Quantum control of spin-correlations in ultracold lattice gases

We demonstrate that it is possible to prepare a lattice gas of ultracold atoms with a desired non-classical spin-correlation function using atom-light interaction of the kind routinely employed in quantum spin polarization spectroscopy. Our method is based on quantum non-demolition (QND) measurement and feedback, and allows in particular to create on demand exponentially or algebraically decaying correlations, as well as a certain degree of multi-partite entanglement.Comment: 2 figure

Kif15 functions as an active mechanical ratchet

Kif15 is a kinesin-12 that contributes critically to bipolar spindle assembly in humans. Here we use force-ramp experiments in an optical trap to probe the mechanics of single Kif15 molecules under hindering or assisting loads and in a variety of nucleotide states. Whilst unloaded Kif15 is established to be highly processive, we find that under hindering loads, Kif15 takes <∼10 steps. As hindering load is increased, Kif15 forestep:backstep ratio decreases exponentially, with stall occurring at 6 pN. By contrast, under assisting loads, Kif15 detaches readily and rapidly, even from its AMPPNP state. Kif15 mechanics thus depend markedly on the loading direction. Kif15 interacts with a binding partner, Tpx2, and we show that Tpx2 locks Kif15 to microtubules under both hindering and assisting loads. Overall, our data predict that Kif15 in the central spindle will act as a mechanical ratchet, supporting spindle extension but resisting spindle compression

Modified spin-wave theory with ordering vector optimization I: frustrated bosons on the spatially anisotropic triangular lattice

We investigate a system of frustrated hardcore bosons, modeled by an XY antiferromagnet on the spatially anisotropic triangular lattice, using Takahashi's modified spin-wave (MSW) theory. In particular we implement ordering vector optimization on the ordered reference state of MSW theory, which leads to significant improvement of the theory and accounts for quantum corrections to the classically ordered state. The MSW results at zero temperature compare favorably to exact diagonalization (ED) and projected entangled-pair state (PEPS) calculations. The resulting zero-temperature phase diagram includes a 1D quasi-ordered phase, a 2D Neel ordered phase, and a 2D spiraling ordered phase. We have strong indications that the various ordered or quasi-ordered phases are separated by spin-liquid phases with short-range correlations, in analogy to what has been predicted for the Heisenberg model on the same lattice. Within MSW theory we also explore the finite-temperature phase diagram. We find that the zero-temperature long-range-ordered phases turn into quasi-ordered phases (up to a Berezinskii-Kosterlitz-Thouless temperature), while zero-temperature quasi-ordered phases become short-range correlated at finite temperature. These results show that modified spin-wave theory is very well suited for describing ordered and quasi-ordered phases of frustrated XY spins (or, equivalently, of frustrated lattice bosons) both at zero and finite temperatures. While MSW theory, just as other theoretical methods, cannot describe spin-liquid phases, its breakdown provides a fast method for singling out Hamiltonians which may feature these intriguing quantum phases. We thus suggest a tool for guiding our search for interesting systems whose properties are necessarily studied with a physical quantum simulator.Comment: 40 pages, 16 figure

A Diffusion Model Analysis

Effects of stimulus length on reaction times (RTs) in the lexical decision task are the topic of extensive research. While slower RTs are consistently found for longer pseudo-words, a finding coined the word length effect (WLE), some studies found no effects for words, and yet others reported faster RTs for longer words. Moreover, the WLE depends on the orthographic transparency of a language, with larger effects in more transparent orthographies. Here we investigate processes underlying the WLE in lexical decision in German-English bilinguals using a diffusion model (DM) analysis, which we compared to a linear regression approach. In the DM analysis, RT-accuracy distributions are characterized using parameters that reflect latent sub-processes, in particular evidence accumulation and decision-independent perceptual encoding, instead of typical parameters such as mean RT and accuracy. The regression approach showed a decrease in RTs with length for pseudo-words, but no length effect for words. However, DM analysis revealed that the null effect for words resulted from opposing effects of length on perceptual encoding and rate of evidence accumulation. Perceptual encoding times increased with length for words and pseudo-words, whereas the rate of evidence accumulation increased with length for real words but decreased for pseudo-words. A comparison between DM parameters in German and English suggested that orthographic transparency affects perceptual encoding, whereas effects of length on evidence accumulation are likely to reflect contextual information and the increase in available perceptual evidence with length. These opposing effects may account for the inconsistent findings on WLEs

Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab

We describe a case of progressive multifocal leukoencephalopathy (PML) caused by infection with the human polyomavirus JC virus in a patient with B-cell small lymphocytic leukemia who was treated with rituximab. The first symptoms of PML appeared immediately following the last of five cycles of rituximab, cyclophosphamide and pentostatin. Magnetic resonance imaging revealed changes consistent with PML, although JC virus DNA was not detected by polymerase chain reaction assay of the cerebrospinal fluid. A stereotactic biopsy of the brain showed histological changes consistent with PML, while electron microscopy revealed JC virus particles attached to the nuclei of astrocytes. The patient was treated supportively but died 53 days after the initial onset of symptoms

HST/WFC3 Observations of an Off-Nuclear Superbubble in Arp 220

We present a high spatial resolution optical and infrared study of the circumnuclear region in Arp 220, a late-stage galaxy merger. Narrowband imaging using HST/WFC3 has resolved the previously observed peak in H$\alpha$+[NII] emission into a bubble-shaped feature. This feature measures 1.6" in diameter, or 600 pc, and is only 1" northwest of the western nucleus. The bubble is aligned with the western nucleus and the large-scale outflow axis seen in X-rays. We explore several possibilities for the bubble origin, including a jet or outflow from a hidden active galactic nucleus (AGN), outflows from high levels of star formation within the few hundred pc nuclear gas disk, or an ultraluminous X-ray source. An obscured AGN or high levels of star formation within the inner $\sim$100 pc of the nuclei are favored based on the alignment of the bubble and energetics arguments.Comment: Accepted for publication in ApJ. 12 pages, 10 figure

Early respiratory viral infections in infants with cystic fibrosis

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Background Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. Methods Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months of life. Results Seventy infants were enrolled, mean age 3.1 ± 0.8 months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0–10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. Conclusions Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF

Prospects for harnessing biocide resistance for bioremediation and detoxification

Prokaryotes in natural environments respond rapidly to high concentrations of chemicals and physical stresses. Exposure to anthropogenic toxic substancessuch as oil, chlorinated solvents, or antibioticsfavors the evolution of resistant phenotypes, some of which can use contaminants as an exclusive carbon source or as electron donors and acceptors. Microorganisms similarly adapt to extreme pH, metal, or osmotic stress. The metabolic plasticity of prokaryotes can thus be harnessed for bioremediation and can be exploited in a variety of ways, ranging from stimulated natural attenuation to bioaugmentation and from wastewater treatment to habitat restoration.We thank H. Stroo (Stroo Consulting) and C. Aziz (Ramboll) for providing photographs of bioaugmentation with OHRB, and H. Patzelt (Mazoon Environmental and Technological Services) for providing photographs of bioaugmentation with halophilic microorganisms. Funding: S.A., I.S.-A., and A.J.M.S. are supported by the Netherlands Ministry of Education, Culture and Science (project 024.002.002) and advanced ERC grant (project 323009). H.S. and S.A. were supported by a grant of BE-Basic-FES funds from the Dutch Ministry of Economic Affairs. H.S., J.R.v.d.M., and H.J.H. were supported by the European Commission (BACSIN, contract 211684; P4SB, contract 633962).info:eu-repo/semantics/publishedVersio

Many-body localization in a quantum simulator with programmable random disorder

When a system thermalizes it loses all local memory of its initial conditions. This is a general feature of open systems and is well described by equilibrium statistical mechanics. Even within a closed (or reversible) quantum system, where unitary time evolution retains all information about its initial state, subsystems can still thermalize using the rest of the system as an effective heat bath. Exceptions to quantum thermalization have been predicted and observed, but typically require inherent symmetries or noninteracting particles in the presence of static disorder. The prediction of many-body localization (MBL), in which disordered quantum systems can fail to thermalize in spite of strong interactions and high excitation energy, was therefore surprising and has attracted considerable theoretical attention. Here we experimentally generate MBL states by applying an Ising Hamiltonian with long-range interactions and programmably random disorder to ten spins initialized far from equilibrium. We observe the essential signatures of MBL: memory retention of the initial state, a Poissonian distribution of energy level spacings, and entanglement growth in the system at long times. Our platform can be scaled to higher numbers of spins, where detailed modeling of MBL becomes impossible due to the complexity of representing such entangled quantum states. Moreover, the high degree of control in our experiment may guide the use of MBL states as potential quantum memories in naturally disordered quantum systems.Comment: 9 pages, 9 figure