New directions in EEG measurement: an investigation into the fidelity of electrical potential sensor signals

Low frequency noise performance is the key indicator in determining the signal to noise ratio of a capacitively coupled sensor when used to acquire electroencephalogram signals. For this reason, a prototype Electric Potential Sensor device based on an auto-zero operational amplifier has been developed and evaluated. The absence of 1/f noise in these devices makes them ideal for use with signal frequencies ~10 Hz or less. The active electrodes are designed to be physically and electrically robust and chemically and biochemically inert. They are electrically insulated (anodized) and have diameters of 12 mm or 18 mm. In both cases, the sensors are housed in inert stainless steel machined housings with the electronics fabricated in surface mount components on a printed circuit board compatible with epoxy potting compounds. Potted sensors are designed to be immersed in alcohol for sterilization purposes. A comparative study was conducted with a commercial wet gel electrode system. These studies comprised measurements of both free running electroencephalogram and Event Related Potentials. Quality of the recorded electroencephalogram was assessed using three methods of inspection of raw signal, comparing signal to noise ratios, and Event Related Potentials noise analysis. A strictly comparable signal to noise ratio was observed and the overall conclusion from these comparative studies is that the noise performance of the new sensor is appropriate

On a problem of A. Weil

A topological invariant of the geodesic laminations on a modular surface is constructed. The invariant has a continuous part (the tail of a continued fraction) and a combinatorial part (the singularity data). It is shown, that the invariant is complete, i.e. the geodesic lamination can be recovered from the invariant. The continuous part of the invariant has geometric meaning of a slope of lamination on the surface.Comment: to appear Beitr\"age zur Algebra und Geometri

Impact of DM direct searches and the LHC analyses on branon phenomenology

Dark Matter direct detection experiments are able to exclude interesting parameter space regions of particle models which predict an important amount of thermal relics. We use recent data to constrain the branon model and to compute the region that is favored by CDMS measurements. Within this work, we also update present colliders constraints with new studies coming from the LHC. Despite the present low luminosity, it is remarkable that for heavy branons, CMS and ATLAS measurements are already more constraining than previous analyses performed with TEVATRON and LEP data.Comment: 17 pages, 2 figure

Using the atmospheric CO2 growth rate to constrain the CO2 flux from land use and land cover change since 1900

We explore the ability of the atmospheric CO2 record since 1900 to constrain the source of CO2 from land use and land cover change (hereafter “land use”), taking account of uncertainties in other terms in the global carbon budget. We find that the atmospheric constraint favors land use CO2 flux estimates with lower decadal variability and can identify potentially erroneous features, such as emission peaks around 1960 and after 2000, in some published estimates. Furthermore, we resolve an offset in the global carbon budget that is most plausibly attributed to the land use flux. This correction shifts the mean land use flux since 1900 across 20 published estimates down by 0.35 PgC year−1 to 1.04 ± 0.57 PgC year−1, which is within the range but at the low end of these estimates. We show that the atmospheric CO2 record can provide insights into the time history of the land use flux that may reduce uncertainty in this term and improve current understanding and projections of the global carbon cycle. © 2022 The Authors. Global Change Biology published by John Wiley Sons Ltd

Response of VIRGO detectors to pre-big-bang gravitons

The sensitivity achievable by a pair of VIRGO detectors to stochastic and isotropic gravitational wave backgrounds produced in pre-big-bang models is discussed in view of the development of a second VIRGO interferometer. We describe a semi-analytical technique allowing to compute the signal-to-noise ratio for (monotonic or non-monotonic) logarithmic energy spectra of relic gravitons of arbitrary slope. We apply our results to the case of two correlated and coaligned VIRGO detectors and we compute their achievable sensitivities. We perform our calculations both for the usual case of minimal string cosmological scenario and in the case of a non-minimal scenario where a long dilaton dominated phase is present prior to the onset of the ordinary radiation dominated phase. In this framework, we investigate possible improvements of the achievable sensitivities by selective reduction of the thermal contributions (pendulum and pendulum's internal modes) to the noise power spectra of the detectors. Since a reduction of the shot noise does not increase significantly the expected sensitivity of a VIRGO pair (in spite of the relative spatial location of the two detectors) our findings support the experimental efforts directed towards a substantial reduction of thermal noise.Comment: 23 pages in Latex styl

Ergodic Jacobi matrices and conformal maps

We study structural properties of the Lyapunov exponent $\gamma$ and the density of states $k$ for ergodic (or just invariant) Jacobi matrices in a general framework. In this analysis, a central role is played by the function $w=-\gamma+i\pi k$ as a conformal map between certain domains. This idea goes back to Marchenko and Ostrovskii, who used this device in their analysis of the periodic problem

Fall-back crust around a quark-nova compact remnant I: The degenerate shell case with applications to SGRs, AXPs and XDINs

We explore the formation and evolution of debris ejected around quark stars in the Quark Nova scenario, and the application to Soft Gamma-ray Repeaters (SGRs) and Anomolous X-ray Pulsars (AXPs). If an isolated neutron star explodes as a Quark Nova, an Iron-rich shell of degenerate matter forms out of the fall-back (crust) material. Our model can account for many of the observed features of SGRs and AXPs such as: (i) the two types of bursts (giant and regular); (ii) the spin-up and spin-down episodes during and following the bursts with associated persistant increases in $\dot{P}$; (iii) the energetics of the boxing day burst, SGR1806$+$20; (iv) the presence of an Iron line as observed in SGR1900$+$14; (v) the correlation between the far-Infrared and the X-ray fluxes during the bursting episode and the quiescent phase; (vi) the hard X-ray component observed in SGRs during the giant bursts, and (vii) the discrepancy between the ages of SGRs/AXPs and their supernova remnants. We also find a natural evolutionary relationship between SGRs and AXPs in our model which predicts that only the youngest SGRs/AXPs are most likely to exhibit strong bursting. Many features of X-ray Dim Isolated Neutron stars (XDINs) are also accounted for in our model such as, (i) the two-component blackbody spectra; (ii) the absorption lines around 300 eV; and (iii) the excess optical emission.Comment: submitted to Ap

Sensitivity of a VIRGO pair to stochastic GW backgrounds

The sensitivity of a pair of VIRGO interferometers to gravitational waves backgrounds (GW) of cosmological origin is analyzed for the cases of maximal and minimal overlap of the two detectors. The improvements in the detectability prospects of scale-invariant and non-scale-invariant logarithmic energy spectra of relic GW are discussed.Comment: 25 pages in RevTex style with 6 figure

Joint profiling of DNA methylation and chromatin architecture in single cells.

We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues

Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes

Abstract 20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a product of the cytochrome P450 (CYP)-catalyzed [1] -hydroxylation of arachidonic acid, induces oxidative stress and, in clinical studies, is associated with increased body mass index (BMI) and the metabolic syndrome. This study was designed to examine the effects of exogenous 20- HETE on mesenchymal stem cell (MSC)-derived adipocytes. The expression levels of CYP4A11 and CYP4F2 (major 20-HETE synthases in humans) in MSCs decreased during adipocyte differentiation; however, exogenous administration of 20-HETE (0.1–1 M) increased adipogenesis in a dose dependent manner in these cells ( P \u3c 0.05). The inability of a 20-HETE analog to reproduce these effects suggested the involvement of a metabolic product of 20-HETE in mediating its pro-adipogenic effects. A cyclooxygenase (COX)-1 selective inhibitor enhanced, whereas a COX-2 selective or a dual COX-1/2 inhibitor attenuated adipogenesis induced by 20-HETE. The COX-derived metabolite of 20-HETE, 20-OH-PGE 2 , enhanced adipogenesis and lipid accumulation in MSCs. The pro-adipogenic effects of 20-HETE and 20-OH-PGE 2 resulted in the increased expression of the adipogenic regulators PPAR and -catenin in MSC-derived adipocytes. Taken together we show for the fi rst time that 20-HETE-derived COX-2-dependent 20-OH-PGE 2 enhances mature infl amed adipocyte hypertrophy in MSC undergoing adipogenic differentiation. — Kim, D. H., N. Puri, K. Sodhi, J. R. Falck, N. G. Abraham, J. Shapiro, and M. L. Schwartzman. Cyclooxygenase-2 dependent metabolism of 20-HETE increasesadiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes