Daniel DeNicola, Professor of Philosophy

In this issue of Next Page, Professor of Philosophy Daniel DeNicola reveals his appreciation for mysteries, especially those focused on manuscripts or works of art, and how his incessant childhood habit of reading the backs of cereal boxes at breakfast led his parents to buy him a set of Children\u27s Classics and his very own encyclopedia-sold in installments at the supermarket

Dan Gilbert, Levan Professor of Ethics and Management

In this latest edition of Next Page, Dan Gilbert, the David M. LeVan Professor of Ethics and Management, shares with us books that inspired his teaching career, his love of baseball (1,100+ games and counting!), and the activities he’s looking forward to as he shakes off the Gettysburg winter and settles into retirement in sunny Southern California. We will miss you, Dan

Ryan Kerney, Assistant Professor of Biology

In this last Next Page column of 2017, Ryan Kerney, Assistant Professor of Biology, shares some of his favorite science writers in the field of “evo devo;” his go-to science news sources and podcasts (note: “This Week in Parasitism” is a must-listen!); what he would ask Charles Darwin if given the chance; which books he likes to give as gifts; his favorite author of all time; and where he finds great recommendations for what to read next

Engineering Schottky contacts in open-air fabricated heterojunction solar cells to enable high performance and ohmic charge transport.

The efficiencies of open-air processed Cu2O/Zn(1-x)Mg(x)O heterojunction solar cells are doubled by reducing the effect of the Schottky barrier between Zn(1-x)Mg(x)O and the indium tin oxide (ITO) top contact. By depositing Zn(1-x)Mg(x)O with a long band-tail, charge flows through the Zn(1-x)Mg(x)O/ITO Schottky barrier without rectification by hopping between the sub-bandgap states. High current densities are obtained by controlling the Zn(1-x)Mg(x)O thickness to ensure that the Schottky barrier is spatially removed from the p-n junction, allowing the full built-in potential to form, in addition to taking advantage of the increased electrical conductivity of the Zn(1-x)Mg(x)O films with increasing thickness. This work therefore shows that the Zn(1-x)Mg(x)O window layer sub-bandgap state density and thickness are critical parameters that can be engineered to minimize the effect of Schottky barriers on device performance. More generally, these findings show how to improve the performance of other photovoltaic system reliant on transparent top contacts, e.g., CZTS and CIGS.This work was supported by EPSRC of the UK (award number RG3717)This is the accepted manuscript. The final version is available from ACS at http://pubs.acs.org/doi/abs/10.1021/am5058663

Small scale spatial variability of snow density and depth over complex alpine terrain: Implications for estimating snow water equivalent

This study analyzes spatial variability of snow depth and density from measurements made in February and April of 2010 and 2011 in three 1–2 km2 areas within a valley of the central Spanish Pyrenees. Snow density was correlated with snow depth and different terrain characteristics. Regression models were used to predict the spatial variability of snow density, and to assess how the error in computed densities might influence estimates of snow water equivalent (SWE). The variability in snow depth was much greater than that of snow density. The average snow density was much greater in April than in February. The correlations between snow depth and density were generally statistically significant but typically not very high, and their magnitudes and signs were highly variable among sites and surveys. The correlation with other topographic variables showed the same variability in magnitude and sign, and consequently the resulting regression models were very inconsistent, and in general explained little of the variance. Antecedent climatic and snow conditions prior to each survey help highlight the main causes of the contrasting relation shown between snow depth, density and terrain. As a consequence of the moderate spatial variability of snow density relative to snow depth, the absolute error in the SWE estimated from computed densities using the regression models was generally less than 15%. The error was similar to that obtained by relating snow density measurements directly to adjacent snow depths.This work was supported by research projects CGL2011-27536/HID: “Hidrologia nival en el Pirineo central español: variabilidad espacial, importancia hidrológica y su respuesta a la variabilidad y cambio climático”, financed by the Spanish Commission of Science and Technology, and FEDER; ACQWA (FP7-ENV- 2008-1-212250); the projects “La nieve en el Pirineo aragonés: Distribución especial y su respuesta a las condiciones climáticas” and “Efecto de los escenarios de cambio climático sobre la hidrología superficial y la gestión de embalses del Pirineo Aragonés”, financed by “Obra Social La Caixa”; and “Influencia del cambio climático en el turismo de nieve-CTTP1/10”, financed by the Comunidad de Trabajo de los Pirineos, CTP.Peer Reviewe

Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes

Growing evidence shows that improper intake of vitamin B6 increases cancer risk and several studies indicate that diabetic patients have a higher risk of developing tumors. We previously demonstrated that in Drosophila the deficiency of Pyridoxal 5' phosphate (PLP), the active form of vitamin B6, causes chromosome aberrations (CABs), one of cancer prerequisites, and increases hemolymph glucose content. Starting from these data we asked if it was possible to provide a link between the aforementioned studies. Thus, we tested the effect of low PLP levels on DNA integrity in diabetic cells. To this aim we generated two Drosophila models of type 2 diabetes, the first by impairing insulin signaling and the second by rearing flies in high sugar diet. We showed that glucose treatment induced CABs in diabetic individuals but not in controls. More interestingly, PLP deficiency caused high frequencies of CABs in both diabetic models demonstrating that hyperglycemia, combined to reduced PLP level, impairs DNA integrity. PLP-depleted diabetic cells accumulated Advanced Glycation End products (AGEs) that largely contribute to CABs as α-lipoic acid, an AGE inhibitor, rescued not only AGEs but also CABs. These data, extrapolated to humans, indicate that low PLP levels, impacting on DNA integrity, may be considered one of the possible links between diabetes and cancer

Enhanced performance in fluorene-free organometal halide perovskite light-emitting diodes using tunable, low electron affinity oxide electron injectors.

Fluorene-free perovskite light-emitting diodes (LEDs) with low turn-on voltages, higher luminance and sharp, color-pure electroluminescence are obtained by replacing the F8 electron injector with ZnO, which is directly deposited onto the CH3NH3PbBr3 perovskite using spatial atmospheric atomic layer deposition. The electron injection barrier can also be reduced by decreasing the ZnO electron affinity through Mg incorporation, leading to lower turn-on voltages.The authors would like to acknowledge funding from the Cambridge Commonwealth, European and International Trusts, Rutherford Foundation of New Zealand, A*STAR National Science Scholarship, Girton College Cambridge, Gates Cambridge Scholarship, EPSRC (Reference: EP/G060738/1), the ERC Advanced Investigator Grant, Novox, ERC-2009-adG 247276 and Cambridge Display Technology.This is the final version of the article. It was first published by Wiley at http://onlinelibrary.wiley.com/doi/10.1002/adma.201405044/abstract

Shear stress cleaning for surface departiculation

A cleaning technique widely used by the nuclear utility industry for removal of radioactive surface contamination has proven effective at removing non-hazardous contaminant particles as small as 0.1 micrometer. The process employs a controlled high velocity liquid spray inside a vapor containment enclosure to remove particles from a surface. The viscous drag force generated by the cleaning fluid applies a shear stress greater than the adhesion force that holds small particles to a substrate. Fluid mechanics and field tests indicate general cleaning parameters

Validation of an Operationalized Model of Iso-Ahola’s Theory of Tourism Motivation: A Case in Point-to-Point Suborbital Space Travel

The purpose of the study was to validate Snepenger, King, Marshall, and Uysal’s (2006) model of Iso-Ahola’s (1982) theory of tourism motivation for use in point-to-point suborbital space tourism research. No previous research was discovered, which assessed point-to-point suborbital space flight within the theoretical foundation of the theory of tourism motivation. Snepenger et al.’s (2006) model was assessed as published, and exploratory factor analysis (EFA) failed to produce data fitting the four dimensions. The researchers modified the item descriptions based on research. Using a second sample, the modified model was assessed. EFA produced four factors with adequate convergent and discriminant validity. Confirmatory factor analysis produced good model fit with adequate construct validity. The study validated the operationalized model of the theory of tourism motivation in United States participants providing a valid and reliable scale for use in future suborbital space travel research