Papillitis as the prominent ocular sign in Acquired Immune Deficiency Syndrome (AIDS)

A 29-year old homosexual presented with clinical symptoms and an immunological picture of AIDS syndrome. Ocular involvement started in August 1986 with reduction of visual acuity in the right eye rapidly progressing to amaurosis. The most prominent ophthalmoscopical sign was of papillitis which had, in the beginning, the characteristics of an ischaemic optic neuropathy. Besides this, cotton-wool spots, retinal haemorrhages and limited areas of Cytomegalovirus (CMV) retinitis were found. Choroid was also involved with secondary CMV retinitis. On the other hand, sheathing of retinal vessels and Roth’s spots were absent. Although papilloedema, haemorrhages, cotton-wool exudates and CMV retinitis completely disappeared by October 1986, the general condition aggravated and the patient finally succumbed.peer-reviewe

Ocular manifestations in lepromatous and tuberculoid leprosy

Ocular manifestations of leprosy in 100 patients examined were reported on; -80% were suffering from the lepromatous type of the disease. The most frequent change was loss of eyebrows (40%) which was seen mainly in lepromatous patients. The sclera and cornea were rarely affected separately, but sclerokerato-iridocyclitis was found in 3%. On the other hand, the iris was involved rather more often -16% (atrophy of the iris -4, atrophy of the pupillary margin -3, miosis -1, posterior synechiae -6, keratic precipitates -1, and iris "pearls" -1). The iritis always had an insidious chronic evolution. The origin of the iritis is probably multifactorial: a) neuroparalytic due to involvement of the autonomic nerves supplying the iris muscles, primarily dilator; b) direct effect of Mycobacterium leprae on the iris tissue; and c) immune or auto-immune mechanisms. The posterior uvea was rarely affected (2%). No case of primary glaucoma was detected, but secondary glaucoma due to sclerokerato-iridocyclitis was found in 2 cases. Cataract seems to occur more frequently in leprosy patients (20%) than in the general population. The anterior segment was mostly affected (21%), and all these cases belonged to the lepromatous (16) or borderline lepromatous (5) type.peer-reviewe

Downsizing and Organizational Change Survivors and Victims: Mental Health Issues

Survivors and victims of organizational change are experiencing mental health issues afterdownsizing and organizational change. The purpose of this study was to determine whether whitecollarworkers were aware of major changes in corporate America and how these changes mightaffect them. The research question, “Do survivors or victims of downsizing or organizationalchange experience mental health issues after downsizing or organizational change?” This was thefoundation of this study. This quantitative approach involved surveying 196 white-collar workers intwo industries: manufacturing and health. An analysis showed that the literature has sensationalizedthe health-related problems because only about 20% of the people surveyed acknowledged therewas a problem. The study provided insights into the health-related problems associated withdownsizing or organizational change. Survivors and employees should speak about downsizing andorganizational change, and it affects them and their family members financially, emotionally, andpsychologically

Manatee Occurrence in the Northern Gulf of Mexico, West of Florida

Reports of West Indian manatees (Trichechus manatus) in the US Gulf of Mexico west of Florida have increased during the last decade. We reviewed all available manatee sighting, capture, and carcass records (n = 377) from Alabama, Louisiana, Mississippi, and Texas since the early 1900s; only 40 of these were previously published. Manatees were reported most often in estuarine habitats, usually either near a freshwater source or natural or industrial warm-water springs/runoffs during winter months. The recent increase in manatee records may be due to a combination of increased public awareness and dispersal of manatees, most likely seasonal migrants from Florida. We caution that the presence of artificial warm-water sources outside of the manatee’s traditional range may attract an increasing number of manatees and could increase the incidence of cold-related mortality in this region

Frequency and Correlates of Mild Cognitive Impairment in Myasthenia Gravis

Background: Antibodies against acetylcholine receptors (AChRs) can also target nicotinic AChRs that are present throughout the central nervous system, thus leading to cognitive dysfunctions in patients with myasthenia gravis (MG). However, the presence of cognitive impairment in MG is controversial, and the factors that may influence this risk are almost completely unknown. In this study, the frequency of mild cognitive impairment (MCI) in MG, as well as the clinical, immunological, and behavioral correlates of MCI in MG were evaluated. Methods: A total of 52 patients with MG underwent a comprehensive assessment including motor and functional scales, serological testing, and neuropsychological and behavioral evaluation. Results: The frequency of MCI was 53.8%, and the most impaired cognitive domains were, in order, visuoconstructive/visuospatial skills, memory, and attention. After multivariate analysis, only pyridostigmine use was inversely associated with the presence of MCI, while a trend toward a positive association between MCI and disease severity and arms/legs hyposthenia was found. Correlation analyses showed that daily doses of prednisone and azathioprine significantly correlated with depressive symptomatology, while disease severity significantly correlated with depressive symptomatology and sleep disturbance. Conclusions: The presence of MCI is rather frequent in MG and is characterized by multidomain amnestic impairment. Such preliminary data need further confirmation on larger case series

Monitoring campaign over an edible dormouse population (Glis glis; rodentia: Gliridae) in Sicily: First report of mesocestodiasis

This study reports on the health status of the edible dormouse (Glis glis) living in Nebrodi Park (Sicily, Italy), responsible for nut crop damage in the area. In the frame of a monitoring campaign for potential zoonotic risk involving 30 dormice, rectal and conjunctival swabs and fur and nest content were collected for bacteriological and parasitological examinations, respectively. A large presence of fleas belonging to Monopsyllus sciurorum was found. Necropsy of a dead dormouse revealed an infection of Mesocestoides lineatus, whose cysts were found in the abdomen cavity and on the liver; this is the first report of this in this species. Further studies are necessary to identify their role in the environment, considering the limited knowledge of this species in Italy

Nonequilibrium transport in quantum impurity models: Exact path integral simulations

We simulate the nonequilibrium dynamics of two generic many-body quantum impurity models by employing the recently developed iterative influence-functional path integral method [Phys. Rev. B {\bf 82}, 205323 (2010)]. This general approach is presented here in the context of quantum transport in molecular electronic junctions. Models of particular interest include the single impurity Anderson model and the related spinless two-state Anderson dot. In both cases we study the time evolution of the dot occupation and the current characteristics at finite temperature. A comparison to mean-field results is presented, when applicable

Estudio preliminar de algunas variables de crecimiento y fertilidad en ratones de Bioterio

 In the present work, the results obtained in the comparative study of the growth and fertility of Balb/C and CF-1 mice from the Bioterium of the Faculty of Medicine of the National University of the Northeast are exposed, by modifying the environmental conditions of breeding and reproduction of the animals before and after the moving of the Center to its new facilities. The characteristics studied in both strains were: breeding number, weight according to sex before and after weaning, until to the 15th week of life, and fertility rate. The results obtained show that the moving caused stress in both murine strains, and the effect was manifested in the decrease of growth and fertility rates observed in the animals. These values were not statistically significant, which allows us to conclude that the enrichment of the habitat in the new facilities helped to alleviate in some way the stress of the move. This is the first systematic study carried out for this purpose and lays the foundations for others for monitoring the adaptation and production in the new facilities.En el presente trabajo se exponen los resultados obtenidos en el estudio comparativo del crecimiento y la fertilidad de ratones Balb/C y CF-1 del Bioterio de la Facultad de Medicina de la Universidad Nacional del Nordeste, al modificar las condiciones ambientales de cría y reproducción de los animales previa y posteriormente al traslado del Centro a sus nuevas instalaciones. Las características estudiadas en ambas cepas fueron: número de crías, peso según sexo previo y posterior al destete, hasta la semana 15 de vida y tasa de fertilidad. Los resultados obtenidos muestran que el traslado causó estrés en ambas cepas murinas, cuyo efecto se manifestó en la disminución de las tasas de crecimiento y fertilidad en estos animales experimentales. Estos valores resultaron no significativos estadísticamente, lo que nos permite concluir que el enriquecimiento del hábitat en las nuevas instalaciones ayudó a paliar de alguna manera el estrés de la mudanza. Este es el primer estudio sistemático realizado a este efecto y sienta las bases de otros para el seguimiento de la adaptación y producción en las nuevas instalaciones

La unificación normativa como oportunidad de proyectar la enseñanza unificada en la carrera de Abogacía

Partiendo de asumir con profesionalidad nuestro rol docente, surge el interés de sumarnos a esta comisión. En oportunidad de cursar la capacitación docente en nuestra Facultad, acordamos ciertos criterios respecto de la concepción del proceso de enseñanza-aprendizaje. Ahora, con motivo de la reciente unificación del Derecho Civil y Comercial, nos proponemos aplicarlos, a fin de repensar dichos procesos con foco en el alumno, futuro profesional, que se asoma al estudio de estas ramas que hoy tienen –desde el punto de vista legislativo- un tronco aún más unido.Facultad de Ciencias Jurídicas y Sociale

Molecular analysis of TP53, Ki-Ras and P16 methylation status in tissue and plasma of subjects affected by gastrointestinal cancer (GIC)

BACKGROUND: Despite the improvement in detection and surgical therapy in the last years, the outcome of patients affected by colorectal carcinoma (CRC) remains limited by metastatic relapse. The aim of this study was to investigate the presence of free tumor DNA in the plasma of CRC patients in order to understand its possible prognostic role. PATIENTS AND METHODS: Ki-Ras, TP53 mutations and p16(INK4A) methylation status were prospectively evaluated in tumor tissues and plasma of 66 CRC patients. RESULTS: In 50 of the 66 primitive tumor cases (76%) at least one significant alteration was identified in Ki-Ras and/or TP53 and/or p16(INK4A) genes. Eighteen of the 50 patients presented the same alteration both in the plasma and in the tumor tissue. At univariate analysis, Ki-Ras mutations proved to be significantly related to quicker relapse (P <0.01), whereas only a trend towards statistical significance (P = 0.083) was observed for the TP53 mutations CONCLUSIONS: Detection of Ki-Ras and TP53 mutation in plasma should be significantly related to disease recurrence. These data suggest that patients with a high risk of recurrence can be identified by means of the analysis of tumor-derived plasma DNA with the use of fairly non-invasive techniques