Galois cohomology of Fontaine rings

Let $V$ be a complete discrete valuation ring of mixed characteristic. We express the crystalline cohomology of the special fibre of certain smooth affine $V$-schemes $X=Spec(R)$ tensored with an appropriate ring of $p$-adic periods as the Galois cohomology of the fundamental group of the geometric generic fibre $\pi_1(X_{\bar{V}[1/p]})$ with coefficients in a Fontaine ring constructed from $R$. This is based on Faltings' approach to $p$-adic Hodge theory (the theory of almost étale extensions). Using this we deduce maps from $p$-adic étale cohomology to crystalline cohomology of smooth $V$-schemes. The results are more general, as the semi-stable case is also considered. In the end we derive an alternative proof of the theorem of Tsuji (the semi-stable conjecture of Fontaine-Jannsen)

Editorial entrepreneurial finance for green innovative SMEs

The Autumn 2022 COP27 Conference of the Parties of the United Nations Framework Convention on Climate Change demonstrated that the need for a clear research and policy agenda to assist the financing of early stage Cleantech and green SMEs innovation and green practice adoption has never been greater. Green, cleantech innovators hold important keys to unlocking vital globally game changing technologies that can scale-up to mitigate climate change and humanity’s wider environmental damage to ensure planetary sustainability. The paper provides a contemporary overview of the financing issues facing green SME innovators and adopters by reviewing seven papers published in this IEEE Transactions on Engineering Management Special Issue on green entrepreneurial finance. The papers provide deep insights into SMEs’ external financing requirements, barriers to private finance and the shortcomings of public tax and financing policies. This editorial paper concludes with a series of key recommendations for researchers, SME finance practitioners and public policymakers which provide guidance for more holistic policies to deliver longer horizon patient capital investing and facilitate green innovation commercialization, scale-up and adoption for a sustainable plane

Redefining SME Productivity Measurement and Assessment for a Low Carbon Economy

YesThe UK faces the joint economic policy challenges of raising productivity and tackling climate change. This report challenges prevailing narrow market-based views of productivity, by examining the £4bn UK early stage Cleantech innovation finance market. We find that Cleantech innovation is frequently capital intensive and long horizon (5-10+ years), measured by shorterterm technology readiness level (TRL) and intellectual property (IP) progression. Longer-term sustainable productivity impacts remain little understood and, where applied, narrowly relate to customer adoption. This leads to Cleantech environmental impact investor logics that primarily relate to end user financial value (customer sales). There is little consideration for non-market values from, for example, circular economy (CE) and wider environmental spillover impacts (e.g. supply chains). Whilst few Cleantechs currently successfully commercialise, a small proportion exhibit high employment and sales growth and global environmental impact. Improved understanding of the broader environmental impacts of Cleantechs, through the adoption of environmental impact metrics (EIMs) can (i) add to a more holistic notion of productivity and (ii) improve the efficiency of the finance escalator, enabling more Cleantechs to contribute significantly to establishing the UK as a globally leading low carbon economy.ESR

Assessment of Dual Schistosome Infection Prevalence from Urine in An Endemic Community of Ghana By Molecular Diagnostic Approach

Schistosomiasis is an important Neglected Tropical Disease caused by blood parasites called schistosomes. In sub-Saharan Africa, two major human schistosomes, namely Schistosoma mansoni and S. haematobium, often occur sympatrically and is responsible for almost 90% of the affected 290 million people worldwide. We have utilized a highly sensitive and specific assay by amplifying species-specific cell-free repeat DNA fragments by polymerase chain reaction to detect either single or dual schistosome infection from a single urine sample from a broad age group. In this study, we have tested filtered urine samples collected from 163 individuals aged 3–63 years, mostly children (median age 10), to evaluate the prevalence of single and dual infections for S. mansoni and S. haematobium in Tomefa community in the Greater Accra region of Ghana. 40–50 mL of urine was filtered through a 12.5 cm Whatman # 3 filter paper in the field. The filter papers were dried, packed individually in sealable plastic bags with a desiccant, and shipped to Marquette University, where DNA was isolated and PCR amplification was carried out with species-specific primers. Disease prevalence was found to be 46.6% for S. mansoni and 48.5% for S. haematobium. Most importantly, 23.3% of participants had dual infections. All of the samples were detected without any cross amplification. The data was evaluated for four age groups and infection rate was highest for the age group of 3–12 years, with more S. haematobium infections than S. mansoni infections. We found a high prevalence of both S. haematobium and S. mansoni infection and a significant proportion of dual infection for the Tomefa community, which in most cases would be missed by traditional parasitological examination of urine or stool. Our highly sensitive and specific approach for detecting underlying multiple schistosome infections is an effective means to detect low intensity infections and would enhance the effectiveness of surveillance and Mass Drug Administration control programs of schistosomiasis

Isothermal Recombinase Polymerase amplification (RPA) of Schistosoma haematobium DNA and oligochromatographic lateral flow detection

© 2015 Rosser et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The attached file is the published version of the article

Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries

© 2015 Knowles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The attached file is the published version of the article

A protease-based biosensor for the detection of schistosome cercariae

Parasitic diseases affect millions of people worldwide, causing debilitating illnesses and death. Rapid and cost-effective approaches to detect parasites are needed, especially in resource-limited settings. A common signature of parasitic diseases is the release of specific proteases by the parasites at multiple stages during their life cycles. To this end, we engineered several modular Escherichia coli and Bacillus subtilis whole-cell-based biosensors which incorporate an interchangeable protease recognition motif into their designs. Herein, we describe how several of our engineered biosensors have been applied to detect the presence and activity of elastase, an enzyme released by the cercarial larvae stage of Schistosoma mansoni. Collectively, S. mansoni and several other schistosomes are responsible for the infection of an estimated 200 million people worldwide. Since our biosensors are maintained in lyophilised cells, they could be applied for the detection of S. mansoni and other parasites in settings without reliable cold chain access

Demand-side financing for maternal and newborn health: what do we know about factors that affect implementation of cash transfers and voucher programmes?

BackgroundDemand-side financing (DSF) interventions, including cash transfers and vouchers, have been introduced to promote maternal and newborn health in a range of low- and middle-income countries. These interventions vary in design but have typically been used to increase health service utilisation by offsetting some financial costs for users, or increasing household income and incentivising 'healthy behaviours'. This article documents experiences and implementation factors associated with use of DSF in maternal and newborn health.MethodsA secondary analysis (using an adapted Supporting the Use of Research Evidence framework - SURE) was performed on studies that had previously been identified in a systematic review of evidence on DSF interventions in maternal and newborn health.ResultsThe article draws on findings from 49 quantitative and 49 qualitative studies. The studies give insights on difficulties with exclusion of migrants, young and multiparous women, with demands for informal fees at facilities, and with challenges maintaining quality of care under increasing demand. Schemes experienced difficulties if communities faced long distances to reach participating facilities and poor access to transport, and where there was inadequate health infrastructure and human resources, shortages of medicines and problems with corruption. Studies that documented improved care-seeking indicated the importance of adequate programme scope (in terms of programme eligibility, size and timing of payments and voucher entitlements) to address the issue of concern, concurrent investments in supply-side capacity to sustain and/or improve quality of care, and awareness generation using community-based workers, leaders and women's groups. ConclusionsEvaluations spanning more than 15 years of implementation of DSF programmes reveal a complex picture of experiences that reflect the importance of financial and other social, geographical and health systems factors as barriers to accessing care. Careful design of DSF programmes as part of broader maternal and newborn health initiatives would need to take into account these barriers, the behaviours of staff and the quality of care in health facilities. Research is still needed on the policy context for DSF schemes in order to understand how they become sustainable and where they fit, or do not fit, with plans to achieve equitable universal health coverage