Sambutan Rektor Untversitas Hasanuddin

Kegembiraan dan kebahagiaan kami saat ini sungguh sulit kami nyatakan metrikasi takarannya, antara lain karena penyelenggaraan acara yang bermakna sangat penting ini dihadiri oleh Bapak Ketua LIPI, Bapak Gubernur, para akademisi dan berbagai pihak yang berlatar belakang aneka profesi dan kegiatan baik dari Kawasan Timur Indonesia maupun reprentasi lembaga-lembaga yang kompenten secara nasional

Comparison of Functional Outcome of Total Knee Replacement Between Cruciate Retaining and Cruciate Substituting Prosthesis in Cipto Mangunkusumo Hospital

Background.Total knee replacement is a procedure of choice in the management of severe osteoarthritis. Currently two types of prosthesis are widely used, cruciate retaining and cruciate substituting. Experts have not yet reached agreement regarding which one is better. This study is aimed to compare functional outcome between cruciate retaining and substituting prosthesis. Materials and methods.This study was a randomized single-blinded clinical trial. Patients with severe osteoarthritis were divided into two groups and evaluated before operation. First group underwent cruciate retaining total knee replacement, and the other cruciate substituting total knee replacement. Functional outcome was evaluated in 3 and 6 months after operation, regarding the knee flexion angle and International Knee Documentation Committee score.Results.There were 14 patients. Mean knee flexion angle of cruciate retaining in 3 and 6 months were 105.0 degrees and 113.3 degrees respectively, whereas cruciate substituting were 118.1 degrees and 126.2 degrees. International Knee Documentation Committee score of cruciate retaining in 3 and 6 months were 49.0 and 59.4 respectively, while cruciate substituting were 52.6 and 63.8. There were significant differences in flexion angles between cruciate retaining and cruciate substituting groups at 3 months (p=0.006) and 6 months (p=0.018). No significant difference was demonstrated in International Knee Documentation Committee score between cruciate retaining and cruciate substituting groups at 3 months (p=0.053) and 6 months (p=0.240).Conclusions.Functional outcome regarding the knee flexion angle of cruciate substituting group was 13.1 degrees better in 3 months and 12.9 degrees in 6 months compared to cruciate retaining group. Functional outcome based on International Knee Documentation Committee score score did not show significant differences between two groups whether 3 or 6 months after operation

Multiscale Modeling of Thiol Overoxidation in Peroxiredoxins by Hydrogen Peroxide

In this work, we employ a multiscale quantum-classical mechanics (QM/MM) scheme to investigate the chemical reactivity of sulfenic acids toward hydrogen peroxide, both in aqueous solution and in the protein environment of the peroxiredoxin alkyl hydroperoxide reductase E from Mycobacterium tuberculosis (MtAhpE). The reaction of oxidation of cysteine with hydrogen peroxides, catalyzed by peroxiredoxins, is usually accelerated several orders of magnitude in comparison with the analogous reaction in solution. The resulting cysteine sulfenic acid is then reduced in other steps of the catalytic cycle, recovering the original thiol. However, under some conditions, the sulfenic acid can react with another equivalent of oxidant to form a sulfinic acid. This process is called overoxidation and has been associated with redox signaling. Herein, we employed a multiscale scheme based on density function theory calculations coupled to the classical AMBER force field, developed in our group, to establish the molecular basis of thiol overoxidation by hydrogen peroxide. Our results suggest that residues that play key catalytic roles in the oxidation of MtAhpE are not relevant in the overoxidation process. Indeed, the calculations propose that the process is unfavored by this particular enzyme microenvironment.Fil: Semelak, Jonathan Alexis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; ArgentinaFil: Battistini, F.. Barcelona Institute of Science and Technology; EspañaFil: Radi, R.. Universidad de la República; UruguayFil: Trujillo, M.. Universidad de la República; UruguayFil: Zeida, A.. Universidad de la República; UruguayFil: Estrin, Dario Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentin

New Investor Class Program Sebagai Sarana Literasi dan Inklusi Pasar Modal

ABSTRAK Adanya ketertarikan dari akademisi dan masyarakat untuk menjadi investor pasar modal di Bursa Efek Indonesia, namun tanpa dukungan dan pengetahuan tentang apa dan bagaimana cara berinvestasi di pasar modal. Hal ini menjadikan latar belakang pengabdian pada masyarakat untuk edukasi literasi dan inklusi pasar modal.Maka dari itu untuk mendukung hal tersebut diadakan program NICP (New Investor Class Program) yang diselenggarakan oleh PT. Reliance Sekuritas Indonesia, Tbk melalui GIBEI-FE UNSIL-RELI.Program ini bertujuan untuk mengedukasi secara menyeluruh mengenai literasi dan inklusi pasar modal untuk menjadi seorang investor yang berkualitas di pasar modal dan tentunya dapat meningkatkan jumlah investor pasar modal khususnya di Kota Tasikmalaya. Luaran kegiatan program ini adalah kemampuan menangkap peluang Investor dan calon investor pada kegiatan kuliah umum pasar modal serta pengenalan pasar modal pada seluruh kalangan masyarakat, peningkatan pengetahuan Investor/calon investor serta kalangan masyarakat akan pasar modal, Peningkatan Jumlah Investor dalam pembukaan rekening saham, Peningkatan pengetahuan dan kemampuan dalam berinvestasi di Pasar Modal Kata Kunci: bursa efek Indonesia; inklusi; literasi; pasar modal.ABSTRACT There is interest from academics and the public to become capital market investors in the Indonesia Stock Exchange, but without the support and knowledge of what and how to invest in the capital market. This makes the background of community service for literacy education and capital market inclusion. Therefore to support this, a NICP (New Investor Class Program) program is held by PT. Reliance Sekuritas Indonesia, Tbk through GIBEI-FE UNSIL-RELI. This program aims to thoroughly educate the literacy and capital market inclusion to become a quality investor in the capital market and can certainly increase the number of capital market investors, especially in the City of Tasikmalaya. The output of this program is the ability to capture the opportunities of investors and prospective investors in capital market public lectures and the introduction of capital markets to all people, increase investor / prospective investor knowledge and the public about the capital market, increase the number of investors in opening stock accounts, increase knowledge and the ability to invest in the Capital Market.Keywords: capital market; inclusion; Indonesia stock exchange; literacy

A Framework to Support Ubiquitous Healthcare Monitoring and Diagnostic for Sickle Cell Disease

Recent technology advances based on smart devices have improved the medical facilities and become increasingly popular in association with real-time health monitoring and remote/personals health-care. Healthcare organisations are still required to pay more attention for some improvements in terms of cost-effectiveness and maintaining efficiency, and avoid patients to take admission at hospital. Sickle cell disease (SCD) is one of the most challenges chronic obtrusive disease that facing healthcare, affects a large numbers of people from early childhood. Currently, the vast majority of hospitals and healthcare sectors are using manual approach that depends completely on patient input, which can be slowly analysed, time consuming and stressful. This work proposes an alert system that could send instant information to the doctors once detects serious condition from the collected data of the patient. In addition, this work offers a system that can analyse datasets automatically in order to reduce error rate. A machine-learning algorithm was applied to perform the classification process. Two experiments were conducted to classify SCD patients from normal patients using machine learning algorithm in which 99 % classification accuracy was achieved using the Instance-based learning algorithm

Evaluation of FHIT gene alterations in ovarian cancer.

The FHIT gene, recently cloned and mapped on chromosome 3p14.2, has frequently been found to be abnormal in several established cancer cell lines and primary tumours. As alterations of chromosome 3p are common events in ovarian cancers with breakpoint sites at 3p14.2, we decided to investigate the role of FHIT in human ovarian tumorigenesis. Fifty-four primary ovarian carcinomas were studied by reverse transcription of FHIT mRNA followed by polymerase chain reaction (PCR) amplification and sequencing of products. The same tumours and matched normal tissues were also investigated for loss of heterozygosity using three microsatellite markers located inside the gene. We found an abnormal transcript of the FHIT gene in two cases (4%) and allelic losses in eight cases (15%). Twelve (22%) of the 54 tumours investigated belonged to young patients with a family history of breast/ovarian cancer. In none of these cases was the FHITgene found to be altered. Our results indicate that FHITplays a role in a small proportion of ovarian carcinomas

Pelatihan Kewirausahaan Dengan Membuat Buket Snack Serbagai Alternatif Buah Tangan bagi Santri Miftahul Huda Al Husna Kecamatan Bungursari Kota Tasikmalaya

Tren pemberian buah tangan atau hadiah berupa buket bunga khususnya kepada orang terkasih sudah menjadi hal yang biasa bagi kawula muda sekarang. Namun kadangkala hadiah buket tersebut nantinya akan menjadi layu dan menjadi sampah. Buket snack menjadi salah satu alternative pengganti hadiah buket bunga selain harganya lebih mudah terjangkau juga bermanfaat karena bisa dimakan. Dalam pembuatannya diperlukan keterampilan khusus agar dapat bernilai jual tinggi, oleh karena itu dalam pengabdian pada masyarakat yang dilaksanakan pada para santri Miftahul Huda Alhusna sebagai salah satu pelatihan kewirausahaan diberikan pelatihan membuat buket snack sebagai salah satu alternative buah tangan dimana nantinya dengan inovasi pembuatan buket snack ini dapat mengembangkan jiwa kewirausahaan para santri. Kegiatan ini diikuti oleh 12 orang santri Miftahul Huda Alhusna Kecamatan Bungursari Kota Tasikmalaya selama kurang lebih 6 jam dimana kegiatan awal berupa seminar kewirausahaan dari dosen kewirausahaan dan pemasaran Fakultas Ekonomi Universitas Siliwangi kemudian praktek dan pelatihan pembuatan buket snack dengan memanfaatkan limbah kertas sebagai bahan penyangga buket agar lebih ekonomis. Hasil akhir kegiatan ini para santri mahir dan dapat berkresai sendiri mengembangkan bakat dan keterampilan dalam pembuatan buket snack sehingga bisa menjadi nilai jual yang tinggi dan menciptakan inovasi baru sehingga konsumen tidak merasa bosan dengan buket yang itu-itu saja