivity performances regarding salvage logging carried out by ground-based systems. In fact, a common post-disturbance management approach is salvage logging which consists of the widespread removal of damaged trees. In this research, system productivity and the cost of salvage logging are analysed in European beech stands affected by wet snow. The accretion of heavy wet snow poses the greatest risk to forests in the Northern Hemisphere. This type of snow attaches more effectively to tree crowns and branches when temperatures are close to freezing at the time of precipitation. As a result, trees may break or bend and may be uprooted when the soil is unfrozen. This study has been implemented to evaluate the productivity and cost-effectiveness of extraction in salvage logging deployed with a skidder in beech stands affected by two different types of wet snow damage. The results show that the productivity of the four-wheel-drive cable skidder, despite operating in salvage cutting with a removal intensity of 10%, is 14.73 m3·SMH–1, similar to skidder performances in ‘ordinary’ cuttings. Skidder’s productive time was 86% of the scheduled time, whereas the delays were due to organisational reasons, mechanical delays, and adverse weather conditions. The mean travel speed of the cable skidder obtained in this study is close to the results obtained from other studies on similar machines. The costs per unit are lower than effective cost consumptions for the other cable skidders and agricultural tractors, adapted for skidding operated in hardwood salvage logging. Therefore, under the given conditions, the operation of the fourwheel-drive cable skidder is viable from a silvicultural, technical, and economic point of view in the salvage operation logging

Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension

<p>Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH. Anorectic drugs such as dexfenfluramine (Dfen) have been associated with the development of PAH. Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Thus here we assess the role of CYP1B1 in the development of Dfen-induced PAH.</p> <p>Methods and results: Dfen (5 mg kg−1 day−1 PO for 28 days) increased right ventricular pressure and pulmonary vascular remodelling in female mice only. Mice dosed with Dfen showed increased whole lung expression of CYP1B1 and Dfen-induced PAH was ablated in CYP1B1−/− mice. In line with this, Dfen up-regulated expression of CYP1B1 in PASMCs from PAH patients (PAH-PASMCs) and Dfen-mediated proliferation of PAH-PASMCs was ablated by pharmacological inhibition of CYP1B1. Dfen increased expression of tryptophan hydroxylase 1 (Tph1; the rate-limiting enzyme in the synthesis of serotonin) in PAH-PASMCs and both Dfen-induced proliferation and Dfen-induced up-regulation of CYP1B1 were ablated by inhibition of Tph1. 17β-Oestradiol increased expression of both Tph1 and CYP1B1 in PAH-PASMCs, and Dfen and 17β-oestradiol had synergistic effects on proliferation of PAH-PASMCs. Finally, ovariectomy protected against Dfen-induced PAH in female mice.</p> <p>Conclusion: CYP1B1 is critical in the development of Dfen-induced PAH in mice in vivo and proliferation of PAH-PASMCs in vitro. CYP1B1 may provide a novel therapeutic target for PAH.</p&gt

Steps towards the hyperfine splitting measurement of the muonic hydrogen ground state: pulsed muon beam and detection system characterization

The high precision measurement of the hyperfine splitting of the muonic-hydrogen atom ground state with pulsed and intense muon beam requires careful technological choices both in the construction of a gas target and of the detectors. In June 2014, the pressurized gas target of the FAMU experiment was exposed to the low energy pulsed muon beam at the RIKEN RAL muon facility. The objectives of the test were the characterization of the target, the hodoscope and the X-ray detectors. The apparatus consisted of a beam hodoscope and X-rays detectors made with high purity Germanium and Lanthanum Bromide crystals. In this paper the experimental setup is described and the results of the detector characterization are presented.Comment: 22 pages, 14 figures, published and open access on JINS

Experimental determination of the energy dependence of the rate of the muon transfer reaction from muonic hydrogen to oxygen for collision energies up to 0.1 eV

We report the first experimental determination of the collision-energy dependence of the muon transfer rate from the ground state of muonic hydrogen to oxygen at near-thermal energies. A sharp increase by nearly an order of magnitude in the energy range 0 - 70 meV was found that is not observed in other gases. The results set a reliable reference for quantum-mechanical calculations of low-energy processes with exotic atoms, and provide firm ground for the measurement of the hyperfine splitting in muonic hydrogen and the determination of the Zemach radius of the proton by the FAMU collaboration.Comment: 30 pages, 10 figure

Search for Doubly-Charged Higgs Boson Production at HERA

A search for the single production of doubly-charged Higgs bosons H^{\pm \pm} in ep collisions is presented. The signal is searched for via the Higgs decays into a high mass pair of same charge leptons, one of them being an electron. The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment at HERA. No evidence for doubly-charged Higgs production is observed and mass dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only decays into an electron and a muon via a coupling of electromagnetic strength h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3, masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl