4,950 research outputs found
New directions in EEG measurement: an investigation into the fidelity of electrical potential sensor signals
Low frequency noise performance is the key indicator in determining the signal to noise ratio of a capacitively coupled sensor when used to acquire electroencephalogram signals. For this reason, a prototype Electric Potential Sensor device based on an auto-zero operational amplifier has been developed and evaluated. The absence of 1/f noise in these devices makes them ideal for use with signal frequencies ~10 Hz or less. The active electrodes are designed to be physically and electrically robust and chemically and biochemically inert. They are electrically insulated (anodized) and have diameters of 12 mm or 18 mm. In both cases, the sensors are housed in inert stainless steel machined housings with the electronics fabricated in surface mount components on a printed circuit board compatible with epoxy potting compounds. Potted sensors are designed to be immersed in alcohol for sterilization purposes. A comparative study was conducted with a commercial wet gel electrode system. These studies comprised measurements of both free running electroencephalogram and Event Related Potentials. Quality of the recorded electroencephalogram was assessed using three methods of inspection of raw signal, comparing signal to noise ratios, and Event Related Potentials noise analysis. A strictly comparable signal to noise ratio was observed and the overall conclusion from these comparative studies is that the noise performance of the new sensor is appropriate
On a problem of A. Weil
A topological invariant of the geodesic laminations on a modular surface is
constructed. The invariant has a continuous part (the tail of a continued
fraction) and a combinatorial part (the singularity data). It is shown, that
the invariant is complete, i.e. the geodesic lamination can be recovered from
the invariant. The continuous part of the invariant has geometric meaning of a
slope of lamination on the surface.Comment: to appear Beitr\"age zur Algebra und Geometri
Impact of DM direct searches and the LHC analyses on branon phenomenology
Dark Matter direct detection experiments are able to exclude interesting
parameter space regions of particle models which predict an important amount of
thermal relics. We use recent data to constrain the branon model and to compute
the region that is favored by CDMS measurements. Within this work, we also
update present colliders constraints with new studies coming from the LHC.
Despite the present low luminosity, it is remarkable that for heavy branons,
CMS and ATLAS measurements are already more constraining than previous analyses
performed with TEVATRON and LEP data.Comment: 17 pages, 2 figure
Using the atmospheric CO2 growth rate to constrain the CO2 flux from land use and land cover change since 1900
We explore the ability of the atmospheric CO2 record since 1900 to constrain the source of CO2 from land use and land cover change (hereafter âland useâ), taking account of uncertainties in other terms in the global carbon budget. We find that the atmospheric constraint favors land use CO2 flux estimates with lower decadal variability and can identify potentially erroneous features, such as emission peaks around 1960 and after 2000, in some published estimates. Furthermore, we resolve an offset in the global carbon budget that is most plausibly attributed to the land use flux. This correction shifts the mean land use flux since 1900 across 20 published estimates down by 0.35 PgC yearâ1 to 1.04 ± 0.57 PgC yearâ1, which is within the range but at the low end of these estimates. We show that the atmospheric CO2 record can provide insights into the time history of the land use flux that may reduce uncertainty in this term and improve current understanding and projections of the global carbon cycle. © 2022 The Authors. Global Change Biology published by John Wiley Sons Ltd
Response of VIRGO detectors to pre-big-bang gravitons
The sensitivity achievable by a pair of VIRGO detectors to stochastic and
isotropic gravitational wave backgrounds produced in pre-big-bang models is
discussed in view of the development of a second VIRGO interferometer. We
describe a semi-analytical technique allowing to compute the signal-to-noise
ratio for (monotonic or non-monotonic) logarithmic energy spectra of relic
gravitons of arbitrary slope. We apply our results to the case of two
correlated and coaligned VIRGO detectors and we compute their achievable
sensitivities. We perform our calculations both for the usual case of minimal
string cosmological scenario and in the case of a non-minimal scenario where a
long dilaton dominated phase is present prior to the onset of the ordinary
radiation dominated phase. In this framework, we investigate possible
improvements of the achievable sensitivities by selective reduction of the
thermal contributions (pendulum and pendulum's internal modes) to the noise
power spectra of the detectors. Since a reduction of the shot noise does not
increase significantly the expected sensitivity of a VIRGO pair (in spite of
the relative spatial location of the two detectors) our findings support the
experimental efforts directed towards a substantial reduction of thermal noise.Comment: 23 pages in Latex styl
Ergodic Jacobi matrices and conformal maps
We study structural properties of the Lyapunov exponent and the
density of states for ergodic (or just invariant) Jacobi matrices in a
general framework. In this analysis, a central role is played by the function
as a conformal map between certain domains. This idea goes
back to Marchenko and Ostrovskii, who used this device in their analysis of the
periodic problem
Fall-back crust around a quark-nova compact remnant I: The degenerate shell case with applications to SGRs, AXPs and XDINs
We explore the formation and evolution of debris ejected around quark stars
in the Quark Nova scenario, and the application to Soft Gamma-ray Repeaters
(SGRs) and Anomolous X-ray Pulsars (AXPs). If an isolated neutron star explodes
as a Quark Nova, an Iron-rich shell of degenerate matter forms out of the
fall-back (crust) material. Our model can account for many of the observed
features of SGRs and AXPs such as: (i) the two types of bursts (giant and
regular); (ii) the spin-up and spin-down episodes during and following the
bursts with associated persistant increases in ; (iii) the energetics
of the boxing day burst, SGR180620; (iv) the presence of an Iron line as
observed in SGR190014; (v) the correlation between the far-Infrared and the
X-ray fluxes during the bursting episode and the quiescent phase; (vi) the hard
X-ray component observed in SGRs during the giant bursts, and (vii) the
discrepancy between the ages of SGRs/AXPs and their supernova remnants. We also
find a natural evolutionary relationship between SGRs and AXPs in our model
which predicts that only the youngest SGRs/AXPs are most likely to exhibit
strong bursting. Many features of X-ray Dim Isolated Neutron stars (XDINs) are
also accounted for in our model such as, (i) the two-component blackbody
spectra; (ii) the absorption lines around 300 eV; and (iii) the excess optical
emission.Comment: submitted to Ap
Sensitivity of a VIRGO pair to stochastic GW backgrounds
The sensitivity of a pair of VIRGO interferometers to gravitational waves
backgrounds (GW) of cosmological origin is analyzed for the cases of maximal
and minimal overlap of the two detectors. The improvements in the detectability
prospects of scale-invariant and non-scale-invariant logarithmic energy spectra
of relic GW are discussed.Comment: 25 pages in RevTex style with 6 figure
Joint profiling of DNA methylation and chromatin architecture in single cells.
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues
Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes
Abstract 20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a product of the cytochrome P450 (CYP)-catalyzed [1] -hydroxylation of arachidonic acid, induces oxidative stress and, in clinical studies, is associated with increased body mass index (BMI) and the metabolic syndrome. This study was designed to examine the effects of exogenous 20- HETE on mesenchymal stem cell (MSC)-derived adipocytes.
The expression levels of CYP4A11 and CYP4F2 (major 20-HETE synthases in humans) in MSCs decreased during adipocyte differentiation; however, exogenous administration of 20-HETE (0.1â1 M) increased adipogenesis in a dose dependent manner in these cells ( P \u3c 0.05). The inability of a 20-HETE analog to reproduce these effects suggested the involvement of a metabolic product of 20-HETE in mediating its pro-adipogenic effects. A cyclooxygenase (COX)-1 selective inhibitor enhanced, whereas a COX-2 selective or a dual COX-1/2 inhibitor attenuated adipogenesis induced by 20-HETE. The COX-derived metabolite of 20-HETE, 20-OH-PGE 2 , enhanced adipogenesis and lipid accumulation in MSCs. The pro-adipogenic effects of 20-HETE and 20-OH-PGE 2 resulted in the increased expression of the adipogenic regulators PPAR and -catenin in MSC-derived adipocytes. Taken together we show for the fi rst time that 20-HETE-derived COX-2-dependent 20-OH-PGE 2 enhances mature infl amed adipocyte hypertrophy in MSC undergoing adipogenic differentiation. â Kim, D. H., N. Puri, K. Sodhi, J. R. Falck, N. G. Abraham, J. Shapiro, and M. L. Schwartzman. Cyclooxygenase-2 dependent metabolism of 20-HETE increasesadiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes
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