Connecting existing cemeteries saving good soils (for livings)

Background: Urban sprawl consumes and degrades productive soils worldwide. Fast and safe decomposition of corpses requires high-quality functional soils, and land use which competes with both agriculture and buildings. On one hand, cremation does not require much land, but it has a high energy footprint, produces atmospheric pollution, and is unacceptable to some religious communities. On the other hand, as exhumations are not practiced, "green burials" require more surface area than current burial practices, so a new paradigm for managing land use is required. Conclusions: In this paper, we propose a concept for 'green belt communalities' (i.e., ecological corridors with multiple, yet flexible, uses and services for future generations). With the expansion of urban centers, ecological corridors gradually disappear. Cemeteries for burial plots preclude alternative uses of the land for a long time. By combining these two aspects (need for connectivity and land take imposed by cemeteries), two positive results can be achieved: protecting memories of the past and connecting ecosystems with multiple-use corridors. This new paradigm works best in flat or hilly terrain where there are already several urban agglomerations that contain traditional cemeteries. Stakeholders who might consider this concept are local administrators, planners, and the communities of individuals who share specific beliefs on burial systems

MODELLING OF POWDER FLOW IN ROTATIONAL MOULDING

Rotational moulding is a widely used technological process to obtain hollow plastic articles, in which polymer powders melt within a rotating mould. The first step in modelling the melting process is to analyse the kinematics of the powder in the rotating system. To this goal, a series of experimental observations was performed on a rotating cylinder partially filled with a powder (Sand X, average size 460 microns) with known physical characteristics (such as angles of repose and angles of approach). A phenomenological model was then developed, based on the assumption that the powder behaves as a Bingham-plastic fluid, obtaining theoretical predictions which were in good agreement with the experimental measurements

Ejection force of tubular injection moldings. Part II : a prediction model

The integrated knowledge of the injection molding process and the material changes induced by processing is essential to guarantee the quality of technical parts. In the case of parts with deep cavities, quite often the ejection phase of the molding cycle is critical. Thus, in the mold design stage, the aspects associated with the ejection system will require special consideration. In particular, the prediction of the ejection force will contribute to optimizing the mold design and to guarantee the integrity of the moldings. In this work, a simulation algorithm based on a thermomechanical model is described and their predictions are compared with experimental data obtained from a fully-instrumented mold (pressure, temperature, and force). Three common thermoplastics polymers were used for the tubular moldings: a semicrystalline polypropylene and two amorphous thermoplastics: polystyrene and polycarbonate. The thermomechanical model is based on the assumption of the polymer behavior changing from purely viscous to purely elastic below a transition point. This point corresponds to solidification determined by temperature in the case of amorphous materials and by critical crystallinity for semicrystalline polymers. The model results for the ejection force closely agree with the experimental data for the three materials used

Identification of a Maturation Plasma Cell Index through a Highly Sensitive Droplet Digital PCR Assay Gene Expression Signature Validation in Newly Diagnosed Multiple Myeloma Patients

DNA microarrays and RNA-based sequencing approaches are considered important discovery tools in clinical medicine. However, cross-platform reproducibility studies undertaken so far have highlighted that microarrays are not able to accurately measure gene expression, particularly when they are expressed at low levels. Here, we consider the employment of a digital PCR assay (ddPCR) to validate a gene signature previously identified by gene expression profile. This signature included ten Hedgehog (HH) pathways' genes able to stratify multiple myeloma (MM) patients according to their self-renewal status. Results show that the designed assay is able to validate gene expression data, both in a retrospective as well as in a prospective cohort. In addition, the plasma cells' differentiation status determined by ddPCR was further confirmed by other techniques, such as flow cytometry, allowing the identification of patients with immature plasma cells' phenotype (i.e., expressing CD19+/CD81+ markers) upregulating HH genes, as compared to others, whose plasma cells lose the expression of these markers and were more differentiated. To our knowledge, this is the first technical report of gene expression data validation by ddPCR instead of classical qPCR. This approach permitted the identification of a Maturation Index through the integration of molecular and phenotypic data, able to possibly define upfront the differentiation status of MM patients that would be clinically relevant in the future

LIDAR observation of PSCs in the arctic and antarctic

Polar Stratospheric Clouds and aerosols are here reported which do not clearly corresponding to present interpretations. They were monitored in the Antarctic and in the Arctic from 1989 to 1995 and therefore refer both to the pre-Pinatubo, the Pinatubo and after Pinatubo period. Such cases comprehend non depolarizing PSCs and warm depolarizing aerosols. Non Depolarizing PSCs have been observed over Dumont d'Urville, Antarctica during the POLE experiment (1989-today) and over Sodankyla during SESAME. For the case of Sodankyla particle size evaluation for non depolarizing PSCs were carried out with interesting results. An index of refraction has been used for Mie calculations which may well correspond to the one expected for a diluted ternary solution of H2O/H2SO4/HNO3PublishedFirenze, Italy1.8. Osservazioni di geofisica ambientaleope

Survival Risk Scores for Real-Life Relapsed/Refractory Multiple Myeloma Patients Receiving Elotuzumab or Carfilzomib In Combination With Lenalidomide and Dexamethasone as Salvage Therapy: Analysis of 919 Cases Outside Clinical Trials

The present study aimed to develop two survival risk scores (RS) for overall survival (OS, SRSKRd/EloRd) and progression-free survival (PFS, PRSKRd/EloRd) in 919 relapsed/refractory multiple myeloma (RRMM) patients who received carfilzomib, lenalidomide, and dexamethasone (KRd)/elotuzumab, lenalidomide, and dexamethasone (EloRd). The median OS was 35.4 months, with no significant difference between the KRd arm versus the EloRd arm. In the multivariate analysis, advanced ISS (HR = 1.31; P = 0.025), interval diagnosis–therapy (HR = 1.46; P = 0.001), number of previous lines of therapies (HR = 1.96; P < 0.0001), older age (HR = 1.72; P < 0.0001), and prior lenalidomide exposure (HR = 1.30; P = 0.026) remained independently associated with death. The median PFS was 20.3 months, with no difference between the two strategies. The multivariate model identified a significant progression/death risk increase for ISS III (HR = 1.37; P = 0.002), >3 previous lines of therapies (HR = 1.67; P < 0.0001), older age (HR = 1.64; P < 0.0001), and prior lenalidomide exposure (HR = 1.35; P = 0.003). Three risk SRSKRd/EloRd categories were generated: low-risk (134 cases, 16.5%), intermediate-risk (467 cases, 57.3%), and high-risk categories (213 cases, 26.2%). The 1- and 2-year OS probability rates were 92.3% and 83.8% for the low-risk (HR = 1, reference category), 81.1% and 60.6% (HR = 2.73; P < 0.0001) for the intermediate-risk, and 65.5% and 42.5% (HR = 4.91; P < 0.0001) for the high-risk groups, respectively. Notably, unlike the low-risk group, which did not cross the median timeline, the OS median values were 36.6 and 18.6 months for the intermediate- and high-risk cases, respectively. Similarly, three PRSKRd/EloRd risk categories were engendered. Based on such grouping, 338 (41.5%) cases were allocated in the low-, 248 (30.5%) in the intermediate-, and 228 (28.0%) in the high-risk groups. The 1- and 2-year PFS probability rates were 71.4% and 54.5% for the low-risk (HR = 1, reference category), 68.9% and 43.7% (HR = 1.95; P < 0.0001) for the intermediate-risk, and 48.0% and 27.1% (HR = 3.73; P < 0.0001) for the high-risk groups, respectively. The PFS median values were 29.0, 21.0, and 11.7 months for the low-, intermediate-, and high-risk cases. This analysis showed 2.7- and 4.9-fold increased risk of death for the intermediate- and high-risk cases treated with KRd/EloRd as salvage therapy. The combined progression/death risks of the two categories were increased 1.3- and 2.2-fold compared to the low-risk group. In conclusion, SRSKRd/EloRd and PRSKRd/EloRd may represent accessible and globally applicable models in daily clinical practice and ultimately represent a prognostic tool for RRMM patients who received KRd or EloRd

Chemical characterization of cloud episodes at a ridge site in Tuscan Appennines, Italy

Cloudwater samples were collected from November 1992 to March 1995 in Vallombrosa, a mountain site of the Tuscan Apennines (central Italy). Chemical analyses show that all examined inorganic ions contributed significantly to the total ionic content (TIC). The ratio SO4/NO4 ranged from 0.92 to 3.46 and was > 1 for 86% of samples. There is a wide range in the chemical composition of the cloudwater. The total ionic content ranged from 640 to 7476 Aeq l 1 and pH from 3.17 to 6.22. The liquid water content (LWC) ranged from 0.06 to 0.94 g m 3 and electrical conductivity from 47 to 485 AV 1. The total ionic content decreases while the liquid water content increases. Also analyzed were soluble trace metals (Fe, Pb, Cu, Mn, Cd, Al), synthetic anionic surfactants and the methanesulphonic acid. Chemical analyses evidenced in some cases a high concentration of organic matter. The meteorological analysis for a few samples of individual passages was carried out for the possibility of establishing a correspondence between meteorological events and chemical composition. The sources (marine, crustal and anthropogenic) of chemical components were deduced