© 2015 Knowles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  The attached file is the published version of the article

A Danso-Appiah

A Garba

A Koukounari

Alan Fenwick

Amadou Garba

AN Gouvras

B Gryseels

BL Webster

Bonnie L. Webster

CF Robert

CM Gower

D De Clercq

David Rollinson

F Mutapi

GC Webbe

Giovanna Raso

GS Nelson

H Friis

H Poole

I Talla

J Vercruysse

J Zwang

JC Ernould

Joanne P. Webster

JP Webster

JR Stothard

L Meurs

LA Tchuem Tchuente

MA Smith

ME Woolhouse

MF Abdel-Wahab

Moussa Sacko

N Lodh

N Rujeni

NS Mansour

Oumar T. Diaw

P Cunin

P Steinman

PJ Skelly

PL Olliaro

R Labbo

RF Sturrock

RJ Dobson

S Losada

Sarah C. L. Knowles

T Huyse

T Vos

V Southgate

PLoS Neglected Tropical Diseases

English

PubMed

Background

In many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood.
Methodology/Principal Findings

Here we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and Mali) to test whether the impact of praziquantel (PZQ) treatment, subsequent levels of re-infection or long-term infection dynamics are altered by co-infection. In all countries, positive associations between the two species prevailed at baseline: infection by one species tended to predict infection intensity for the other, with the strength of association varying across sites. Encouragingly, we found little evidence that co-infection influenced PZQ efficacy: species-specific egg reduction rates (ERR) and cure rates (CR) did not differ significantly with co-infection, and variation in treatment success was largely geographical. In Senegal, despite positive associations at baseline, children with S. mansoni co-infection at the time of treatment were less intensely re-infected by S. haematobium than those with single infections, suggesting competition between the species may occur post-treatment. Furthermore, the proportion of schistosome infections attributable to S. mansoni increased over time in all three countries examined.
Conclusions/Significance

These findings suggest that while co-infection between urinary and intestinal schistosomes may not directly affect PZQ treatment efficacy, competitive interspecific interactions may influence epidemiological patterns of re-infection post-treatment. While re-infection patterns differed most strongly according to geographic location, interspecific interactions also seem to play a role, and could cause the community composition in mixed species settings to shift as disease control efforts intensify, a situation with implications for future disease management in this multi-species system.
Author Summary

In many parts of Africa both urinary and intestinal schistosomiasis are endemic, and mixed species infections can be common. However, little is known about potential within-host interactions between the causative parasites, S. haematobium and S. mansoni, and how these might influence treatment success and post-treatment patterns of re-infection. Here, we bring together datasets from three West African countries to examine the epidemiological evidence for interactions between these two schistosome species relevant to the impact of treatment programmes using praziquantel (PZQ). Encouragingly, PZQ efficacy (in a double 40mg/kg dose format) was not significantly altered by co-infection, though since co-infections tended to be heavier, complete clearance was less likely than for single species infections. Despite positive associations in infection intensity for these two species at baseline, Senegalese children that were successfully treated for S. haematobium showed less intense re-infection if they were co-infected with S. mansoni at the point of treatment. Furthermore, in all three settings, the proportion of infections attributable to S. mansoni increased over successive rounds of PZQ treatment. These data suggest asymmetric competition may occur between S. haematobium and S. mansoni in the context of drug treatment, which may alter schistosome species composition as PZQ-based control programmes proceed

Knowles, SCL

Webster, BL

Garba, A

Sacko, M

Diaw, O

Fenwick, A

Rollinson, D

Webster, JP

Spiral - Imperial College Digital Repository

Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries

Background: In many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood. Methodology/Principal Findings: Here we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and Mali) to test whether the impact of praziquantel (PZQ) treatment, subsequent levels of re-infection or long-term infection dynamics are altered by co-infection. In all countries, positive associations between the two species prevailed at baseline: infection by one species tended to predict infection intensity for the other, with the strength of association varying across sites. Encouragingly, we found little evidence that co-infection influenced PZQ efficacy: species-specific egg reduction rates (ERR) and cure rates (CR) did not differ significantly with co-infection, and variation in treatment success was largely geographical. In Senegal, despite positive associations at baseline, children with S. mansoni co-infection at the time of treatment were less intensely re-infected by S. haematobium than those with single infections, suggesting competition between the species may occur post-treatment. Furthermore, the proportion of schistosome infections attributable to S. mansoni increased over time in all three countries examined. Conclusions/Significance: These findings suggest that while co-infection between urinary and intestinal schistosomes may not directly affect PZQ treatment efficacy, competitive interspecific interactions may influence epidemiological patterns of re-infection post-treatment. While re-infection patterns differed most strongly according to geographic location, interspecific interactions also seem to play a role, and could cause the community composition in mixed species settings to shift as disease control efforts intensify, a situation with implications for future disease management in this multi-species system

Knowles, Sarah C. L.

Webster, Bonnie L.

Garba, Amadou

Sacko, Moussa

Diaw, Oumar T.

Fenwick, Alan

Rollinson, David

Webster, Joanne P.

Dryad Digital Repository (Duke University)

Data from: Epidemiological interactions between urogenital and intestinal human schistosomiasis in the context of praziquantel treatment across three West African countries

Diaw, OT

Knowles, S C L

Webster, B L

Diaw, O T

Webster, J P

RVC Research Online

<div>BackgroundIn many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood.Methodology/Principal FindingsHere we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and Mali) to test whether the impact of praziquantel (PZQ) treatment, subsequent levels of re-infection or long-term infection dynamics are altered by co-infection. In all countries, positive associations between the two species prevailed at baseline: infection by one species tended to predict infection intensity for the other, with the strength of association varying across sites. Encouragingly, we found little evidence that co-infection influenced PZQ efficacy: species-specific egg reduction rates (ERR) and cure rates (CR) did not differ significantly with co-infection, and variation in treatment success was largely geographical. In Senegal, despite positive associations at baseline, children with S. mansoni co-infection at the time of treatment were less intensely re-infected by S. haematobium than those with single infections, suggesting competition between the species may occur post-treatment. Furthermore, the proportion of schistosome infections attributable to S. mansoni increased over time in all three countries examined.Conclusions/SignificanceThese findings suggest that while co-infection between urinary and intestinal schistosomes may not directly affect PZQ treatment efficacy, competitive interspecific interactions may influence epidemiological patterns of re-infection post-treatment. While re-infection patterns differed most strongly according to geographic location, interspecific interactions also seem to play a role, and could cause the community composition in mixed species settings to shift as disease control efforts intensify, a situation with implications for future disease management in this multi-species system.</div

Sarah C. L. Knowles (813792)

Bonnie L. Webster (125666)

Amadou Garba (125686)

Moussa Sacko (264313)

Oumar T. Diaw (370706)

Alan Fenwick (35322)

David Rollinson (103447)

Joanne P. Webster (125673)

The Francis Crick Institute

Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries

Crossref

© 2015 Knowles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.  The attached file is the published version of the article.NHM Repositor

Natural History Museum Repository

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BACKGROUND:In many parts of sub-Saharan Africa, urogenital and intestinal schistosomiasis co-occur, and mixed species infections containing both Schistosoma haematobium and S. mansoni can be common. During co-infection, interactions between these two species are possible, yet the extent to which such interactions influence disease dynamics or the outcome of control efforts remains poorly understood. METHODOLOGY/PRINCIPAL FINDINGS:Here we analyse epidemiological data from three West African countries co-endemic for urogenital and intestinal schistosomiasis (Senegal, Niger and Mali) to test whether the impact of praziquantel (PZQ) treatment, subsequent levels of re-infection or long-term infection dynamics are altered by co-infection. In all countries, positive associations between the two species prevailed at baseline: infection by one species tended to predict infection intensity for the other, with the strength of association varying across sites. Encouragingly, we found little evidence that co-infection influenced PZQ efficacy: species-specific egg reduction rates (ERR) and cure rates (CR) did not differ significantly with co-infection, and variation in treatment success was largely geographical. In Senegal, despite positive associations at baseline, children with S. mansoni co-infection at the time of treatment were less intensely re-infected by S. haematobium than those with single infections, suggesting competition between the species may occur post-treatment. Furthermore, the proportion of schistosome infections attributable to S. mansoni increased over time in all three countries examined. CONCLUSIONS/SIGNIFICANCE:These findings suggest that while co-infection between urinary and intestinal schistosomes may not directly affect PZQ treatment efficacy, competitive interspecific interactions may influence epidemiological patterns of re-infection post-treatment. While re-infection patterns differed most strongly according to geographic location, interspecific interactions also seem to play a role, and could cause the community composition in mixed species settings to shift as disease control efforts intensify, a situation with implications for future disease management in this multi-species system

Sarah C L Knowles

Bonnie L Webster

Oumar T Diaw

Joanne P Webster

Directory of Open Access Journals

Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries.

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https://researchonline.rvc.ac.uk/id/eprint/9437/1/9437.pdf

Epidemiological Interactions between Urogenital and Intestinal Human Schistosomiasis in the Context of Praziquantel Treatment across Three West African Countries

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Spiral - Imperial College Digital Repository

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